{"id":"https://openalex.org/W4417314892","doi":"https://doi.org/10.1158/0008-5472.30883264","title":"Supplementary Figure S12 from Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma","display_name":"Supplementary Figure S12 from Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W4417314892","doi":"https://doi.org/10.1158/0008-5472.30883264"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.30883264","doi":"https://doi.org/10.1158/0008-5472.30883264","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.30883264","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.30883264","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071191729","display_name":"Guofei Cui","orcid":"https://orcid.org/0009-0005-5624-0403","observed_orcids":["https://orcid.org/0009-0005-5624-0403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guofei Cui","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5624-0403","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076955106","display_name":"Yi Zhou","orcid":"https://orcid.org/0009-0009-5559-3417","observed_orcids":["https://orcid.org/0009-0009-5559-3417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5559-3417","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071098126","display_name":"Weiting Liao","orcid":"https://orcid.org/0000-0003-0667-2046","observed_orcids":["https://orcid.org/0000-0003-0667-2046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiting Liao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0667-2046","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104798846","display_name":"Eleonora Cossu","orcid":"https://orcid.org/0009-0004-3437-0066","observed_orcids":["https://orcid.org/0009-0004-3437-0066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleonora Cossu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-3437-0066","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112733522","display_name":"Matthias Evert","orcid":"https://orcid.org/0009-0004-3978-8058","observed_orcids":["https://orcid.org/0009-0004-3978-8058"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias Evert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-3978-8058","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452834","display_name":"Shu Zhang","orcid":"https://orcid.org/0009-0005-0368-9397","observed_orcids":["https://orcid.org/0009-0005-0368-9397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-0368-9397","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040373155","display_name":"Jingxiao Wang","orcid":"https://orcid.org/0000-0002-7799-781X","observed_orcids":["https://orcid.org/0000-0002-7799-781X","https://orcid.org/0000-0002-3807-7754","https://orcid.org/0000-0001-8070-9543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingxiao Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7799-781X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010391574","display_name":"Shanshan Deng","orcid":"https://orcid.org/0000-0003-4646-5885","observed_orcids":["https://orcid.org/0000-0003-4646-5885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanshan Deng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4646-5885","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099382429","display_name":"Andrew Yonemura","orcid":"https://orcid.org/0009-0009-5701-8678","observed_orcids":["https://orcid.org/0009-0009-5701-8678"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Yonemura","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5701-8678","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089214395","display_name":"Lucie David","orcid":"https://orcid.org/0009-0008-0819-7107","observed_orcids":["https://orcid.org/0009-0008-0819-7107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucie David","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-0819-7107","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112636204","display_name":"Meng Michelle Xu","orcid":"https://orcid.org/0000-0002-6118-9965","observed_orcids":["https://orcid.org/0000-0002-6118-9965","https://orcid.org/0009-0007-1639-5640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meng Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6118-9965","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119606313","display_name":"Juliette M. Doumergue","orcid":"https://orcid.org/0009-0003-6827-4761","observed_orcids":["https://orcid.org/0009-0003-6827-4761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juliette M. Doumergue","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6827-4761","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108989754","display_name":"Xinjun Lu","orcid":"https://orcid.org/0000-0002-7643-0854","observed_orcids":["https://orcid.org/0000-0002-7643-0854"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinjun Lu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7643-0854","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029404221","display_name":"Lihui Yang","orcid":"https://orcid.org/0009-0005-1261-1444","observed_orcids":["https://orcid.org/0009-0005-1261-1444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lihui Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-1261-1444","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091167951","display_name":"Jinghua Li","orcid":"https://orcid.org/0000-0002-6755-955X","observed_orcids":["https://orcid.org/0000-0002-6755-955X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinghua Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6755-955X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013275364","display_name":"Binyong Liang","orcid":"https://orcid.org/0009-0006-2749-7434","observed_orcids":["https://orcid.org/0009-0006-2749-7434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Binyong Liang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-2749-7434","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015132037","display_name":"Haichuan Wang","orcid":"https://orcid.org/0000-0002-6886-5698","observed_orcids":["https://orcid.org/0000-0002-6886-5698","https://orcid.org/0009-0004-3790-0704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haichuan Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6886-5698","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hongwei Xu","orcid":"https://orcid.org/0000-0002-1411-3722","observed_orcids":["https://orcid.org/0000-0002-1411-3722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongwei Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1411-3722","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110145057","display_name":"Sheng Wen Zhong","orcid":"https://orcid.org/0009-0000-6178-4505","observed_orcids":["https://orcid.org/0009-0000-6178-4505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheng Zhong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-6178-4505","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042435594","display_name":"Youping Deng","orcid":"https://orcid.org/0000-0002-5951-8213","observed_orcids":["https://orcid.org/0000-0002-5951-8213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youping Deng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5951-8213","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091038323","display_name":"Diego Francesco Calvisi","orcid":"https://orcid.org/0000-0002-6038-8567","observed_orcids":["https://orcid.org/0000-0002-6038-8567"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diego F. Calvisi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6038-8567","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101579555","display_name":"Jinqiu Zhao","orcid":"https://orcid.org/0000-0001-9745-3230","observed_orcids":["https://orcid.org/0000-0001-9745-3230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinqiu Zhao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9745-3230","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363101","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-9588-0164","observed_orcids":["https://orcid.org/0000-0002-9588-0164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9588-0164","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066878095","display_name":"Xue Wang","orcid":"https://orcid.org/0009-0009-4148-0788","observed_orcids":["https://orcid.org/0009-0009-4148-0788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xue Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4148-0788","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxm1","display_name":"FOXM1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/crispr-guide-rna","display_name":"CRISPR guide RNA","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8320000171661377},{"id":"https://openalex.org/keywords/gsk-3-inhibition","display_name":"GSK3 inhibition","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tsc2","display_name":"TSC2","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7321000099182129},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6816999912261963},{"id":"https://openalex.org/C2779422105","wikidata":"https://www.wikidata.org/wiki/Q21109261","display_name":"TSC2","level":4,"score":0.6276000142097473},{"id":"https://openalex.org/C170240278","wikidata":"https://www.wikidata.org/wiki/Q17928773","display_name":"FOXM1","level":4,"score":0.5149999856948853},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5084999799728394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48539999127388},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.39719998836517334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3671000003814697},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3614000082015991},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.35040000081062317},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3174000084400177},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27399998903274536},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2547999918460846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.30883264","doi":"https://doi.org/10.1158/0008-5472.30883264","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.30883264","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.30883264","doi":"https://doi.org/10.1158/0008-5472.30883264","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.30883264","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414161605","https://openalex.org/W4417341958","https://openalex.org/W2955210207","https://openalex.org/W2947381342","https://openalex.org/W2403478927","https://openalex.org/W3094006110","https://openalex.org/W2804564166","https://openalex.org/W2886084318","https://openalex.org/W2971891399","https://openalex.org/W2915259748"],"abstract_inverted_index":{"Efficiency":[0],"of":[1],"CRISPR":[2],"guide":[3],"RNA":[4],"Foxm1":[5,9],"against":[6],"the":[7],"mouse":[8],"gene":[10]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-12-15T00:00:00"}
