{"id":"https://openalex.org/W4417286604","doi":"https://doi.org/10.21203/rs.3.rs-10598602/v1","title":"High-Risk Transition Zone Prostate Cancers Confer a Heightened Risk for Positive Surgical Margins After Radical Prostatectomy","display_name":"High-Risk Transition Zone Prostate Cancers Confer a Heightened Risk for Positive Surgical Margins After Radical Prostatectomy","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4417286604","doi":"https://doi.org/10.21203/rs.3.rs-10598602/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10598602/v1","doi":"https://doi.org/10.21203/rs.3.rs-10598602/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10598602/v1","pdf_url":"https://www.researchsquare.com/article/rs-10598602/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10598602/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100363101","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-9588-0164","observed_orcids":["https://orcid.org/0000-0002-9588-0164"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["First Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101455579","display_name":"Haodong Xu","orcid":"https://orcid.org/0000-0001-6381-6304","observed_orcids":["https://orcid.org/0000-0001-6381-6304"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haodong Xu","raw_affiliation_strings":["First Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007433995","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0002-7973-8416","observed_orcids":["https://orcid.org/0000-0002-7973-8416"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["First Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135611465","display_name":"Zhenyu Hang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Hang","raw_affiliation_strings":["First Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tianyi Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyi Xia","raw_affiliation_strings":["Nantong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantong University","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100369755","display_name":"Chen Li","orcid":"https://orcid.org/0000-0001-5385-6249","observed_orcids":["https://orcid.org/0000-0001-5385-6249","https://orcid.org/0009-0002-8498-0562","https://orcid.org/0009-0007-2357-644X"]},"institutions":[{"id":"https://openalex.org/I4210125177","display_name":"Wuxi No.2 People's Hospital","ror":"https://ror.org/0399zkh42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125177"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Li","raw_affiliation_strings":["Wuxi No.2 People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuxi No.2 People's Hospital","institution_ids":["https://openalex.org/I4210125177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147065389","display_name":"Zhenfan Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhenfan Wang","raw_affiliation_strings":["Suzhou Ninth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suzhou Ninth People\u2019s Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002365671","display_name":"Yuxin Lin","orcid":"https://orcid.org/0000-0001-6543-0317","observed_orcids":["https://orcid.org/0000-0001-6543-0317"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Lin","raw_affiliation_strings":["First Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100743117","display_name":"Yuhua Huang","orcid":"https://orcid.org/0000-0002-0341-0078","observed_orcids":["https://orcid.org/0000-0002-0341-0078","https://orcid.org/0000-0002-4161-1866","https://orcid.org/0009-0007-7958-6196","https://orcid.org/0000-0001-5853-2489"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhua Huang","raw_affiliation_strings":["First Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725526","display_name":"Jianquan Hou","orcid":"https://orcid.org/0000-0001-9416-3713","observed_orcids":["https://orcid.org/0000-0001-9416-3713","https://orcid.org/0000-0002-3445-2625","https://orcid.org/0000-0001-7049-0701"]},"institutions":[{"id":"https://openalex.org/I4392738115","display_name":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","ror":"https://ror.org/04n3e7v86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4392738115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianquan Hou","raw_affiliation_strings":["The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","institution_ids":["https://openalex.org/I4392738115"]}]},{"author_position":"last","author":{"id":null,"display_name":"Xuedong Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuedong Wei","raw_affiliation_strings":["First Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/positive-surgical-margins","display_name":"positive surgical margins","score":0.9679999947547913},{"id":"https://openalex.org/keywords/laparoscopic-radical-prostatectomy","display_name":"laparoscopic radical prostatectomy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/nerve-sparing-surgery","display_name":"nerve-sparing surgery","score":0.847000002861023},{"id":"https://openalex.org/keywords/multiparametric-mri","display_name":"multiparametric MRI","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8055999875068665},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.7384999990463257},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6200000047683716},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5742999911308289},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5364999771118164},{"id":"https://openalex.org/C2779819210","wikidata":"https://www.wikidata.org/wiki/Q6488115","display_name":"Laparoscopic radical prostatectomy","level":5,"score":0.4950999915599823},{"id":"https://openalex.org/C2778913397","wikidata":"https://www.wikidata.org/wiki/Q7646216","display_name":"Surgical margin","level":3,"score":0.42739999294281006},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.4131999909877777},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3538999855518341},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.3240000009536743},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.28790000081062317},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.26440000534057617}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21203/rs.3.rs-10598602/v1","doi":"https://doi.org/10.21203/rs.3.rs-10598602/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10598602/v1","pdf_url":"https://www.researchsquare.com/article/rs-10598602/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.2139/ssrn.5905236","doi":"https://doi.org/10.2139/ssrn.5905236","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5905236","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10598602/v1","doi":"https://doi.org/10.21203/rs.3.rs-10598602/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10598602/v1","pdf_url":"https://www.researchsquare.com/article/rs-10598602/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5535701846","display_name":null,"funder_award_id":"32200533","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6443670983","display_name":null,"funder_award_id":"82572292","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6540350942","display_name":null,"funder_award_id":"BK20241796","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417286604.pdf","grobid_xml":"https://content.openalex.org/works/W4417286604.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410299730","https://openalex.org/W3026657249","https://openalex.org/W4392760848","https://openalex.org/W2023627046","https://openalex.org/W2921868494","https://openalex.org/W2038448849","https://openalex.org/W1981416955","https://openalex.org/W4388267635","https://openalex.org/W2586733798","https://openalex.org/W4413133575"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Despite":[2,106],"the":[3,23,83,116,129,163],"elevated":[4,68,130],"risk":[5,191],"of":[6,170],"positive":[7],"surgical":[8,38],"margins":[9],"(PSM)":[10],"in":[11,77,95,101,139,159,168,192,235],"certain":[12],"transition":[13],"zone":[14,74],"(TZ)":[15],"prostate":[16],"cancers":[17],"after":[18,54],"laparoscopic":[19],"radical":[20],"prostatectomy":[21],"(LRP),":[22],"underlying":[24],"causes":[25],"remain":[26],"unclear.":[27],"This":[28,41],"study":[29,43],"seeks":[30],"to":[31,35,72,188,210],"identify":[32],"key":[33],"determinants":[34],"inform":[36],"personalized":[37],"strategies.":[39],"Methods":[40],"retrospective":[42],"included":[44],"451":[45],"patients":[46,92],"from":[47],"three":[48],"high-volume":[49],"centers":[50],"who":[51],"underwent":[52],"LRP":[53],"preoperative":[55],"multiparametric":[56],"magnetic":[57],"resonance":[58],"imaging":[59],"between":[60,110],"2022":[61],"and":[62,80,112,144,161],"2023.":[63],"Results":[64],"TZ":[65,96,114,127,171,178,194,201,223],"tumors":[66,76,97,179,195,224],"exhibited":[67,120,180],"PSM":[69,94,108,118,131,172,176,190,215],"rates":[70,109],"compared":[71],"peripheral":[73],"(PZ)":[75],"both":[78],"pT2":[79,126,213],"pT3.":[81],"In":[82,212],"pT3":[84,200],"cohort,":[85],"clinical":[86,123,183,203],"under-staging":[87,204],"was":[88,133,152,196],"more":[89,121,154,181,229],"frequent":[90],"among":[91],"with":[93,147,225],"(69%":[98],"vs.":[99,137,157,166],"28%":[100],"PZ,":[102,140],"P":[103],"<":[104],"0.01).":[105],"comparable":[107],"under-staged":[111,117],"correctly-staged":[113],"tumors,":[115,128,202],"cases":[119],"favorable":[122],"characteristics.":[124],"For":[125,199],"rate":[132],"predominantly":[134],"apex":[135,177,193,222],"(36%":[136],"21%":[138],"p":[141],"=":[142],"0.03)":[143],"strongly":[145],"associated":[146],"nerve-sparing":[148],"surgery":[149],"(NS).":[150],"NS":[151,234],"performed":[153],"frequently":[155],"(59%":[156],"19%":[158],"PZ)":[160,169],"constituted":[162],"majority":[164],"(86%":[165],"29%":[167],"cases.":[173,237],"Furthermore,":[174],"these":[175,236],"adverse":[182,226],"features.":[184],"Accordingly,":[185],"a":[186,206],"model":[187],"predict":[189],"established.":[197],"Conclusions":[198],"is":[205,217],"critical":[207],"factor":[208],"leading":[209],"PSM.":[211],"disease,":[214],"prevention":[216],"paramount":[218],"when":[219],"operating":[220],"on":[221],"features,":[227],"necessitating":[228],"stringent":[230],"selection":[231],"criteria":[232],"for":[233]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-12-12T00:00:00"}
