{"id":"https://openalex.org/W4417211169","doi":"https://doi.org/10.1055/s-0045-1813889","title":"Evaluating astrocyte reactivity as a therapeutic target and diagnostic tool in perinatal brain injury","display_name":"Evaluating astrocyte reactivity as a therapeutic target and diagnostic tool in perinatal brain injury","publication_year":2025,"publication_date":"2025-12-01","ids":{"openalex":"https://openalex.org/W4417211169","doi":"https://doi.org/10.1055/s-0045-1813889"},"language":"en","primary_location":{"id":"doi:10.1055/s-0045-1813889","doi":"https://doi.org/10.1055/s-0045-1813889","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0045-1813889","pdf_url":null,"source":{"id":"https://openalex.org/S72845316","display_name":"Zeitschrift f\u00fcr Geburtshilfe und Neonatologie","issn_l":"0948-2393","issn":["0948-2393","1439-1651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Geburtshilfe und Neonatologie","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023587852","display_name":"Amanda Brosius Lutz","orcid":"https://orcid.org/0000-0002-6063-0480","observed_orcids":["https://orcid.org/0000-0002-6063-0480"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A Brosius Lutz","raw_affiliation_strings":["Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","University of Bern, Department for BioMedical Research, Bern, Schweiz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Department for BioMedical Research, Bern, Schweiz","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P Renz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P Renz","raw_affiliation_strings":["Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","University of Bern, Department for BioMedical Research, Bern, Schweiz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Department for BioMedical Research, Bern, Schweiz","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087311434","display_name":"Marel Steinfort","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M Steinfort","raw_affiliation_strings":["Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","University of Bern, Department for BioMedical Research, Bern, Schweiz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Department for BioMedical Research, Bern, Schweiz","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026923926","display_name":"Elisabeth Liedtke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"E Liedtke","raw_affiliation_strings":["Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","University of Bern, Department for BioMedical Research, Bern, Schweiz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Department for BioMedical Research, Bern, Schweiz","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Sing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Sing","raw_affiliation_strings":["Emory University, Department of Genetics, Emory, GA, Vereinigte Staaten"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Department of Genetics, Emory, GA, Vereinigte Staaten","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047694802","display_name":"Val\u00e9rie Haesler","orcid":"https://orcid.org/0000-0001-8470-0052","observed_orcids":["https://orcid.org/0000-0001-8470-0052"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"V Haesler","raw_affiliation_strings":["Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","University of Bern, Department for BioMedical Research, Bern, Schweiz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Department for BioMedical Research, Bern, Schweiz","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082808793","display_name":"Shane Antony Liddelow","orcid":"https://orcid.org/0000-0002-0840-1437","observed_orcids":["https://orcid.org/0000-0002-0840-1437"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Liddelow","raw_affiliation_strings":["New York University, Deparment of Neuroscience, New York, NY, Vereinigte Staaten"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University, Deparment of Neuroscience, New York, NY, Vereinigte Staaten","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043980648","display_name":"David H. Rowitch","orcid":"https://orcid.org/0000-0002-0079-0060","observed_orcids":["https://orcid.org/0000-0002-0079-0060"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Rowitch","raw_affiliation_strings":["University of Cambridge, Pediatrics, Cambridge, Vereinigtes K\u00f6nigreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge, Pediatrics, Cambridge, Vereinigtes K\u00f6nigreich","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008594669","display_name":"Steven A. Sloan","orcid":"https://orcid.org/0000-0001-7769-7684","observed_orcids":["https://orcid.org/0000-0001-7769-7684"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Sloan","raw_affiliation_strings":["Emory University, Department of Genetics, Emory, GA, Vereinigte Staaten"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Department of Genetics, Emory, GA, Vereinigte Staaten","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031495521","display_name":"Andreina Schoeberlein","orcid":"https://orcid.org/0000-0002-6716-9551","observed_orcids":["https://orcid.org/0000-0002-6716-9551"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A Schoeberlein","raw_affiliation_strings":["Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","University of Bern, Department for BioMedical Research, Bern, Schweiz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Department for BioMedical Research, Bern, Schweiz","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021781647","display_name":"Daniel Surbek","orcid":"https://orcid.org/0000-0001-7705-1584","observed_orcids":["https://orcid.org/0000-0001-7705-1584"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D Surbek","raw_affiliation_strings":["Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","University of Bern, Department for BioMedical Research, Bern, Schweiz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inselspital, Bern University Hospital, Department of Obstetrics and Gynecology, Bern, Schweiz","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Department for BioMedical Research, Bern, Schweiz","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.46080965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"229","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.7379999756813049},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.6050000190734863},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.5809999704360962},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/astrocyte-secretome","display_name":"astrocyte secretome","score":0.800000011920929},{"id":"https://openalex.org/keywords/maternal-blood-biomarkers","display_name":"maternal blood biomarkers","score":0.6690000295639038},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.5040000081062317},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6079999804496765},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.6890000104904175},{"id":"https://openalex.org/keywords/c1q","display_name":"C1q","score":0.9179999828338623},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.7099999785423279},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.39899998903274536},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.6858000159263611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6377000212669373},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4837999939918518},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.37139999866485596},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36039999127388},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.29490000009536743},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C2780164069","wikidata":"https://www.wikidata.org/wiki/Q2694437","display_name":"Perinatal asphyxia","level":3,"score":0.226500004529953},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22579999268054962},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.2232999950647354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0045-1813889","doi":"https://doi.org/10.1055/s-0045-1813889","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0045-1813889","pdf_url":null,"source":{"id":"https://openalex.org/S72845316","display_name":"Zeitschrift f\u00fcr Geburtshilfe und Neonatologie","issn_l":"0948-2393","issn":["0948-2393","1439-1651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Geburtshilfe und Neonatologie","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414563551","https://openalex.org/W3127096603","https://openalex.org/W4400041329","https://openalex.org/W2997733320","https://openalex.org/W4313451810","https://openalex.org/W3122769134","https://openalex.org/W6891655341","https://openalex.org/W4319164657","https://openalex.org/W2329652408","https://openalex.org/W2412253741"],"abstract_inverted_index":{"Introduction":[0],"Hypoxic":[1],"and":[2,13,30,44,65,74,93,118,135,199,217,234,248,269,319,356,359,372,444,466],"inflammatory":[3],"insults":[4],"to":[5,19,67,162,201,286,344],"the":[6,11,46,85,126,154,203,210,301,342,377,388,424,442],"developing":[7],"human":[8,320],"brain":[9,182,264,282,412,480],"between":[10],"23rd":[12],"32nd":[14],"week":[15],"of":[16,22,34,49,83,88,179,191,205,231,300,380,391,400,410,417,426,441,446,455],"gestation":[17],"lead":[18],"long-term":[20,50],"disruption":[21],"myelination":[23,354],"accompanied":[24],"by":[25],"reactive":[26,89,130,207,243,302,324,347,392,447],"changes":[27,166],"in":[28,53,91,96,112,133,140,151,167,173,195,209,225,291,305,309,330,383,403,420,430,449,464,482],"astrocytes":[29,58,90,131,208,325,348,448],"microglia.":[31],"This":[32,451],"pattern":[33],"injury":[35,42,413,481],"is":[36,45,79],"known":[37],"as":[38,114,177,385,387,408,458],"perinatal":[39],"white":[40,335],"matter":[41,336],"(WMI)":[43],"major":[47],"form":[48,132,345],"neurologic":[51],"morbidity":[52],"infants":[54],"born":[55],"preterm.":[56],"Reactive":[57],"are":[59,99,326],"increasingly":[60],"recognized":[61],"for":[62,476],"their":[63,94],"diversity":[64],"ability":[66,343],"actively":[68],"influence":[69],"disease":[70,97,141],"outcomes,":[71],"both":[72],"positively":[73],"negatively.":[75],"While":[76],"astrocyte":[77,110,149,168,244,249,289,303,381,393,401,456],"reactivity":[78,111,150,169,290,382,402,457],"a":[80,115,137,144,459],"histological":[81],"hallmark":[82],"WMI,":[84,192],"molecular":[86,378],"identity":[87],"WMI":[92,113,134,152,384,404,465],"role":[95,139,445],"pathophysiology":[98],"still":[100],"unclear.":[101],"Here":[102],"we":[103,124,147,158,193],"report":[104],"our":[105,439,471],"recent":[106],"progress":[107],"towards":[108,469],"evaluating":[109],"therapeutic":[116,462],"target":[117,463],"diagnostic":[119,474],"tool.":[120],"In":[121,143,185,316],"one":[122],"approach,":[123],"test":[125],"hypothesis":[127],"that":[128,405],"neuroinflammatory":[129,206,242,323,346],"play":[136],"causal":[138],"outcomes.":[142],"second":[145],"aim,":[146],"characterize":[148],"at":[153,266],"single-cell":[155],"level.":[156],"Finally,":[157],"conduct":[159],"proof-of-principle":[160],"experiments":[161,311,419],"determine":[163],"whether":[164],"early":[165,411],"might":[170],"be":[171],"detectable":[172],"maternal":[174,292,431],"peripheral":[175,293,432],"circulation":[176],"biomarkers":[178,409],"impending":[180],"fetal":[181,288],"injury.":[183,214,273],"Methods":[184],"an":[186],"established":[187],"hypoxia/inflammation":[188],"mouse":[189,262,313],"model":[190],"used":[194],"situ":[196],"hybridization":[197],"(ISH)":[198,247],"qRTPCR":[200],"investigate":[202],"presence":[204],"corpus":[211,352],"callosum":[212,353],"after":[213,272],"Myelination":[215],"(MBP)":[216],"behavior":[218],"(Rotarod,":[219],"Novel":[220],"Object":[221],"Test)":[222],"was":[223,259,277,295],"assessed":[224],"transgenic":[226],"(TKO)":[227],"mice":[228,318,340,422],"lacking":[229,341],"expression":[230],"Tnf,":[232],"Il1a,":[233],"C1q.":[235],"Human":[236],"postmortem":[237,321],"brains":[238],"were":[239],"labeled":[240],"with":[241,308,333,364,479],"marker":[245,250],"C3":[246],"GFAP":[251],"(IHC).":[252],"Single":[253,368],"nucleus":[254,369],"RNA":[255,370],"sequencing":[256,371],"(10x":[257],"Genomics)":[258],"performed":[260,278],"on":[261,279],"whole":[263],"samples":[265],"12":[267],"hours":[268],"four":[270],"days":[271],"Visium":[274,373],"spatial":[275,374,389],"transcriptomics":[276,375],"corresponding":[280],"coronal":[281],"sections.":[283],"The":[284,435],"potential":[285,460],"detect":[287],"blood":[294],"tested":[296],"using":[297],"proteomic":[298],"analysis":[299,396],"secretome":[304],"vitro":[306],"combined":[307],"vivo":[310],"during":[312,414],"pregnancy.":[314,415],"Results":[315],"wildtype":[317,366],"brains,":[322],"significantly":[327,350],"more":[328],"abundant":[329],"injured":[331,365],"compared":[332,363],"control":[334],"(p<0.01).":[337],"Injured":[338],"TKO":[339],"exhibit":[349],"improved":[351],"(p<0.01)":[355],"motor":[357],"(p<0.005)":[358],"cognitive":[360],"(p<0.05)":[361],"performance":[362],"mice.":[367],"elucidate":[376],"nature":[379,443],"well":[386],"distribution":[390],"sub-types.":[394],"Proteomic":[395],"reveals":[397],"secretome-based":[398],"signatures":[399,429],"could":[406],"serve":[407],"Proof":[416],"principle":[418],"pregnant":[421],"indicate":[423],"feasibility":[425],"detecting":[427,477],"these":[428],"circulation.":[433],"Conclusions":[434],"results":[436],"presented":[437],"improve":[438],"understanding":[440],"WMI.":[450],"work":[452],"enables":[453],"evaluation":[454],"novel":[461],"makes":[467],"steps":[468],"expanding":[470],"very":[472],"limited":[473],"toolbox":[475],"fetuses":[478],"utero.":[483],"Publication":[484],"History":[485],"Article":[486],"published":[487],"online:":[488],"10":[489],"December":[490],"2025":[491],"\u00a9":[492],"2025.":[493],"Thieme.":[494],"All":[495],"rights":[496],"reserved.":[497],"Georg":[498],"Thieme":[499],"Verlag":[500],"KG":[501],"Oswald-Hesse-Stra\u00dfe":[502],"50,":[503],"70469":[504],"Stuttgart,":[505],"Germany":[506]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-12-11T00:00:00"}