{"id":"https://openalex.org/W4417207129","doi":"https://doi.org/10.1016/j.rpth.2025.103096","title":"HTRS2025.P2.77 Once every two weeks administration of Mim8 prophylaxis for patients with hemophilia A with or without inhibitors: Interim safety and efficacy analysis of the FRONTIER4 open-label extension study","display_name":"HTRS2025.P2.77 Once every two weeks administration of Mim8 prophylaxis for patients with hemophilia A with or without inhibitors: Interim safety and efficacy analysis of the FRONTIER4 open-label extension study","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4417207129","doi":"https://doi.org/10.1016/j.rpth.2025.103096"},"language":"en","primary_location":{"id":"doi:10.1016/j.rpth.2025.103096","doi":"https://doi.org/10.1016/j.rpth.2025.103096","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2025.103096","pdf_url":"https://www.rpthjournal.org/article/S2475-0379(25)00420-0/pdf","source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.rpthjournal.org/article/S2475-0379(25)00420-0/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053742746","display_name":"Vlady Ostrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106615","display_name":"Novo Nordisk (United States)","ror":"https://ror.org/011y67d23","country_code":"US","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210106615","https://openalex.org/I4210159963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vlady Ostrow","raw_affiliation_strings":["Novo Nordisk Inc, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Inc, United States","institution_ids":["https://openalex.org/I4210106615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007594357","display_name":"Atanas Banchev","orcid":"https://orcid.org/0000-0001-6148-3737","observed_orcids":["https://orcid.org/0000-0001-6148-3737"]},"institutions":[{"id":"https://openalex.org/I2801370615","display_name":"Queen Giovanna Hospital","ror":"https://ror.org/050fh0z31","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I2801370615"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Atanas Banchev","raw_affiliation_strings":["Paediatric Haematology and Oncology Department, University Hospital Tsaritsa Giovanna \u2013 ISUL, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Haematology and Oncology Department, University Hospital Tsaritsa Giovanna \u2013 ISUL, Sofia, Bulgaria","institution_ids":["https://openalex.org/I2801370615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067149049","display_name":"Johanna A. Kremer Hovinga","orcid":"https://orcid.org/0000-0002-1300-7135","observed_orcids":["https://orcid.org/0000-0002-1300-7135"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Johanna A. Kremer Hovinga","raw_affiliation_strings":["Department of Hematology and Central Hematology Laboratory, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Central Hematology Laboratory, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064079929","display_name":"Jerzy Windyga","orcid":"https://orcid.org/0000-0001-7877-4784","observed_orcids":["https://orcid.org/0000-0001-7877-4784"]},"institutions":[{"id":"https://openalex.org/I4210090876","display_name":"Instytut Hematologii i Transfuzjologi","ror":"https://ror.org/00csw7971","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210090876"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jerzy Windyga","raw_affiliation_strings":["Department of Hemostasis Disorders and Internal Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemostasis Disorders and Internal Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland","institution_ids":["https://openalex.org/I4210090876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050723834","display_name":"V\u00edctor Jim\u00e9nez\u2010Yuste","orcid":"https://orcid.org/0000-0003-3937-3499","observed_orcids":["https://orcid.org/0000-0003-3937-3499"]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Victor Jim\u00e9nez-Yuste","raw_affiliation_strings":["Hospital Universitario La Paz, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario La Paz, Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I2800562746","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061196119","display_name":"Julien Bovet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julien Bovet","raw_affiliation_strings":["Novo Nordisk, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Llenalia Mar\u00eda Garc\u00eda Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267240","display_name":"Novo Nordisk Pharma, SA (Spain)","ror":"https://ror.org/01v7kg426","country_code":"ES","type":"company","lineage":["https://openalex.org/I4405267240"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Llenalia Mar\u00eda Garc\u00eda Fern\u00e1ndez","raw_affiliation_strings":["Novo Nordisk, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk, Madrid, Spain","institution_ids":["https://openalex.org/I4405267240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004338432","display_name":"Guy A. Young","orcid":"https://orcid.org/0000-0001-6013-1254","observed_orcids":["https://orcid.org/0000-0001-6013-1254"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy Young","raw_affiliation_strings":["Cancer and Blood Disease Institute, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Blood Disease Institute, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, US","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047434427","display_name":"Tadashi Matsushita","orcid":"https://orcid.org/0000-0002-3646-3125","observed_orcids":["https://orcid.org/0000-0002-3646-3125"]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Matsushita","raw_affiliation_strings":["Nagoya University Hospital, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University Hospital, Nagoya, Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064355731","display_name":"Pratima Chowdary","orcid":"https://orcid.org/0000-0002-6690-8586","observed_orcids":["https://orcid.org/0000-0002-6690-8586"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pratima Chowdary","raw_affiliation_strings":["Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801138448"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103243877","display_name":"Kaan Kavakl\u0131","orcid":"https://orcid.org/0000-0003-1174-1958","observed_orcids":["https://orcid.org/0000-0003-1174-1958"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kaan Kavakli","raw_affiliation_strings":["Department of Pediatric Hematology, Ege University Children's Hospital, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology, Ege University Children's Hospital, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]}],"institutions":[],"countries_distinct_count":8,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":{"value":2250,"currency":"USD","value_usd":2250},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45039683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":null,"first_page":"103096","last_page":"103096"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.8420000076293945},{"id":"https://openalex.org/keywords/factor-viii-inhibitors","display_name":"factor VIII inhibitors","score":0.824999988079071},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.6899999976158142},{"id":"https://openalex.org/keywords/open-label-extension","display_name":"open-label extension","score":0.7870000004768372},{"id":"https://openalex.org/keywords/annualized-bleeding-rate","display_name":"annualized bleeding rate","score":0.8450000286102295},{"id":"https://openalex.org/keywords/bleeding-events","display_name":"bleeding events","score":0.4729999899864197},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9045000076293945},{"id":"https://openalex.org/C2776957806","wikidata":"https://www.wikidata.org/wiki/Q4895105","display_name":"Interim","level":2,"score":0.6797999739646912},{"id":"https://openalex.org/C2780765947","wikidata":"https://www.wikidata.org/wiki/Q12033531","display_name":"Administration (probate law)","level":2,"score":0.6244000196456909},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.507099986076355},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3799000084400177},{"id":"https://openalex.org/C2778029271","wikidata":"https://www.wikidata.org/wiki/Q5421931","display_name":"Extension (predicate logic)","level":2,"score":0.37860000133514404},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3598000109195709},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.33309999108314514},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3197000026702881},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.2957000136375427},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2630999982357025}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.rpth.2025.103096","doi":"https://doi.org/10.1016/j.rpth.2025.103096","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2025.103096","pdf_url":"https://www.rpthjournal.org/article/S2475-0379(25)00420-0/pdf","source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:634eb0f90dfa48989a84137fea4141b7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/634eb0f90dfa48989a84137fea4141b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis, Vol 9, Iss , Pp 103096- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.rpth.2025.103096","doi":"https://doi.org/10.1016/j.rpth.2025.103096","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2025.103096","pdf_url":"https://www.rpthjournal.org/article/S2475-0379(25)00420-0/pdf","source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417207129.pdf","grobid_xml":"https://content.openalex.org/works/W4417207129.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405044045","https://openalex.org/W4417206891","https://openalex.org/W4407439258","https://openalex.org/W4417010252","https://openalex.org/W7169625627","https://openalex.org/W7158494673","https://openalex.org/W7223098112","https://openalex.org/W7204545807","https://openalex.org/W4414979188","https://openalex.org/W7220407700"],"abstract_inverted_index":{"Background:":[0],"Mim8":[1,48],"(denecimig)":[2],"is":[3],"a":[4,18],"next-generation,":[5],"activated":[6],"factor":[7,30],"VIII":[8,31],"mimetic,":[9],"fully":[10],"human":[11],"bispecific":[12],"IgG4":[13],"antibody":[14],"in":[15,84],"development":[16],"as":[17],"subcutaneous":[19],"prophylaxis":[20,81],"for":[21,67],"patients":[22],"with":[23,27,52],"hemophilia":[24],"A":[25],"(HA)":[26],"or":[28,78],"without":[29],"inhibitors.":[32],"In":[33],"the":[34,44,62,85],"phase":[35,86],"2,":[36],"open":[37],"label,":[38],"multiple":[39],"ascending":[40],"dose":[41,64],"part":[42],"of":[43,75],"FRONTIER1":[45],"study":[46,89],"(NCT04204408),":[47],"was":[49],"well":[50],"tolerated":[51],"no":[53],"safety":[54,74],"concerns":[55],"and":[56,73],"few":[57],"treated":[58],"bleeding":[59,70],"episodes":[60],"beyond":[61],"lowest":[63],"cohort.":[65],"Efficacy":[66],"reducing":[68],"annualized":[69],"rate":[71],"(ABR)":[72],"weekly":[76],"(QW)":[77],"monthly":[79],"(QM)":[80],"were":[82],"established":[83],"3":[87],"FRONTIER2":[88],"(NCT05053139).":[90]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-12-10T00:00:00"}