{"id":"https://openalex.org/W4417153409","doi":"https://doi.org/10.1111/crj.70146","title":"Endothelial\u2010Derived Extracellular Vesicles During Exercise in COPD Patients","display_name":"Endothelial\u2010Derived Extracellular Vesicles During Exercise in COPD Patients","publication_year":2025,"publication_date":"2025-12-01","ids":{"openalex":"https://openalex.org/W4417153409","doi":"https://doi.org/10.1111/crj.70146","pmid":"https://pubmed.ncbi.nlm.nih.gov/41354622"},"language":"en","primary_location":{"id":"doi:10.1111/crj.70146","doi":"https://doi.org/10.1111/crj.70146","is_oa":true,"landing_page_url":"https://doi.org/10.1111/crj.70146","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/crj.70146","source":{"id":"https://openalex.org/S102581529","display_name":"The Clinical Respiratory Journal","issn_l":"1752-6981","issn":["1752-6981","1752-699X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/crj.70146","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037496944","display_name":"Samuel C. Okpechi","orcid":"https://orcid.org/0009-0008-3679-2915","observed_orcids":["https://orcid.org/0009-0008-3679-2915"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel\u00a0C. Okpechi","raw_affiliation_strings":["Cancer Research Technology Program, Molecular Pharmacology Program Frederick National Laboratory for Cancer Research  Frederick Maryland USA","Department of Biochemistry and Molecular Biology Louisiana State University Health Sciences Center and School of Medicine  New Orleans Louisiana USA","Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA","Cancer Research Technology Program, Molecular Pharmacology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA","Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Technology Program, Molecular Pharmacology Program Frederick National Laboratory for Cancer Research  Frederick Maryland USA","institution_ids":["https://openalex.org/I4210130649"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology Louisiana State University Health Sciences Center and School of Medicine  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]},{"raw_affiliation_string":"Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"Cancer Research Technology Program, Molecular Pharmacology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210130649"]},{"raw_affiliation_string":"Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030375542","display_name":"Dorota Danuta Wyczechowska","orcid":"https://orcid.org/0000-0002-8940-6861","observed_orcids":["https://orcid.org/0000-0002-8940-6861"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorota Wyczechowska","raw_affiliation_strings":["Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA","Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109283609","display_name":"Bennett P. deBoisblanc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801463575","display_name":"University Medical Center New Orleans","ror":"https://ror.org/02zrb2v54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I2801463575","https://openalex.org/I75420490"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett DeBoisblanc","raw_affiliation_strings":["Comprehensive Pulmonary Hypertension Center University Medical Center  New Orleans Louisiana USA","Section of Pulmonary/Critical Care and Allergy/Immunology Louisiana State University Health Sciences Center  New Orleans Louisiana USA","Comprehensive Pulmonary Hypertension Center, University Medical Center, New Orleans, Louisiana, USA","Section of Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Pulmonary Hypertension Center University Medical Center  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I2801463575"]},{"raw_affiliation_string":"Section of Pulmonary/Critical Care and Allergy/Immunology Louisiana State University Health Sciences Center  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"Comprehensive Pulmonary Hypertension Center, University Medical Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I2801463575"]},{"raw_affiliation_string":"Section of Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043228244","display_name":"Jessica L. Johnson","orcid":"https://orcid.org/0000-0002-2514-5391","observed_orcids":["https://orcid.org/0000-0002-2514-5391"]},"institutions":[{"id":"https://openalex.org/I2801463575","display_name":"University Medical Center New Orleans","ror":"https://ror.org/02zrb2v54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I2801463575","https://openalex.org/I75420490"]},{"id":"https://openalex.org/I32208735","display_name":"Husson University","ror":"https://ror.org/05rp6gx35","country_code":"US","type":"education","lineage":["https://openalex.org/I32208735"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica\u00a0L. Johnson","raw_affiliation_strings":["College of Health and Pharmacy Husson University School of Pharmacy  Bangor Maine USA","Comprehensive Pulmonary Hypertension Center University Medical Center  New Orleans Louisiana USA","College of Health and Pharmacy, Husson University School of Pharmacy, Bangor, Maine, USA","Comprehensive Pulmonary Hypertension Center, University Medical Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health and Pharmacy Husson University School of Pharmacy  Bangor Maine USA","institution_ids":["https://openalex.org/I32208735"]},{"raw_affiliation_string":"Comprehensive Pulmonary Hypertension Center University Medical Center  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I2801463575"]},{"raw_affiliation_string":"College of Health and Pharmacy, Husson University School of Pharmacy, Bangor, Maine, USA","institution_ids":["https://openalex.org/I32208735"]},{"raw_affiliation_string":"Comprehensive Pulmonary Hypertension Center, University Medical Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I2801463575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016671074","display_name":"Mohamed Ahmed Ghonim","orcid":"https://orcid.org/0000-0001-9404-2698","observed_orcids":["https://orcid.org/0000-0001-9404-2698"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["EG","US"],"is_corresponding":false,"raw_author_name":"Mohamed\u00a0A. Ghonim","raw_affiliation_strings":["Department of Host\u2010Microbe Interactions St. Jude Children's Research Hospital  Memphis Tennessee USA","Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA","The Department of Microbiology and Immunology, Faculty of Pharmacy Al\u2010Azhar University  Cairo Egypt","Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA","The Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Host\u2010Microbe Interactions St. Jude Children's Research Hospital  Memphis Tennessee USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"The Department of Microbiology and Immunology, Faculty of Pharmacy Al\u2010Azhar University  Cairo Egypt","institution_ids":["https://openalex.org/I184834183"]},{"raw_affiliation_string":"Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"The Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043544752","display_name":"Natalie Norwood Bauer","orcid":"https://orcid.org/0000-0002-6612-1302","observed_orcids":["https://orcid.org/0000-0002-6612-1302"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Bauer","raw_affiliation_strings":["Department of Pharmacology and Center for Lung Biology University of South Alabama College of Medicine  Mobile Alabama USA","Department of Pharmacology and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Center for Lung Biology University of South Alabama College of Medicine  Mobile Alabama USA","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Pharmacology and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, Alabama, USA","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032576507","display_name":"Hamid A. Boulares","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamid\u00a0A. Boulares","raw_affiliation_strings":["Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA","Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056280960","display_name":"Matthew R. Lammi","orcid":"https://orcid.org/0000-0001-5125-1801","observed_orcids":["https://orcid.org/0000-0001-5125-1801"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I2801463575","display_name":"University Medical Center New Orleans","ror":"https://ror.org/02zrb2v54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I2801463575","https://openalex.org/I75420490"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew\u00a0R. Lammi","raw_affiliation_strings":["Comprehensive Pulmonary Hypertension Center University Medical Center  New Orleans Louisiana USA","Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA","Section of Pulmonary/Critical Care and Allergy/Immunology Louisiana State University Health Sciences Center  New Orleans Louisiana USA","Comprehensive Pulmonary Hypertension Center, University Medical Center, New Orleans, Louisiana, USA","Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","Section of Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Pulmonary Hypertension Center University Medical Center  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I2801463575"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Section of Pulmonary/Critical Care and Allergy/Immunology Louisiana State University Health Sciences Center  New Orleans Louisiana USA","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"Comprehensive Pulmonary Hypertension Center, University Medical Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I2801463575"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Section of Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5056280960"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I2801463575","https://openalex.org/I75420490"],"apc_list":{"value":2310,"currency":"USD","value_usd":2310},"apc_paid":{"value":2310,"currency":"USD","value_usd":2310},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23194512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"12","first_page":"e70146","last_page":"e70146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.968999981880188},{"id":"https://openalex.org/keywords/iloprost","display_name":"iloprost","score":0.9819999933242798},{"id":"https://openalex.org/keywords/prostacyclin-analogues","display_name":"prostacyclin analogues","score":0.9020000100135803},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7239999771118164},{"id":"https://openalex.org/keywords/pulmonary-vasculature","display_name":"pulmonary vasculature","score":0.8370000123977661},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7429999709129333},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.8659999966621399},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.734000027179718},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ve-cadherin","display_name":"VE-cadherin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.996999979019165},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.7639999985694885},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7092000246047974},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5995000004768372},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.5329999923706055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45249998569488525},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.45159998536109924},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.44530001282691956},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.41130000352859497},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40400001406669617},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.39480000734329224},{"id":"https://openalex.org/C2993351451","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Cigarette smoke","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36800000071525574},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.2987000048160553},{"id":"https://openalex.org/C2781103887","wikidata":"https://www.wikidata.org/wiki/Q20817139","display_name":"Iloprost","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.28610000014305115},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.27970001101493835}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/crj.70146","doi":"https://doi.org/10.1111/crj.70146","is_oa":true,"landing_page_url":"https://doi.org/10.1111/crj.70146","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/crj.70146","source":{"id":"https://openalex.org/S102581529","display_name":"The Clinical Respiratory Journal","issn_l":"1752-6981","issn":["1752-6981","1752-699X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical Respiratory Journal","raw_type":"journal-article"},{"id":"pmid:41354622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41354622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The clinical respiratory journal","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dd6dbc3b793743bd9f5af1568130a9e9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dd6dbc3b793743bd9f5af1568130a9e9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Clinical Respiratory Journal, Vol 19, Iss 12, Pp n/a-n/a (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12682462","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12682462/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Respir J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/crj.70146","doi":"https://doi.org/10.1111/crj.70146","is_oa":true,"landing_page_url":"https://doi.org/10.1111/crj.70146","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/crj.70146","source":{"id":"https://openalex.org/S102581529","display_name":"The Clinical Respiratory Journal","issn_l":"1752-6981","issn":["1752-6981","1752-699X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical Respiratory Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1442797807","display_name":null,"funder_award_id":"1\u2010P306\u2010M\u2010206932\u201001A1","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1995393677","display_name":null,"funder_award_id":"104940","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4370236196","display_name":null,"funder_award_id":"GM104940","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417153409.pdf","grobid_xml":"https://content.openalex.org/works/W4417153409.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2115533377","https://openalex.org/W2116830337","https://openalex.org/W2159401023","https://openalex.org/W2519321703","https://openalex.org/W2533281949","https://openalex.org/W2911663685","https://openalex.org/W3014697912","https://openalex.org/W3135012396","https://openalex.org/W3208050637","https://openalex.org/W4304183732"],"related_works":[],"abstract_inverted_index":{"INTRODUCTION:":[0],"There":[1,88],"are":[2],"no":[3,90],"treatments":[4],"directly":[5],"targeting":[6],"the":[7,20,35,40],"pulmonary":[8,13],"vasculature":[9],"in":[10,29,51,59,104,137],"chronic":[11],"obstructive":[12],"disease":[14],"(COPD),":[15],"and":[16,39,106,121],"further":[17],"characterization":[18],"of":[19,37,65,93,140],"underlying":[21],"endothelial":[22],"cell":[23],"(EC)":[24],"abnormalities":[25],"could":[26],"be":[27],"helpful":[28],"drug":[30],"development.":[31],"METHODS:":[32],"We":[33],"investigated":[34],"influence":[36],"exercise":[38,132],"prostacyclin":[41],"analog":[42],"iloprost":[43,94],"on":[44,95,119],"extracellular":[45],"vesicles":[46],"derived":[47],"from":[48],"ECs":[49],"(eEVs)":[50],"15":[52],"moderate-severe":[53],"COPD":[54,79],"patients":[55],"who":[56],"were":[57,89],"enrolled":[58],"a":[60,71,82,101,134,138],"randomized,":[61],"placebo-controlled":[62],"crossover":[63],"trial":[64],"iloprost.":[66],"RESULTS:":[67],"Active":[68],"smokers":[69],"had":[70,81],"profile":[72,83],"consistent":[73,84],"with":[74,85],"inflammatory-derived":[75],"EVs,":[76],"while":[77],"exacerbation-prone":[78],"subjects":[80],"apoptosis-derived":[86],"eEVs.":[87],"significant":[91,102],"effects":[92],"eEV":[96,128],"levels.":[97],"However,":[98],"there":[99],"was":[100],"increase":[103,136],"CD144+":[105],"CD31+/CD144+":[107],"EVs":[108],"1":[109],"h":[110],"after":[111],"exercise.":[112],"CONCLUSIONS:":[113],"Endothelial-derived":[114],"EV":[115],"profiles":[116],"differed":[117],"based":[118],"smoking":[120],"exacerbation":[122],"history.":[123],"Iloprost":[124],"did":[125],"not":[126],"affect":[127],"levels,":[129],"although":[130],"maximal":[131],"induced":[133],"delayed":[135],"subset":[139],"eEVs,":[141],"possibly":[142],"through":[143],"shear":[144],"stress.":[145]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-12-08T00:00:00"}
