{"id":"https://openalex.org/W4417153194","doi":"https://doi.org/10.1002/jat.70021","title":"Brass\u2010Derived Copper and Zinc Induce Oxidative Stress and Autophagy\u2010Mediated Nephrotoxicity in Channa punctatus","display_name":"Brass\u2010Derived Copper and Zinc Induce Oxidative Stress and Autophagy\u2010Mediated Nephrotoxicity in Channa punctatus","publication_year":2025,"publication_date":"2025-12-07","ids":{"openalex":"https://openalex.org/W4417153194","doi":"https://doi.org/10.1002/jat.70021","pmid":"https://pubmed.ncbi.nlm.nih.gov/41354620"},"language":"en","primary_location":{"id":"doi:10.1002/jat.70021","doi":"https://doi.org/10.1002/jat.70021","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.70021","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040518707","display_name":"Abha Trivedi","orcid":"https://orcid.org/0000-0002-3671-1256","observed_orcids":["https://orcid.org/0000-0002-3671-1256"]},"institutions":[{"id":"https://openalex.org/I139858224","display_name":"M.J.P. Rohilkhand University","ror":"https://ror.org/02e3nay30","country_code":"IN","type":"education","lineage":["https://openalex.org/I139858224"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Abha Trivedi","raw_affiliation_strings":["Toxicogenomics Laboratory, Department of Animal Science M.J.P. Rohilkhand University  Bareilly India","Toxicogenomics Laboratory, Department of Animal Science, M.J.P. Rohilkhand University, Bareilly, India"],"raw_orcid":"https://orcid.org/0000-0002-3671-1256","affiliations":[{"raw_affiliation_string":"Toxicogenomics Laboratory, Department of Animal Science M.J.P. Rohilkhand University  Bareilly India","institution_ids":["https://openalex.org/I139858224"]},{"raw_affiliation_string":"Toxicogenomics Laboratory, Department of Animal Science, M.J.P. Rohilkhand University, Bareilly, India","institution_ids":["https://openalex.org/I139858224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063075934","display_name":"Sunil P. Trivedi","orcid":"https://orcid.org/0000-0003-3957-8128","observed_orcids":["https://orcid.org/0000-0003-3957-8128","https://orcid.org/0000-0002-5575-8201"]},"institutions":[{"id":"https://openalex.org/I186246823","display_name":"University of Lucknow","ror":"https://ror.org/03bdeag60","country_code":"IN","type":"education","lineage":["https://openalex.org/I186246823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sunil\u00a0P. Trivedi","raw_affiliation_strings":["Department of Zoology Lucknow University  Lucknow India","Department of Zoology, Lucknow University, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology Lucknow University  Lucknow India","institution_ids":["https://openalex.org/I186246823"]},{"raw_affiliation_string":"Department of Zoology, Lucknow University, Lucknow, India","institution_ids":["https://openalex.org/I186246823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111180798","display_name":"Vaishnavi Saxena","orcid":"https://orcid.org/0009-0006-2823-2171","observed_orcids":["https://orcid.org/0009-0006-2823-2171"]},"institutions":[{"id":"https://openalex.org/I139858224","display_name":"M.J.P. Rohilkhand University","ror":"https://ror.org/02e3nay30","country_code":"IN","type":"education","lineage":["https://openalex.org/I139858224"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vaishnavi Saxena","raw_affiliation_strings":["Toxicogenomics Laboratory, Department of Animal Science M.J.P. Rohilkhand University  Bareilly India","Toxicogenomics Laboratory, Department of Animal Science, M.J.P. Rohilkhand University, Bareilly, India"],"raw_orcid":"https://orcid.org/0009-0006-2823-2171","affiliations":[{"raw_affiliation_string":"Toxicogenomics Laboratory, Department of Animal Science M.J.P. Rohilkhand University  Bareilly India","institution_ids":["https://openalex.org/I139858224"]},{"raw_affiliation_string":"Toxicogenomics Laboratory, Department of Animal Science, M.J.P. Rohilkhand University, Bareilly, India","institution_ids":["https://openalex.org/I139858224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108922954","display_name":"Neeti Arya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139858224","display_name":"M.J.P. Rohilkhand University","ror":"https://ror.org/02e3nay30","country_code":"IN","type":"education","lineage":["https://openalex.org/I139858224"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neeti Arya","raw_affiliation_strings":["Toxicogenomics Laboratory, Department of Animal Science M.J.P. Rohilkhand University  Bareilly India","Toxicogenomics Laboratory, Department of Animal Science, M.J.P. Rohilkhand University, Bareilly, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicogenomics Laboratory, Department of Animal Science M.J.P. Rohilkhand University  Bareilly India","institution_ids":["https://openalex.org/I139858224"]},{"raw_affiliation_string":"Toxicogenomics Laboratory, Department of Animal Science, M.J.P. Rohilkhand University, Bareilly, India","institution_ids":["https://openalex.org/I139858224"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093281770","display_name":"Jumman Bakhasha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139858224","display_name":"M.J.P. Rohilkhand University","ror":"https://ror.org/02e3nay30","country_code":"IN","type":"education","lineage":["https://openalex.org/I139858224"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jumman Bakhasha","raw_affiliation_strings":["Toxicogenomics Laboratory, Department of Animal Science M.J.P. Rohilkhand University  Bareilly India","Toxicogenomics Laboratory, Department of Animal Science, M.J.P. Rohilkhand University, Bareilly, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicogenomics Laboratory, Department of Animal Science M.J.P. Rohilkhand University  Bareilly India","institution_ids":["https://openalex.org/I139858224"]},{"raw_affiliation_string":"Toxicogenomics Laboratory, Department of Animal Science, M.J.P. Rohilkhand University, Bareilly, India","institution_ids":["https://openalex.org/I139858224"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040518707"],"corresponding_institution_ids":["https://openalex.org/I139858224"],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":1.2184,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.78133985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"46","issue":"6","first_page":"2167","last_page":"2180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.9309999942779541},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":1.0},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8500000238418579},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/channa-punctata","display_name":"Channa punctatus","score":0.9509999752044678},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.6579999923706055},{"id":"https://openalex.org/keywords/autophagy-related-genes","display_name":"autophagy-related genes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.7390000224113464},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.8259999752044678},{"id":"https://openalex.org/keywords/freshwater-fish","display_name":"freshwater fish","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8077999949455261},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.7358999848365784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.703000009059906},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6287999749183655},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.6134999990463257},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6132000088691711},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.542900025844574},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5203999876976013},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.5164999961853027},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.4846999943256378},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.48420000076293945},{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.4659999907016754},{"id":"https://openalex.org/C2778290051","wikidata":"https://www.wikidata.org/wiki/Q10724674","display_name":"Zinc toxicity","level":3,"score":0.45590001344680786},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4535999894142151},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4401000142097473},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.43869999051094055},{"id":"https://openalex.org/C2778302132","wikidata":"https://www.wikidata.org/wiki/Q4215775","display_name":"Metal toxicity","level":3,"score":0.40799999237060547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39629998803138733},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3781000077724457},{"id":"https://openalex.org/C2778404011","wikidata":"https://www.wikidata.org/wiki/Q5168803","display_name":"Copper toxicity","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C2778248901","wikidata":"https://www.wikidata.org/wiki/Q5282371","display_name":"Dismutase","level":4,"score":0.2994999885559082},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2904999852180481},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.2770000100135803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26840001344680786}],"mesh":[{"descriptor_ui":"D000095982","descriptor_name":"Channa punctata","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095982","descriptor_name":"Channa punctata","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jat.70021","doi":"https://doi.org/10.1002/jat.70021","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.70021","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},{"id":"pmid:41354620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41354620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied toxicology : JAT","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7778000235557556,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G174428275","display_name":null,"funder_award_id":"09/0522(19,151)/2024-EMR-I","funder_id":"https://openalex.org/F4320320721","funder_display_name":"Council of Scientific and Industrial Research, India"},{"id":"https://openalex.org/G446994686","display_name":null,"funder_award_id":"16\u20109(June 2019)/2019(NET/CSIR)","funder_id":"https://openalex.org/F4320320721","funder_display_name":"Council of Scientific and Industrial Research, India"}],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1979783084","https://openalex.org/W2004367631","https://openalex.org/W2048549213","https://openalex.org/W2107277218","https://openalex.org/W2625682565","https://openalex.org/W2778210587","https://openalex.org/W2782095363","https://openalex.org/W2901787673","https://openalex.org/W2944020455","https://openalex.org/W2952049976","https://openalex.org/W3009166263","https://openalex.org/W3038033037","https://openalex.org/W3047398659","https://openalex.org/W3091168166","https://openalex.org/W3128515718","https://openalex.org/W3164886754","https://openalex.org/W3200048310","https://openalex.org/W4206770943","https://openalex.org/W4206967727","https://openalex.org/W4280611196","https://openalex.org/W4283789825","https://openalex.org/W4291414834","https://openalex.org/W4367839469","https://openalex.org/W4385588552","https://openalex.org/W4385794336","https://openalex.org/W4392059362","https://openalex.org/W4392289051","https://openalex.org/W4395111248","https://openalex.org/W4396873534","https://openalex.org/W4402839505","https://openalex.org/W4404759427","https://openalex.org/W4404863735","https://openalex.org/W4406482265","https://openalex.org/W4411077577","https://openalex.org/W4412187612","https://openalex.org/W4412392369","https://openalex.org/W4412479285"],"related_works":[],"abstract_inverted_index":{"Brass":[0],"toxicity":[1,222],"has":[2],"emerged":[3],"as":[4,196,217],"a":[5,65,173,197],"pressing":[6],"environmental":[7],"concern,":[8],"with":[9,68,134,213],"its":[10],"dual-metal":[11],"burden":[12],"of":[13,33,44,61,88,128,137,141,200,220],"copper":[14],"(Cu)":[15],"and":[16,38,40,48,51,55,85,90,102,107,112,132,161,181,209],"zinc":[17],"(Zn)":[18],"from":[19],"industrial":[20],"discharges":[21],"continuing":[22],"to":[23,147],"jeopardize":[24],"aquatic":[25],"ecosystem":[26],"health.":[27],"This":[28],"study":[29],"investigates":[30],"the":[31,59,142],"effects":[32],"environmentally":[34],"relevant":[35],"concentrations":[36],"(ERC)":[37],"10%":[39],"20%":[41],"elevated":[42,97],"levels":[43],"Cu":[45,89],"(0.85,":[46],"0.935,":[47],"1.02":[49],"mg/L)":[50,57],"Zn":[52,91],"(1.2,":[53],"1.32,":[54],"1.44":[56],"on":[58],"kidney":[60],"Channa":[62],"punctatus":[63],"during":[64],"60-day":[66],"exposure,":[67],"sampling":[69],"conducted":[70],"at":[71,165],"15-day":[72],"intervals":[73],"under":[74],"controlled":[75],"laboratory":[76],"conditions.":[77],"Results":[78],"revealed":[79],"significant":[80],"(p":[81],"<":[82],"0.05),":[83],"dose-":[84],"time-dependent":[86],"accumulation":[87],"in":[92,145,187,223],"renal":[93,154],"tissues,":[94],"accompanied":[95],"by":[96],"reactive":[98],"oxygen":[99],"species":[100],"(ROS)":[101],"lipid":[103],"peroxidation":[104],"(LPO)":[105],"levels,":[106],"increased":[108],"superoxide":[109],"dismutase":[110],"(SOD)":[111],"catalase":[113],"(CAT)":[114],"activities,":[115],"whereas":[116],"reduced":[117],"glutathione":[118],"(GSH)":[119],"content":[120],"declined":[121],"markedly.":[122],"qRT-PCR":[123],"analysis":[124,170],"demonstrated":[125],"pronounced":[126],"upregulation":[127],"atg5,":[129],"beclin1,":[130],"lc3,":[131],"ulk1b":[133],"concomitant":[135],"downregulation":[136],"mTOR,":[138],"suggesting":[139],"activation":[140],"autophagic":[143],"pathway":[144],"response":[146],"oxidative":[148],"stress.":[149],"Histopathological":[150],"examination":[151],"confirmed":[152],"progressive":[153],"degeneration,":[155],"including":[156],"glomerular":[157],"degenerative":[158],"cells,":[159],"vacuolization,":[160],"epithelial":[162],"disorganization,":[163],"especially":[164],"higher":[166],"concentrations.":[167],"Principal":[168],"component":[169],"(PCA)":[171],"indicated":[172],"strong":[174],"association":[175],"among":[176],"ROS,":[177],"antioxidant":[178],"enzymes,":[179],"LPO,":[180],"autophagy":[182],"genes,":[183],"emphasizing":[184],"redox-autophagy":[185],"coupling":[186],"metal-induced":[188],"stress":[189],"responses.":[190],"Collectively,":[191],"these":[192],"findings":[193],"identify":[194],"brass":[195,221],"key":[198],"driver":[199],"nephrotoxicity,":[201],"where":[202],"chronic":[203],"Cu-Zn":[204],"release":[205],"disrupts":[206],"redox":[207],"balance":[208],"induces":[210],"cytotoxic":[211],"autophagy,":[212],"autophagy-related":[214],"genes":[215],"serving":[216],"sensitive":[218],"biomarkers":[219],"freshwater":[224],"ecosystems.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-12-08T00:00:00"}