{"id":"https://openalex.org/W4417153174","doi":"https://doi.org/10.1093/jambio/lxaf300","title":"Strain-specific modulation of biofilm and motility in Pseudomonas aeruginosa by Danshen-derived compounds and their impact on antibiotic susceptibility","display_name":"Strain-specific modulation of biofilm and motility in Pseudomonas aeruginosa by Danshen-derived compounds and their impact on antibiotic susceptibility","publication_year":2025,"publication_date":"2025-11-28","ids":{"openalex":"https://openalex.org/W4417153174","doi":"https://doi.org/10.1093/jambio/lxaf300","pmid":"https://pubmed.ncbi.nlm.nih.gov/41358822"},"language":"en","primary_location":{"id":"doi:10.1093/jambio/lxaf300","doi":"https://doi.org/10.1093/jambio/lxaf300","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jambio/lxaf300","pdf_url":null,"source":{"id":"https://openalex.org/S39794811","display_name":"Journal of Applied Microbiology","issn_l":"1364-5072","issn":["1364-5072","1365-2672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University Department of Clinical Laboratory, , Xi\u2019an 710003 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University Department of Clinical Laboratory, , Xi\u2019an 710003 ,","institution_ids":["https://openalex.org/I4210142339","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068143863","display_name":"Kaichong Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaichong Jiang","raw_affiliation_strings":["Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,","institution_ids":["https://openalex.org/I4210142339","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114048083","display_name":"Yafei Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yafei Zhou","raw_affiliation_strings":["Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,","institution_ids":["https://openalex.org/I4210142339","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102879957","display_name":"Rui Zhou","orcid":"https://orcid.org/0000-0002-2228-2884","observed_orcids":["https://orcid.org/0000-0002-2228-2884"]},"institutions":[{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zhou","raw_affiliation_strings":["Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,","institution_ids":["https://openalex.org/I4210142339","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022693074","display_name":"Wen Huang","orcid":"https://orcid.org/0000-0002-0010-3056","observed_orcids":["https://orcid.org/0000-0002-0010-3056"]},"institutions":[{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Huang","raw_affiliation_strings":["Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,","institution_ids":["https://openalex.org/I4210142339","https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yinong Huang","orcid":"https://orcid.org/0009-0003-1728-6594","observed_orcids":["https://orcid.org/0009-0003-1728-6594"]},"institutions":[{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yinong Huang","raw_affiliation_strings":["Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,"],"raw_orcid":"https://orcid.org/0009-0003-1728-6594","affiliations":[{"raw_affiliation_string":"Shaanxi Institute for Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Affiliated Children\u2019s Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710003 ,","institution_ids":["https://openalex.org/I4210142339","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210142339","https://openalex.org/I87445476"],"apc_list":{"value":2864,"currency":"GBP","value_usd":3777},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23250783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"136","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9980000257492065},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9200000166893005},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.902999997138977},{"id":"https://openalex.org/keywords/bacterial-motility","display_name":"bacterial motility","score":0.984000027179718},{"id":"https://openalex.org/keywords/salvia-miltiorrhiza","display_name":"Salvia miltiorrhiza","score":0.9520000219345093},{"id":"https://openalex.org/keywords/diterpenes","display_name":"diterpenoids","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dihydrotanshinone-i","display_name":"dihydrotanshinone I","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tanshinone-i","display_name":"tanshinone I","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-susceptibility","display_name":"antibiotic susceptibility","score":0.6909999847412109},{"id":"https://openalex.org/keywords/ceftazidime","display_name":"ceftazidime","score":0.9309999942779541},{"id":"https://openalex.org/keywords/wspr","display_name":"WSPR","score":0.984000027179718},{"id":"https://openalex.org/keywords/psla","display_name":"pslA","score":0.996999979019165},{"id":"https://openalex.org/keywords/strain-specific-effects","display_name":"strain-specific effects","score":0.6869999766349792},{"id":"https://openalex.org/keywords/biofilm-eradication","display_name":"biofilm eradication","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9315000176429749},{"id":"https://openalex.org/C2776968632","wikidata":"https://www.wikidata.org/wiki/Q808845","display_name":"Ceftazidime","level":4,"score":0.8493000268936157},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.7365000247955322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7271000146865845},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7103000283241272},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6836000084877014},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.4943999946117401},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.48510000109672546},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.34779998660087585},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3181999921798706},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2500999867916107}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027561","descriptor_name":"Salvia miltiorrhiza","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D027561","descriptor_name":"Salvia miltiorrhiza","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D027561","descriptor_name":"Salvia miltiorrhiza","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jambio/lxaf300","doi":"https://doi.org/10.1093/jambio/lxaf300","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jambio/lxaf300","pdf_url":null,"source":{"id":"https://openalex.org/S39794811","display_name":"Journal of Applied Microbiology","issn_l":"1364-5072","issn":["1364-5072","1365-2672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Microbiology","raw_type":"journal-article"},{"id":"pmid:41358822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41358822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5999262464","display_name":null,"funder_award_id":"2025JC-YBQN-1203","funder_id":"https://openalex.org/F4320324173","funder_display_name":"Natural Science Foundation of Shaanxi Province"},{"id":"https://openalex.org/G7149803078","display_name":null,"funder_award_id":"xzy012022129","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320324173","display_name":"Natural Science Foundation of Shaanxi Province","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1967239401","https://openalex.org/W1969537603","https://openalex.org/W1974157620","https://openalex.org/W2034472211","https://openalex.org/W2043535514","https://openalex.org/W2058965595","https://openalex.org/W2070300719","https://openalex.org/W2095721618","https://openalex.org/W2102677849","https://openalex.org/W2104493016","https://openalex.org/W2111416348","https://openalex.org/W2127535305","https://openalex.org/W2157495301","https://openalex.org/W2418269076","https://openalex.org/W2551129953","https://openalex.org/W2763900685","https://openalex.org/W2766800094","https://openalex.org/W2787181633","https://openalex.org/W2938373565","https://openalex.org/W2955344024","https://openalex.org/W4281679483","https://openalex.org/W4385666583","https://openalex.org/W4387963223","https://openalex.org/W4389436230","https://openalex.org/W4390483054","https://openalex.org/W4407163702","https://openalex.org/W4411864256"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Multidrug-resistant":[1],"(MDR)":[2],"Pseudomonas":[3],"aeruginosa":[4,32,60,176],"poses":[5],"major":[6],"therapeutic":[7],"challenges":[8],"due":[9],"to":[10],"biofilm-associated":[11],"tolerance":[12],"and":[13,36,55,62,69,82,98,113,141,148,179,181],"limited":[14],"antibiotic":[15,37],"efficacy.":[16],"Lipophilic":[17],"diterpenoids":[18,170],"from":[19],"Salvia":[20],"miltiorrhiza":[21],"(Danshen)":[22],"have":[23],"reported":[24],"antimicrobial":[25],"potential,":[26],"but":[27,90,131],"their":[28],"effects":[29,173],"on":[30,174],"P.":[31,59,175],"biofilm":[33,53,87,92,111,177],"phenotypes,":[34],"motility,":[35,180],"susceptibility":[38],"remain":[39],"poorly":[40],"defined.":[41],"METHODS":[42],"AND":[43],"RESULTS:":[44],"Five":[45],"Danshen-derived":[46,169],"compounds":[47],"were":[48],"tested":[49],"for":[50],"antibacterial":[51],"activity,":[52],"modulation,":[54],"motility":[56],"inhibition":[57],"in":[58,94,116,123,128,133,145,151,165],"PAO1":[61,86,146],"two":[63],"MDR":[64,95,117,129,166,187],"clinical":[65],"isolates":[66,96,130],"(designated":[67],"XCH-MDR-01":[68],"XCH-MDR-02).":[70],"Antibacterial":[71],"activity":[72,185],"was":[73,126],"negligible":[74],"(MIC":[75],">":[76],"256":[77],"\u00b5mol":[78,105],"L-1).":[79,106],"Dihydrotanshinone":[80],"I":[81,84,156,159],"tanshinone":[83,158],"enhanced":[85,121],"formation":[88,93,178],"(20%-30%)":[89],"inhibited":[91],"(40%-50%)":[97],"disrupted":[99],"established":[100],"biofilms":[101,122],"(50%-60%":[102],"at":[103],"50":[104],"Confocal":[107],"microscopy":[108],"confirmed":[109],"reduced":[110,160],"density":[112],"altered":[114],"architecture":[115],"isolates,":[118],"contrasting":[119],"with":[120,143,154],"PAO1.":[124,134],"Motility":[125],"suppressed":[127],"unaffected":[132],"qPCR":[135],"showed":[136],"strain-specific":[137,172],"regulation":[138],"of":[139],"wspR":[140],"pslA,":[142],"upregulation":[144],"(2-3-fold)":[147],"downregulation":[149],"(\u223c50%)":[150],"XCH-MDR-01.":[152],"Co-treatment":[153],"dihydrotanshinone":[155],"or":[157],"ceftazidime":[161,184],"MICs":[162],"by":[163],"4-8-fold":[164],"isolates.":[167,188],"CONCLUSIONS:":[168],"exert":[171],"selectively":[182],"potentiate":[183],"against":[186]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-12-09T00:00:00"}
