{"id":"https://openalex.org/W4417080336","doi":"https://doi.org/10.1016/j.bbr.2025.115985","title":"Age-dependent effects of intranasal oxytocin administration were revealed by resting brain entropy (BEN)","display_name":"Age-dependent effects of intranasal oxytocin administration were revealed by resting brain entropy (BEN)","publication_year":2025,"publication_date":"2025-12-06","ids":{"openalex":"https://openalex.org/W4417080336","doi":"https://doi.org/10.1016/j.bbr.2025.115985","pmid":"https://pubmed.ncbi.nlm.nih.gov/41360155"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbr.2025.115985","doi":"https://doi.org/10.1016/j.bbr.2025.115985","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbr.2025.115985","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbr.2025.115985","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011265334","display_name":"Donghui Song","orcid":"https://orcid.org/0000-0003-3722-0413","observed_orcids":["https://orcid.org/0000-0003-3722-0413"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]},{"id":"https://openalex.org/I4391768142","display_name":"State Key Laboratory of Cognitive Neuroscience and Learning","ror":"https://ror.org/059y0zb32","country_code":"CN","type":"facility","lineage":["https://openalex.org/I25254941","https://openalex.org/I4391768142"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Donghui Song","raw_affiliation_strings":["Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China. Electronic address: donghuipsy@gmail.com"],"raw_orcid":"https://orcid.org/0000-0003-3722-0413","affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China. Electronic address: donghuipsy@gmail.com","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I25254941","https://openalex.org/I4391768142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100443555","display_name":"Ze Wang","orcid":"https://orcid.org/0000-0002-8339-5567","observed_orcids":["https://orcid.org/0000-0002-8339-5567"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ze Wang","raw_affiliation_strings":["Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: ze.wang@som.umaryland.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: ze.wang@som.umaryland.edu","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011265334","https://openalex.org/A5100443555"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I25254941","https://openalex.org/I4391768142"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":4.022,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.94319453,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"500","issue":null,"first_page":"115985","last_page":"115985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intranasal-oxytocin","display_name":"intranasal oxytocin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/brain-entropy","display_name":"brain entropy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.7630000114440918},{"id":"https://openalex.org/keywords/temporoparietal-junction","display_name":"temporoparietal junction","score":0.8349999785423279},{"id":"https://openalex.org/keywords/fractional-amplitude-of-low-frequency-fluctuations","display_name":"fractional amplitude of low-frequency fluctuations","score":0.9879999756813049},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/resting-state-brain-activity","display_name":"resting-state brain activity","score":0.5649999976158142},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.7871999740600586},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5899999737739563},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5246999859809875},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5113000273704529},{"id":"https://openalex.org/C2779875032","wikidata":"https://www.wikidata.org/wiki/Q2940216","display_name":"Temporoparietal junction","level":4,"score":0.4959999918937683},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48739999532699585},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.483599990606308},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.42750000953674316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4250999987125397},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.4133000075817108},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4058000147342682},{"id":"https://openalex.org/C181612422","wikidata":"https://www.wikidata.org/wiki/Q14908140","display_name":"Oxytocin receptor","level":3,"score":0.3837999999523163},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.36169999837875366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33410000801086426},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.314300000667572},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.29840001463890076},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.25780001282691956}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbr.2025.115985","doi":"https://doi.org/10.1016/j.bbr.2025.115985","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbr.2025.115985","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},{"id":"doi:10.1101/2024.11.25.625152","doi":"https://doi.org/10.1101/2024.11.25.625152","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.11.25.625152","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41360155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41360155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural brain research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbr.2025.115985","doi":"https://doi.org/10.1016/j.bbr.2025.115985","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbr.2025.115985","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":119,"referenced_works":["https://openalex.org/W616889049","https://openalex.org/W618310327","https://openalex.org/W1536234704","https://openalex.org/W1750764127","https://openalex.org/W1851299844","https://openalex.org/W1862394037","https://openalex.org/W1965231812","https://openalex.org/W1975008822","https://openalex.org/W1981648524","https://openalex.org/W1990134753","https://openalex.org/W1994692081","https://openalex.org/W1998476154","https://openalex.org/W2007919714","https://openalex.org/W2009494091","https://openalex.org/W2014530731","https://openalex.org/W2015140100","https://openalex.org/W2020519533","https://openalex.org/W2020926765","https://openalex.org/W2021053759","https://openalex.org/W2028964134","https://openalex.org/W2039714243","https://openalex.org/W2043356371","https://openalex.org/W2045704700","https://openalex.org/W2049168807","https://openalex.org/W2052644075","https://openalex.org/W2055442583","https://openalex.org/W2055559081","https://openalex.org/W2057409098","https://openalex.org/W2057967199","https://openalex.org/W2061226698","https://openalex.org/W2069221001","https://openalex.org/W2078021745","https://openalex.org/W2083913872","https://openalex.org/W2088599339","https://openalex.org/W2099601730","https://openalex.org/W2100634972","https://openalex.org/W2100831964","https://openalex.org/W2113619522","https://openalex.org/W2116649573","https://openalex.org/W2118421222","https://openalex.org/W2118796430","https://openalex.org/W2124133779","https://openalex.org/W2124757386","https://openalex.org/W2125447065","https://openalex.org/W2136573752","https://openalex.org/W2136974459","https://openalex.org/W2146224339","https://openalex.org/W2148726987","https://openalex.org/W2153367517","https://openalex.org/W2161502085","https://openalex.org/W2170938715","https://openalex.org/W2307347893","https://openalex.org/W2315385594","https://openalex.org/W2463516915","https://openalex.org/W2560890473","https://openalex.org/W2597672229","https://openalex.org/W2608509684","https://openalex.org/W2613162307","https://openalex.org/W2618490415","https://openalex.org/W2758456928","https://openalex.org/W2760380281","https://openalex.org/W2794350434","https://openalex.org/W2794814093","https://openalex.org/W2796462748","https://openalex.org/W2799379448","https://openalex.org/W2803808353","https://openalex.org/W2890128620","https://openalex.org/W2892647046","https://openalex.org/W2903559564","https://openalex.org/W2914003068","https://openalex.org/W2922249583","https://openalex.org/W2937872047","https://openalex.org/W2949397924","https://openalex.org/W2951049825","https://openalex.org/W2951583631","https://openalex.org/W2974776061","https://openalex.org/W2990790395","https://openalex.org/W2999970138","https://openalex.org/W3023013569","https://openalex.org/W3049568087","https://openalex.org/W3086906848","https://openalex.org/W3103998285","https://openalex.org/W3112368366","https://openalex.org/W3131878313","https://openalex.org/W3134532145","https://openalex.org/W3149736664","https://openalex.org/W3157270867","https://openalex.org/W3197131787","https://openalex.org/W3206860915","https://openalex.org/W4206688347","https://openalex.org/W4210697252","https://openalex.org/W4210735104","https://openalex.org/W4221063873","https://openalex.org/W4221120190","https://openalex.org/W4225246927","https://openalex.org/W4292738033","https://openalex.org/W4294021982","https://openalex.org/W4385728818","https://openalex.org/W4385798763","https://openalex.org/W4386810796","https://openalex.org/W4387654010","https://openalex.org/W4388282923","https://openalex.org/W4392133391","https://openalex.org/W4392380953","https://openalex.org/W4392814352","https://openalex.org/W4396968405","https://openalex.org/W4399427115","https://openalex.org/W4399701238","https://openalex.org/W4399721898","https://openalex.org/W4400822643","https://openalex.org/W4400952701","https://openalex.org/W4401338748","https://openalex.org/W4405971184","https://openalex.org/W4406558226","https://openalex.org/W4406852052","https://openalex.org/W4408166507","https://openalex.org/W4409638061","https://openalex.org/W4412364936","https://openalex.org/W7223465265"],"related_works":["https://openalex.org/W4388282923","https://openalex.org/W4387654010","https://openalex.org/W4221063873","https://openalex.org/W4401853905","https://openalex.org/W4415551777","https://openalex.org/W7140176718","https://openalex.org/W3134532145","https://openalex.org/W2789964053","https://openalex.org/W2795613311","https://openalex.org/W2914003068"],"abstract_inverted_index":{"Oxytocin":[0],"(OT),":[1],"a":[2,25,59,86,152],"neuropeptide":[3],"known":[4],"for":[5,32],"its":[6],"role":[7],"in":[8,90,100,105,120,125,143,193],"social":[9],"behavior,":[10],"has":[11],"unclear":[12],"neural":[13,28,44],"mechanisms":[14],"when":[15],"administered":[16],"intranasally,":[17],"especially":[18],"across":[19],"different":[20],"ages.":[21],"Brain":[22],"entropy":[23],"(BEN),":[24],"metric":[26],"of":[27,116,156,166,178],"irregularity,":[29],"shows":[30],"promise":[31],"revealing":[33],"OT's":[34],"neurophysiological":[35],"effects.":[36],"This":[37],"study":[38],"examined":[39],"whether":[40],"BEN":[41,82,99,150],"could":[42],"detect":[43],"changes":[45,182],"induced":[46],"by":[47,56],"intranasal":[48,75],"OT":[49,76,97,110,128,159,184,194],"and":[50,67,136,140,169],"how":[51],"these":[52],"effects":[53],"are":[54],"modulated":[55],"age.":[57],"In":[58],"randomized,":[60],"double-blind,":[61],"placebo-controlled":[62],"trial,":[63],"young":[64],"adults":[65,69],"(YA)":[66],"older":[68],"(OA)":[70],"were":[71],"assigned":[72],"to":[73,191],"receive":[74],"or":[77],"placebo":[78],"(PL).":[79],"Using":[80],"fMRI-based":[81],"mapping,":[83],"we":[84],"identified":[85],"significant":[87],"age-dependent":[88],"effect":[89],"the":[91,113,121,133,138,176],"left":[92,134,139],"temporoparietal":[93],"junction":[94],"(TPJ),":[95],"where":[96],"increased":[98],"YA":[101],"but":[102],"decreased":[103],"it":[104],"OA.":[106],"Further":[107],"analyses":[108],"showed":[109],"also":[111],"elevated":[112],"fractional":[114],"amplitude":[115],"low-frequency":[117],"fluctuations":[118],"(fALFF)":[119],"same":[122],"region,":[123],"particularly":[124],"YA.":[126],"Additionally,":[127],"enhanced":[129],"functional":[130],"connectivity":[131],"within":[132],"TPJ":[135,142],"between":[137],"right":[141],"both":[144],"age":[145],"groups.":[146],"These":[147],"results":[148],"establish":[149],"as":[151],"sensitive":[153],"biomarker":[154],"capable":[155],"capturing":[157],"age-specific":[158],"effects,":[160],"providing":[161],"information":[162],"beyond":[163],"traditional":[164],"measures":[165],"oscillatory":[167],"power":[168],"temporal":[170],"synchronization.":[171],"The":[172],"findings":[173],"suggest":[174],"that":[175],"timing":[177],"post-administration":[179],"brain":[180],"state":[181],"under":[183],"may":[185],"vary":[186],"with":[187],"age,":[188],"potentially":[189],"due":[190],"differences":[192],"receptor":[195],"density.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-12-06T00:00:00"}