{"id":"https://openalex.org/W4417078167","doi":"https://doi.org/10.1038/s41598-025-30886-6","title":"Extraction, LC-QTOF-MS profiling of bacterial menaquinone (MK) and characterization of CuFe2O4 nanoparticles loaded MK: potential anti-cancer via gene expression","display_name":"Extraction, LC-QTOF-MS profiling of bacterial menaquinone (MK) and characterization of CuFe2O4 nanoparticles loaded MK: potential anti-cancer via gene expression","publication_year":2025,"publication_date":"2025-12-06","ids":{"openalex":"https://openalex.org/W4417078167","doi":"https://doi.org/10.1038/s41598-025-30886-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/41353281","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12789059"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-025-30886-6","doi":"https://doi.org/10.1038/s41598-025-30886-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-30886-6","pdf_url":"https://www.nature.com/articles/s41598-025-30886-6_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-025-30886-6_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067037198","display_name":"Reem M. Farsi","orcid":"https://orcid.org/0000-0001-7593-8018","observed_orcids":["https://orcid.org/0000-0001-7593-8018"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Reem M. Farsi","raw_affiliation_strings":["Faculty of Science, Department of Biological Sciences, King Abdul-Aziz University, Jeddah, Saudi Arabia. rfarsi@kau.edu.sa","Faculty of Science, Department of Biological Sciences, King Abdul-Aziz University, Jeddah, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Department of Biological Sciences, King Abdul-Aziz University, Jeddah, Saudi Arabia. rfarsi@kau.edu.sa","institution_ids":["https://openalex.org/I185163786"]},{"raw_affiliation_string":"Faculty of Science, Department of Biological Sciences, King Abdul-Aziz University, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102858493","display_name":"Mohamed S. Abdelwahab","orcid":"https://orcid.org/0000-0001-8609-878X","observed_orcids":["https://orcid.org/0000-0001-8609-878X"]},"institutions":[{"id":"https://openalex.org/I4405258152","display_name":"Matrouh University","ror":"https://ror.org/006wtk122","country_code":"EG","type":"education","lineage":["https://openalex.org/I4405258152"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mohamed S. Abdelwahab","raw_affiliation_strings":["Faculty of Education, Physics and Chemistry Department, Matrouh University, Mersa Matrouh, Egypt. mohamed-said-science@hotmail.com","Faculty of Education, Physics and Chemistry Department, Matrouh University, Mersa Matrouh, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Education, Physics and Chemistry Department, Matrouh University, Mersa Matrouh, Egypt. mohamed-said-science@hotmail.com","institution_ids":["https://openalex.org/I4405258152"]},{"raw_affiliation_string":"Faculty of Education, Physics and Chemistry Department, Matrouh University, Mersa Matrouh, Egypt","institution_ids":["https://openalex.org/I4405258152"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067037198","https://openalex.org/A5102858493"],"corresponding_institution_ids":["https://openalex.org/I185163786","https://openalex.org/I4405258152"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.3591,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.39218795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"16","issue":"1","first_page":"1194","last_page":"1194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.09319999814033508,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10922","display_name":"Magnetic Properties and Synthesis of Ferrites","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copper-ferrite-nanoparticles","display_name":"copper ferrite nanoparticles","score":0.9049999713897705},{"id":"https://openalex.org/keywords/vitamin-k2","display_name":"vitamin K2","score":0.9549999833106995},{"id":"https://openalex.org/keywords/halophilic-bacteria","display_name":"halophilic bacteria","score":0.953000009059906},{"id":"https://openalex.org/keywords/bacterial-extracts","display_name":"bacterial extracts","score":0.47999998927116394},{"id":"https://openalex.org/keywords/nanoparticle-functionalization","display_name":"nanoparticle functionalization","score":0.7919999957084656},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7450000047683716},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9639999866485596},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.546999990940094},{"id":"https://openalex.org/keywords/marine-natural-products","display_name":"marine natural products","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6966999769210815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6362000107765198},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5881999731063843},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5080000162124634},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.412200003862381},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4018000066280365},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.398499995470047},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.38449999690055847},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3668999969959259},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.366100013256073},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3630000054836273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3546000123023987},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3443000018596649},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3253999948501587},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3206000030040741},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.31619998812675476},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.3142000138759613},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C92880739","wikidata":"https://www.wikidata.org/wiki/Q2639556","display_name":"Nanocomposite","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2606000006198883},{"id":"https://openalex.org/C37210646","wikidata":"https://www.wikidata.org/wiki/Q5105088","display_name":"Ferrite (magnet)","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25459998846054077}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024482","descriptor_name":"Vitamin K 2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D024482","descriptor_name":"Vitamin K 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024482","descriptor_name":"Vitamin K 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-025-30886-6","doi":"https://doi.org/10.1038/s41598-025-30886-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-30886-6","pdf_url":"https://www.nature.com/articles/s41598-025-30886-6_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:41353281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41353281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12789059","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12789059/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:33101c3675354863bb2a8c3702c879d1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/33101c3675354863bb2a8c3702c879d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1, Pp 1-19 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-025-30886-6","doi":"https://doi.org/10.1038/s41598-025-30886-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-30886-6","pdf_url":"https://www.nature.com/articles/s41598-025-30886-6_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417078167.pdf","grobid_xml":"https://content.openalex.org/works/W4417078167.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W452465010","https://openalex.org/W2034812894","https://openalex.org/W2035035771","https://openalex.org/W2075196511","https://openalex.org/W2082357294","https://openalex.org/W2089784158","https://openalex.org/W2118526562","https://openalex.org/W2164361309","https://openalex.org/W2282509758","https://openalex.org/W2736358667","https://openalex.org/W2899155995","https://openalex.org/W2947120240","https://openalex.org/W2963420860","https://openalex.org/W2973494578","https://openalex.org/W2982248578","https://openalex.org/W3087474054","https://openalex.org/W3090589867","https://openalex.org/W3092116237","https://openalex.org/W3114988170","https://openalex.org/W3118712849","https://openalex.org/W3119115704","https://openalex.org/W3124119591","https://openalex.org/W3124805942","https://openalex.org/W3129298162","https://openalex.org/W3155299987","https://openalex.org/W3159619917","https://openalex.org/W3166597738","https://openalex.org/W3176601331","https://openalex.org/W3193617675","https://openalex.org/W3196730820","https://openalex.org/W3197545765","https://openalex.org/W3198131103","https://openalex.org/W3204828637","https://openalex.org/W3215778090","https://openalex.org/W4200192816","https://openalex.org/W4206317593","https://openalex.org/W4221115671","https://openalex.org/W4280613613","https://openalex.org/W4283453165","https://openalex.org/W4296118021","https://openalex.org/W4296143832","https://openalex.org/W4307844065","https://openalex.org/W4311674796","https://openalex.org/W4311808418","https://openalex.org/W4315490712","https://openalex.org/W4319081113","https://openalex.org/W4366722957","https://openalex.org/W4377292687","https://openalex.org/W4377293116","https://openalex.org/W4379517799","https://openalex.org/W4384557425","https://openalex.org/W4386195686","https://openalex.org/W4386195741","https://openalex.org/W4386374789","https://openalex.org/W4387204689","https://openalex.org/W4387778339","https://openalex.org/W4388107241","https://openalex.org/W4389522831","https://openalex.org/W4392799685","https://openalex.org/W4392858947","https://openalex.org/W4396214429","https://openalex.org/W4399058881","https://openalex.org/W4400421622","https://openalex.org/W4400881663","https://openalex.org/W4401970090","https://openalex.org/W4403506068","https://openalex.org/W4405322208","https://openalex.org/W4406231831","https://openalex.org/W4406805446","https://openalex.org/W4406852517","https://openalex.org/W4407681133","https://openalex.org/W4410386270","https://openalex.org/W4411116232","https://openalex.org/W4413103265","https://openalex.org/W4413253647","https://openalex.org/W4413362058","https://openalex.org/W4413401628","https://openalex.org/W4413751886","https://openalex.org/W4414285344"],"related_works":["https://openalex.org/W4417431216","https://openalex.org/W7160949300","https://openalex.org/W4375851080","https://openalex.org/W4389522831","https://openalex.org/W7133940641","https://openalex.org/W4399471827","https://openalex.org/W2070262613","https://openalex.org/W7215321179","https://openalex.org/W7117363327","https://openalex.org/W4294992174"],"abstract_inverted_index":{"Ferrite":[0],"nanoparticles":[1,6,67],"(FNPs),":[2],"especially":[3],"copper":[4],"ferrite":[5],"(CuFe\u2082O\u2084":[7,68,147],"NPs),":[8],"are":[9],"a":[10,26,34,116,127,143],"promising":[11],"platform":[12],"in":[13,47,120,136,157],"nanomedicine":[14],"for":[15],"targeted":[16],"cancer":[17,159],"treatment.":[18],"Consequently,":[19],"unique":[20],"CuFe\u2082O\u2084":[21],"NPs":[22,71,99],"were":[23,72],"functionalized":[24],"with":[25,101],"bioactive":[27],"extract":[28],"derived":[29],"from":[30,39],"Salinicoccus":[31],"sp.":[32],"RM1,":[33],"halophilic":[35],"bacterial":[36,44],"strain":[37],"obtained":[38],"the":[40,87,93,163],"Red":[41],"Sea.":[42],"The":[43],"extract,":[45],"abundant":[46],"menaquinone":[48],"(MK)":[49],"homologs":[50],"(MK-4":[51],"to":[52,64,154],"MK-13)":[53],"as":[54,59],"verified":[55],"by":[56,161],"LC-QTOF-MS,":[57],"used":[58],"an":[60,110],"excellent":[61],"functionalizing":[62],"agent":[63],"produced":[65],"MK-loaded":[66],"NPs-MK).":[69],"Prepared":[70],"analyzed":[73],"using":[74],"XRD,":[75],"FT-IR,":[76],"SEM,":[77],"EDX,":[78],"particle":[79],"size":[80],"analysis":[81],"and":[82,90,115,139],"magnetic":[83],"susceptibility":[84],"analysis,":[85],"confirming":[86],"effective":[88],"production":[89],"functionalization":[91],"of":[92,112,142],"NPs.":[94],"CuFe":[95],"2":[96],"O":[97],"4":[98],"modified":[100],"MK":[102],"exhibited":[103],"significant":[104],"cytotoxicity":[105],"against":[106],"MCF-7":[107],"cells,":[108],"yielding":[109],"IC\u2085\u2080":[111],"48.94":[113],"\u00b5g/ml":[114],"notable":[117],"45%":[118],"reduction":[119],"BCL-2":[121],"expression,":[122],"while":[123],"BAX":[124],"expression":[125],"experienced":[126],"marginal":[128],"3.4%":[129],"rise.":[130],"This":[131],"study":[132],"demonstrates":[133],"its":[134],"strength":[135],"innovative":[137],"design":[138],"comprehensive":[140],"characterization":[141],"novel":[144],"anti-cancer":[145],"nanocomposite":[146],"NPs-MK),":[148],"utilizing":[149],"sustainably":[150],"sourced":[151],"marine":[152],"MKs":[153],"induce":[155],"apoptosis":[156],"breast":[158],"cells":[160],"modulating":[162],"BAX/BCL-2":[164],"gene":[165],"ratio.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-12-06T00:00:00"}