{"id":"https://openalex.org/W4417076775","doi":"https://doi.org/10.1016/s2352-3018(25)00200-0","title":"Fixed-dose combination bictegravir\u2013emtricitabine\u2013tenofovir alafenamide twice-daily for treatment of HIV during rifampicin-based tuberculosis treatment (INSIGHT Study): a phase 2b, open-label, randomised non-comparative trial","display_name":"Fixed-dose combination bictegravir\u2013emtricitabine\u2013tenofovir alafenamide twice-daily for treatment of HIV during rifampicin-based tuberculosis treatment (INSIGHT Study): a phase 2b, open-label, randomised non-comparative trial","publication_year":2025,"publication_date":"2025-12-01","ids":{"openalex":"https://openalex.org/W4417076775","doi":"https://doi.org/10.1016/s2352-3018(25)00200-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/41344350","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12745350"},"language":"en","primary_location":{"id":"doi:10.1016/s2352-3018(25)00200-0","doi":"https://doi.org/10.1016/s2352-3018(25)00200-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2352-3018(25)00200-0","pdf_url":null,"source":{"id":"https://openalex.org/S2531945440","display_name":"The Lancet HIV","issn_l":"2352-3018","issn":["2352-3018","2405-4704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"The Lancet HIV","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/s2352-3018(25)00200-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045674018","display_name":"Anushka Naidoo","orcid":"https://orcid.org/0000-0001-9550-9501","observed_orcids":["https://orcid.org/0000-0001-9550-9501"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Anushka Naidoo","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: anushka.naidoo@caprisa.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: anushka.naidoo@caprisa.org","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058948786","display_name":"Kogieleum Naidoo","orcid":"https://orcid.org/0000-0002-8874-6661","observed_orcids":["https://orcid.org/0000-0002-8874-6661","https://orcid.org/0000-0002-2758-3459","https://orcid.org/0009-0001-4278-7724"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Kogieleum Naidoo","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044443465","display_name":"Marothi P Letsoalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Marothi P Letsoalo","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085759873","display_name":"Roeland E. Wasmann","orcid":"https://orcid.org/0000-0002-5769-8150","observed_orcids":["https://orcid.org/0000-0002-5769-8150"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Roeland E Wasmann","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049213645","display_name":"Gillian Dorse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gillian Dorse","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053056943","display_name":"Rubeshan Perumal","orcid":"https://orcid.org/0000-0001-8892-2904","observed_orcids":["https://orcid.org/0000-0001-8892-2904"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Rubeshan Perumal","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035982137","display_name":"Mahomed\u2010Yunus S. Moosa","orcid":"https://orcid.org/0000-0001-6191-4023","observed_orcids":["https://orcid.org/0000-0001-6191-4023"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Mahomed-Yunus S Moosa","raw_affiliation_strings":["Department of Infectious Diseases, Nelson R Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Nelson R Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emmanuella C Osuala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Emmanuella C Osuala","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024454613","display_name":"Resha Boodhram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Resha Boodhram","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038057527","display_name":"Benjamin Chimukangara","orcid":"https://orcid.org/0000-0002-8391-4531","observed_orcids":["https://orcid.org/0000-0002-8391-4531"]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["US","ZA"],"is_corresponding":false,"raw_author_name":"Benjamin Chimukangara","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Department of Critical Care Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA; Department of Virology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Department of Critical Care Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA; Department of Virology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I4210155647","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053945845","display_name":"Lubbe Wiesner","orcid":"https://orcid.org/0000-0002-9070-8699","observed_orcids":["https://orcid.org/0000-0002-9070-8699"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Lubbe Wiesner","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042956469","display_name":"Dennis M Israelski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Israelski","raw_affiliation_strings":["Gilead Sciences, Foster City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences, Foster City, CA, USA","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056892721","display_name":"Paolo Denti","orcid":"https://orcid.org/0000-0001-7494-079X","observed_orcids":["https://orcid.org/0000-0001-7494-079X"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Paolo Denti","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James F Rooney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F Rooney","raw_affiliation_strings":["Gilead Sciences, Foster City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences, Foster City, CA, USA","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kelly E Dooley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly E Dooley","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anushka Naidoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Anushka Naidoo","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: anushka.naidoo@caprisa.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: anushka.naidoo@caprisa.org","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kelly E. Dooley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly E. Dooley","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kogieleum Naidoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Kogieleum Naidoo","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gillian Dorse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gillian Dorse","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rubeshan Perumal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Rubeshan Perumal","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Resha Boodhram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Resha Boodhram","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Busisiwe Ntsalaze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Busisiwe Ntsalaze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Samiksha Byroo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samiksha Byroo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ellisha Francis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellisha Francis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Anokhee Leela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anokhee Leela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Rosemary Gray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosemary Gray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bhavna Maharaj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhavna Maharaj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Nompumelelo Zungu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nompumelelo Zungu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Phindile Msomi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phindile Msomi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Claudia Shozi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Shozi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Radhamoney Narasimmulu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radhamoney Narasimmulu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Nokuzola Cwazibe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nokuzola Cwazibe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Rajesperi Venter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajesperi Venter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Saras Pather","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saras Pather","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Nokwanda Depargo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nokwanda Depargo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Silindile Tenza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silindile Tenza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Patience Mbatha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patience Mbatha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Marothi P. Letsoalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Marothi P. Letsoalo","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mxolisi Mahlangu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mxolisi Mahlangu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Natasha Samsunder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natasha Samsunder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zanele Mchunu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zanele Mchunu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Avanthi Moodley-Reddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Avanthi Moodley-Reddy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lungile Maphumulo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lungile Maphumulo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Adejumoke Abiose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adejumoke Abiose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012071177","display_name":"Emmanuella Chinonso Osuala","orcid":"https://orcid.org/0000-0002-2035-0935","observed_orcids":["https://orcid.org/0000-0002-2035-0935"]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Emmanuella C. Osuala","raw_affiliation_strings":["Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I95023434"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045674018"],"corresponding_institution_ids":["https://openalex.org/I10947320","https://openalex.org/I2800715850","https://openalex.org/I95023434"],"apc_list":{"value":7280,"currency":"USD","value_usd":7280},"apc_paid":null,"fwci":2.6849,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.9089796,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"e9","last_page":"e20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/hiv-tb-co-infection","display_name":"HIV/TB coinfection","score":0.7360000014305115},{"id":"https://openalex.org/keywords/bictegravir","display_name":"bictegravir","score":0.8899999856948853},{"id":"https://openalex.org/keywords/emtricitabine","display_name":"emtricitabine","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tenofovir-alafenamide","display_name":"tenofovir alafenamide","score":1.0},{"id":"https://openalex.org/keywords/dolutegravir","display_name":"dolutegravir","score":0.921999990940094},{"id":"https://openalex.org/keywords/fixed-dose-combination-antiretroviral-therapy","display_name":"fixed-dose combination antiretroviral therapy","score":0.906000018119812},{"id":"https://openalex.org/keywords/twice-daily-dosing","display_name":"twice-daily dosing","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hiv-viral-suppression","display_name":"HIV viral suppression","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6539999842643738},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7099999785423279},{"id":"https://openalex.org/keywords/hiv-1-rna","display_name":"HIV-1 RNA","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9736999869346619},{"id":"https://openalex.org/C2911190787","wikidata":"https://www.wikidata.org/wiki/Q22075912","display_name":"Tenofovir alafenamide","level":5,"score":0.7516999840736389},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6589999794960022},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.604200005531311},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5878999829292297},{"id":"https://openalex.org/C3019056677","wikidata":"https://www.wikidata.org/wiki/Q1189184","display_name":"Tb treatment","level":3,"score":0.46230000257492065},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4318000078201294},{"id":"https://openalex.org/C2909923361","wikidata":"https://www.wikidata.org/wiki/Q2339584","display_name":"Directly Observed Therapy","level":3,"score":0.4011000096797943},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.38199999928474426},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.3684000074863434},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.3490000069141388},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.34389999508857727},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3319999873638153},{"id":"https://openalex.org/C2982822547","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Medical treatment","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.29820001125335693},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C2776991065","wikidata":"https://www.wikidata.org/wiki/Q3935297","display_name":"Rifapentine","level":5,"score":0.2806999981403351},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C502991105","wikidata":"https://www.wikidata.org/wiki/Q5133849","display_name":"Clinical research","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2669999897480011},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.2565000057220459},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.2558000087738037},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.2524999976158142},{"id":"https://openalex.org/C2909201284","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"AIDS-Related Opportunistic Infections","level":5,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D000068679","descriptor_name":"Emtricitabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068679","descriptor_name":"Emtricitabine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000068679","descriptor_name":"Emtricitabine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000068679","descriptor_name":"Emtricitabine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000068698","descriptor_name":"Tenofovir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068698","descriptor_name":"Tenofovir","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000068698","descriptor_name":"Tenofovir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006575","descriptor_name":"Heterocyclic Compounds, 3-Ring","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013019","descriptor_name":"South Africa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s2352-3018(25)00200-0","doi":"https://doi.org/10.1016/s2352-3018(25)00200-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2352-3018(25)00200-0","pdf_url":null,"source":{"id":"https://openalex.org/S2531945440","display_name":"The Lancet HIV","issn_l":"2352-3018","issn":["2352-3018","2405-4704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"The Lancet HIV","raw_type":"journal-article"},{"id":"pmid:41344350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41344350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The lancet. HIV","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:pubmedcentral.nih.gov:12745350","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41344350/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet HIV","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/s2352-3018(25)00200-0","doi":"https://doi.org/10.1016/s2352-3018(25)00200-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2352-3018(25)00200-0","pdf_url":null,"source":{"id":"https://openalex.org/S2531945440","display_name":"The Lancet HIV","issn_l":"2352-3018","issn":["2352-3018","2405-4704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"The Lancet HIV","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1316585220","display_name":"Dolutegravir for the treatment of HIV in patients with Tuberculosis in KwaZulu-Natal South Africa","funder_award_id":"K43TW011437","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G2658137819","display_name":"Second Generation InSTIs for the Treatment of HIV-1 in patients with TB co-infection on Rifampicin-based Treatment in KwaZulu Natal, South Africa","funder_award_id":"R01AI152142","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2860292804","display_name":null,"funder_award_id":"R01AI152142","funder_id":"https://openalex.org/F4320320672","funder_display_name":"South African Medical Research Council"},{"id":"https://openalex.org/G9000909486","display_name":"Mentoring Investigators in HIV and Tuberculosis Therapeutics Research","funder_award_id":"K24AI150349","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320320672","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1970755954","https://openalex.org/W2067602940","https://openalex.org/W2116382218","https://openalex.org/W2120074558","https://openalex.org/W2120113475","https://openalex.org/W2154164013","https://openalex.org/W2160104000","https://openalex.org/W2171909957","https://openalex.org/W2586083164","https://openalex.org/W2752494178","https://openalex.org/W2753489952","https://openalex.org/W2804301217","https://openalex.org/W2919556156","https://openalex.org/W2963143205","https://openalex.org/W3003135182","https://openalex.org/W3082911581","https://openalex.org/W3108956197","https://openalex.org/W4210547859","https://openalex.org/W4244459571","https://openalex.org/W4308882968","https://openalex.org/W4377292587","https://openalex.org/W4394770776"],"related_works":["https://openalex.org/W4308882968","https://openalex.org/W7117567215","https://openalex.org/W2944376193","https://openalex.org/W4244459571","https://openalex.org/W7155020447","https://openalex.org/W3033333369","https://openalex.org/W4403343246","https://openalex.org/W2588766650","https://openalex.org/W2803164097","https://openalex.org/W2753489952"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-12-03T00:00:00"}
