{"id":"https://openalex.org/W4417023688","doi":"https://doi.org/10.1007/s00044-025-03511-4","title":"Synthesis and biological evaluation of coumarin-based urea derivatives demonstrating apoptosis-inducing and anti-angiogenic properties for non-small cell lung cancer treatment","display_name":"Synthesis and biological evaluation of coumarin-based urea derivatives demonstrating apoptosis-inducing and anti-angiogenic properties for non-small cell lung cancer treatment","publication_year":2025,"publication_date":"2025-12-05","ids":{"openalex":"https://openalex.org/W4417023688","doi":"https://doi.org/10.1007/s00044-025-03511-4"},"language":"en","primary_location":{"id":"doi:10.1007/s00044-025-03511-4","doi":"https://doi.org/10.1007/s00044-025-03511-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00044-025-03511-4","pdf_url":null,"source":{"id":"https://openalex.org/S36909932","display_name":"Medicinal Chemistry Research","issn_l":"1054-2523","issn":["1054-2523","1554-8120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100658149","display_name":"Zirui Chen","orcid":"https://orcid.org/0009-0004-4849-5003","observed_orcids":["https://orcid.org/0009-0004-4849-5003","https://orcid.org/0009-0004-6236-9150","https://orcid.org/0009-0007-3189-7147"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zirui Chen","raw_affiliation_strings":["Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qi Liao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Liao","raw_affiliation_strings":["Periplaneta americana and Innovative Drugs Key Laboratory of Sichuan Province, Chengdu, 610072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Periplaneta americana and Innovative Drugs Key Laboratory of Sichuan Province, Chengdu, 610072, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007632416","display_name":"Pengyu Zhao","orcid":"https://orcid.org/0000-0002-9905-5188","observed_orcids":["https://orcid.org/0000-0002-9905-5188"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengyu Zhao","raw_affiliation_strings":["School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113101858","display_name":"Yuefei Geng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuefei Geng","raw_affiliation_strings":["Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100641777","display_name":"Jianguo Wen","orcid":"https://orcid.org/0000-0003-0952-118X","observed_orcids":["https://orcid.org/0000-0003-0952-118X","https://orcid.org/0000-0002-1574-6812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianguo Wen","raw_affiliation_strings":["Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453861","display_name":"Shu Liu","orcid":"https://orcid.org/0000-0003-2165-5471","observed_orcids":["https://orcid.org/0000-0003-2165-5471","https://orcid.org/0009-0001-6877-1915","https://orcid.org/0009-0000-8342-8958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu Liu","raw_affiliation_strings":["Periplaneta americana and Innovative Drugs Key Laboratory of Sichuan Province, Chengdu, 610072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Periplaneta americana and Innovative Drugs Key Laboratory of Sichuan Province, Chengdu, 610072, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014753059","display_name":"Yanping Tang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanping Tang","raw_affiliation_strings":["Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113922679","display_name":"Chenjuan Zeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chenjuan Zeng","raw_affiliation_strings":["Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061952937","display_name":"Tingting Yan","orcid":"https://orcid.org/0000-0002-2368-9248","observed_orcids":["https://orcid.org/0000-0002-2368-9248"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tingting Yan","raw_affiliation_strings":["Periplaneta americana and Innovative Drugs Key Laboratory of Sichuan Province, Chengdu, 610072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Periplaneta americana and Innovative Drugs Key Laboratory of Sichuan Province, Chengdu, 610072, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024242005","display_name":"Yongmei Shen","orcid":"https://orcid.org/0000-0001-6008-4822","observed_orcids":["https://orcid.org/0000-0001-6008-4822"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yongmei Shen","raw_affiliation_strings":["Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031677654","display_name":"Funeng Geng","orcid":"https://orcid.org/0000-0003-3748-4187","observed_orcids":["https://orcid.org/0000-0003-3748-4187"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Funeng Geng","raw_affiliation_strings":["Periplaneta americana and Innovative Drugs Key Laboratory of Sichuan Province, Chengdu, 610072, China","School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China","Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Periplaneta americana and Innovative Drugs Key Laboratory of Sichuan Province, Chengdu, 610072, China","institution_ids":[]},{"raw_affiliation_string":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China","institution_ids":["https://openalex.org/I53411278"]},{"raw_affiliation_string":"Sichuan GoodDoctor Panxi Pharmaceutical Co., Ltd, Xichang City, Liangshan Prefecture, 615000, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024242005","https://openalex.org/A5031677654","https://openalex.org/A5061952937"],"corresponding_institution_ids":["https://openalex.org/I53411278"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.2787,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46663606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"35","issue":"2","first_page":"384","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11973","display_name":"Plant chemical constituents analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/huvec-tube-formation","display_name":"HUVEC tube formation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8859999775886536},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/natural-product-derivatives","display_name":"natural product derivatives","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6931999921798706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.680899977684021},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6682999730110168},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6283000111579895},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.5920000076293945},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5769000053405762},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.531499981880188},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5263000130653381},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5206000208854675},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5073999762535095},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4936999976634979},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4763999879360199},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.40290001034736633},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.385699987411499},{"id":"https://openalex.org/C2778807442","wikidata":"https://www.wikidata.org/wiki/Q6152005","display_name":"Treatment of lung cancer","level":3,"score":0.37880000472068787},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36419999599456787},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3050999939441681},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30469998717308044},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.2833999991416931},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.27059999108314514},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00044-025-03511-4","doi":"https://doi.org/10.1007/s00044-025-03511-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00044-025-03511-4","pdf_url":null,"source":{"id":"https://openalex.org/S36909932","display_name":"Medicinal Chemistry Research","issn_l":"1054-2523","issn":["1054-2523","1554-8120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1541546104","https://openalex.org/W2283752873","https://openalex.org/W2599306944","https://openalex.org/W2694664878","https://openalex.org/W2784371446","https://openalex.org/W2936810562","https://openalex.org/W2969925621","https://openalex.org/W2976334328","https://openalex.org/W2991251974","https://openalex.org/W3023160744","https://openalex.org/W3025613212","https://openalex.org/W3027428490","https://openalex.org/W3135347519","https://openalex.org/W3140967360","https://openalex.org/W3161633235","https://openalex.org/W3200033087","https://openalex.org/W3203315574","https://openalex.org/W3206646160","https://openalex.org/W4312194774","https://openalex.org/W4376226672","https://openalex.org/W4391344295","https://openalex.org/W4395481778","https://openalex.org/W4396229721","https://openalex.org/W4396700765","https://openalex.org/W4399043238","https://openalex.org/W4402601362","https://openalex.org/W4403627162","https://openalex.org/W4408477360","https://openalex.org/W4408884794","https://openalex.org/W4408913877"],"related_works":["https://openalex.org/W4412974252","https://openalex.org/W2761849826","https://openalex.org/W4206533354","https://openalex.org/W1976096573","https://openalex.org/W7171715721","https://openalex.org/W4311465446","https://openalex.org/W2751593380","https://openalex.org/W7212191883","https://openalex.org/W1536280314","https://openalex.org/W7132844369"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-12-05T00:00:00"}