{"id":"https://openalex.org/W4417023398","doi":"https://doi.org/10.1182/blood-2025-5567","title":"Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia. a randomized national fi-LMC comparative trial of two therapeutic strategies.","display_name":"Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia. a randomized national fi-LMC comparative trial of two therapeutic strategies.","publication_year":2025,"publication_date":"2025-11-03","ids":{"openalex":"https://openalex.org/W4417023398","doi":"https://doi.org/10.1182/blood-2025-5567"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2025-5567","doi":"https://doi.org/10.1182/blood-2025-5567","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2025-5567","pdf_url":"https://ashpublications.org/blood/article-pdf/146/Supplement 1/5567/2461460/blood-8314-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/146/Supplement 1/5567/2461460/blood-8314-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085118674","display_name":"\u00c9milie Cayssials","orcid":"https://orcid.org/0000-0003-1654-5948","observed_orcids":["https://orcid.org/0000-0003-1654-5948"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Cayssials","raw_affiliation_strings":["1CHU de Poitiers, Hematology, Poitiers, France","2CIC INSERM 1402, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CHU de Poitiers, Hematology, Poitiers, France","institution_ids":["https://openalex.org/I4210111187"]},{"raw_affiliation_string":"2CIC INSERM 1402, Poitiers, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jose Torregrosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jose Torregrosa","raw_affiliation_strings":["1CHU de Poitiers, Hematology, Poitiers, France","2CIC INSERM 1402, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CHU de Poitiers, Hematology, Poitiers, France","institution_ids":["https://openalex.org/I4210111187"]},{"raw_affiliation_string":"2CIC INSERM 1402, Poitiers, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091218534","display_name":"Fr\u00e9d\u00e9ric Bauduer","orcid":"https://orcid.org/0000-0002-7687-3743","observed_orcids":["https://orcid.org/0000-0002-7687-3743"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frederic Bauduer","raw_affiliation_strings":["3Universit\u00e9 de Bordeaux, Coll\u00e8gue des Sciences de la Sant\u00e9, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Universit\u00e9 de Bordeaux, Coll\u00e8gue des Sciences de la Sant\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I15057530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041434329","display_name":"Viviane Dubruille","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Viviane Dubruille","raw_affiliation_strings":["4CHU de Nantes, Hematology, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4CHU de Nantes, Hematology, Nantes, France","institution_ids":["https://openalex.org/I3019204325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056337631","display_name":"Val\u00e9rie Coiteux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210155195","display_name":"H\u00f4pital Claude Huriez","ror":"https://ror.org/05cpv3t46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210155195"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valerie Coiteux","raw_affiliation_strings":["5H\u00f4pital Huriez, CHU de Lille, Hematology, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5H\u00f4pital Huriez, CHU de Lille, Hematology, Lille, France","institution_ids":["https://openalex.org/I3018718406","https://openalex.org/I4210155195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004066423","display_name":"Fran\u00e7oise Huguet","orcid":"https://orcid.org/0000-0002-9576-8578","observed_orcids":["https://orcid.org/0000-0002-9576-8578","https://orcid.org/0000-0002-5302-5784"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francoise Huguet","raw_affiliation_strings":["6Institut Universitaire du Cancer de Toulouse, Hematology, Toulouse, France","7CHU de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Institut Universitaire du Cancer de Toulouse, Hematology, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]},{"raw_affiliation_string":"7CHU de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090388430","display_name":"Corentin Orvain","orcid":"https://orcid.org/0000-0002-8717-0824","observed_orcids":["https://orcid.org/0000-0002-8717-0824","https://orcid.org/0000-0003-1849-0186"]},"institutions":[{"id":"https://openalex.org/I4210112910","display_name":"Centre Hospitalier Universitaire d'Angers","ror":"https://ror.org/0250ngj72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210112910"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Corentin Orvain","raw_affiliation_strings":["8CHU d'Angers, Hematology, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8CHU d'Angers, Hematology, Angers, France","institution_ids":["https://openalex.org/I4210112910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064243705","display_name":"Gabrielle Roth-Gu\u00e9pin","orcid":"https://orcid.org/0009-0006-9270-9472","observed_orcids":["https://orcid.org/0009-0006-9270-9472"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gabrielle Roth-Guepin","raw_affiliation_strings":["9CHRU de Nancy, Hematology, Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9CHRU de Nancy, Hematology, Nancy, France","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052564121","display_name":"Philippe H. Rousselot","orcid":"https://orcid.org/0000-0003-3238-4494","observed_orcids":["https://orcid.org/0000-0003-3238-4494"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210159263","display_name":"Centre Hospitalier de Versailles","ror":"https://ror.org/053evvt91","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210159263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Rousselot","raw_affiliation_strings":["10Centre Hospitalier de Versailles, Hematology, Versailles, France","11U1184 Universit\u00e9 Paris Saclay, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Centre Hospitalier de Versailles, Hematology, Versailles, France","institution_ids":["https://openalex.org/I4210159263"]},{"raw_affiliation_string":"11U1184 Universit\u00e9 Paris Saclay, Paris, France","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011833868","display_name":"Am\u00e9lie Penot","orcid":"https://orcid.org/0009-0006-8275-5686","observed_orcids":["https://orcid.org/0009-0006-8275-5686"]},"institutions":[{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amelie Penot","raw_affiliation_strings":["12CHU de Limoges, Hematology, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12CHU de Limoges, Hematology, Limoges, France","institution_ids":["https://openalex.org/I4210118469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037458186","display_name":"Claire Calmettes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Calmettes","raw_affiliation_strings":["13Centre Hospitalier de P\u00e9rigueux, P\u00e9rigueux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Centre Hospitalier de P\u00e9rigueux, P\u00e9rigueux, France","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012805294","display_name":"Jean\u2010Christophe Ianotto","orcid":"https://orcid.org/0000-0001-9074-7287","observed_orcids":["https://orcid.org/0000-0001-9074-7287"]},"institutions":[{"id":"https://openalex.org/I4210132604","display_name":"Centre Hospitalier R\u00e9gional Universitaire de Brest","ror":"https://ror.org/03evbwn87","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210132604","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Christophe Ianotto","raw_affiliation_strings":["14CHU de Brest, Hematology, Brest, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14CHU de Brest, Hematology, Brest, France","institution_ids":["https://openalex.org/I4210132604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068342352","display_name":"Laurence Legros","orcid":"https://orcid.org/0000-0002-9567-7879","observed_orcids":["https://orcid.org/0000-0002-9567-7879"]},"institutions":[{"id":"https://openalex.org/I4210162942","display_name":"Bic\u00eatre Hospital","ror":"https://ror.org/05c9p1x46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210162942","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Legros","raw_affiliation_strings":["15H\u00f4pital Bic\u00eatre, Hematology, Le Kremlin-Bic\u00eatre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15H\u00f4pital Bic\u00eatre, Hematology, Le Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I4210162942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041250094","display_name":"Maud Voldoire","orcid":"https://orcid.org/0009-0006-3351-4309","observed_orcids":["https://orcid.org/0009-0006-3351-4309"]},"institutions":[{"id":"https://openalex.org/I4210135503","display_name":"H\u00f4pital priv\u00e9 du Confluent","ror":"https://ror.org/043x6pn39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210135503"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maud Voldoire","raw_affiliation_strings":["16H\u00f4pital Priv\u00e9 du Confluent, Hematology, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16H\u00f4pital Priv\u00e9 du Confluent, Hematology, Nantes, France","institution_ids":["https://openalex.org/I4210135503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058778299","display_name":"Samia Madene","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samia Madene-Haroune","raw_affiliation_strings":["17Centre Hospitalier Mont de Marsan, Hematology, Mont de Marsan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17Centre Hospitalier Mont de Marsan, Hematology, Mont de Marsan, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anne Parry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133838","display_name":"Centre Hospitalier Annecy Genevois","ror":"https://ror.org/03deam493","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210133838"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Parry","raw_affiliation_strings":["18Centre Hospitalier Annecy-Gennevois, Annecy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18Centre Hospitalier Annecy-Gennevois, Annecy, France","institution_ids":["https://openalex.org/I4210133838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089102838","display_name":"Christophe Roul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141638","display_name":"Centre Hospitalier de La Rochelle","ror":"https://ror.org/0446mfw72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210141638"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Roul","raw_affiliation_strings":["19Centre Hospitalier de La Rochelle, La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"19Centre Hospitalier de La Rochelle, La Rochelle, France","institution_ids":["https://openalex.org/I4210141638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069328342","display_name":"St\u00e9phane Girault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephane Girault","raw_affiliation_strings":["20Centre Hospitalier de Brive, Hematology, Brive, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"20Centre Hospitalier de Brive, Hematology, Brive, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059641957","display_name":"Gian Matteo Pica","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109185","display_name":"Centre Hospitalier M\u00e9tropole Savoie","ror":"https://ror.org/01r35jx22","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210109185"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gian Matteo Pica","raw_affiliation_strings":["21Centre Hospitalier Metropole Savoie, Chamb\u00e9ry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"21Centre Hospitalier Metropole Savoie, Chamb\u00e9ry, France","institution_ids":["https://openalex.org/I4210109185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068630847","display_name":"Antoine Machet","orcid":"https://orcid.org/0000-0003-4958-3908","observed_orcids":["https://orcid.org/0000-0003-4958-3908"]},"institutions":[{"id":"https://openalex.org/I4210095477","display_name":"Centre Hospitalier Universitaire de Tours","ror":"https://ror.org/00jpq0w62","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210095477"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Machet","raw_affiliation_strings":["22CHU de Tours, Hematology, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"22CHU de Tours, Hematology, Tours, France","institution_ids":["https://openalex.org/I4210095477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034803218","display_name":"Fran\u00e7ois Lifermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144072","display_name":"Centre Hospitalier de Dax \u2013C\u00f4te d\u2019Argent","ror":"https://ror.org/03mg0pe18","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210144072"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francois Lifermann","raw_affiliation_strings":["23Centre Hospitalier Dax-C\u00f4te d'Argent, Dax, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"23Centre Hospitalier Dax-C\u00f4te d'Argent, Dax, France","institution_ids":["https://openalex.org/I4210144072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034704802","display_name":"Laly Nsiala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laly Nsiala-Makunza","raw_affiliation_strings":["1CHU de Poitiers, Hematology, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CHU de Poitiers, Hematology, Poitiers, France","institution_ids":["https://openalex.org/I4210111187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079148801","display_name":"Maria Pilar Gallego Hernanz","orcid":"https://orcid.org/0009-0009-1999-0204","observed_orcids":["https://orcid.org/0009-0009-1999-0204"]},"institutions":[{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maria Pilar Gallego Hernanz","raw_affiliation_strings":["1CHU de Poitiers, Hematology, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1CHU de Poitiers, Hematology, Poitiers, France","institution_ids":["https://openalex.org/I4210111187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051036198","display_name":"Nicolas Gr\u00e9goire","orcid":"https://orcid.org/0000-0001-6436-3757","observed_orcids":["https://orcid.org/0000-0001-6436-3757"]},"institutions":[{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Gregoire","raw_affiliation_strings":["24CHU de Poitiers, Pharmacology, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"24CHU de Poitiers, Pharmacology, Poitiers, France","institution_ids":["https://openalex.org/I4210111187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063576269","display_name":"Sandrine Lefeuvre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandrine Lefeuvre","raw_affiliation_strings":["24CHU de Poitiers, Pharmacology, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"24CHU de Poitiers, Pharmacology, Poitiers, France","institution_ids":["https://openalex.org/I4210111187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075844368","display_name":"Fran\u00e7ois\u2010Xavier Mahon","orcid":"https://orcid.org/0000-0003-1545-6775","observed_orcids":["https://orcid.org/0000-0003-1545-6775"]},"institutions":[{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francois-Xavier Mahon","raw_affiliation_strings":["25Institut Bergoni\u00e9, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"25Institut Bergoni\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I4210134409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106514264","display_name":"Karine Garnier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karine Garnier","raw_affiliation_strings":["26CHU de Poitiers, DRC, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"26CHU de Poitiers, DRC, Poitiers, France","institution_ids":["https://openalex.org/I4210111187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006400001","display_name":"Jean\u2010Claude Chomel","orcid":"https://orcid.org/0000-0001-9227-1104","observed_orcids":["https://orcid.org/0000-0001-9227-1104"]},"institutions":[{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Claude Chomel","raw_affiliation_strings":["27CHU de Poitiers, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"27CHU de Poitiers, Poitiers, France","institution_ids":["https://openalex.org/I4210111187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022425277","display_name":"St\u00e9phanie Ragot","orcid":"https://orcid.org/0000-0002-2874-0655","observed_orcids":["https://orcid.org/0000-0002-2874-0655"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Ragot","raw_affiliation_strings":["2CIC INSERM 1402, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2CIC INSERM 1402, Poitiers, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007454329","display_name":"Lydia Roy","orcid":"https://orcid.org/0000-0002-1833-9673","observed_orcids":["https://orcid.org/0000-0002-1833-9673"]},"institutions":[{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lydia Roy","raw_affiliation_strings":["28H\u00f4pital Universitaire Henri Mondor, Cr\u00e9teil, France","29Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"28H\u00f4pital Universitaire Henri Mondor, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I3019246885","https://openalex.org/I4210130325"]},{"raw_affiliation_string":"29Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I197681013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082189560","display_name":"Franck Emmanuel Nicolini","orcid":"https://orcid.org/0000-0002-3192-4199","observed_orcids":["https://orcid.org/0000-0002-3192-4199","https://orcid.org/0000-0003-3779-1996","https://orcid.org/0000-0002-3499-5080"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]},{"id":"https://openalex.org/I4210125048","display_name":"Centre de Recherche en Canc\u00e9rologie de Lyon","ror":"https://ror.org/02mgw3155","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210096427","https://openalex.org/I4210105738","https://openalex.org/I4210125048"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Nicolini","raw_affiliation_strings":["30Centre L\u00e9on B\u00e9rard, Hematology, Lyon, France","31CRCL INSERM U1052, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"30Centre L\u00e9on B\u00e9rard, Hematology, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]},{"raw_affiliation_string":"31CRCL INSERM U1052, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125048"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":28,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":"Supplement 1","first_page":"5567","last_page":"5567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.972000002861023},{"id":"https://openalex.org/keywords/treatment-free-remission","display_name":"treatment-free remission","score":0.9750000238418579},{"id":"https://openalex.org/keywords/dose-de-escalation","display_name":"dose de-escalation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/second-generation-tkis","display_name":"second-generation TKIs","score":0.7269999980926514},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.859000027179718},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bosutinib","display_name":"bosutinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.6309999823570251},{"id":"https://openalex.org/keywords/chronic-phase-cml","display_name":"chronic phase CML","score":0.5329999923706055},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.5170000195503235},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.9203000068664551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.832099974155426},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5828999876976013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5353000164031982},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.47929999232292175},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.477400004863739},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46630001068115234},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.43939998745918274},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4074000120162964},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3756999969482422},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.3353999853134155},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2874000072479248},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2784999907016754},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25780001282691956},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.2549000084400177},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.25440001487731934},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2025-5567","doi":"https://doi.org/10.1182/blood-2025-5567","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2025-5567","pdf_url":"https://ashpublications.org/blood/article-pdf/146/Supplement 1/5567/2461460/blood-8314-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2025-5567","doi":"https://doi.org/10.1182/blood-2025-5567","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2025-5567","pdf_url":"https://ashpublications.org/blood/article-pdf/146/Supplement 1/5567/2461460/blood-8314-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417023398.pdf","grobid_xml":"https://content.openalex.org/works/W4417023398.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"The":[2],"permanent":[3],"discontinuation":[4,104,161,201,307,476],"of":[5,29,34,53,60,112,121,187,204,337,357,363,392,405,430,440,447,453,462,470,511,528,542,556,581,590,606,612],"treatments":[6],"with":[7,158,223,255,353,438],"tyrosine":[8],"kinase":[9],"inhibitors":[10],"(TKIs)":[11],"(treatment-free":[12],"remission,":[13],"TFR)":[14],"has":[15,66],"become":[16],"a":[17,71,86,97,135,156,163,168,171,224,228,348,354,360,451,533,574,621],"major":[18,397],"goal":[19],"in":[20,143,190,195,215,259],"chronic":[21,216,295],"myeloid":[22],"leukemia":[23],"(CML)":[24],"to":[25,45,77,94,102,117,146,181,264,322,460,523,547,577,602,631],"prevent":[26],"the":[27,47,51,58,109,119,128,196,260,343,380,390,403,431,468,471,543,579,586,595,610,640],"occurrence":[28],"adverse":[30],"events,":[31],"improve":[32,46],"quality":[33],"life,":[35],"and":[36,57,126,167,239,285,309,359,396,414,434,497,517,565,588,594,624],"reduce":[37],"treatment":[38,103,160,200,240,257,427,496,504,513,558],"costs.":[39],"Various":[40],"strategies":[41],"are":[42,133,193,372],"being":[43,424],"evaluated":[44],"TFR":[48,106,148,331],"rate,":[49],"including":[50],"use":[52],"second-generation":[54],"TKIs":[55],"(2G-TKIs)":[56],"addition":[59],"interferon":[61],"alpha.":[62],"Interestingly,":[63],"greater":[64],"success":[65],"been":[67,457],"observed":[68],"by":[69,178,639,645],"introducing":[70],"dose":[72,98,113,173,492],"reduction":[73],"phase":[74,88,166,175,217,433],"(half-dose)":[75],"prior":[76,101,180,263,302,310],"TKI":[78,267,303,306,370,408,432,443,597,607],"cessation":[79,371],"(UK":[80],"DESTINY":[81],"trial).":[82],"Here,":[83],"we":[84,115],"present":[85],"comparative,":[87],"III,":[89],"prospective":[90],"clinical":[91,141],"trial":[92,142,572],"designed":[93],"demonstrate":[95,524,603],"that":[96,525,604,634],"de-escalation":[99,129,174,472,493,605],"strategy":[100,473,494],"optimizes":[105],"rates.":[107],"Beyond":[108],"expected":[110],"benefits":[111],"de-escalation,":[114],"aim":[116,522,601],"study":[118,486],"recovery":[120],"anti-leukemic":[122,591],"immune":[123,641],"effectors":[124],"before":[125],"after":[127,162],"phase.":[130],"Methods":[131],"We":[132,520,600,628],"conducting":[134],"prospective,":[136],"randomized,":[137],"open-label,":[138],"multicenter,":[139],"French":[140],"CML":[144,213],"(NCT05753384)":[145],"compare":[147],"outcomes":[149],"at":[150,426],"24":[151],"months":[152,186,262],"(primary":[153],"endpoint)":[154],"between":[155,342,351,585],"group":[157,169],"sudden":[159,475],"12-month":[164,172],"maintenance":[165],"undergoing":[170],"(dosage":[176],"reduced":[177,406],"50%)":[179],"cessation.":[182],"After":[183],"these":[184],"12":[185],"therapy,":[188],"patients":[189,214,324,366,383,393,455,613],"both":[191],"arms":[192,198],"eligible":[194],"two":[197,344],"for":[199,244,248,253,270,330,375,418,515],"upon":[202],"confirmation":[203],"sustained":[205],"deep":[206],"molecular":[207,229,398],"response":[208,230,399],"(DMR).":[209],"Inclusion":[210],"criteria":[211,292],"include":[212,293,389],"(CML-CP),":[218],"aged":[219],"\u2265":[220,231,236,300],"18":[221],"years,":[222],"typical":[225],"BCR::ABL1":[226],"transcript,":[227],"4":[232,506],"log":[233],"(MR4)":[234],"lasting":[235],"1":[237],"year,":[238],"duration":[241],"\u22654":[242,251],"years":[243,247,252,507,510],"imatinib,":[245],"\u22653":[246],"2G-TKIs,":[249,518],"or":[250,508],"both,":[254],"no":[256],"changes":[258],"6":[261],"inclusion.":[265],"Minimum":[266],"doses":[268],"required":[269,514],"eligibility":[271],"are:":[272],"imatinib":[273,339,516],"(\u2265":[274,278,282,287],"300":[275,283],"mg/day),":[276,280,284],"dasatinib":[277],"50":[279],"nilotinib":[281],"bosutinib":[286],"200":[288],"mg/day).":[289],"Main":[290],"exclusion":[291],"uncontrolled":[294],"disease,":[296],"ECOG":[297],"performance":[298],"status":[299],"3,":[301],"resistance,":[304],"previous":[305],"attempts,":[308],"allogenic":[311],"stem":[312],"cell":[313],"transplantation.":[314],"A":[315,539],"dynamic":[316],"randomization":[317],"process":[318],"(minimization)":[319],"is":[320,423,477,532,546,637],"used":[321],"allocate":[323],"while":[325],"balancing":[326],"known":[327],"prognostic":[328],"factors":[329],"(treatment":[332],"duration,":[333,335],"DMR":[334,377,395,498],"type":[336],"TKI:":[338],"versus":[340],"2G-TKIs)":[341],"groups.":[345],"To":[346],"detect":[347],"25%":[349],"difference":[350],"arms,":[352],"two-sided":[355],"alpha":[356],"5%":[358],"statistical":[361],"power":[362],"80%,":[364],"60":[365],"per":[367],"arm":[368],"achieving":[369,625],"required.":[373],"Accounting":[374],"possible":[376],"loss":[378],"during":[379,401],"treatment,":[381,402,618],"170":[382],"must":[384],"be":[385],"enrolled.":[386],"Secondary":[387],"endpoints":[388],"proportion":[391,611],"maintaining":[394,620],"(MMR)":[400],"impact":[404],"plasma":[407,442,596],"levels":[409],"on":[410,491],"innate":[411,550,646],"lymphocyte":[412],"reactivity,":[413],"their":[415],"predictive":[416,555],"value":[417],"successful":[419,537,557],"discontinuation.":[420],"Longitudinal":[421],"immunomonitoring":[422,545],"conducted":[425],"initiation,":[428],"end":[429],"throughout":[435],"discontinuation,":[436,559],"along":[437],"assessment":[439],"residual":[441,529],"concentrations.":[444],"Results":[445],"As":[446],"August":[448],"5,":[449],"2025,":[450],"total":[452],"163":[454],"had":[456],"enrolled":[458],"(95.8%":[459],"completion":[461],"recruitment).":[463],"If":[464],"our":[465,479],"hypothesis":[466,580],"about":[467],"superiority":[469],"over":[474],"confirmed,":[478],"findings":[480],"may":[481,561],"inform":[482,566],"future":[483,567],"recommendations.":[484],"Our":[485],"will":[487],"provide":[488,632],"critical":[489,534],"data":[490],"(optimal":[495],"durations)":[499],"as":[500,502],"well":[501],"early":[503],"discontinuation:":[505],"3":[509],"standard-dose":[512],"respectively.":[519],"also":[521,629],"immunologic":[526],"surveillance":[527],"leukemic":[530],"cells":[531,593],"factor":[535],"predicting":[536],"TFR.":[538,627],"key":[540],"objective":[541],"planned":[544],"identify":[548],"an":[549,582],"T":[551,647],"cell-based":[552],"immunological":[553],"signature":[554],"which":[560],"guide":[562],"personalized":[563],"management":[564],"immunotherapeutic":[568],"strategies.":[569],"Finally,":[570],"this":[571,635],"offers":[573],"unique":[575],"opportunity":[576],"explore":[578],"inverse":[583],"correlation":[584],"number":[587],"function":[589],"effector":[592],"levels.":[598],"Conclusions":[599],"therapy":[608],"improves":[609],"who":[614],"can":[615],"successfully":[616],"discontinue":[617],"thus":[619],"stable":[622],"MR4":[623],"prolonged":[626],"seek":[630],"evidence":[633],"benefit":[636],"supported":[638],"system":[642],"effectors,":[643],"particularly":[644],"cells.":[648]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-12-05T00:00:00"}