{"id":"https://openalex.org/W4417023186","doi":"https://doi.org/10.1182/blood-2025-5905","title":"Identification and functional characterization of a novel best-in-class anti-CD79b CAR T cell immunotherapy using a multidimensional screening strategy","display_name":"Identification and functional characterization of a novel best-in-class anti-CD79b CAR T cell immunotherapy using a multidimensional screening strategy","publication_year":2025,"publication_date":"2025-11-03","ids":{"openalex":"https://openalex.org/W4417023186","doi":"https://doi.org/10.1182/blood-2025-5905"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2025-5905","doi":"https://doi.org/10.1182/blood-2025-5905","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2025-5905","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060622255","display_name":"Jean Lemoine","orcid":"https://orcid.org/0000-0001-5833-6728","observed_orcids":["https://orcid.org/0000-0001-5833-6728"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Lemoine","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038475711","display_name":"Guido Ghilardi","orcid":"https://orcid.org/0000-0002-0095-3579","observed_orcids":["https://orcid.org/0000-0002-0095-3579"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guido Ghilardi","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Lee","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044141236","display_name":"Luca Paruzzo","orcid":"https://orcid.org/0000-0002-6505-0194","observed_orcids":["https://orcid.org/0000-0002-6505-0194"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luca Paruzzo","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044906308","display_name":"Francesco Morena","orcid":"https://orcid.org/0000-0001-9407-0576","observed_orcids":["https://orcid.org/0000-0001-9407-0576"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Morena","raw_affiliation_strings":["4Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073503794","display_name":"Vincenzo Maria Perriello","orcid":"https://orcid.org/0000-0003-4105-9087","observed_orcids":["https://orcid.org/0000-0003-4105-9087"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Perriello","raw_affiliation_strings":["5Institute of Hematology and Center for Hemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Institute of Hematology and Center for Hemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100753807","display_name":"Ziyu Li","orcid":"https://orcid.org/0000-0003-4239-7192","observed_orcids":["https://orcid.org/0000-0003-4239-7192"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziyu Li","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110947396","display_name":"Ivan Cohen","orcid":"https://orcid.org/0009-0005-9085-7642","observed_orcids":["https://orcid.org/0009-0005-9085-7642"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Cohen","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007052435","display_name":"Ositadimma H. Ugwuanyi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ositadimma Ugwuanyi","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083380786","display_name":"Raymone Pajarillo","orcid":"https://orcid.org/0000-0003-3299-0929","observed_orcids":["https://orcid.org/0000-0003-3299-0929"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymone Pajarillo","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108036559","display_name":"Yunlin Zhang","orcid":"https://orcid.org/0000-0002-5608-0615","observed_orcids":["https://orcid.org/0000-0002-5608-0615"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunlin Zhang","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047130754","display_name":"Puneeth Guruprasad","orcid":"https://orcid.org/0000-0001-9615-1935","observed_orcids":["https://orcid.org/0000-0001-9615-1935"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puneeth Guruprasad","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ruchi Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruchi Patel","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015896987","display_name":"Elise A. Chong","orcid":"https://orcid.org/0000-0001-8895-1625","observed_orcids":["https://orcid.org/0000-0001-8895-1625"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise Chong","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088286702","display_name":"Sunita Dwivedy Nasta","orcid":"https://orcid.org/0000-0002-8981-2931","observed_orcids":["https://orcid.org/0000-0002-8981-2931"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunita Dwivedy Nasta","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019666650","display_name":"Stefan Klaus Barta","orcid":"https://orcid.org/0000-0002-3280-5271","observed_orcids":["https://orcid.org/0000-0002-3280-5271"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Barta","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035811221","display_name":"Alfred L. Garfall","orcid":"https://orcid.org/0000-0003-2791-5748","observed_orcids":["https://orcid.org/0000-0003-2791-5748"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred Garfall","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042844727","display_name":"Daniel Jeffrey Landsburg","orcid":"https://orcid.org/0000-0002-5077-4181","observed_orcids":["https://orcid.org/0000-0002-5077-4181"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Landsburg","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005058090","display_name":"Jakub Svoboda","orcid":"https://orcid.org/0000-0002-6359-7065","observed_orcids":["https://orcid.org/0000-0002-6359-7065"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jakub Svoboda","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059770942","display_name":"Sam Sadigh","orcid":"https://orcid.org/0000-0003-2557-7415","observed_orcids":["https://orcid.org/0000-0003-2557-7415"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam Sadigh","raw_affiliation_strings":["6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062887811","display_name":"Mariusz A. Wasik","orcid":"https://orcid.org/0000-0002-1988-3670","observed_orcids":["https://orcid.org/0000-0002-1988-3670"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariusz Wasik","raw_affiliation_strings":["6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082309221","display_name":"Siddharth Bhattacharyya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddharth Bhattacharyya","raw_affiliation_strings":["6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066274068","display_name":"Patrizia Porazzi","orcid":"https://orcid.org/0000-0002-1372-7482","observed_orcids":["https://orcid.org/0000-0002-1372-7482"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrizia Porazzi","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080630441","display_name":"Stephen J. Schuster","orcid":"https://orcid.org/0000-0002-3376-8978","observed_orcids":["https://orcid.org/0000-0002-3376-8978"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Schuster","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008077055","display_name":"Brunangelo Falini","orcid":"https://orcid.org/0000-0002-7198-5965","observed_orcids":["https://orcid.org/0000-0002-7198-5965"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Brunangelo Falini","raw_affiliation_strings":["5Institute of Hematology and Center for Hemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Institute of Hematology and Center for Hemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088355904","display_name":"Marco Ruella","orcid":"https://orcid.org/0000-0003-4301-5811","observed_orcids":["https://orcid.org/0000-0003-4301-5811"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco Ruella","raw_affiliation_strings":["1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"2Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":"Supplement 1","first_page":"5905","last_page":"5905"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd79b","display_name":"CD79b","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/large-b-cell-lymphoma","display_name":"large B-cell lymphoma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.550000011920929},{"id":"https://openalex.org/keywords/polatuzumab-vedotin","display_name":"polatuzumab vedotin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hinge-domain","display_name":"hinge domain","score":0.6669999957084656},{"id":"https://openalex.org/keywords/4-1bb-costimulation","display_name":"4-1BB costimulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/interferon-gamma-production","display_name":"IFN-gamma production","score":0.7149999737739563},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.8873999714851379},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.6711000204086304},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5346999764442444},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.49810001254081726},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48539999127388},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4846000075340271},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4767000079154968},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.43549999594688416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4293000102043152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4077000021934509},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.37779998779296875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3711000084877014},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3513000011444092},{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.3504999876022339},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.34929999709129333},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.33559998869895935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3294999897480011},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.32910001277923584},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.29840001463890076},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29440000653266907},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C2778191690","wikidata":"https://www.wikidata.org/wiki/Q422324","display_name":"Brentuximab vedotin","level":4,"score":0.28700000047683716},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.26019999384880066}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2025-5905","doi":"https://doi.org/10.1182/blood-2025-5905","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2025-5905","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Chimeric":[2],"antigen":[3,34],"receptor":[4],"T":[5,70,280],"cell":[6,18,185],"therapy":[7],"targeting":[8],"CD19":[9,33],"(CART19)":[10],"has":[11],"revolutionized":[12],"the":[13,61,118,182,193,253,294,310,315,321,407,459,476,513,519,551,584,611,618],"treatment":[14],"of":[15,56,64,127,195,235,239,415,451,471,579,586],"large":[16],"B":[17],"lymphomas":[19],"(LBCL).":[20],"However,":[21,72],"most":[22,295,311,619],"patients":[23],"either":[24],"fail":[25],"to":[26,32,89,192,229,252,305,326,351,525,560,573],"respond":[27],"or":[28,144,151],"relapse,":[29],"frequently":[30],"due":[31],"loss.":[35],"In":[36,117,218,320],"this":[37,76],"context,":[38],"CD79,":[39],"which":[40],"is":[41],"highly":[42],"expressed":[43],"on":[44,274,283],"B-cell":[45,97],"malignancies,":[46],"emerges":[47],"as":[48,84,293,429,431,554,617],"a":[49,91,100,113,125,156,161,242,413,467,569,635],"promising":[50],"alternative":[51],"target.":[52],"The":[53,402],"clinical":[54,74,640],"success":[55],"polatuzumab":[57,289,388,422,529,555],"vedotin":[58],"further":[59],"supports":[60],"therapeutic":[62],"relevance":[63],"CD79":[65],"targeting,":[66],"particularly":[67,642],"with":[68,249,269,335,387,412,444,466,499,505,583,605],"CAR":[69,129],"cells.":[71],"for":[73,96,170,395,479,639],"utility,":[75],"product":[77],"should":[78],"be":[79],"at":[80,232],"least":[81],"equally":[82],"effective":[83,296],"CART19.":[85],"Therefore,":[86],"we":[87,111,121,324,600],"sought":[88],"develop":[90,107,574],"best-in-class":[92],"anti-CD79":[93],"CART":[94,371,405,517,542],"(CART79)":[95],"malignancies":[98],"using":[99,131,181,265,346,393,484],"multidimensional":[101],"screening":[102,115,345],"strategy.Methods":[103],"and":[104,123,146,160,177,214,308,343,362,366,399,503,528,533,596,626],"Results:":[105],"To":[106],"an":[108],"optimal":[109],"CART79,":[110],"implemented":[112],"two-phase":[114],"strategy.":[116],"first":[119],"phase,":[120,323],"engineered":[122],"screened":[124],"library":[126],"24":[128],"constructs":[130,154,372],"6":[132,196,221,258,316],"different":[133],"public":[134],"domain":[135,159],"single-chain":[136],"variable":[137],"fragments":[138],"(scFvs),":[139],"two":[140],"scFv":[141,453],"orientations":[142,374],"(H-L":[143],"L-H)":[145],"2":[147],"hinge":[148],"domains":[149],"(CD8a":[150],"truncIgG4).":[152,217],"All":[153],"included":[155],"CD8":[157],"transmembrane":[158],"4-1BB":[162],"co-stimulatory":[163],"domain.":[164],"Constructs":[165],"were":[166,261,333,364,384,490],"evaluated":[167,262],"in":[168,263,299,391,442,446,492,494,521,550,592,594,597,628,643],"vitro":[169,392],"expansion":[171,523],"potential":[172],"(CTV":[173],"proliferation),":[174],"cytotoxicity":[175,420],"(luciferase-based),":[176],"cytokine":[178,397],"production":[179,246],"(ELISA)":[180],"CD79+":[183],"LBCL":[184],"line":[186,443],"OCI-Ly18.":[187],"This":[188,440,566,632],"functional":[189,607],"screen":[190],"led":[191],"selection":[194],"top":[197,259,636],"candidates":[198,260,604],"(polatuzumab":[199],"L-H":[200,203,206,216,290,389,423,530,556],"truncIgG4,":[201,207,210],"4447":[202,205,208],"CD8a,":[204,213],"H-L":[209,212,404,457,515,540,613],"4450":[211,215],"particular,":[219],"these":[220],"CART79":[222,255,297,318,383,575,633],"demonstrated":[223,406,545],"significantly":[224,243,418],"higher":[225],"specific":[226,353,409],"killing":[227,410],"compared":[228,251,385,524,559],"CART19":[230,306,435,527],"(p<0.001)":[231],"day":[233],"D6":[234],"coculture.":[236],"Further,":[237],"all":[238,464],"them":[240],"had":[241],"increased":[244],"interferon-gamma":[245],"when":[247],"cocultured":[248],"OCI-Ly18":[250,271,394,501],"other":[254,480],"(p<0.05).":[256],"These":[257,381,488],"vivo":[264,493,522,598,629],"NSG":[266,495],"mice":[267,332,496,544,563],"injected":[268,497],"5x106":[270],"cells":[272,281,502,508],"subcutaneously":[273,498],"D0,":[275],"followed":[276,339],"by":[277,340,576],"2.5x106":[278],"CAR+":[279],"intravenously":[282],"D15.":[284],"At":[285,510,536],"D15":[286],"post-CART":[287],"injection,":[288],"truncIgG4":[291,377,390,424,516,531,541,557,614],"emerged":[292,616],"candidate":[298,637],"vivo,":[300],"achieving":[301],"tumor":[302,548,630],"control":[303],"comparable":[304],"(p=0.25)":[307],"demonstrating":[309,621],"consistent":[312],"response":[313],"among":[314,463],"tested":[317],"constructs.":[319],"second":[322],"aimed":[325],"discover":[327],"novel":[328,452,587],"anti-CD79b":[329,358,588],"binders.":[330,354],"Balb/c":[331],"immunized":[334],"human":[336,348],"CD79b":[337],"antigen,":[338],"hybridoma":[341],"generation":[342,585],"immunohistochemical":[344],"frozen":[347],"tonsil":[349],"sections":[350],"identify":[352],"Two":[355],"new":[356,370,382],"murine":[357],"scFvs":[359,582],"(clones":[360],"128":[361],"151)":[363],"identified":[365,601],"incorporated":[367],"into":[368],"4":[369],"(2":[373],"per":[375],"clone,":[376],"hinge,":[378],"41BB-CD3z":[379],"construct).":[380],"head-to-head":[386],"cytotoxicity,":[396,625],"secretion,":[398],"proliferation":[400],"assays.":[401],"151":[403,456,514,539,612],"highest":[408,460],"activity":[411],"mean":[414],"85.5%,":[416],"showing":[417,454],"greater":[419],"than":[421,434],"(70.8%,":[425],"p":[426,437],"=":[427,438],"0.049)":[428],"well":[430,474],"numerically":[432],"better":[433],"(77.4%,":[436],"0.16).":[439],"was":[441],"our":[445],"silico":[447],"mechanical":[448,461],"properties":[449],"modeling":[450],"that":[455],"exhibited":[458],"stability":[462],"tested,":[465],"peak":[468],"unbinding":[469],"force":[470],"648.92":[472],"kJ/mol/nm,":[473],"above":[475],"range":[477,553],"observed":[478],"clones":[481],"(361.77-531.91":[482],"kJ/mol/nm)":[483],"steered":[485],"molecular":[486],"dynamics.":[487],"observations":[489],"confirmed":[491],"5\u00d7106":[500],"treated":[504,543,562],"2.5\u00d7106":[506],"CART+":[507],"intravenously.":[509],"D14":[511],"post-injection,":[512,538],"showed":[518],"best":[520],"both":[526],"(p=0.040":[532],"0.045,":[534],"respectively).":[535],"D21":[537],"effectively":[546],"controlled":[547],"growth":[549],"same":[552],"(p=0.45)":[558],"UTD":[561],"(p=0.048).":[564],"Conclusions:":[565],"study":[567],"presents":[568],"rational,":[570],"stepwise":[571],"strategy":[572],"combining":[577],"engineering":[578],"publicly":[580],"available":[581],"scFvs.":[589],"Through":[590],"comprehensive":[591],"silico,":[593],"vitro,":[595],"evaluation,":[599],"several":[602],"lead":[603],"superior":[606],"properties.":[608],"Among":[609],"them,":[610],"construct":[615],"effective,":[620],"robust":[622],"binding,":[623],"potent":[624],"strong":[627],"control.":[631],"represents":[634],"option":[638],"development,":[641],"CART19-refractory":[644],"LBCL.":[645]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-12-05T00:00:00"}