{"id":"https://openalex.org/W4417019487","doi":"https://doi.org/10.1182/blood-2025-776","title":"Liposomal mitoxantrone versus chidamide in relapsed/refractory peripheral T-cell lymphoma: Final analysis from the multicenter, prospective randomized phase 3 study","display_name":"Liposomal mitoxantrone versus chidamide in relapsed/refractory peripheral T-cell lymphoma: Final analysis from the multicenter, prospective randomized phase 3 study","publication_year":2025,"publication_date":"2025-11-03","ids":{"openalex":"https://openalex.org/W4417019487","doi":"https://doi.org/10.1182/blood-2025-776"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2025-776","doi":"https://doi.org/10.1182/blood-2025-776","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2025-776","pdf_url":"https://ashpublications.org/blood/article-pdf/146/Supplement 1/776/2464404/blood-3351-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/146/Supplement 1/776/2464404/blood-3351-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018905374","display_name":"Yan Gao","orcid":"https://orcid.org/0000-0002-7282-4530","observed_orcids":["https://orcid.org/0000-0002-7282-4530"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gao Yan","raw_affiliation_strings":["1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009583844","display_name":"Huijing Wu","orcid":"https://orcid.org/0000-0003-3224-1733","observed_orcids":["https://orcid.org/0000-0003-3224-1733"]},"institutions":[{"id":"https://openalex.org/I4210160841","display_name":"Hubei Cancer Hospital","ror":"https://ror.org/05p38yh32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160841"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huijing Wu","raw_affiliation_strings":["2Hubei Cancer Hospital, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hubei Cancer Hospital, Wuhan, China","institution_ids":["https://openalex.org/I4210160841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741380","display_name":"Qingyuan Zhang","orcid":"https://orcid.org/0000-0001-8116-5293","observed_orcids":["https://orcid.org/0000-0001-8116-5293","https://orcid.org/0000-0001-7618-4393","https://orcid.org/0000-0002-1763-9412","https://orcid.org/0000-0002-5003-8897"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyuan Zhang","raw_affiliation_strings":["3Harbin Medical University Cancer Hospital, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Harbin Medical University Cancer Hospital, Harbin, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040300450","display_name":"Yu Sung Yang","orcid":"https://orcid.org/0000-0002-3513-8865","observed_orcids":["https://orcid.org/0000-0002-3513-8865"]},"institutions":[{"id":"https://openalex.org/I4210148548","display_name":"Fujian Provincial Cancer Hospital","ror":"https://ror.org/058ms9w43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148548"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Yang","raw_affiliation_strings":["4Fujian Provincial Cancer Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Fujian Provincial Cancer Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I4210148548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000632526","display_name":"Zengjun Li","orcid":"https://orcid.org/0000-0003-0787-8089","observed_orcids":["https://orcid.org/0000-0003-0787-8089"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zengjun Li","raw_affiliation_strings":["5Cancer Hospital of Shandong First Medical University, Jinan, China","7The First Affiliated Hospital of Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cancer Hospital of Shandong First Medical University, Jinan, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"7The First Affiliated Hospital of Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043730556","display_name":"Hui Zhou","orcid":"https://orcid.org/0000-0001-8668-3743","observed_orcids":["https://orcid.org/0000-0001-8668-3743","https://orcid.org/0009-0004-9979-6551"]},"institutions":[{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhou","raw_affiliation_strings":["6Hunan Cancer Hospital, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Hunan Cancer Hospital, Changsha, China","institution_ids":["https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yajun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajun Li","raw_affiliation_strings":["6Hunan Cancer Hospital, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Hunan Cancer Hospital, Changsha, China","institution_ids":["https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634433","display_name":"Zhifeng Li","orcid":"https://orcid.org/0000-0003-3908-0012","observed_orcids":["https://orcid.org/0000-0003-3908-0012"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhifeng Li","raw_affiliation_strings":["5Cancer Hospital of Shandong First Medical University, Jinan, China","7The First Affiliated Hospital of Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cancer Hospital of Shandong First Medical University, Jinan, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"7The First Affiliated Hospital of Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080081094","display_name":"Aimin Zang","orcid":"https://orcid.org/0000-0001-6777-1959","observed_orcids":["https://orcid.org/0000-0001-6777-1959"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aimin Zang","raw_affiliation_strings":["8Affiliated Hospital of Hebei University, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Affiliated Hospital of Hebei University, Baoding, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014892945","display_name":"Xun Lai","orcid":"https://orcid.org/0000-0002-2775-0800","observed_orcids":["https://orcid.org/0000-0002-2775-0800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xun Lai","raw_affiliation_strings":["9Yunnan Cancer Hospital, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Yunnan Cancer Hospital, Kunming, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103570336","display_name":"Weiping Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiping Tao","raw_affiliation_strings":["10Renmin Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Renmin Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325793","display_name":"Fei Li","orcid":"https://orcid.org/0000-0002-1206-9684","observed_orcids":["https://orcid.org/0000-0002-1206-9684","https://orcid.org/0000-0001-5737-8555"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Li","raw_affiliation_strings":["11The First Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11The First Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029493707","display_name":"Zhihua Yao","orcid":"https://orcid.org/0000-0002-5352-4575","observed_orcids":["https://orcid.org/0000-0002-5352-4575"]},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihua Yao","raw_affiliation_strings":["12Henan Cancer Hospital, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Henan Cancer Hospital, Zhengzhou, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101846707","display_name":"Jie Cui","orcid":"https://orcid.org/0000-0003-3849-4184","observed_orcids":["https://orcid.org/0000-0003-3849-4184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Cui","raw_affiliation_strings":["13Gansu Cancer Hospital, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Gansu Cancer Hospital, Lanzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100463094","display_name":"Yao Z. Liu","orcid":"https://orcid.org/0000-0003-1782-7322","observed_orcids":["https://orcid.org/0000-0003-1782-7322"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]},{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Liu","raw_affiliation_strings":["14Chongqing University Cancer Hospital, Chongqing, China","17CSPC Pharmaceutical Group Limited, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Chongqing University Cancer Hospital, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"17CSPC Pharmaceutical Group Limited, Shijiazhuang, China","institution_ids":["https://openalex.org/I4387153926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103254652","display_name":"Liping Su","orcid":"https://orcid.org/0009-0006-6238-1234","observed_orcids":["https://orcid.org/0009-0006-6238-1234","https://orcid.org/0000-0002-2146-589X"]},"institutions":[{"id":"https://openalex.org/I4210102673","display_name":"Shanxi Provincial Cancer Hospital","ror":"https://ror.org/01790dx02","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Su","raw_affiliation_strings":["15Shanxi Cancer Hospital, Taiyuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Shanxi Cancer Hospital, Taiyuan, China","institution_ids":["https://openalex.org/I4210102673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670410","display_name":"Liling Zhang","orcid":"https://orcid.org/0000-0002-0198-2603","observed_orcids":["https://orcid.org/0000-0002-0198-2603","https://orcid.org/0009-0000-1715-7141"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liling Zhang","raw_affiliation_strings":["16Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343606","display_name":"Yanping Liu","orcid":"https://orcid.org/0009-0009-9729-2890","observed_orcids":["https://orcid.org/0009-0009-9729-2890"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]},{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanping Liu","raw_affiliation_strings":["14Chongqing University Cancer Hospital, Chongqing, China","17CSPC Pharmaceutical Group Limited, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Chongqing University Cancer Hospital, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"17CSPC Pharmaceutical Group Limited, Shijiazhuang, China","institution_ids":["https://openalex.org/I4387153926"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Shi","raw_affiliation_strings":["17CSPC Pharmaceutical Group Limited, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17CSPC Pharmaceutical Group Limited, Shijiazhuang, China","institution_ids":["https://openalex.org/I4387153926"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lijun Xin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijun Xin","raw_affiliation_strings":["17CSPC Pharmaceutical Group Limited, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17CSPC Pharmaceutical Group Limited, Shijiazhuang, China","institution_ids":["https://openalex.org/I4387153926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114186220","display_name":"Chuanchuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuanchuan Wang","raw_affiliation_strings":["17CSPC Pharmaceutical Group Limited, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17CSPC Pharmaceutical Group Limited, Shijiazhuang, China","institution_ids":["https://openalex.org/I4387153926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347066","display_name":"Yitao Wang","orcid":"https://orcid.org/0000-0002-1516-4548","observed_orcids":["https://orcid.org/0000-0002-1516-4548"]},"institutions":[{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yitao Wang","raw_affiliation_strings":["17CSPC Pharmaceutical Group Limited, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17CSPC Pharmaceutical Group Limited, Shijiazhuang, China","institution_ids":["https://openalex.org/I4387153926"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113664461","display_name":"Hui-Qiang Huang","orcid":"https://orcid.org/0000-0001-7500-8056","observed_orcids":["https://orcid.org/0000-0001-7500-8056"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiqiang Huang","raw_affiliation_strings":["1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":20,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":"Supplement 1","first_page":"776","last_page":"776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chidamide","display_name":"chidamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8119999766349792},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.8299999833106995},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/liposomal-chemotherapy","display_name":"liposomal chemotherapy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.4569999873638153},{"id":"https://openalex.org/keywords/peripheral-t-cell-lymphoma-not-otherwise-specified","display_name":"peripheral T-cell lymphoma, not otherwise specified","score":0.8930000066757202},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6129999756813049},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.47999998927116394},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8198999762535095},{"id":"https://openalex.org/C2780923524","wikidata":"https://www.wikidata.org/wiki/Q239426","display_name":"Mitoxantrone","level":3,"score":0.7400000095367432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.574400007724762},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.5726000070571899},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5432999730110168},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4099000096321106},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38580000400543213},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3668999969959259},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36489999294281006},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3522999882698059},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3467999994754791},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.3000999987125397},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.2741999924182892},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.26820001006126404},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2025-776","doi":"https://doi.org/10.1182/blood-2025-776","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2025-776","pdf_url":"https://ashpublications.org/blood/article-pdf/146/Supplement 1/776/2464404/blood-3351-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2025-776","doi":"https://doi.org/10.1182/blood-2025-776","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2025-776","pdf_url":"https://ashpublications.org/blood/article-pdf/146/Supplement 1/776/2464404/blood-3351-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417019487.pdf","grobid_xml":"https://content.openalex.org/works/W4417019487.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4417001948","https://openalex.org/W4417018897","https://openalex.org/W4310106211","https://openalex.org/W3210703642","https://openalex.org/W4387650318","https://openalex.org/W2623222337","https://openalex.org/W3197187328","https://openalex.org/W3217782726","https://openalex.org/W2601168549","https://openalex.org/W4389235319"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Outcomes":[2],"for":[3,20,45,139],"patients":[4,119,213,245,333,551],"with":[5,28,125,353,361,501,542,552],"relapsed/refractory":[6],"(R/R)":[7],"peripheral":[8],"T-cell":[9],"lymphomas":[10],"(R/R-PTCLs)":[11],"are":[12],"poor.":[13],"Single":[14],"agent":[15],"overall":[16,197,547],"response":[17,194],"rates":[18,371],"(ORRs)":[19],"R/R-PTCLs":[21,126],"generally":[22,396],"fall":[23],"within":[24],"the":[25,87,161,171,177,232,267,274,277,289,299,318,336,342,378,387,410,415,463,469,480,495,527,534],"20-35%":[26],"range,":[27],"a":[29,140,209],"median":[30,261,278],"progression-free":[31],"survival":[32,198],"(PFS)":[33],"of":[34,91,142,211,243,251,263,429,456,488,526,536],"less":[35],"than":[36,413,467],"4":[37],"months.":[38],"Thus,":[39],"there":[40],"is":[41,107],"an":[42,108,543],"urgent":[43],"need":[44],"more":[46,477],"effective":[47],"therapies":[48],"that":[49,533],"can":[50],"provide":[51],"deep":[52],"remissions":[53],"or":[54,145,222,432],"long-term":[55],"disease":[56],"control.":[57],"Liposomal":[58],"mitoxantrone":[59],"(Lipo-MIT,":[60],"manufactured":[61],"by":[62,170,190,317],"CSPC":[63],"Zhongqi":[64],"Pharmaceutical":[65],"Technology":[66],"(Shijiazhuang)":[67],"Co.,":[68],"Ltd.)":[69],"monotherapy":[70],"exhibited":[71],"promising":[72],"and":[73,89,200,216,238,270,292,381,393,404,438,449,545],"durable":[74],"antitumor":[75],"activity":[76],"in":[77,101,123,176,266,273,288,298,335,377,386,409,414,462,468,479,550],"phase":[78,112,529],"2":[79],"study.":[80],"This":[81,105],"study":[82,106,114,252,518],"was":[83,167,282,347,460,476,492,538],"designed":[84],"to":[85,131,158,160,206,219,341,510,540],"evaluate":[86],"efficacy":[88,522,535],"safety":[90,258,548],"Lipo-MIT":[92,134,162,220,268,290,343,354,379,411,464,537],"versus":[93,355],"chidamide":[94,146,155,223,256,275,300,337,362,388,416,470,481,541],"(an":[95],"oral":[96],"subtype-selective":[97],"histone":[98],"deacetylase":[99],"inhibitor)":[100],"this":[102],"population.":[103,180],"Methods":[104],"open-label,":[109],"active-controlled,":[110],"randomized":[111],"3":[113,431,530],"(ClinicalTrials.gov":[115],"identifier":[116],"NCT04668690).":[117],"Eligible":[118],"from":[120,154],"32":[121],"sites":[122],"China":[124],"were":[127,156,214,228,314,372,395,406,442,512],"randomly":[128,217],"assigned":[129,218],"1:1":[130],"receive":[132],"either":[133],"(20":[135],"mg/m\u00b2,":[136],"IV,":[137],"Q4W,":[138],"maximum":[141],"6-8":[143],"cycles)":[144],"(30":[147],"mg,":[148],"twice":[149],"weekly).":[150],"Patients":[151],"who":[152],"failed":[153],"permitted":[157],"crossover":[159],"group.":[163,344],"The":[164,368,401,427,486,517,524],"primary":[165,521],"endpoint":[166],"PFS":[168,188,279,392],"assessed":[169,189,316],"Independent":[172],"Review":[173],"Committee":[174],"(IRC)":[175],"intention-to-treat":[178],"(ITT)":[179],"Secondary":[181],"endpoints":[182],"included,":[183],"but":[184],"not":[185],"limited":[186],"to,":[187],"investigators,":[191],"ORR,":[192,423],"complete":[193],"(CR)":[195],"rate,":[196,419],"(OS),":[199],"safety.":[201],"Results":[202],"From":[203],"April":[204],"2021":[205],"October":[207],"2024,":[208],"total":[210,242],"193":[212],"enrolled":[215],"(n=97)":[221],"(n=96)":[224],"groups.":[225],"Baseline":[226],"characteristics":[227],"essentially":[229],"balanced":[230],"between":[231,444,494],"two":[233,496],"groups,":[234],"including":[235],"AITL,":[236],"PTCL-NOS,":[237],"ENKTCL":[239],"subtypes.":[240],"A":[241,453],"190":[244],"received":[246],"at":[247],"least":[248],"one":[249],"dose":[250],"drug":[253],"(Lipo-MIT":[254],"n=95;":[255,257],"population).":[259],"At":[260],"follow-up":[262],"11.1":[264],"months":[265,272,284,294,349,357],"group":[269,291,301,338,380,412,417,465,471,482],"8.4":[271],"group,":[276,389],"per":[280],"IRC":[281],"7.5":[283],"(95%":[285,295,350,358,374,383],"CI:":[286,296,307,327,351,359,366,375,384],"4.2-12.0)":[287],"2.6":[293],"1.9-3.7)":[297],"(hazard":[302],"ratio":[303],"[HR]":[304],"0.58,":[305],"95%":[306,326,365],"0.41-0.81;":[308],"P":[309,329],"=":[310,330],"0.0008).":[311],"Similar":[312],"results":[313],"obtained":[315],"investigators":[319],"(7.6":[320],"vs":[321,421,425,447,451,484,499,514],"2.5":[322],"months,":[323],"HR":[324],"0.63,":[325],"0.45-0.88;":[328],"0.0035).":[331],"Twenty-seven":[332],"(28.1%)":[334],"crossed":[339],"over":[340],"Median":[345],"OS":[346,370,394],"14.0":[348],"10.8-23.4)":[352],"8.8":[356],"7.2-11.6)":[360],"(HR":[363],"0.78,":[364],"0.54-1.13).":[367],"18-month":[369],"45.4%":[373],"34.2-56.0)":[376],"35.3%":[382],"25.2-45.5)":[385],"respectively.":[390],"Both":[391],"consistent":[397],"across":[398],"key":[399],"subgroups.":[400],"CR":[402],"rate":[403],"ORR":[405],"significantly":[407],"higher":[408,433,454],"(CR":[418],"13.4%":[420],"7.3%;":[422],"36.1%":[424],"18.8%).":[426],"incidences":[428],"grade":[430,505],"treatment-emergent":[434],"adverse":[435],"event":[436],"(TEAEs)":[437],"serious":[439],"AEs":[440,511],"(SAEs)":[441],"similar":[443],"groups":[445,497],"(78.9%":[446],"81.1%":[448],"43.2%":[450],"45.3%).":[452],"incidence":[455,487],"leukopenia":[457],"(any":[458,474,490],"grade)":[459,475,491],"reported":[461],"(85.3%)":[466],"(69.5%).":[472],"Thrombocytopenia":[473],"common":[478],"(57.9%":[483],"78.9%).":[485],"cardiotoxicity":[489],"comparable":[493],"(21.1%":[498],"30.5%),":[500],"most":[502],"events":[503],"being":[504],"1-2.":[506],"Treatment":[507],"discontinuations":[508],"due":[509],"15.8%":[513],"14.7%.":[515],"Conclusion":[516],"met":[519],"its":[520],"endpoint.":[523],"outcome":[525],"present":[528],"trial":[531],"demonstrated":[532],"superior":[539],"acceptable":[544],"manageable":[546],"profile":[549],"R/R":[553],"PTCL.":[554]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-12-05T00:00:00"}