{"id":"https://openalex.org/W4417007147","doi":"https://doi.org/10.1182/blood-2025-2205","title":"Multiple myeloma with \u22651% circulating plasma cells in peripheral blood has a poor prognosis","display_name":"Multiple myeloma with \u22651% circulating plasma cells in peripheral blood has a poor prognosis","publication_year":2025,"publication_date":"2025-11-03","ids":{"openalex":"https://openalex.org/W4417007147","doi":"https://doi.org/10.1182/blood-2025-2205"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2025-2205","doi":"https://doi.org/10.1182/blood-2025-2205","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2025-2205","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112920835","display_name":"Kosuke Miki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210105346","display_name":"Asahikawa City Hospital","ror":"https://ror.org/0291hsm26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105346"]},{"id":"https://openalex.org/I4210113341","display_name":"Sapporo Hokuyu Hospital","ror":"https://ror.org/024czvm93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210113341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Miki","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","2Hokkaido University Faculty of Medicine, Department of Hematology, Sapporo, Japan","3Sapporo Hokuyu Hospital, Department of Hematology, Sapporo, Japan","4Asahikawa City Hospital, Department of Hematology, Asahikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"2Hokkaido University Faculty of Medicine, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"3Sapporo Hokuyu Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210113341"]},{"raw_affiliation_string":"4Asahikawa City Hospital, Department of Hematology, Asahikawa, Japan","institution_ids":["https://openalex.org/I4210105346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011751372","display_name":"Koh Izumiyama","orcid":"https://orcid.org/0000-0002-0762-6255","observed_orcids":["https://orcid.org/0000-0002-0762-6255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koh Izumiyama","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","5Aiiku Hospital, Blood Disorders Center, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"5Aiiku Hospital, Blood Disorders Center, Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060826606","display_name":"Kentaro Wakasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114170","display_name":"Obihiro Kosei General Hospital","ror":"https://ror.org/027fjzp74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114170"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Wakasa","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","6Hokkaido P.W.F.A.C. Obihiro-Kosei General Hospital, Department of Hematology, Obihiro, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"6Hokkaido P.W.F.A.C. Obihiro-Kosei General Hospital, Department of Hematology, Obihiro, Japan","institution_ids":["https://openalex.org/I4210114170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022184748","display_name":"Satoshi Yamamoto","orcid":"https://orcid.org/0000-0001-6408-626X","observed_orcids":["https://orcid.org/0000-0001-6408-626X"]},"institutions":[{"id":"https://openalex.org/I4210147254","display_name":"Sapporo City General Hospital","ror":"https://ror.org/0498kr054","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210147254"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Yamamoto","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","7Sapporo City General Hospital, Department of Hematology, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"7Sapporo City General Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210147254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055469200","display_name":"Tsuyoshi Sato","orcid":"https://orcid.org/0000-0002-1109-196X","observed_orcids":["https://orcid.org/0000-0002-1109-196X"]},"institutions":[{"id":"https://openalex.org/I180680657","display_name":"Iwate Medical University","ror":"https://ror.org/04cybtr86","country_code":"JP","type":"education","lineage":["https://openalex.org/I180680657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Sato","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","8Iwate Medical University, Department of Hematology and Oncology, Iwate, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"8Iwate Medical University, Department of Hematology and Oncology, Iwate, Japan","institution_ids":["https://openalex.org/I180680657"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tomoya Harada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102055","display_name":"Kin-ikyo Chuo Hospital","ror":"https://ror.org/01jckan13","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Harada","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","9Kin-ikyo Chuo Hospital, Department of Hematology, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"9Kin-ikyo Chuo Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210102055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087578118","display_name":"Hajime Senjo","orcid":"https://orcid.org/0000-0002-5382-5167","observed_orcids":["https://orcid.org/0000-0002-5382-5167"]},"institutions":[{"id":"https://openalex.org/I4210108351","display_name":"Kushiro Rosai Hospital","ror":"https://ror.org/01s9rzk09","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108351"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Senjo","raw_affiliation_strings":["10Kushiro Rosai Hospital, Department of Hematology, Kushiro, Japan","1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Kushiro Rosai Hospital, Department of Hematology, Kushiro, Japan","institution_ids":["https://openalex.org/I4210108351"]},{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066823150","display_name":"Takuto Tachita","orcid":"https://orcid.org/0000-0003-2564-0568","observed_orcids":["https://orcid.org/0000-0003-2564-0568"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]},{"id":"https://openalex.org/I4210165489","display_name":"Hirosaki University Hospital","ror":"https://ror.org/05s3b4196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I146516829","https://openalex.org/I4210165489"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuto Tachita","raw_affiliation_strings":["11Hirosaki University Hospital, Department of Gastroenterology, Hematology and Clinical Immunology, Hirosaki, Japan","1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Hirosaki University Hospital, Department of Gastroenterology, Hematology and Clinical Immunology, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829","https://openalex.org/I4210165489"]},{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024008720","display_name":"Masahiro Chiba","orcid":"https://orcid.org/0000-0003-2731-6091","observed_orcids":["https://orcid.org/0000-0003-2731-6091"]},"institutions":[{"id":"https://openalex.org/I4210105346","display_name":"Asahikawa City Hospital","ror":"https://ror.org/0291hsm26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105346"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Chiba","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","4Asahikawa City Hospital, Department of Hematology, Asahikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"4Asahikawa City Hospital, Department of Hematology, Asahikawa, Japan","institution_ids":["https://openalex.org/I4210105346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007588535","display_name":"Tetsuyuki Igarashi","orcid":"https://orcid.org/0000-0003-0099-225X","observed_orcids":["https://orcid.org/0000-0003-0099-225X"]},"institutions":[{"id":"https://openalex.org/I4210117610","display_name":"Tenshi Hospital","ror":"https://ror.org/0282s7q36","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210117610"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuyuki Igarashi","raw_affiliation_strings":["12Tenshi Hospital, Department of Hematology, Sapporo, Japan","1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Tenshi Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210117610"]},{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110417594","display_name":"T Saga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102055","display_name":"Kin-ikyo Chuo Hospital","ror":"https://ror.org/01jckan13","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Saga","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","9Kin-ikyo Chuo Hospital, Department of Hematology, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"9Kin-ikyo Chuo Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210102055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003214925","display_name":"Masayo Yamamoto","orcid":"https://orcid.org/0000-0003-2001-199X","observed_orcids":["https://orcid.org/0000-0003-2001-199X"]},"institutions":[{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayo Yamamoto","raw_affiliation_strings":["13Asahikawa Medical University, Department of Internal Medicine, Division of Hematology, Asahikawa, Japan","1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Asahikawa Medical University, Department of Internal Medicine, Division of Hematology, Asahikawa, Japan","institution_ids":["https://openalex.org/I147809708"]},{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014667404","display_name":"Kouhei Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113341","display_name":"Sapporo Hokuyu Hospital","ror":"https://ror.org/024czvm93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210113341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouhei Okada","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","3Sapporo Hokuyu Hospital, Department of Hematology, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"3Sapporo Hokuyu Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210113341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010046270","display_name":"Hideki Goto","orcid":"https://orcid.org/0000-0001-8361-9973","observed_orcids":["https://orcid.org/0000-0001-8361-9973"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Goto","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","2Hokkaido University Faculty of Medicine, Department of Hematology, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"2Hokkaido University Faculty of Medicine, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100922415","display_name":"Yukari Takeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104287","display_name":"Tonan Hospital","ror":"https://ror.org/01gtph098","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukari Takeda","raw_affiliation_strings":["14Tonan Hospital, Department of Hematology, Sapporo, Japan","1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Tonan Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210104287"]},{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111816013","display_name":"Mutsumi Takahata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121725","display_name":"Sapporo Kosei General Hospital","ror":"https://ror.org/029jhw134","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210121725"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mutsumi Takahata","raw_affiliation_strings":["15Sapporo-Kosei General Hospital, Department of Hematology, Sapporo, Japan","1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Sapporo-Kosei General Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210121725"]},{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076101717","display_name":"Tatsuo Oyake","orcid":"https://orcid.org/0000-0002-8457-2211","observed_orcids":["https://orcid.org/0000-0002-8457-2211"]},"institutions":[{"id":"https://openalex.org/I180680657","display_name":"Iwate Medical University","ror":"https://ror.org/04cybtr86","country_code":"JP","type":"education","lineage":["https://openalex.org/I180680657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Oyake","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","8Iwate Medical University, Department of Hematology and Oncology, Iwate, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"8Iwate Medical University, Department of Hematology and Oncology, Iwate, Japan","institution_ids":["https://openalex.org/I180680657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049902336","display_name":"Katsuya Fujimoto","orcid":"https://orcid.org/0000-0003-1643-0390","observed_orcids":["https://orcid.org/0000-0003-1643-0390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katsuya Fujimoto","raw_affiliation_strings":["16NHO Hokkaido Cancer Center, Department of Hematology, Sapporo, Japan","1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16NHO Hokkaido Cancer Center, Department of Hematology, Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110950391","display_name":"Yoshihito Haseyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104287","display_name":"Tonan Hospital","ror":"https://ror.org/01gtph098","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihito Haseyama","raw_affiliation_strings":["14Tonan Hospital, Department of Hematology, Sapporo, Japan","1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Tonan Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210104287"]},{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086856159","display_name":"Kazunori Murai","orcid":"https://orcid.org/0000-0002-7353-3495","observed_orcids":["https://orcid.org/0000-0002-7353-3495"]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Murai","raw_affiliation_strings":["17Iwate Prefectural Central Hospital, Department of Hematology, Morioka, Japan","1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17Iwate Prefectural Central Hospital, Department of Hematology, Morioka, Japan","institution_ids":["https://openalex.org/I4210090926"]},{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051449739","display_name":"Toshimichi Ishihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102055","display_name":"Kin-ikyo Chuo Hospital","ror":"https://ror.org/01jckan13","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshimichi Ishihara","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","9Kin-ikyo Chuo Hospital, Department of Hematology, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"9Kin-ikyo Chuo Hospital, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I4210102055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021620288","display_name":"Shigeki Ito","orcid":"https://orcid.org/0000-0002-3899-6603","observed_orcids":["https://orcid.org/0000-0002-3899-6603"]},"institutions":[{"id":"https://openalex.org/I180680657","display_name":"Iwate Medical University","ror":"https://ror.org/04cybtr86","country_code":"JP","type":"education","lineage":["https://openalex.org/I180680657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Ito","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","8Iwate Medical University, Department of Hematology and Oncology, Iwate, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"8Iwate Medical University, Department of Hematology and Oncology, Iwate, Japan","institution_ids":["https://openalex.org/I180680657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041455800","display_name":"Takanori Teshima","orcid":"https://orcid.org/0000-0002-0941-271X","observed_orcids":["https://orcid.org/0000-0002-0941-271X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Teshima","raw_affiliation_strings":["1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","2Hokkaido University Faculty of Medicine, Department of Hematology, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Japan Hematolgy Study Group (NJHSG), Sapporo, Japan","institution_ids":[]},{"raw_affiliation_string":"2Hokkaido University Faculty of Medicine, Department of Hematology, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":"Supplement 1","first_page":"2205","last_page":"2205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/plasma-cell-leukemia","display_name":"plasma cell leukemia","score":0.871999979019165},{"id":"https://openalex.org/keywords/circulating-plasma-cells","display_name":"circulating plasma cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/peripheral-blood-smear","display_name":"peripheral blood smear","score":0.7039999961853027},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/newly-diagnosed-multiple-myeloma","display_name":"newly diagnosed multiple myeloma","score":0.8840000033378601},{"id":"https://openalex.org/keywords/diagnostic-criteria","display_name":"diagnostic criteria","score":0.460999995470047},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"cytogenetics","score":0.49399998784065247},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.4970000088214874},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6809999942779541},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.6990000009536743},{"id":"https://openalex.org/keywords/ldh","display_name":"LDH","score":0.5270000100135803},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.6010000109672546},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.8531000018119812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8460999727249146},{"id":"https://openalex.org/C2780353925","wikidata":"https://www.wikidata.org/wiki/Q7201765","display_name":"Plasma cell leukemia","level":3,"score":0.7196999788284302},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.6762999892234802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6165000200271606},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.5094000101089478},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.48260000348091125},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4553999900817871},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4350999891757965},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.3652999997138977},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C2909882984","wikidata":"https://www.wikidata.org/wiki/Q777473","display_name":"Helsinki declaration","level":4,"score":0.32839998602867126},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.3273000121116638},{"id":"https://openalex.org/C188758523","wikidata":"https://www.wikidata.org/wiki/Q6947334","display_name":"Myeloma protein","level":3,"score":0.31949999928474426},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31299999356269836},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C2909638373","wikidata":"https://www.wikidata.org/wiki/Q1706485","display_name":"Plasma cell neoplasm","level":4,"score":0.2736000120639801},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2678000032901764},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2535000145435333}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2025-2205","doi":"https://doi.org/10.1182/blood-2025-2205","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2025-2205","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3217094546","https://openalex.org/W4394872831","https://openalex.org/W2900522247","https://openalex.org/W2244988349","https://openalex.org/W2980405531","https://openalex.org/W4309444973","https://openalex.org/W4405040454","https://openalex.org/W2944104838","https://openalex.org/W4387003533","https://openalex.org/W4283368515"],"abstract_inverted_index":{"Abstract":[0],"[Introduction]":[1],"Plasma":[2],"cell":[3,14,328,350,628],"leukemia":[4],"(PCL)":[5],"is":[6],"a":[7,583,597],"rare":[8],"and":[9,29,136,138,169,173,199,206,280,298,378,427,470,480,630],"aggressive":[10],"form":[11],"of":[12,23,33,48,74,93,122,386,616,622],"plasma":[13,26],"dyscrasia,":[15],"historically":[16],"defined":[17],"in":[18,35,51,81,108,119,140,163,193,203,294,338,345,375,560,568,634],"1974":[19],"as":[20],"the":[21,45,54,90,141,166,177,234,291,376,390,446,450,620],"presence":[22],"\u226520%":[24],"circulating":[25],"cells":[27],"(CPCs)":[28],"an":[30],"absolute":[31],"count":[32],"\u22652,000/\u03bcL":[34],"peripheral":[36,155,188,561],"blood.":[37],"The":[38,158,223,571],"International":[39],"Myeloma":[40],"Working":[41],"Group":[42,146],"(IMWG)":[43],"updated":[44],"diagnostic":[46,124],"definition":[47],"primary":[49],"PCL":[50,123],"2021,":[52],"reducing":[53],"CPC":[55,617],"threshold":[56],"to":[57,65,111,233,440,476,503,539],"\u22655%":[58],"based":[59],"on":[60],"equivalent":[61],"survival":[62,368],"outcomes":[63,107,474,537],"compared":[64,232,502],"\u226520%.":[66],"Recent":[67],"studies":[68],"suggest":[69],"that":[70,434],"even":[71],"lower":[72,237],"levels":[73,262],"CPCs":[75,101,148,197,225,380,392,403,472,492,522,543,559,580,604],"(\u22652%)":[76],"may":[77,581],"confer":[78],"poor":[79],"prognosis":[80,460,501],"newly":[82],"diagnosed":[83,133],"multiple":[84],"myeloma":[85],"(NDMM).":[86],"To":[87],"further":[88],"clarify":[89],"prognostic":[91,613],"implications":[92],"low-level":[94],"CPCs,":[95,443],"we":[96],"investigated":[97],"whether":[98,113],"morphologically":[99,150],"identified":[100,557],"\u22651%":[102,198,224,377,391,402,471,521,558],"are":[103],"associated":[104,406,457],"with":[105,165,196,217,383,407,458,467,486,491,520,541,603],"inferior":[106,396,408],"NDMM,":[109],"aiming":[110],"assess":[112],"such":[114],"cases":[115],"might":[116],"warrant":[117],"consideration":[118],"future":[120],"revisions":[121],"criteria.":[125],"[Methods]":[126],"We":[127],"retrospectively":[128],"analyzed":[129],"854":[130,183],"NDMM":[131,569],"patients":[132,184,344,466,490,519,540,602],"between":[134,220,314],"2017":[135],"2023":[137],"registered":[139],"North":[142],"Japan":[143],"Hematology":[144],"Study":[145],"database.":[147],"were":[149,161,174,191,201,312,321],"assessed":[151],"at":[152],"diagnosis":[153],"using":[154],"blood":[156,189,562],"smears.":[157],"study":[159],"procedures":[160],"conducted":[162],"accordance":[164],"Helsinki":[167],"Declaration":[168],"institutional":[170,178],"ethical":[171],"guidelines":[172],"approved":[175],"by":[176],"review":[179],"boards.":[180],"[Results]":[181],"Among":[182,489],"from":[185],"15":[186],"facilities,":[187],"smears":[190],"evaluable":[192],"829.":[194],"Patients":[195],"<1%":[200,235,379,487,542],"observed":[202],"77":[204],"(9.3%)":[205],"752":[207],"(90.7%),":[208],"respectively.":[209,342],"Median":[210,366],"age":[211],"was":[212,304,370,404,456],"72":[213],"years":[214],"(range,":[215],"30\u201394),":[216],"no":[218],"difference":[219],"groups":[221,289],"(p=0.20).":[222],"group":[226,347,393],"exhibited":[227],"significantly":[228,395,481,564],"worse":[229,482],"baseline":[230],"characteristics":[231],"group:":[236],"hemoglobin":[238],"(8.15":[239],"vs":[240,248,257,264,277,307,340,354,363,372,388,512,551],"9.58":[241],"g/dL,":[242],"p<0.001),":[243,251,259,267],"higher":[244,260,285],"serum":[245],"creatinine":[246],"(1.89":[247],"1.58":[249],"mg/dL,":[250],"more":[252,268],"frequent":[253,269],"elevated":[254],"LDH":[255],"(48.1%":[256,306],"22.6%,":[258],"\u03b22-microglobulin":[261],"(13.5":[263],"7.5":[265],"mg/L,":[266],"high-risk":[270,636],"cytogenetics":[271],"[t(4;14),":[272],"t(14;16),":[273],"or":[274,317,357,527,608],"del(17p)]":[275],"(39.0%":[276],"23.8%,":[278],"p=0.004),":[279],"R2-ISS":[281,424,453],"distribution":[282],"skewed":[283],"toward":[284],"stages":[286],"(p=0.002).":[287],"Both":[288],"showed":[290,499,536],"highest":[292],"proportion":[293],"stage":[295,425,454,462,468,477,484],"III":[296,455,469,485],"(37.7%":[297],"38.7%,":[299],"respectively).":[300],"Bone":[301],"lesion":[302],"incidence":[303],"similar":[305],"45.3%,":[308],"p=0.74).":[309],"Induction":[310],"regimens":[311,320],"comparable":[313,475,538],"groups;":[315],"bortezomib-":[316],"daratumumab-based":[318],"doublet/triplet":[319],"most":[322],"commonly":[323],"used.":[324],"Upfront":[325,590],"autologous":[326],"stem":[327],"transplantation":[329],"(ASCT)":[330],"after":[331,418],"induction":[332,594],"therapy":[333,351,595,629],"without":[334],"regimen":[335],"change":[336],"occurred":[337],"19.4%":[339],"17.2%,":[341],"Few":[343],"either":[346],"received":[348],"CAR-T":[349,627],"(1":[352],"[1.3%]":[353],"4":[355],"[0.5%])":[356],"bispecific":[358,631],"monoclonal":[359,632],"antibodies":[360,633],"(4":[361],"[5.2%]":[362],"12":[364],"[1.6%]).":[365],"overall":[367,451],"(OS)":[369],"37.9":[371],"98.7":[373],"months":[374],"groups,":[381],"respectively,":[382],"5-year":[384],"OS":[385,397,409],"36.5%":[387],"65.1%;":[389],"had":[394,473],"(p<0.0001).":[398],"In":[399,449],"multivariate":[400],"analysis,":[401],"independently":[405],"(hazard":[410],"ratio":[411],"[HR]":[412],"2.39,":[413],"95%":[414],"CI":[415],"1.65\u20133.45,":[416],"p<0.001)":[417],"adjusting":[419],"for":[420,587,601],"age,":[421],"renal":[422],"function,":[423],"III-IV,":[426],"t(11;14).":[428],"Restricted":[429],"cubic":[430],"spline":[431],"analysis":[432],"demonstrated":[433],"mortality":[435,566,572],"risk":[436,447,567,573,588],"increased":[437,565],"steeply":[438],"up":[439],"approximately":[441],"1%":[442,579],"beyond":[444,575],"which":[445],"plateaued.":[448],"cohort,":[452],"better":[459],"than":[461,483],"IV":[463,478],"(p<0.01);":[464],"however,":[465],"(p=0.625)":[479],"CPCs.":[488],"\u22651%,":[493],"those":[494,504,533],"who":[495,505,534],"underwent":[496],"upfront":[497],"ASCT":[498,591],"improved":[500],"did":[506,535],"not":[507,510,549,552],"(median":[508,547],"OS:":[509,548],"reached":[511,550],"33.6":[513],"months,":[514],"p=0.048).":[515],"Although":[516],"relatively":[517],"few":[518],"achieved":[523],"complete":[524],"response":[525],"(CR)":[526],"minimal":[528],"residual":[529],"disease":[530],"(MRD)":[531],"negativity,":[532],"achieving":[544],"these":[545],"endpoints":[546],"reached,":[553],"p=0.19).":[554],"[Conclusion]":[555],"Morphologically":[556],"confers":[563],"patients.":[570],"plateaus":[574],"this":[576,635],"threshold,":[577],"suggesting":[578],"represent":[582],"clinically":[584],"meaningful":[585,612],"cutoff":[586],"stratification.":[589],"following":[592],"successful":[593],"remains":[596],"key":[598],"therapeutic":[599,624],"approach":[600],"\u22651%.":[605],"Achieving":[606],"CR":[607],"MRD":[609],"negativity":[610],"provides":[611],"benefit":[614],"regardless":[615],"status,":[618],"underscoring":[619],"importance":[621],"novel":[623],"approaches":[625],"including":[626],"population.":[637]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-12-04T00:00:00"}