{"id":"https://openalex.org/W4416967006","doi":"https://doi.org/10.1002/cbdv.202501941","title":"Ethnopharmacological Insights Into Chamaelirium luteum (L.) Gray: Traditional Uses, Phytochemistry, and Pharmacological Potential","display_name":"Ethnopharmacological Insights Into Chamaelirium luteum (L.) Gray: Traditional Uses, Phytochemistry, and Pharmacological Potential","publication_year":2025,"publication_date":"2025-12-03","ids":{"openalex":"https://openalex.org/W4416967006","doi":"https://doi.org/10.1002/cbdv.202501941","pmid":"https://pubmed.ncbi.nlm.nih.gov/41337655"},"language":"en","primary_location":{"id":"doi:10.1002/cbdv.202501941","doi":"https://doi.org/10.1002/cbdv.202501941","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202501941","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101646416","display_name":"Hailing Wang","orcid":"https://orcid.org/0000-0002-6976-8806","observed_orcids":["https://orcid.org/0000-0002-6976-8806"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hailing Wang","raw_affiliation_strings":["School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","institution_ids":["https://openalex.org/I192327786"]},{"raw_affiliation_string":"School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Yin","raw_affiliation_strings":["School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","institution_ids":["https://openalex.org/I192327786"]},{"raw_affiliation_string":"School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115695055","display_name":"Yinan Wang","orcid":"https://orcid.org/0009-0000-7046-5127","observed_orcids":["https://orcid.org/0009-0000-7046-5127"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinan Wang","raw_affiliation_strings":["School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","institution_ids":["https://openalex.org/I192327786"]},{"raw_affiliation_string":"School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101745968","display_name":"Yuan Tian","orcid":"https://orcid.org/0000-0002-2215-7151","observed_orcids":["https://orcid.org/0000-0002-2215-7151"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Tian","raw_affiliation_strings":["School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","institution_ids":["https://openalex.org/I192327786"]},{"raw_affiliation_string":"School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103845209","display_name":"Xin Meng","orcid":"https://orcid.org/0009-0009-4169-3687","observed_orcids":["https://orcid.org/0009-0009-4169-3687"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Meng","raw_affiliation_strings":["School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China"],"raw_orcid":"https://orcid.org/0009-0009-4169-3687","affiliations":[{"raw_affiliation_string":"School of Pharmacy Heilongjiang University of Chinese Medicine  Harbin P. R. China","institution_ids":["https://openalex.org/I192327786"]},{"raw_affiliation_string":"School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, P. R. China","institution_ids":["https://openalex.org/I192327786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103845209"],"corresponding_institution_ids":["https://openalex.org/I192327786"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.2611,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52144715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"23","issue":"2","first_page":"e01941","last_page":"e01941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10431","display_name":"Ethnobotanical and Medicinal Plants Studies","score":0.0917000025510788,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.06939999759197235,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chamaelirium-luteum","display_name":"Chamaelirium luteum","score":1.0},{"id":"https://openalex.org/keywords/melanthiaceae","display_name":"Melanthiaceae","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ethnobotany","display_name":"ethnobotany","score":0.8539999723434448},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.746999979019165},{"id":"https://openalex.org/keywords/native-american-medicine","display_name":"Native American medicine","score":0.7120000123977661},{"id":"https://openalex.org/keywords/women-s-reproductive-health","display_name":"women's reproductive health","score":0.8379999995231628},{"id":"https://openalex.org/keywords/gynecological-diseases","display_name":"gynecological diseases","score":0.8970000147819519},{"id":"https://openalex.org/keywords/phytochemistry","display_name":"phytochemistry","score":0.8320000171661377},{"id":"https://openalex.org/keywords/steroidal-saponins","display_name":"steroidal saponins","score":0.9330000281333923},{"id":"https://openalex.org/keywords/diosgenin","display_name":"diosgenin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7919999957084656},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/phenolic-acids","display_name":"phenolic acids","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lignans","display_name":"lignans","score":0.8970000147819519},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.925000011920929},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9769999980926514},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/toxicology","display_name":"toxicology","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.6980000138282776},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6568999886512756},{"id":"https://openalex.org/C202216756","wikidata":"https://www.wikidata.org/wiki/Q841408","display_name":"Ethnobotany","level":3,"score":0.47049999237060547},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4018999934196472},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3939000070095062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3138999938964844},{"id":"https://openalex.org/C2779824472","wikidata":"https://www.wikidata.org/wiki/Q207123","display_name":"Herb","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C3018122547","wikidata":"https://www.wikidata.org/wiki/Q5690813","display_name":"Health benefits","level":2,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008519","descriptor_name":"Medicine, Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020834","descriptor_name":"Ethnopharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cbdv.202501941","doi":"https://doi.org/10.1002/cbdv.202501941","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202501941","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},{"id":"pmid:41337655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41337655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biodiversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1965981532","https://openalex.org/W1968599011","https://openalex.org/W2006974638","https://openalex.org/W2008383752","https://openalex.org/W2011814478","https://openalex.org/W2036234818","https://openalex.org/W2039750716","https://openalex.org/W2040391996","https://openalex.org/W2047882449","https://openalex.org/W2056634831","https://openalex.org/W2058681467","https://openalex.org/W2089853825","https://openalex.org/W2097724805","https://openalex.org/W2112127037","https://openalex.org/W2143690549","https://openalex.org/W2148709085","https://openalex.org/W2237828173","https://openalex.org/W2323101086","https://openalex.org/W2565383127","https://openalex.org/W2941125651","https://openalex.org/W2951902079","https://openalex.org/W2969377001","https://openalex.org/W2997704321","https://openalex.org/W3003385877","https://openalex.org/W3022612002","https://openalex.org/W3030751252","https://openalex.org/W3080581218","https://openalex.org/W3104218582","https://openalex.org/W3110187971","https://openalex.org/W3128061772","https://openalex.org/W4205535257","https://openalex.org/W4210708517","https://openalex.org/W4211093950","https://openalex.org/W4230971839","https://openalex.org/W4231489491","https://openalex.org/W4238295540","https://openalex.org/W4249898105","https://openalex.org/W4303943873","https://openalex.org/W4381839435","https://openalex.org/W4384525127","https://openalex.org/W4385737811","https://openalex.org/W4390883951","https://openalex.org/W4394622703","https://openalex.org/W4406100413","https://openalex.org/W4407176716","https://openalex.org/W4410511159","https://openalex.org/W4410759409"],"related_works":[],"abstract_inverted_index":{"Chamaelirium":[0],"luteum":[1],"(L.)":[2],"Gray,":[3],"commonly":[4],"known":[5],"as":[6],"False":[7],"Unicorn":[8],"or":[9],"Fairy":[10],"Wand,":[11],"is":[12],"a":[13],"perennial":[14],"herb":[15],"in":[16,129],"the":[17,101],"Melanthiaceae":[18],"family,":[19],"native":[20],"to":[21,118],"eastern":[22],"North":[23],"America.":[24],"Traditionally":[25],"used":[26],"by":[27],"Native":[28],"American":[29],"tribes,":[30],"it":[31],"has":[32],"been":[33],"especially":[34],"valued":[35],"for":[36,123],"promoting":[37],"women's":[38],"reproductive":[39],"health.":[40],"Ethnobotanical":[41],"records":[42],"highlight":[43],"its":[44,124],"therapeutic":[45],"properties,":[46],"including":[47,59],"anti-inflammatory,":[48],"antioxidant,":[49],"and":[50,77,83,105,126],"cytotoxic":[51],"effects.":[52],"Phytochemical":[53],"investigations":[54],"have":[55],"identified":[56],"bioactive":[57],"compounds,":[58],"steroidal":[60],"saponins":[61],"(e.g.,":[62,69,74],"diosgenin,":[63],"\u223c2.5%":[64],"dry":[65],"weight),":[66],"phenolic":[67],"acids":[68],"gallic":[70],"acid,":[71],"\u223c1.2%),":[72],"flavonoids":[73],"quercetin,":[75],"\u223c0.8%),":[76],"lignans,":[78],"which":[79],"exhibit":[80],"anti-tumor,":[81],"antibacterial,":[82],"immunomodulatory":[84],"activities.":[85],"Modern":[86],"applications":[87],"include":[88],"managing":[89],"gynecological":[90],"disorders,":[91],"though":[92],"clinical":[93],"evidence":[94],"remains":[95],"limited.":[96],"This":[97],"review":[98],"critically":[99],"evaluates":[100],"botany,":[102],"phytochemistry,":[103],"pharmacology,":[104],"toxicology":[106],"of":[107],"C.":[108],"luteum,":[109],"integrating":[110],"traditional":[111],"knowledge":[112],"with":[113],"recent":[114],"scientific":[115],"advances":[116],"(2015-2024)":[117],"propose":[119],"future":[120],"research":[121],"directions":[122],"safe":[125],"effective":[127],"use":[128],"medicine.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-12-03T00:00:00"}