{"id":"https://openalex.org/W4416940468","doi":"https://doi.org/10.3390/dermato5040023","title":"Cutaneous Marginal Zone Lymphoproliferation Arising from Circumorificial Plasmacytosis During Nivolumab Therapy for Urothelial Carcinoma","display_name":"Cutaneous Marginal Zone Lymphoproliferation Arising from Circumorificial Plasmacytosis During Nivolumab Therapy for Urothelial Carcinoma","publication_year":2025,"publication_date":"2025-12-03","ids":{"openalex":"https://openalex.org/W4416940468","doi":"https://doi.org/10.3390/dermato5040023"},"language":"en","primary_location":{"id":"doi:10.3390/dermato5040023","doi":"https://doi.org/10.3390/dermato5040023","is_oa":true,"landing_page_url":"https://doi.org/10.3390/dermato5040023","pdf_url":"https://www.mdpi.com/2673-6179/5/4/23/pdf","source":{"id":"https://openalex.org/S4210178129","display_name":"Dermato","issn_l":"2673-6179","issn":["2673-6179"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermato","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2673-6179/5/4/23/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055279662","display_name":"Thilo Gambichler","orcid":"https://orcid.org/0000-0001-7862-3695","observed_orcids":["https://orcid.org/0000-0001-7862-3695"]},"institutions":[{"id":"https://openalex.org/I155976169","display_name":"Witten/Herdecke University","ror":"https://ror.org/00yq55g44","country_code":"DE","type":"education","lineage":["https://openalex.org/I155976169"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thilo Gambichler","raw_affiliation_strings":["Department of Dermatology, Christian Hospital Unna, 59423 Unna, Germany","Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany","Dortmund Hospital gGmbH and Faculty of Health, Witten/Herdecke University, 44122 Dortmund, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7862-3695","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Christian Hospital Unna, 59423 Unna, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]},{"raw_affiliation_string":"Dortmund Hospital gGmbH and Faculty of Health, Witten/Herdecke University, 44122 Dortmund, Germany","institution_ids":["https://openalex.org/I155976169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109096224","display_name":"Heinz\u2010Wolfram Bernd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinz-Wolfram Bernd","raw_affiliation_strings":["H\u00e4matopathologie L\u00fcbeck, Consultation and Reference Center for Lymphoma and Bone Marrow Diagnostics, 23562 L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00e4matopathologie L\u00fcbeck, Consultation and Reference Center for Lymphoma and Bone Marrow Diagnostics, 23562 L\u00fcbeck, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093802962","display_name":"Sera Selina Weyer-Fahlbusch","orcid":"https://orcid.org/0009-0009-9509-6271","observed_orcids":["https://orcid.org/0009-0009-9509-6271"]},"institutions":[{"id":"https://openalex.org/I155976169","display_name":"Witten/Herdecke University","ror":"https://ror.org/00yq55g44","country_code":"DE","type":"education","lineage":["https://openalex.org/I155976169"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sera Weyer-Fahlbusch","raw_affiliation_strings":["Dortmund Hospital gGmbH and Faculty of Health, Witten/Herdecke University, 44122 Dortmund, Germany"],"raw_orcid":"https://orcid.org/0009-0009-9509-6271","affiliations":[{"raw_affiliation_string":"Dortmund Hospital gGmbH and Faculty of Health, Witten/Herdecke University, 44122 Dortmund, Germany","institution_ids":["https://openalex.org/I155976169"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anke L\u00fccke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155976169","display_name":"Witten/Herdecke University","ror":"https://ror.org/00yq55g44","country_code":"DE","type":"education","lineage":["https://openalex.org/I155976169"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anke L\u00fccke","raw_affiliation_strings":["Department of Pathology, Dortmund Hospital, University Witten/Herdecke, 44122 Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dortmund Hospital, University Witten/Herdecke, 44122 Dortmund, Germany","institution_ids":["https://openalex.org/I155976169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059744280","display_name":"Johann Lorenzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155976169","display_name":"Witten/Herdecke University","ror":"https://ror.org/00yq55g44","country_code":"DE","type":"education","lineage":["https://openalex.org/I155976169"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johann Lorenzen","raw_affiliation_strings":["Department of Pathology, Dortmund Hospital, University Witten/Herdecke, 44122 Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dortmund Hospital, University Witten/Herdecke, 44122 Dortmund, Germany","institution_ids":["https://openalex.org/I155976169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007615241","display_name":"Laura Susok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155976169","display_name":"Witten/Herdecke University","ror":"https://ror.org/00yq55g44","country_code":"DE","type":"education","lineage":["https://openalex.org/I155976169"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Susok","raw_affiliation_strings":["Dortmund Hospital gGmbH and Faculty of Health, Witten/Herdecke University, 44122 Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dortmund Hospital gGmbH and Faculty of Health, Witten/Herdecke University, 44122 Dortmund, Germany","institution_ids":["https://openalex.org/I155976169"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055279662"],"corresponding_institution_ids":["https://openalex.org/I155976169","https://openalex.org/I904495901"],"apc_list":{"value":1000,"currency":"CHF","value_usd":1207},"apc_paid":{"value":1000,"currency":"CHF","value_usd":1207},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3705691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"4","first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.03610000014305115,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marginal-zone-lymphoma","display_name":"marginal zone lymphoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mucocutaneous-lesions","display_name":"mucocutaneous lesions","score":0.628000020980835},{"id":"https://openalex.org/keywords/ebv","display_name":"EBV","score":0.6000000238418579},{"id":"https://openalex.org/keywords/pd-1-pd-l1-blockade","display_name":"PD-1/PD-L1 blockade","score":0.7279999852180481},{"id":"https://openalex.org/keywords/immunophenotyping","display_name":"immunophenotyping","score":0.6690000295639038},{"id":"https://openalex.org/keywords/immunoglobulin-heavy-chain-gene-rearrangement","display_name":"immunoglobulin heavy chain gene rearrangement","score":0.7120000123977661},{"id":"https://openalex.org/keywords/overdiagnosis","display_name":"overdiagnosis","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2778709411","wikidata":"https://www.wikidata.org/wiki/Q7201798","display_name":"Plasmacytosis","level":3,"score":0.7032999992370605},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6509000062942505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.61080002784729},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4397999942302704},{"id":"https://openalex.org/C2779380147","wikidata":"https://www.wikidata.org/wiki/Q3832900","display_name":"Splenic marginal zone lymphoma","level":4,"score":0.42480000853538513},{"id":"https://openalex.org/C2776995267","wikidata":"https://www.wikidata.org/wiki/Q4165484","display_name":"Lymphoproliferative disorders","level":3,"score":0.4156999886035919},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.3571999967098236},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.3278000056743622},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.32429999113082886},{"id":"https://openalex.org/C2910423619","wikidata":"https://www.wikidata.org/wiki/Q1778287","display_name":"Lymphoplasmacytic Lymphoma","level":4,"score":0.3231000006198883},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.3003999888896942},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29789999127388},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C2776396001","wikidata":"https://www.wikidata.org/wiki/Q250694","display_name":"Plasma cell","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.2800000011920929},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.25110000371932983}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/dermato5040023","doi":"https://doi.org/10.3390/dermato5040023","is_oa":true,"landing_page_url":"https://doi.org/10.3390/dermato5040023","pdf_url":"https://www.mdpi.com/2673-6179/5/4/23/pdf","source":{"id":"https://openalex.org/S4210178129","display_name":"Dermato","issn_l":"2673-6179","issn":["2673-6179"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermato","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:6f72f4d34909478599216470fda258ca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6f72f4d34909478599216470fda258ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dermato, Vol 5, Iss 4, p 23 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/dermato5040023","doi":"https://doi.org/10.3390/dermato5040023","is_oa":true,"landing_page_url":"https://doi.org/10.3390/dermato5040023","pdf_url":"https://www.mdpi.com/2673-6179/5/4/23/pdf","source":{"id":"https://openalex.org/S4210178129","display_name":"Dermato","issn_l":"2673-6179","issn":["2673-6179"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermato","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416940468.pdf","grobid_xml":"https://content.openalex.org/works/W4416940468.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1537902465","https://openalex.org/W1995944331","https://openalex.org/W2415053822","https://openalex.org/W2898917524","https://openalex.org/W3110892144","https://openalex.org/W3193623843","https://openalex.org/W3194164778","https://openalex.org/W3215711665","https://openalex.org/W4251682354","https://openalex.org/W4297708972","https://openalex.org/W4308684381","https://openalex.org/W4378576315","https://openalex.org/W4385830368","https://openalex.org/W4386865727","https://openalex.org/W4390605606","https://openalex.org/W4396575787","https://openalex.org/W4405819297","https://openalex.org/W4409374320","https://openalex.org/W4413054632","https://openalex.org/W4413440654","https://openalex.org/W4413780447"],"related_works":[],"abstract_inverted_index":{"Immune":[0],"checkpoint":[1],"inhibitors":[2],"(ICIs),":[3],"particularly":[4],"PD-1/PD-L1":[5],"antibodies,":[6],"have":[7,79],"significantly":[8],"improved":[9],"outcomes":[10],"in":[11,82,207,223,246,317],"a":[12,50,71,118,134,157,164,180,190,216,231,273],"variety":[13],"of":[14,109,123,138,159,173,226,240,249,257,269,287,304],"solid":[15],"tumors,":[16],"including":[17,298],"urothelial":[18,114],"carcinoma.":[19],"However,":[20],"their":[21],"use":[22],"is":[23,49,308],"frequently":[24,32],"associated":[25],"with":[26,60,84,93,113,163,194,319],"immune-related":[27],"adverse":[28],"events":[29],"(irAEs)":[30],"which":[31],"affect":[33],"the":[34,107,124,224,238,247,253,259,284,292],"skin":[35],"and":[36,70,142,145,171,176,198,212,233,242,267,290,300,313],"mucous":[37],"membranes.":[38],"Among":[39],"these,":[40],"plasma-cell-rich":[41],"infiltrates":[42,69],"are":[43],"exceptionally":[44],"rare.":[45],"Circumorificial":[46],"plasmacytosis":[47],"(COP)":[48],"rare,":[51],"predominantly":[52],"reactive":[53,241],"condition":[54],"typically":[55],"involving":[56],"mucosal":[57],"transition":[58],"zones,":[59],"histologic":[61],"features":[62,256],"characterized":[63],"by":[64,205],"dense,":[65],"polyclonal":[66],"plasma":[67,140,161,181],"cell":[68,182],"benign":[72],"clinical":[73,265],"course.":[74],"Only":[75],"two":[76],"case":[77,108,229,282],"reports":[78],"described":[80],"COP":[81],"association":[83],"ICI":[85,250],"therapy":[86],"and,":[87],"to":[88,310],"date,":[89],"transformation":[90],"or":[91],"overlap":[92],"lymphoproliferative":[94],"disorders":[95],"such":[96,305],"as":[97],"marginal":[98,217],"zone":[99,218],"lymphoma":[100],"has":[101],"not":[102],"been":[103],"documented.":[104],"We":[105],"report":[106],"an":[110],"86-year-old":[111],"male":[112],"carcinoma":[115],"who":[116],"developed":[117],"progressive,":[119],"ulcerated,":[120],"bleeding":[121],"lesion":[122,254],"lower":[125],"lip":[126],"during":[127],"adjuvant":[128],"nivolumab":[129],"therapy.":[130,251],"Histologic":[131],"examination":[132],"revealed":[133,189],"dense":[135],"subepithelial":[136],"infiltrate":[137],"mature":[139],"cells":[141,162,201],"lymphocytes.":[143],"Direct":[144],"indirect":[146],"immunofluorescence":[147],"studies":[148],"were":[149,202],"negative,":[150],"excluding":[151],"autoimmune":[152],"blistering":[153],"disorders.":[154],"Immunohistochemistry":[155],"showed":[156],"predominance":[158],"CD138-positive":[160],"moderate":[165],"kappa":[166],"light-chain":[167],"shift,":[168],"CD19":[169],"expression,":[170],"absence":[172],"CD56,":[174],"Cyclin-D1,":[175],"CD117,":[177],"arguing":[178],"against":[179],"neoplasm.":[183],"Molecular":[184],"analysis":[185],"via":[186],"multiplex":[187],"PCR":[188],"clonal":[191,243],"B-cell":[192,244,262],"population":[193],"distinct":[195],"IgH":[196],"rearrangements,":[197],"some":[199],"EBV-positive":[200],"also":[203],"identified":[204],"EBER":[206],"situ":[208],"hybridization.":[209],"The":[210],"histopathologic":[211],"molecular":[213,301],"findings":[214],"suggested":[215],"lymphoma-like,":[219],"plasmacytic":[220],"proliferation":[221],"arising":[222],"setting":[225],"COP.":[227],"This":[228,281],"illustrates":[230],"rare":[232,306],"diagnostically":[234],"challenging":[235],"constellation":[236],"at":[237],"intersection":[239],"proliferations":[245],"context":[248],"Although":[252],"demonstrated":[255],"clonality,":[258],"overall":[260],"low":[261],"content,":[263],"indolent":[264,321],"course,":[266],"lack":[268],"systemic":[270,315],"involvement":[271],"support":[272],"reactive,":[274],"immunodeficiency-associated":[275],"lymphoproliferation":[276],"rather":[277],"than":[278],"overt":[279],"lymphoma.":[280],"expands":[283],"known":[285],"spectrum":[286],"mucocutaneous":[288],"irAEs":[289],"highlights":[291],"need":[293],"for":[294],"careful":[295],"clinicopathologic":[296],"correlation,":[297],"immunophenotyping":[299],"diagnostics.":[302],"Awareness":[303],"presentations":[307],"essential":[309],"avoid":[311],"overdiagnosis":[312],"unnecessary":[314],"treatment":[316],"patients":[318],"otherwise":[320],"lesions.":[322]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-12-03T00:00:00"}