{"id":"https://openalex.org/W4416901641","doi":"https://doi.org/10.1158/2326-6066.30761384","title":"Supplementary Figure S12 from ATOR-4066, a Bispecific Antibody Targeting CD40 and CEACAM5, Induces Strong Myeloid and T Cell\u2013Dependent Tumor Immunity and Synergizes with PD-1 Blockade","display_name":"Supplementary Figure S12 from ATOR-4066, a Bispecific Antibody Targeting CD40 and CEACAM5, Induces Strong Myeloid and T Cell\u2013Dependent Tumor Immunity and Synergizes with PD-1 Blockade","publication_year":2025,"publication_date":"2025-12-02","ids":{"openalex":"https://openalex.org/W4416901641","doi":"https://doi.org/10.1158/2326-6066.30761384"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.30761384","doi":"https://doi.org/10.1158/2326-6066.30761384","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.30761384","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.30761384","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037943815","display_name":"Hampus Andersson","orcid":"https://orcid.org/0009-0007-9517-5864","observed_orcids":["https://orcid.org/0009-0007-9517-5864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hampus Andersson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-9517-5864","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031616716","display_name":"Ida Elin Maria Uddback","orcid":"https://orcid.org/0000-0001-6007-5918","observed_orcids":["https://orcid.org/0000-0001-6007-5918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ida Uddb\u00e4ck","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6007-5918","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098722372","display_name":"Tova Hermodsson","orcid":"https://orcid.org/0009-0000-2062-7888","observed_orcids":["https://orcid.org/0009-0000-2062-7888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tova Hermodsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-2062-7888","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012070715","display_name":"Mona Celander","orcid":"https://orcid.org/0009-0009-5886-9941","observed_orcids":["https://orcid.org/0009-0009-5886-9941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mona Celander","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5886-9941","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100578495","display_name":"Amulya Krishna Shetty","orcid":"https://orcid.org/0009-0003-7827-8715","observed_orcids":["https://orcid.org/0009-0003-7827-8715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amulya Krishna Shetty","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-7827-8715","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070016509","display_name":"Lill Ljung","orcid":"https://orcid.org/0000-0003-4810-8136","observed_orcids":["https://orcid.org/0000-0003-4810-8136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lill Ljung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4810-8136","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021639097","display_name":"Anneli Nilsson","orcid":"https://orcid.org/0000-0002-2468-4035","observed_orcids":["https://orcid.org/0000-0002-2468-4035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anneli Nilsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2468-4035","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073829192","display_name":"Anette Sundstedt","orcid":"https://orcid.org/0000-0001-9216-1386","observed_orcids":["https://orcid.org/0000-0001-9216-1386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anette Sundstedt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9216-1386","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072019967","display_name":"Laura von Schantz","orcid":"https://orcid.org/0000-0003-1236-3135","observed_orcids":["https://orcid.org/0000-0003-1236-3135"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura von Schantz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1236-3135","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008420464","display_name":"Laura A. Varas","orcid":"https://orcid.org/0000-0001-8083-0888","observed_orcids":["https://orcid.org/0000-0001-8083-0888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura A. Varas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8083-0888","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020569823","display_name":"Mattias Levin","orcid":"https://orcid.org/0009-0004-8378-7837","observed_orcids":["https://orcid.org/0009-0004-8378-7837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mattias Levin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-8378-7837","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003121489","display_name":"Anna S\u00e4ll","orcid":"https://orcid.org/0000-0001-5287-2984","observed_orcids":["https://orcid.org/0000-0001-5287-2984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna S\u00e4ll","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5287-2984","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054499855","display_name":"Dietmar Weilguny","orcid":"https://orcid.org/0009-0001-8625-0638","observed_orcids":["https://orcid.org/0009-0001-8625-0638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dietmar Weilguny","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-8625-0638","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kim Jansson","orcid":"https://orcid.org/0009-0002-9342-0452","observed_orcids":["https://orcid.org/0009-0002-9342-0452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim Jansson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-9342-0452","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034448965","display_name":"Sara Fritzell","orcid":"https://orcid.org/0000-0003-1079-2614","observed_orcids":["https://orcid.org/0000-0003-1079-2614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Fritzell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1079-2614","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068228532","display_name":"Karin H\u00e4gerbrand","orcid":"https://orcid.org/0009-0004-5662-6990","observed_orcids":["https://orcid.org/0009-0004-5662-6990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karin H\u00e4gerbrand","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-5662-6990","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043590900","display_name":"Malin Lindstedt","orcid":"https://orcid.org/0000-0001-9136-1087","observed_orcids":["https://orcid.org/0000-0001-9136-1087"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malin Lindstedt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9136-1087","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001191544","display_name":"Peter Ellmark","orcid":"https://orcid.org/0000-0002-6687-1250","observed_orcids":["https://orcid.org/0000-0002-6687-1250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Ellmark","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6687-1250","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cd40","display_name":"CD40","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ceacam5","display_name":"CEACAM5","score":1.0},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/t-cell-dependent-immune-response","display_name":"T cell-dependent immunity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2994430510","wikidata":"https://www.wikidata.org/wiki/Q3270846","display_name":"Myeloid cells","level":3,"score":0.6901000142097473},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6607999801635742},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5569999814033508},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.5048999786376953},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4997999966144562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4941999912261963},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.39910000562667847},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.38510000705718994},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3790000081062317},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3720000088214874},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3628000020980835},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3400000035762787},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.33559998869895935},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2667999863624573}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2326-6066.30761384","doi":"https://doi.org/10.1158/2326-6066.30761384","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.30761384","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30761384","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_S12_from_ATOR-4066_a_Bispecific_Antibody_Targeting_CD40_and_CEACAM5_Induces_Strong_Myeloid_and_T_Cell_Dependent_Tumor_Immunity_and_Synergizes_with_PD-1_Blockade/30761384","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.30761384","doi":"https://doi.org/10.1158/2326-6066.30761384","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.30761384","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416900381","https://openalex.org/W4414085736","https://openalex.org/W4404052847","https://openalex.org/W4388047991","https://openalex.org/W4393086907","https://openalex.org/W4415900220","https://openalex.org/W4361237127","https://openalex.org/W4408133530","https://openalex.org/W6921097019","https://openalex.org/W4361237108"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"S12.":[2],"Representative":[3],"flow":[4],"of":[5],"myeloid":[6],"cells.":[7]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-12-02T00:00:00"}