{"id":"https://openalex.org/W4416879732","doi":"https://doi.org/10.1186/s12917-026-05692-5","title":"Discovery of KC-1: a novel porcine dendritic cell-targeting peptide with potential applications in swine vaccine design","display_name":"Discovery of KC-1: a novel porcine dendritic cell-targeting peptide with potential applications in swine vaccine design","publication_year":2026,"publication_date":"2026-07-22","ids":{"openalex":"https://openalex.org/W4416879732","doi":"https://doi.org/10.1186/s12917-026-05692-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/42897628","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13682161"},"language":"en","primary_location":{"id":"doi:10.1186/s12917-026-05692-5","doi":"https://doi.org/10.1186/s12917-026-05692-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12917-026-05692-5","pdf_url":null,"source":{"id":"https://openalex.org/S197820984","display_name":"BMC Veterinary Research","issn_l":"1746-6148","issn":["1746-6148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12917-026-05692-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015575319","display_name":"Bin Liu","orcid":"https://orcid.org/0000-0002-5051-8006","observed_orcids":["https://orcid.org/0000-0002-5051-8006"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Liu","raw_affiliation_strings":["China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","Key Laboratory of Diagnosis and Treatment for Epizootic Diseases of Animals in Cold Regions of Heilongjiang Province, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","Northeast Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Key Laboratory of Diagnosis and Treatment for Epizootic Diseases of Animals in Cold Regions of Heilongjiang Province, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Northeast Agricultural University","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tian Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405278916","display_name":"Heilongjiang Polytechnic","ror":"https://ror.org/00rms4677","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405278916"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Xia","raw_affiliation_strings":["Heilongjiang Polytechnic, No. 5 Xuefu Road, Nangang District, Harbin, 150086, P.R. China","Heilongjiang Polytechnic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Polytechnic, No. 5 Xuefu Road, Nangang District, Harbin, 150086, P.R. China","institution_ids":["https://openalex.org/I4405278916"]},{"raw_affiliation_string":"Heilongjiang Polytechnic","institution_ids":["https://openalex.org/I4405278916"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chengjie Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengjie Bian","raw_affiliation_strings":["China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","Northeast Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Northeast Agricultural University","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050293293","display_name":"Yanping Jiang","orcid":"https://orcid.org/0000-0002-0931-9507","observed_orcids":["https://orcid.org/0000-0002-0931-9507"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanping Jiang","raw_affiliation_strings":["China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","Northeast Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Northeast Agricultural University","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100673550","display_name":"Wen Cui","orcid":"https://orcid.org/0009-0002-5013-582X","observed_orcids":["https://orcid.org/0009-0002-5013-582X","https://orcid.org/0000-0001-9324-4140"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Cui","raw_affiliation_strings":["China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","Northeast Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Northeast Agricultural University","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333833","display_name":"Jiaxuan Li","orcid":"https://orcid.org/0000-0002-6146-9780","observed_orcids":["https://orcid.org/0000-0002-6146-9780"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxuan Li","raw_affiliation_strings":["China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","Northeast Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Northeast Agricultural University","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100660233","display_name":"Yijing Li","orcid":"https://orcid.org/0000-0003-0574-8520","observed_orcids":["https://orcid.org/0000-0003-0574-8520"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijing Li","raw_affiliation_strings":["China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","Northeast Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Northeast Agricultural University","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100335904","display_name":"Li Wang","orcid":"https://orcid.org/0000-0001-9639-1058","observed_orcids":["https://orcid.org/0000-0001-9639-1058","https://orcid.org/0000-0002-8682-0696"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Wang","raw_affiliation_strings":["China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China. wanglicau@163.com","College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China. wanglicau@163.com","Key Laboratory of Diagnosis and Treatment for Epizootic Diseases of Animals in Cold Regions of Heilongjiang Province, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China. wanglicau@163.com","Northeast Agricultural University"],"raw_orcid":"https://orcid.org/0000-0002-8682-0696","affiliations":[{"raw_affiliation_string":"China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeastern Science Inspection Station, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China. wanglicau@163.com","institution_ids":[]},{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China. wanglicau@163.com","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Key Laboratory of Diagnosis and Treatment for Epizootic Diseases of Animals in Cold Regions of Heilongjiang Province, Northeast Agricultural University, 600 Changjiang Street Xiangfang District, Harbin, 150030, P.R. China. wanglicau@163.com","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Northeast Agricultural University","institution_ids":["https://openalex.org/I169572211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100335904"],"corresponding_institution_ids":["https://openalex.org/I169572211"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00409405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/antigen-delivery","display_name":"antigen delivery","score":0.5040000081062317},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.8109999895095825},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bone-marrow-derived-dendritic-cells","display_name":"bone marrow-derived dendritic cells","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6209999918937683},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5442000031471252},{"id":"https://openalex.org/C104428545","wikidata":"https://www.wikidata.org/wiki/Q4915204","display_name":"Biopanning","level":5,"score":0.5432999730110168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5252000093460083},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4984000027179718},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4754999876022339},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.43540000915527344},{"id":"https://openalex.org/C186268636","wikidata":"https://www.wikidata.org/wiki/Q896217","display_name":"Phage display","level":3,"score":0.38530001044273376},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.35019999742507935},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.3377000093460083},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.33570000529289246},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32600000500679016},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32030001282691956},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C2781241564","wikidata":"https://www.wikidata.org/wiki/Q1347450","display_name":"Epitope mapping","level":4,"score":0.296099990606308},{"id":"https://openalex.org/C2776471321","wikidata":"https://www.wikidata.org/wiki/Q7166526","display_name":"Peptide library","level":4,"score":0.29440000653266907},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2791999876499176},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.266400009393692},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.26249998807907104},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.2508000135421753}],"mesh":[{"descriptor_ui":"D000087506","descriptor_name":"Vaccine Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096202","descriptor_name":"Protein Subunit Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12917-026-05692-5","doi":"https://doi.org/10.1186/s12917-026-05692-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12917-026-05692-5","pdf_url":null,"source":{"id":"https://openalex.org/S197820984","display_name":"BMC Veterinary Research","issn_l":"1746-6148","issn":["1746-6148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Veterinary Research","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-8110404/v1","doi":"https://doi.org/10.21203/rs.3.rs-8110404/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8110404/v1","pdf_url":"https://www.researchsquare.com/article/rs-8110404/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13682161","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682161/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682161/pdf/12917_2026_Article_5692.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Vet Res","raw_type":"Text"},{"id":"pmid:42897628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42897628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC veterinary research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6ed58abc450344b98aebe20fa0701434","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6ed58abc450344b98aebe20fa0701434","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Veterinary Research, Vol 22, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12917-026-05692-5","doi":"https://doi.org/10.1186/s12917-026-05692-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12917-026-05692-5","pdf_url":null,"source":{"id":"https://openalex.org/S197820984","display_name":"BMC Veterinary Research","issn_l":"1746-6148","issn":["1746-6148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Veterinary Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3603701843","display_name":null,"funder_award_id":"32373048","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5158880566","display_name":null,"funder_award_id":"YQ2021C020","funder_id":"https://openalex.org/F4320323085","funder_display_name":"Natural Science Foundation of Heilongjiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323085","display_name":"Natural Science Foundation of Heilongjiang Province","ror":null},{"id":"https://openalex.org/F4320325186","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416879732.pdf","grobid_xml":"https://content.openalex.org/works/W4416879732.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W234499698","https://openalex.org/W1551760143","https://openalex.org/W1661544713","https://openalex.org/W1663595021","https://openalex.org/W1969190415","https://openalex.org/W1980183768","https://openalex.org/W1983414413","https://openalex.org/W2009621891","https://openalex.org/W2032783993","https://openalex.org/W2042170041","https://openalex.org/W2045000601","https://openalex.org/W2059385530","https://openalex.org/W2074222872","https://openalex.org/W2080956086","https://openalex.org/W2085207311","https://openalex.org/W2157884087","https://openalex.org/W2164386465","https://openalex.org/W2172266795","https://openalex.org/W2598922467","https://openalex.org/W2767535966","https://openalex.org/W2776164679","https://openalex.org/W2781884141","https://openalex.org/W2790151483","https://openalex.org/W2801055605","https://openalex.org/W2883216700","https://openalex.org/W2892369450","https://openalex.org/W2981706660","https://openalex.org/W3165933613","https://openalex.org/W3190431840","https://openalex.org/W4206210292","https://openalex.org/W4225246130","https://openalex.org/W4226089140","https://openalex.org/W4283662301","https://openalex.org/W4286560471","https://openalex.org/W4293441844","https://openalex.org/W4296138357","https://openalex.org/W4302304879","https://openalex.org/W4304080458","https://openalex.org/W4309315770","https://openalex.org/W4383314293","https://openalex.org/W4385143915","https://openalex.org/W4386709479","https://openalex.org/W4386736619","https://openalex.org/W4386979695","https://openalex.org/W4387115981","https://openalex.org/W4387358865","https://openalex.org/W4389678691","https://openalex.org/W4392083892","https://openalex.org/W4395070571","https://openalex.org/W4399606960","https://openalex.org/W4401103131","https://openalex.org/W4408095836","https://openalex.org/W4413270682"],"related_works":["https://openalex.org/W4292369529","https://openalex.org/W2964015717","https://openalex.org/W4417153135","https://openalex.org/W4296138357","https://openalex.org/W2171260203","https://openalex.org/W2536188661","https://openalex.org/W4399861029","https://openalex.org/W7062162254","https://openalex.org/W4304080458","https://openalex.org/W2169805815"],"abstract_inverted_index":{"Dendritic":[0],"cells":[1,6],"(DCs)":[2],"are":[3],"key":[4,147],"antigen-presenting":[5],"essential":[7],"for":[8,24,91,264],"initiating":[9],"and":[10,27,41,196,206,223,230,244,261],"regulating":[11],"immune":[12,225],"responses.":[13],"While":[14],"DC":[15,92],"targeting":[16,28],"has":[17],"proven":[18],"to":[19,67,96,103,136,235],"be":[20],"an":[21],"effective":[22],"strategy":[23],"vaccine":[25,42],"enhancement,":[26],"peptides":[29,50],"have":[30],"been":[31],"extensively":[32],"utilized":[33],"as":[34,85,171],"efficient":[35],"delivery":[36,271],"tools":[37],"in":[38,155,185],"DC-targeted":[39,269],"drug":[40],"development,":[43],"there":[44],"remains":[45],"a":[46,69,146,172,221,262],"notable":[47],"scarcity":[48],"of":[49,142,149,158,181,203,217,248,267],"specifically":[51,134],"selected":[52],"through":[53],"porcine":[54,108,118,268],"dendritic":[55,106],"cell":[56],"screening":[57],"platforms.":[58],"In":[59,94],"this":[60,238],"study,":[61],"phage":[62],"display":[63],"biopanning":[64],"was":[65],"employed":[66],"identify":[68],"novel":[70,250],"DC-targeting":[71],"peptide,":[72],"designated":[73],"KC":[74],"(KCCYPNQMAAFA).":[75],"Systematic":[76],"alanine-scanning":[77],"mutagenesis":[78],"identified":[79],"the":[80,86,137,150,156,159,163,178,214,218,241,249,254],"N-terminal":[81,138],"hexapeptide":[82],"KC-1":[83,98,133,182,252],"(KCCYPN)":[84],"minimal":[87],"functional":[88],"epitope":[89],"responsible":[90],"binding.":[93],"addition":[95],"DCs,":[97],"also":[99],"demonstrated":[100,189],"selective":[101],"binding":[102,242],"bone":[104],"marrow-derived":[105],"cells(BM-DCs)and":[107],"alveolar":[109],"macrophages":[110],"(PAMs)":[111],"but":[112],"exhibited":[113],"no":[114],"interaction":[115],"with":[116],"intestinal":[117],"epithelial":[119],"(IPI)":[120],"cells,":[121,125],"swine":[122],"testis":[123],"(ST)":[124],"or":[126],"Vero":[127],"cells.":[128],"Further":[129],"analysis":[130],"revealed":[131],"that":[132,190,211],"binds":[135],"region":[139],"(1-126":[140],"aa)":[141],"SLA-DRB1,":[143],"which":[144],"is":[145],"domain":[148],"MHC":[151],"II":[152],"\u03b2-chain":[153],"involved":[154],"formation":[157],"peptide-binding":[160],"groove.":[161],"Using":[162],"Porcine":[164],"Epidemic":[165],"Diarrhea":[166],"Virus":[167],"(PEDV)":[168],"S1":[169],"subunit":[170],"model":[173],"antigen,":[174,219],"we":[175],"further":[176,265],"evaluated":[177],"immunomodulatory":[179,246],"effects":[180],"on":[183],"DCs":[184,194],"vitro.":[186],"The":[187],"results":[188],"KC-1-S1":[191,212],"significantly":[192],"promoted":[193],"maturation":[195],"T-cell":[197],"proliferation,":[198],"accompanied":[199],"by":[200],"increased":[201],"secretion":[202],"IL-4,":[204],"IL-12,":[205],"IFN-\u03b3.":[207],"These":[208],"findings":[209],"indicate":[210],"enhances":[213],"overall":[215],"immunogenicity":[216],"triggering":[220],"robust":[222],"mixed":[224],"response":[226],"encompassing":[227],"both":[228],"Th1-":[229],"Th2-type":[231],"cytokine":[232],"profiles":[233],"compared":[234],"controls.":[236],"Collectively,":[237],"study":[239],"characterizes":[240],"profile":[243],"preliminary":[245],"activity":[247],"peptide":[251],"at":[253],"cellular":[255],"level,":[256],"providing":[257],"basic":[258],"experimental":[259],"data":[260],"reference":[263],"development":[266],"antigen":[270],"strategies.":[272]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-12-01T00:00:00"}