{"id":"https://openalex.org/W4416877212","doi":"https://doi.org/10.1681/asn.20251bgcg9x0","title":"Effect of Penicillin on Proximal Tubule Secretion in Persons with CKD","display_name":"Effect of Penicillin on Proximal Tubule Secretion in Persons with CKD","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4416877212","doi":"https://doi.org/10.1681/asn.20251bgcg9x0"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20251bgcg9x0","doi":"https://doi.org/10.1681/asn.20251bgcg9x0","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20251bgcg9x0","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027394675","display_name":"Pranav Sandilya Garimella","orcid":"https://orcid.org/0000-0002-6016-4715","observed_orcids":["https://orcid.org/0000-0002-6016-4715"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pranav S. Garimella","raw_affiliation_strings":["University of California San Diego, La Jolla, California, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego, La Jolla, California, United States;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022346670","display_name":"Ronit Katz","orcid":"https://orcid.org/0000-0001-7723-7469","observed_orcids":["https://orcid.org/0000-0001-7723-7469"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronit Katz","raw_affiliation_strings":["University of Washington, Seattle, Washington, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, Washington, United States;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017467320","display_name":"Jesse C. Seegmiller","orcid":"https://orcid.org/0000-0003-2542-6502","observed_orcids":["https://orcid.org/0000-0003-2542-6502"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse C. Seegmiller","raw_affiliation_strings":["University of Minnesota Twin Cities, Minneapolis, Minnesota, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Twin Cities, Minneapolis, Minnesota, United States;","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071585977","display_name":"Michael G. Shlipak","orcid":"https://orcid.org/0000-0002-9559-204X","observed_orcids":["https://orcid.org/0000-0002-9559-204X"]},"institutions":[{"id":"https://openalex.org/I4210143381","display_name":"San Francisco VA Health Care System","ror":"https://ror.org/04g9q2h37","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Shlipak","raw_affiliation_strings":["San Francisco VA Health Care System, San Francisco, California, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Francisco VA Health Care System, San Francisco, California, United States;","institution_ids":["https://openalex.org/I4210143381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054296834","display_name":"Lesley A. Inker","orcid":"https://orcid.org/0000-0003-2820-9482","observed_orcids":["https://orcid.org/0000-0003-2820-9482"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lesley Ann Inker","raw_affiliation_strings":["Tufts Medical Center, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Medical Center, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024425228","display_name":"Joachim H. Ix","orcid":"https://orcid.org/0000-0002-8084-9869","observed_orcids":["https://orcid.org/0000-0002-8084-9869"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joachim H. Ix","raw_affiliation_strings":["University of California San Diego, La Jolla, California, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego, La Jolla, California, United States;","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37711255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"10S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillin","display_name":"penicillin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.843999981880188},{"id":"https://openalex.org/keywords/organic-anion-transporters","display_name":"organic anion transporters","score":0.9869999885559082},{"id":"https://openalex.org/keywords/organic-cation-transporters","display_name":"organic cation transporters","score":1.0},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9129999876022339},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.6759999990463257},{"id":"https://openalex.org/keywords/penicillin-g","display_name":"penicillin G","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7343000173568726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7178000211715698},{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.6951000094413757},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6650000214576721},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6229000091552734},{"id":"https://openalex.org/C3018884230","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Renal tubule","level":3,"score":0.5697000026702881},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.5303000211715698},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.39100000262260437},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3625999987125397},{"id":"https://openalex.org/C2909587778","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Kidney tubules","level":3,"score":0.3352000117301941},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.2989000082015991},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.2720000147819519}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20251bgcg9x0","doi":"https://doi.org/10.1681/asn.20251bgcg9x0","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20251bgcg9x0","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2950950839","https://openalex.org/W3034987696","https://openalex.org/W2610326627","https://openalex.org/W2495572230","https://openalex.org/W3015913382","https://openalex.org/W1954218272","https://openalex.org/W3084246015","https://openalex.org/W4410773517","https://openalex.org/W1902563404","https://openalex.org/W3173230404"],"abstract_inverted_index":{"Background:":[0],"Organic":[1],"anion":[2],"transporters":[3,8],"(OAT)":[4],"and":[5,20,26,84,95,116,124,130,142,153,173,230,240],"organic":[6],"cation":[7],"(OCT)":[9],"are":[10,252],"responsible":[11],"for":[12,122],"the":[13,109,163,194,205],"active":[14],"secretion":[15,89,104,120],"of":[16,24,33,75,113,186,208,211,219,228],"many":[17],"endogenous":[18,52,80],"substances":[19],"drugs.":[21],"Competitive":[22],"inhibition":[23,45],"OAT":[25,83,123,167,212,231,247],"OCT":[27,49,88,125,174,220],"by":[28,46,97,107],"drugs":[29],"may":[30,259],"increase":[31],"risk":[32],"drug-drug":[34,262],"interactions":[35],"(DDIs).":[36],"We":[37],"conducted":[38],"this":[39],"proof-of-concept":[40],"study":[41],"to":[42,160,181,200,254,261],"evaluate":[43],"competitive":[44],"penicillin":[47,134,161,222,229],"(an":[48],"substrate)":[50],"on":[51,246],"proximal":[53,234],"tubular":[54,235],"secretory":[55,168,175,189],"solutes":[56,81,86,126],"in":[57,92],"persons":[58],"with":[59,67,242],"chronic":[60],"kidney":[61],"disease":[62],"(CKD).":[63],"Methods:":[64],"Ten":[65,79],"participants":[66],"eGFR":[68,147],"30-45":[69],"mL/min/1.73m2":[70],"received":[71],"1":[72],"million":[73],"units":[74],"intravenous":[76],"Penicillin":[77],"G.":[78],"marking":[82,87],"nine":[85],"were":[90,144,191],"measured":[91],"paired":[93],"blood":[94],"urine":[96],"liquid":[98],"chromatography-tandem":[99],"mass":[100],"spectrometry":[101],"(LC-MS/MS).":[102],"Tubular":[103],"was":[105,139,148,155,170,177,214],"assessed":[106],"calculating":[108],"urine-to-plasma":[110],"ratio":[111,183],"(UPR)":[112,184],"each":[114],"solute":[115,236],"creating":[117],"a":[118],"summary":[119],"score":[121,169,176],"separately":[127],"at":[128,193],"baseline,":[129],"240":[131,195],"minutes":[132,196],"after":[133,221],"infusion.":[135],"Results:":[136],"Mean":[137],"age":[138],"57":[140],"years,":[141],"50%":[143],"women.":[145],"Baseline":[146],"39":[149],"\u00b1":[150],"6":[151],"ml/min/1.73m2":[152],"albuminuria":[154],"164":[156],"(60-453)":[157],"mg/g.":[158],"Prior":[159],"infusion,":[162],"median":[164],"(IQR)":[165],"composite":[166,209],"17.6":[171],"(5.4-28.2)":[172],"29.9":[178],"(14.7-40.9).":[179],"Urine":[180],"plasma":[182],"levels":[185],"all":[187],"individual":[188],"metabolites":[190],"lower":[192],"post-penicillin":[197],"infusion":[198,223],"compared":[199],"baseline":[201],"(0":[202],"minutes).":[203],"Overall,":[204],"absolute":[206],"suppression":[207],"markers":[210],"clearance":[213,237],"greater":[215],"(Figure)":[216],"than":[217],"that":[218],"(p=":[224],"0.028).":[225],"Conclusion:":[226],"Infusion":[227],"substrate":[232,248],"inhibits":[233],"via":[238],"OATs":[239],"OCTs,":[241],"larger":[243],"effects":[244],"observed":[245],"clearance.":[249],"Future":[250],"studies":[251],"required":[253],"determine":[255],"if":[256],"these":[257],"findings":[258],"contribute":[260],"interactions.":[263],"Funding:":[264],"NIDDK":[265],"Support":[266]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-12-01T00:00:00"}