{"id":"https://openalex.org/W4416845708","doi":"https://doi.org/10.21608/ejchem.2025.435851.12518","title":"Targeting Electronic Cigarette Vapor Induced Genetic and Immune -Biochemical Disturbances using Ginger (Zingiber officinale) Rhizomes, Dandelion (Taraxacum officinale), and Costus (Saussurea lappa) Roots Extracts in Male Rats","display_name":"Targeting Electronic Cigarette Vapor Induced Genetic and Immune -Biochemical Disturbances using Ginger (Zingiber officinale) Rhizomes, Dandelion (Taraxacum officinale), and Costus (Saussurea lappa) Roots Extracts in Male Rats","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416845708","doi":"https://doi.org/10.21608/ejchem.2025.435851.12518"},"language":"en","primary_location":{"id":"doi:10.21608/ejchem.2025.435851.12518","doi":"https://doi.org/10.21608/ejchem.2025.435851.12518","is_oa":false,"landing_page_url":"https://doi.org/10.21608/ejchem.2025.435851.12518","pdf_url":null,"source":{"id":"https://openalex.org/S4210174320","display_name":"Egyptian Journal of Chemistry","issn_l":"0449-2285","issn":["0449-2285","2357-0245"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066416786","display_name":"Alyae Gabal","orcid":"https://orcid.org/0000-0001-8191-3191","observed_orcids":["https://orcid.org/0000-0001-8191-3191"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Alyae Mohamed Salah Gabal","raw_affiliation_strings":["Biochemistry and nutrition department, women faculty for arts, science and education , Ain shams university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and nutrition department, women faculty for arts, science and education , Ain shams university","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120573537","display_name":"Hajar Musaad Saad Abd El-Gwaad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hajar Musaad Saad Abd El-Gwaad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010707046","display_name":"Amira M. Demain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amira M. Demain","raw_affiliation_strings":["Biochemistry and Nutrition    \nDepartment of Biochemistry and Nutrition \nFaculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Nutrition    \nDepartment of Biochemistry and Nutrition \nFaculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34255769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"0","issue":"0","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.19179999828338623,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electronic-cigarette-vapor","display_name":"electronic cigarette vapor","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ginger-extract","display_name":"ginger extract","score":0.6349999904632568},{"id":"https://openalex.org/keywords/dandelion-extract","display_name":"dandelion extract","score":0.8920000195503235},{"id":"https://openalex.org/keywords/herbal-supplementation","display_name":"herbal supplementation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9110000133514404},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.6480000019073486},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.6740000247955322},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6830000281333923},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8389999866485596},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.5170000195503235},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.8870000243186951},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8050000071525574},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.44999998807907104},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6589000225067139},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5953999757766724},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5867999792098999},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49300000071525574},{"id":"https://openalex.org/C2778804639","wikidata":"https://www.wikidata.org/wiki/Q30024","display_name":"Dandelion","level":4,"score":0.49140000343322754},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.4422000050544739},{"id":"https://openalex.org/C2993351451","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Cigarette smoke","level":2,"score":0.3984000086784363},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.36570000648498535},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3434999883174896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3183000087738037},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.28519999980926514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2754000127315521},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2671999931335449}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21608/ejchem.2025.435851.12518","doi":"https://doi.org/10.21608/ejchem.2025.435851.12518","is_oa":false,"landing_page_url":"https://doi.org/10.21608/ejchem.2025.435851.12518","pdf_url":null,"source":{"id":"https://openalex.org/S4210174320","display_name":"Egyptian Journal of Chemistry","issn_l":"0449-2285","issn":["0449-2285","2357-0245"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Introduction":[0],"Electronic":[1],"cigarettes":[2],"(E-cigs)":[3],"vapor":[4,57,125,138,175],"inhalation":[5],"has":[6],"become":[7],"increasingly":[8],"prevalent":[9],"among":[10,310],"youth,":[11],"asserting":[12],"the":[13,62,169,292,314],"necessity":[14],"for":[15,33,106],"more":[16],"research":[17],"into":[18,100],"its":[19],"probable":[20],"detrimental":[21],"effects.":[22],"Recognizing":[23],"natural,":[24],"available,":[25],"and":[26,48,64,71,132,140,146,183,192,204,217,224,229,243,274,334],"safe":[27,300],"solutions":[28],"offers":[29],"a":[30,327],"crucial":[31],"challenge":[32],"safeguarding":[34],"human":[35,337],"health.":[36,338],"The":[37,52,287,319],"effective":[38],"ingredients":[39],"found":[40],"in":[41,61,110,118,128,252],"natural":[42,87,322],"fresh":[43,115],"extracts":[44,81,88,148,153,323],"of":[45,54,157,187,201,215,260,283,317,321],"ginger,":[46,144],"dandelion,":[47],"costus":[49,147,167,253,290],"were":[50,82,91,98,232],"assessed.":[51],"influence":[53],"inhaling":[55,284],"E-cigs":[56,174,285,297],"on":[58],"gene":[59],"expressions":[60,200],"lung":[63,182],"liver,":[65],"hematopoiesis,":[66,269],"oxidative-inflammatory":[67],"status,":[68],"immune":[69,225,273],"response,":[70],"liver-kidney":[72,275],"functions":[73,231,276],"was":[74,211],"measured.":[75],"Moreover":[76],"potential":[77],"protective":[78],"strategies":[79],"employing":[80],"examined.":[83],"Methods":[84],"Freshly":[85],"prepared":[86],"active":[89,258],"constituents":[90],"determined.":[92],"Fifty":[93],"male":[94],"adult":[95],"Sprague-Dawley":[96],"strain":[97],"segregated":[99],"five":[101,133],"groups":[102],"(10":[103],"rats":[104],"each)":[105],"six":[107,281],"weeks.":[108],"Rats":[109,117,127],"group":[111,119,129],"one":[112],"exposed":[113,121,134],"to":[114,122,135,173,177,307,329],"air.":[116],"two":[120],"E-liquid":[123,136],"smoke":[124,137],"(1ml/day).":[126],"three,":[130],"four":[131],"(1ml/day)":[139],"supplemented":[141,254],"daily":[142],"with":[143,166,237,249,289],"dandelion":[145],"(400mg/kg)":[149],"respectively.":[150],"RESULTS":[151],"Tested":[152],"contain":[154],"significant":[155,263,294],"amounts":[156],"total":[158,160],"flavonoids,":[159],"polyphenols,":[161],"showcasing":[162],"strong":[163],"antioxidant":[164,188,221],"properties,":[165],"exhibiting":[168],"highest":[170],"concentrations.":[171],"Exposure":[172],"led":[176],"genetic":[178,267],"changes":[179],"by":[180],"reducing(p\u22640.05)":[181],"liver":[184,228],"expression":[185],"levels":[186],"(Ho-1,":[189],"Nrf2,":[190],"SIRT1),":[191],"anti-apoptotic":[193],"(Bcl-2)":[194],"genes,":[195],"while":[196],"simultaneously":[197],"increasing":[198],"(p\u22640.05)":[199,214,246,265,295],"inflammatory":[202],"(NF-KB),":[203],"apoptotic":[205],"(P53":[206],",Bax)":[207],"genes.":[208],"Additionally,":[209],"there":[210],"an":[212],"overproduction":[213],"oxidants":[216],"pro-inflammatory":[218],"markers.":[219],"Hematopoiesis,":[220],"capacity,":[222],"anti-inflammatory,":[223],"responses":[226,242],"also,":[227],"kidney":[230],"impaired":[233],"(p\u22640.05).":[234],"Contrariwise,":[235],"supplementation":[236,288],"herbal":[238],"plants":[239],"had":[240],"amelioration":[241],"favorably":[244],"affected":[245],"these":[247,331],"indices":[248],"best":[250],"records":[251],"group.":[255],"Conclusion":[256],"Natural":[257],"components":[259],"tested":[261],"herbs":[262],"protected":[264],"against":[266],"alterations,":[268],"oxidative":[270],"stress,":[271],"inflammation,":[272],"disturbances":[277],"that":[278],"arose":[279],"from":[280],"weeks":[282],"vapor.":[286],"showed":[291],"most":[293],"improvements.":[296],"are":[298],"not":[299],"smoking":[301],"cessation":[302],"tool.":[303],"It":[304],"is":[305,324],"recommended":[306],"raise":[308],"awareness":[309],"young":[311],"people":[312],"concerning":[313],"negative":[315],"effects":[316,333],"E-cigs.":[318],"use":[320],"suggested":[325],"as":[326],"way":[328],"counteract":[330],"adverse":[332],"support":[335],"overall":[336]},"counts_by_year":[],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-12-01T00:00:00"}
