{"id":"https://openalex.org/W4416844815","doi":"https://doi.org/10.1158/1078-0432.30750603","title":"Supplementary Figure S3 from BET Bromodomain Inhibition Reverses CDK4/6 Inhibitor Resistance in Estrogen Receptor\u2013Positive Breast Cancer via Induction of miR-34a-5p","display_name":"Supplementary Figure S3 from BET Bromodomain Inhibition Reverses CDK4/6 Inhibitor Resistance in Estrogen Receptor\u2013Positive Breast Cancer via Induction of miR-34a-5p","publication_year":2025,"publication_date":"2025-12-01","ids":{"openalex":"https://openalex.org/W4416844815","doi":"https://doi.org/10.1158/1078-0432.30750603"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.30750603","doi":"https://doi.org/10.1158/1078-0432.30750603","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30750603","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S3_from_BET_Bromodomain_Inhibition_Reverses_CDK4_6_Inhibitor_Resistance_in_Estrogen_Receptor_Positive_Breast_Cancer_via_Induction_of_miR-34a-5p/30750603/1/files/59994315.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S3_from_BET_Bromodomain_Inhibition_Reverses_CDK4_6_Inhibitor_Resistance_in_Estrogen_Receptor_Positive_Breast_Cancer_via_Induction_of_miR-34a-5p/30750603/1/files/59994315.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102482457","display_name":"Renyan Liu","orcid":"https://orcid.org/0009-0009-5676-3350","observed_orcids":["https://orcid.org/0009-0009-5676-3350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renyan Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5676-3350","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087528175","display_name":"Xin Wang","orcid":"https://orcid.org/0009-0007-9132-405X","observed_orcids":["https://orcid.org/0009-0007-9132-405X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-9132-405X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009370475","display_name":"Timothy B. Branigan","orcid":"https://orcid.org/0009-0000-7301-8445","observed_orcids":["https://orcid.org/0009-0000-7301-8445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy B. Branigan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-7301-8445","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015550698","display_name":"Daryl Griffin","orcid":"https://orcid.org/0000-0003-2444-9497","observed_orcids":["https://orcid.org/0000-0003-2444-9497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daryl Griffin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2444-9497","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109290246","display_name":"Caoibhne McSweeney","orcid":"https://orcid.org/0009-0006-4143-5213","observed_orcids":["https://orcid.org/0009-0006-4143-5213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caoibhne McSweeney","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-4143-5213","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017635065","display_name":"Jie Hao","orcid":"https://orcid.org/0000-0002-4610-0563","observed_orcids":["https://orcid.org/0000-0002-4610-0563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Hao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4610-0563","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034379066","display_name":"Constantia Pantelidou","orcid":"https://orcid.org/0000-0003-2750-9352","observed_orcids":["https://orcid.org/0000-0003-2750-9352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Constantia Pantelidou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2750-9352","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080768582","display_name":"Zachary T. Herbert","orcid":"https://orcid.org/0000-0001-9401-2464","observed_orcids":["https://orcid.org/0000-0001-9401-2464"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zachary T. Herbert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9401-2464","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039038038","display_name":"Heta Jadhav","orcid":"https://orcid.org/0009-0000-8291-3409","observed_orcids":["https://orcid.org/0009-0000-8291-3409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heta Jadhav","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-8291-3409","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045419282","display_name":"Geoffrey Ira Shapiro","orcid":"https://orcid.org/0000-0002-3331-4095","observed_orcids":["https://orcid.org/0000-0002-3331-4095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey I. Shapiro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3331-4095","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.1565999984741211,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bet-bromodomain-inhibition","display_name":"BET bromodomain inhibition","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cdk4-6-inhibitor-resistance","display_name":"CDK4/6 inhibitor resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mir-34a-5p","display_name":"miR-34a-5p","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.7544000148773193},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6535999774932861},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5871000289916992},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5346999764442444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4643999934196472},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.43549999594688416},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.39250001311302185},{"id":"https://openalex.org/C2779889926","wikidata":"https://www.wikidata.org/wiki/Q425223","display_name":"Raloxifene","level":5,"score":0.3896999955177307},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.36660000681877136},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.36039999127388},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.3546000123023987},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.3424000144004822},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33320000767707825},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.3271999955177307},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31839999556541443},{"id":"https://openalex.org/C2779634854","wikidata":"https://www.wikidata.org/wiki/Q18037206","display_name":"BRD4","level":5,"score":0.3138999938964844},{"id":"https://openalex.org/C2994037739","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle progression","level":4,"score":0.3093000054359436},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.27619999647140503},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.26350000500679016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2581999897956848},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.25369998812675476},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.25220000743865967},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.25060001015663147}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.30750603","doi":"https://doi.org/10.1158/1078-0432.30750603","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30750603","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S3_from_BET_Bromodomain_Inhibition_Reverses_CDK4_6_Inhibitor_Resistance_in_Estrogen_Receptor_Positive_Breast_Cancer_via_Induction_of_miR-34a-5p/30750603/1/files/59994315.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30750603","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_S3_from_BET_Bromodomain_Inhibition_Reverses_CDK4_6_Inhibitor_Resistance_in_Estrogen_Receptor_Positive_Breast_Cancer_via_Induction_of_miR-34a-5p/30750603","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.30750603","doi":"https://doi.org/10.1158/1078-0432.30750603","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30750603","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S3_from_BET_Bromodomain_Inhibition_Reverses_CDK4_6_Inhibitor_Resistance_in_Estrogen_Receptor_Positive_Breast_Cancer_via_Induction_of_miR-34a-5p/30750603/1/files/59994315.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416844815.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416852238","https://openalex.org/W4414908280","https://openalex.org/W4282967990","https://openalex.org/W3082493030","https://openalex.org/W3049629381","https://openalex.org/W3188531832","https://openalex.org/W2918928681","https://openalex.org/W2792558398","https://openalex.org/W3212605524","https://openalex.org/W2984218122"],"abstract_inverted_index":{"BET":[0],"inhibition":[1],"induces":[2],"molecular":[3],"changes":[4],"that":[5],"contribute":[6],"to":[7],"cell":[8],"cycle":[9],"arrest":[10],"and":[11],"growth":[12],"suppression.":[13]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-12-01T00:00:00"}