{"id":"https://openalex.org/W4416775274","doi":"https://doi.org/10.1126/sciadv.adz3192","title":"Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans","display_name":"Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans","publication_year":2025,"publication_date":"2025-11-26","ids":{"openalex":"https://openalex.org/W4416775274","doi":"https://doi.org/10.1126/sciadv.adz3192","pmid":"https://pubmed.ncbi.nlm.nih.gov/41296857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12652258"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.adz3192","doi":"https://doi.org/10.1126/sciadv.adz3192","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adz3192","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adz3192?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adz3192?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yile Zhai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yile Zhai","raw_affiliation_strings":["Shandong University","Institute of Medical Sciences, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033 Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Institute of Medical Sciences, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033 Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423067","display_name":"Tiantian Wang","orcid":"https://orcid.org/0009-0008-4360-2518","observed_orcids":["https://orcid.org/0009-0008-4360-2518"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiantian Wang","raw_affiliation_strings":["Shandong University","Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010982644","display_name":"Jiangxue Han","orcid":"https://orcid.org/0009-0000-9421-9924","observed_orcids":["https://orcid.org/0009-0000-9421-9924"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangxue Han","raw_affiliation_strings":["Shandong University","Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110629136","display_name":"Mengxiao Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengxiao Wu","raw_affiliation_strings":["Shandong University","Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Meixi Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meixi Gong","raw_affiliation_strings":["Shandong University","Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenfei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenfei Li","raw_affiliation_strings":["Shandong University","Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100443045","display_name":"Zhe Zhang","orcid":"https://orcid.org/0000-0003-3616-6224","observed_orcids":["https://orcid.org/0000-0003-3616-6224","https://orcid.org/0009-0005-0356-8026"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhe Zhang","raw_affiliation_strings":["Shandong University","Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China","Institute of Medical Sciences, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033 Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Institute of Medical Sciences, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033 Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100443045"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.5484,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.84558278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"11","issue":"48","first_page":"eadz3192","last_page":"eadz3192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.1597999930381775,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.6690000295639038},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/female-fertility","display_name":"female fertility","score":0.6589999794960022},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5659999847412109},{"id":"https://openalex.org/keywords/fecundity","display_name":"fecundity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/vitellogenin","display_name":"vitellogenin","score":0.8849999904632568},{"id":"https://openalex.org/keywords/v-type-atpase","display_name":"V-type ATPase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6600000262260437},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.7540000081062317},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8389999866485596},{"id":"https://openalex.org/keywords/age-related-fertility-decline","display_name":"age-related fertility decline","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.9666000008583069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.714900016784668},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6527000069618225},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.49790000915527344},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4896000027656555},{"id":"https://openalex.org/C2779078696","wikidata":"https://www.wikidata.org/wiki/Q83134957","display_name":"Vitellogenin","level":3,"score":0.47510001063346863},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.38769999146461487},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.3871999979019165},{"id":"https://openalex.org/C2775895488","wikidata":"https://www.wikidata.org/wiki/Q5251856","display_name":"Degron","level":5,"score":0.37209999561309814},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.3422999978065491},{"id":"https://openalex.org/C2781321622","wikidata":"https://www.wikidata.org/wiki/Q181409","display_name":"Yolk","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.3165999948978424},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31630000472068787},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.3093999922275543},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3043999969959259},{"id":"https://openalex.org/C145458877","wikidata":"https://www.wikidata.org/wiki/Q7317044","display_name":"Retromer","level":4,"score":0.3019999861717224},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27880001068115234},{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.2766999900341034},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.2703000009059906},{"id":"https://openalex.org/C2778283623","wikidata":"https://www.wikidata.org/wiki/Q18032200","display_name":"TSG101","level":5,"score":0.26669999957084656},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.2646999955177307},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26339998841285706},{"id":"https://openalex.org/C101635128","wikidata":"https://www.wikidata.org/wiki/Q4649768","display_name":"AAA proteins","level":4,"score":0.2630999982357025},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014819","descriptor_name":"Vitellogenins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025262","descriptor_name":"Vacuolar Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1126/sciadv.adz3192","doi":"https://doi.org/10.1126/sciadv.adz3192","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adz3192","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adz3192?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"doi:10.1101/2025.05.16.654472","doi":"https://doi.org/10.1101/2025.05.16.654472","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.16.654472","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/05/19/2025.05.16.654472.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41296857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41296857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1126/sciadv.adz3192","doi":"https://doi.org/10.1126/sciadv.adz3192","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adz3192","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adz3192?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1465287699","display_name":null,"funder_award_id":"202306056","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G1637765100","display_name":null,"funder_award_id":"2023HWYQ","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G2426537402","display_name":null,"funder_award_id":"32170781","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3547765446","display_name":null,"funder_award_id":"ZR2021QC023","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G4270034003","display_name":null,"funder_award_id":"2021JK032","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G6173735215","display_name":null,"funder_award_id":"tsqn202306056","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G8287503708","display_name":null,"funder_award_id":"2023HWYQ-014","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320311026","display_name":"Shandong University","ror":"https://ror.org/0207yh398"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320324731","display_name":"Yunnan University","ror":"https://ror.org/0040axw97"},{"id":"https://openalex.org/F4320327605","display_name":"Southern University of Science and Technology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416775274.pdf","grobid_xml":"https://content.openalex.org/works/W4416775274.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W2029833898","https://openalex.org/W2031145684","https://openalex.org/W2041765469","https://openalex.org/W2049848914","https://openalex.org/W2058333064","https://openalex.org/W2069027654","https://openalex.org/W2071870204","https://openalex.org/W2079683785","https://openalex.org/W2083162774","https://openalex.org/W2083720450","https://openalex.org/W2092668280","https://openalex.org/W2094890759","https://openalex.org/W2098124125","https://openalex.org/W2111211467","https://openalex.org/W2118393994","https://openalex.org/W2127244622","https://openalex.org/W2144277042","https://openalex.org/W2150202137","https://openalex.org/W2156008341","https://openalex.org/W2161518588","https://openalex.org/W2202850844","https://openalex.org/W2266621146","https://openalex.org/W2272597365","https://openalex.org/W2345997946","https://openalex.org/W2472391846","https://openalex.org/W2512777378","https://openalex.org/W2605465471","https://openalex.org/W2769245250","https://openalex.org/W2795853269","https://openalex.org/W2890677998","https://openalex.org/W2921862288","https://openalex.org/W2964417610","https://openalex.org/W2969789965","https://openalex.org/W2981013456","https://openalex.org/W2990149815","https://openalex.org/W3030118581","https://openalex.org/W3046665718","https://openalex.org/W3090831677","https://openalex.org/W3114060472","https://openalex.org/W3118676518","https://openalex.org/W3118705072","https://openalex.org/W3154978233","https://openalex.org/W3187000900","https://openalex.org/W3200536900","https://openalex.org/W3200814578","https://openalex.org/W3201187064","https://openalex.org/W3206780805","https://openalex.org/W4205407177","https://openalex.org/W4211151293","https://openalex.org/W4213260574","https://openalex.org/W4296478674","https://openalex.org/W4296481718","https://openalex.org/W4304687317","https://openalex.org/W4317654033","https://openalex.org/W4320034565","https://openalex.org/W4362706119","https://openalex.org/W4378908391","https://openalex.org/W4387661505","https://openalex.org/W4387949887","https://openalex.org/W4390348389","https://openalex.org/W4391973345","https://openalex.org/W4392159860","https://openalex.org/W4392239021","https://openalex.org/W4392453583","https://openalex.org/W4394741480","https://openalex.org/W4395659497","https://openalex.org/W4399480760","https://openalex.org/W4402355312","https://openalex.org/W4406753434","https://openalex.org/W4408389633","https://openalex.org/W4409593128"],"related_works":["https://openalex.org/W4415203235","https://openalex.org/W4317654033","https://openalex.org/W2769245250","https://openalex.org/W4229735201","https://openalex.org/W2103480401","https://openalex.org/W2736006326","https://openalex.org/W2218106415","https://openalex.org/W7100318807","https://openalex.org/W2118393994","https://openalex.org/W4402704206"],"abstract_inverted_index":{"Abstract":[0],"The":[1,71],"reproductive":[2,65,129,182],"capacity":[3,66],"declines":[4],"markedly":[5],"with":[6,104],"female":[7],"age":[8],"in":[9,19,37,67,79,162],"humans.":[10],"Similarly,":[11],"C.":[12,68],"elegans":[13,69],"exhibit":[14],"a":[15,28,58,172],"rapid":[16],"age-dependent":[17],"decline":[18,142],"fecundity":[20,141],"shortly":[21],"after":[22],"reaching":[23],"adulthood.":[24],"Emerging":[25],"evidence":[26],"suggests":[27],"significant":[29],"link":[30],"between":[31],"proteostasis":[32,63],"disruption":[33],"and":[34,40,64,82,93,106,112,128,150,166,170],"reduced":[35],"fertility":[36],"both":[38],"worms":[39],"humans,":[41],"but":[42],"the":[43,140,158],"regulatory":[44],"mechanisms":[45],"governing":[46],"this":[47],"connection":[48],"are":[49],"not":[50],"fully":[51],"understood.":[52],"Here,":[53],"we":[54],"report":[55],"that":[56,99,134],"LMD-3,":[57],"LysM":[59],"domain":[60],"protein,":[61],"regulates":[62],".":[70],"deficiency":[72],"of":[73,118,143,160],"lmd-3":[74,144],"leads":[75],"to":[76,175,180],"striking":[77],"defects":[78],"oxidation":[80],"resistance":[81],"constitutively":[83],"high":[84],"cellular":[85],"stress":[86,91,95,149],"responses,":[87],"such":[88],"as":[89],"ER":[90],"response":[92],"cytosolic":[94],"response.":[96],"We":[97,131],"demonstrate":[98],"lysosome-localized":[100],"LMD-3":[101,116,161],"protein":[102,126,164],"interacts":[103],"vitellogenin":[105],"V-type":[107],"ATPase,":[108],"which":[109],"drives":[110],"proton-transporting":[111],"lysosomal":[113,119,152],"lumen":[114],"acidification.":[115],"regulation":[117],"function":[120],"is":[121],"essential":[122],"for":[123],"maintaining":[124],"yolk":[125],"homeostasis":[127,165],"health.":[130,183],"also":[132],"identify":[133],"vitamin":[135],"B12":[136],"(meCbl)":[137],"supplementation":[138],"revert":[139],"mutants":[145],"by":[146],"reducing":[147],"oxidative":[148],"improving":[151],"function.":[153],"Together,":[154],"these":[155],"findings":[156],"emphasize":[157],"role":[159],"sustaining":[163],"oocyte":[167],"quality":[168],"control,":[169],"establish":[171],"model":[173],"system":[174],"find":[176],"potent":[177],"therapeutic":[178],"strategies":[179],"increase":[181]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2025-11-27T00:00:00"}