{"id":"https://openalex.org/W4416765915","doi":"https://doi.org/10.7759/cureus.97974","title":"Impaired Human Papillomavirus (HPV) Clearance in a Patient on Upadacitinib for Atopic Dermatitis: A Case of Refractory Genital Warts Resolved After Drug Withdrawal","display_name":"Impaired Human Papillomavirus (HPV) Clearance in a Patient on Upadacitinib for Atopic Dermatitis: A Case of Refractory Genital Warts Resolved After Drug Withdrawal","publication_year":2025,"publication_date":"2025-11-27","ids":{"openalex":"https://openalex.org/W4416765915","doi":"https://doi.org/10.7759/cureus.97974","pmid":"https://pubmed.ncbi.nlm.nih.gov/41466898"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.97974","doi":"https://doi.org/10.7759/cureus.97974","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.97974","pdf_url":"https://www.cureus.com/articles/389020-impaired-human-papillomavirus-hpv-clearance-in-a-patient-on-upadacitinib-for-atopic-dermatitis-a-case-of-refractory-genital-warts-resolved-after-drug-withdrawal.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/389020-impaired-human-papillomavirus-hpv-clearance-in-a-patient-on-upadacitinib-for-atopic-dermatitis-a-case-of-refractory-genital-warts-resolved-after-drug-withdrawal.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089874795","display_name":"Norifumi Kennoki","orcid":"https://orcid.org/0000-0001-6592-3429","observed_orcids":["https://orcid.org/0000-0001-6592-3429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norifumi Kennoki","raw_affiliation_strings":["Sexually Transmitted Infections, Ginza Hikari Clinic, Tokyo, JPN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sexually Transmitted Infections, Ginza Hikari Clinic, Tokyo, JPN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024113300","display_name":"Kyotaro Nohata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyotaro Nohata","raw_affiliation_strings":["Sexually Transmitted Infections, Ginza Hikari Clinic, Tokyo, JPN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sexually Transmitted Infections, Ginza Hikari Clinic, Tokyo, JPN","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Yuta Nakamori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuta Nakamori","raw_affiliation_strings":["Sexually Transmitted Infections, Ginza Hikari Clinic, Tokyo, JPN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sexually Transmitted Infections, Ginza Hikari Clinic, Tokyo, JPN","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2193,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.82344291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"17","issue":"11","first_page":"e97974","last_page":"e97974"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/upadacitinib","display_name":"upadacitinib","score":0.9490000009536743},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/genital-warts","display_name":"genital warts","score":0.9409999847412109},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.8799999952316284},{"id":"https://openalex.org/keywords/jak1-inhibitor","display_name":"JAK1 inhibitor","score":0.6809999942779541},{"id":"https://openalex.org/keywords/drug-induced-immunosuppression","display_name":"drug-induced immunosuppression","score":0.7749999761581421},{"id":"https://openalex.org/keywords/imiquimod","display_name":"imiquimod","score":0.7730000019073486},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.7680000066757202},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8190000057220459},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8769999742507935},{"id":"https://openalex.org/keywords/adverse-drug-interactions","display_name":"adverse drug interactions","score":0.6100000143051147},{"id":"https://openalex.org/keywords/hpv-vaccination","display_name":"HPV vaccination","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.968999981880188},{"id":"https://openalex.org/C2778308922","wikidata":"https://www.wikidata.org/wiki/Q208726","display_name":"Genital warts","level":4,"score":0.7299000024795532},{"id":"https://openalex.org/C2779112978","wikidata":"https://www.wikidata.org/wiki/Q423417","display_name":"Imiquimod","level":2,"score":0.683899998664856},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5167999863624573},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4912000000476837},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.47870001196861267},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4228000044822693},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4011000096797943},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.38420000672340393},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35519999265670776},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.35440000891685486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3521000146865845},{"id":"https://openalex.org/C183021626","wikidata":"https://www.wikidata.org/wiki/Q4620674","display_name":"Sex organ","level":2,"score":0.3382999897003174},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.32440000772476196},{"id":"https://openalex.org/C2779136573","wikidata":"https://www.wikidata.org/wiki/Q101971","display_name":"Common warts","level":3,"score":0.30379998683929443},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C2776824251","wikidata":"https://www.wikidata.org/wiki/Q423445","display_name":"Cidofovir","level":3,"score":0.2732999920845032},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C2778062832","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Drug withdrawal","level":3,"score":0.2531000077724457},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.25130000710487366},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.97974","doi":"https://doi.org/10.7759/cureus.97974","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.97974","pdf_url":"https://www.cureus.com/articles/389020-impaired-human-papillomavirus-hpv-clearance-in-a-patient-on-upadacitinib-for-atopic-dermatitis-a-case-of-refractory-genital-warts-resolved-after-drug-withdrawal.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmid:41466898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41466898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:12743636","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12743636/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cureus","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7759/cureus.97974","doi":"https://doi.org/10.7759/cureus.97974","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.97974","pdf_url":"https://www.cureus.com/articles/389020-impaired-human-papillomavirus-hpv-clearance-in-a-patient-on-upadacitinib-for-atopic-dermatitis-a-case-of-refractory-genital-warts-resolved-after-drug-withdrawal.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416765915.pdf","grobid_xml":"https://content.openalex.org/works/W4416765915.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1928599069","https://openalex.org/W1972776583","https://openalex.org/W1990639420","https://openalex.org/W2003727998","https://openalex.org/W2004748213","https://openalex.org/W2068965703","https://openalex.org/W2095995872","https://openalex.org/W2105707846","https://openalex.org/W2160787138","https://openalex.org/W2884090647","https://openalex.org/W3164705475","https://openalex.org/W4367693323","https://openalex.org/W4385898971","https://openalex.org/W4388863091"],"related_works":[],"abstract_inverted_index":{"We":[0],"report":[1],"a":[2,9,29,164],"case":[3,100],"of":[4,73,116,131,146,166,170,189],"refractory":[5],"condyloma":[6,123],"acuminatum":[7],"in":[8,93,113,187],"young":[10],"woman":[11],"receiving":[12],"upadacitinib":[13,60],"for":[14,104],"moderate-to-severe":[15],"atopic":[16],"dermatitis.":[17],"The":[18,125],"patient":[19],"developed":[20],"widespread":[21],"genital":[22,171,191],"and":[23,44,79,134,173,199],"perianal":[24],"warts":[25],"while":[26,63],"on":[27],"upadacitinib,":[28],"selective":[30],"Janus":[31],"kinase":[32],"1":[33],"(JAK1)":[34],"inhibitor.":[35],"Despite":[36],"appropriate":[37],"topical":[38],"treatment":[39],"with":[40,56,163],"imiquimod,":[41],"adjunctive":[42],"cryotherapy,":[43],"herbal":[45],"immunomodulatory":[46,155],"agents,":[47],"the":[48,57,76,94,102,114,194],"lesions":[49,77],"remained":[50],"resistant":[51],"to":[52,107,139,157,178,205],"therapy.":[53],"After":[54],"consultation":[55],"prescribing":[58,153],"dermatologist,":[59],"was":[61,65,83],"discontinued":[62],"imiquimod":[64],"continued":[66],"as":[67,122],"monotherapy.":[68],"Remarkably,":[69],"within":[70,85],"several":[71],"weeks":[72],"drug":[74],"cessation,":[75],"regressed,":[78],"complete":[80],"clinical":[81,207],"resolution":[82],"observed":[84],"three":[86],"months.":[87],"No":[88],"recurrence":[89],"has":[90],"been":[91],"noted":[92],"10":[95],"months":[96],"following":[97],"clearance.":[98,141],"This":[99],"underscores":[101],"potential":[103],"JAK1":[105],"inhibition":[106],"impair":[108],"cellular":[109],"antiviral":[110],"immunity,":[111],"particularly":[112],"context":[115],"human":[117],"papillomavirus":[118],"(HPV)-related":[119],"diseases":[120],"such":[121],"acuminatum.":[124],"immunologic":[126],"mechanism":[127],"may":[128,183,203],"involve":[129],"suppression":[130],"interferon-\u03b3,":[132],"interleukin-2,":[133],"other":[135],"cytokine":[136],"pathways":[137],"critical":[138],"viral":[140],"Clinicians":[142],"should":[143],"be":[144,184],"aware":[145],"this":[147],"possible":[148],"adverse":[149],"interaction,":[150],"especially":[151],"when":[152],"systemic":[154,196],"agents":[156],"sexually":[158],"active":[159],"patients":[160],"or":[161],"those":[162],"history":[165],"HPV":[167,175],"infection.":[168],"Consideration":[169],"examination":[172],"prophylactic":[174],"vaccination":[176],"prior":[177],"initiating":[179],"JAK":[180],"inhibitor":[181],"therapy":[182],"warranted.":[185],"Furthermore,":[186],"cases":[188],"treatment-resistant":[190],"warts,":[192],"reassessing":[193],"patient's":[195],"immune":[197],"status":[198],"current":[200],"immunosuppressive":[201],"medications":[202],"lead":[204],"improved":[206],"outcomes.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-11-28T00:00:00"}