{"id":"https://openalex.org/W4416764899","doi":"https://doi.org/10.1158/1541-7786.30733178","title":"Figure 7 from MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer","display_name":"Figure 7 from MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer","publication_year":2025,"publication_date":"2025-11-27","ids":{"openalex":"https://openalex.org/W4416764899","doi":"https://doi.org/10.1158/1541-7786.30733178"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.30733178","doi":"https://doi.org/10.1158/1541-7786.30733178","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.30733178","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.30733178","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075105508","display_name":"Nami Yamashita","orcid":"https://orcid.org/0000-0001-7182-1090","observed_orcids":["https://orcid.org/0000-0001-7182-1090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nami Yamashita","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7182-1090","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090815270","display_name":"Yoshihiro Morimoto","orcid":"https://orcid.org/0000-0003-2687-9933","observed_orcids":["https://orcid.org/0000-0003-2687-9933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiro Morimoto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2687-9933","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037062908","display_name":"Atsushi Fushimi","orcid":"https://orcid.org/0000-0003-1328-8835","observed_orcids":["https://orcid.org/0000-0003-1328-8835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsushi Fushimi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1328-8835","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013660351","display_name":"Rehan Ahmad","orcid":"https://orcid.org/0000-0003-2612-2818","observed_orcids":["https://orcid.org/0000-0003-2612-2818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rehan Ahmad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2612-2818","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036087604","display_name":"Atrayee Bhattacharya","orcid":"https://orcid.org/0000-0002-3322-6175","observed_orcids":["https://orcid.org/0000-0002-3322-6175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atrayee Bhattacharya","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3322-6175","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078157913","display_name":"Tatsuaki Daimon","orcid":"https://orcid.org/0000-0003-4997-452X","observed_orcids":["https://orcid.org/0000-0003-4997-452X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuaki Daimon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4997-452X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086171353","display_name":"Naoki Haratake","orcid":"https://orcid.org/0000-0002-3098-4798","observed_orcids":["https://orcid.org/0000-0002-3098-4798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Haratake","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3098-4798","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067076071","display_name":"Yuka Inoue","orcid":"https://orcid.org/0000-0001-5793-6086","observed_orcids":["https://orcid.org/0000-0001-5793-6086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuka Inoue","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5793-6086","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010644036","display_name":"Satoshi Ishikawa","orcid":"https://orcid.org/0000-0002-6015-8921","observed_orcids":["https://orcid.org/0000-0002-6015-8921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Ishikawa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6015-8921","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101725188","display_name":"Masaaki Yamamoto","orcid":"https://orcid.org/0000-0001-7719-1800","observed_orcids":["https://orcid.org/0000-0001-7719-1800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaaki Yamamoto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7719-1800","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080152839","display_name":"Tsuyoshi Hata","orcid":"https://orcid.org/0000-0001-6616-9069","observed_orcids":["https://orcid.org/0000-0001-6616-9069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsuyoshi Hata","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6616-9069","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032527233","display_name":"Sayuri Akiyoshi","orcid":"https://orcid.org/0000-0002-1237-5366","observed_orcids":["https://orcid.org/0000-0002-1237-5366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sayuri Akiyoshi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1237-5366","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056585446","display_name":"Qiang Hu","orcid":"https://orcid.org/0000-0002-4090-5539","observed_orcids":["https://orcid.org/0000-0002-4090-5539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiang Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4090-5539","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tao Liu","orcid":"https://orcid.org/0000-0002-8818-8313","observed_orcids":["https://orcid.org/0000-0002-8818-8313"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8818-8313","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011722423","display_name":"Henry G. Withers","orcid":"https://orcid.org/0000-0002-9746-9352","observed_orcids":["https://orcid.org/0000-0002-9746-9352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Withers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9746-9352","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100339600","display_name":"Song Liu","orcid":"https://orcid.org/0000-0001-6351-2941","observed_orcids":["https://orcid.org/0000-0001-6351-2941","https://orcid.org/0000-0003-2827-6319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Song Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6351-2941","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045419282","display_name":"Geoffrey Ira Shapiro","orcid":"https://orcid.org/0000-0002-3331-4095","observed_orcids":["https://orcid.org/0000-0002-3331-4095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey I. Shapiro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3331-4095","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037162068","display_name":"Tomoharu Yoshizumi","orcid":"https://orcid.org/0000-0002-4497-1816","observed_orcids":["https://orcid.org/0000-0002-4497-1816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoharu Yoshizumi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4497-1816","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028515700","display_name":"Mark D. Long","orcid":"https://orcid.org/0000-0003-1120-8176","observed_orcids":["https://orcid.org/0000-0003-1120-8176"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark D. Long","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1120-8176","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067054634","display_name":"Donald W. Kufe","orcid":"https://orcid.org/0000-0001-5743-8888","observed_orcids":["https://orcid.org/0000-0001-5743-8888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald Kufe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5743-8888","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.4708999991416931,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.4708999991416931,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.155799999833107,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.048700001090765,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muc1-c","display_name":"MUC1-C","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pbrm1","display_name":"PBRM1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/irf-1","display_name":"IRF1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-damage-resistance","display_name":"DNA damage resistance","score":0.7429999709129333},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.5830000042915344},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6930000185966492},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7039999961853027},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.5149999856948853},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C32300475","wikidata":"https://www.wikidata.org/wiki/Q18027992","display_name":"IRF1","level":4,"score":0.781499981880188},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6302000284194946},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6040999889373779},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.5662000179290771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.438400000333786},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.43790000677108765},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4368000030517578},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4122999906539917},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4032999873161316},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36899998784065247},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35920000076293945},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.3499999940395355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34779998660087585},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.34139999747276306},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3337000012397766},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3321000039577484},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.31869998574256897},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28839999437332153},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2653000056743622},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2549000084400177}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.30733178","doi":"https://doi.org/10.1158/1541-7786.30733178","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.30733178","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.30733178","doi":"https://doi.org/10.1158/1541-7786.30733178","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.30733178","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310360171","https://openalex.org/W4392702670","https://openalex.org/W4416764786","https://openalex.org/W4396588269","https://openalex.org/W4416764850","https://openalex.org/W4416764789","https://openalex.org/W4200198108","https://openalex.org/W4416764885","https://openalex.org/W4220981105","https://openalex.org/W4416764800"],"abstract_inverted_index":{"MUC1":[0,36,56],"and":[1,14,26,38,57,60,69,96,140,150,156,167,178,195,206,223,254],"PBRM1":[2,39,121],"associate":[3,131],"with":[4,44,48,92,103,132,252,259],"decreases":[5],"in":[6,65,84,106,124,135,143,164,174,188,237],"responsiveness":[7],"of":[8,55,72,81,154,172,190,193,202,213],"TNBC":[9,45,74,90,107],"tumors":[10,91],"to":[11,127,160,219,233,240,250],"chemotherapy.":[12],"A":[13,200],"B,":[15],"Kaplan\u2013Meier":[16],"curves":[17],"for":[18],"relapse-free":[19],"survival":[20],"created":[21,258],"by":[22,146],"the":[23,35,114,137,175,211,220],"public":[24],"database":[25],"web":[27],"application":[28],"KM":[29],"plotter":[30],"(http://kmplot.com/":[31],"analysis/)":[32],"based":[33,112],"on":[34,113],"(A)":[37],"(B)":[40],"expression":[41,54,83,100,122,158],"levels.":[42],"Patients":[43],"were":[46,101],"stratified":[47,102],"high":[49],"(red)":[50],"or":[51],"low":[52],"(black)":[53],"PBRM1.":[58,128],"C":[59],"D,":[61],"Representative":[62],"MUC1-C":[63,82,99,119,186,204],"staining":[64],"cell":[66,93],"membrane":[67,94],"(C)":[68],"cytosol/nuclear":[70,97],"(D)":[71],"primary":[73],"samples":[75],"(magnifications,":[76,87],"\u00d720).":[77],"Insets":[78],"highlight":[79],"localization":[80],"cancer":[85],"cells":[86],"\u00d7100).":[88],"E,":[89],"(left)":[95],"(right)":[98],"sTIL":[104],"levels":[105],"samples.":[108],"F,":[109],"Proposed":[110],"model":[111],"present":[115],"data":[116],"demonstrating":[117],"that":[118,217,245],"induces":[120],"and,":[123],"turn,":[125],"binds":[126],"MUC1-C/PBRM1":[129],"complexes":[130,169],"(i)":[133],"STAT1":[134,145,155],"activating":[136,144],"IRF1":[138,142,157],"gene":[139,215],"(ii)":[141],"increasing":[147],"chromatin":[148,208],"accessibility":[149],"their":[151],"transcription.":[152],"Induction":[153],"contributes":[159,239],"a":[161,241,247],"feed-forward":[162],"circuit":[163,244],"which":[165,236],"MUC1-C/PBRM1/STAT1":[166],"MUC1-C/PBRM1/IRF1":[168],"drive":[170],"activation":[171,187,205],"genes":[173],"type":[176],"I":[177],"II":[179],"IFN":[180,214],"pathways.":[181],"In":[182],"this":[183],"way,":[184],"prolonged":[185],"settings":[189],"repetitive":[191],"cycles":[192],"damage":[194,225],"repair":[196],"promote":[197],"chronic":[198],"inflammation.":[199],"consequence":[201],"persistent":[203],"PBRM1-mediated":[207],"remodeling":[209],"is":[210,231],"establishment":[212],"signatures":[216],"contribute":[218],"CSC":[221],"state":[222,249],"DNA":[224,227],"resistance.":[226],"damage-induced":[228],"inflammatory":[229],"signaling":[230],"coupled":[232],"immune":[234],"evasion,":[235],"turn":[238],"MUC1-C/PBRM1-driven":[242],"auto-inductive":[243],"integrates":[246],"refractory":[248],"treatment":[251],"genotoxic":[253],"immunotherapeutic":[255],"agents.":[256],"Figure":[257],"BioRender.com.":[260],"*,":[261],"P":[262],"\u2264":[263],"0.05.":[264]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-28T00:00:00"}
