{"id":"https://openalex.org/W4416764786","doi":"https://doi.org/10.1158/1541-7786.30733193","title":"Figure 2 from MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer","display_name":"Figure 2 from MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer","publication_year":2025,"publication_date":"2025-11-27","ids":{"openalex":"https://openalex.org/W4416764786","doi":"https://doi.org/10.1158/1541-7786.30733193"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.30733193","doi":"https://doi.org/10.1158/1541-7786.30733193","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.30733193","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.30733193","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075105508","display_name":"Nami Yamashita","orcid":"https://orcid.org/0000-0001-7182-1090","observed_orcids":["https://orcid.org/0000-0001-7182-1090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nami Yamashita","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7182-1090","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090815270","display_name":"Yoshihiro Morimoto","orcid":"https://orcid.org/0000-0003-2687-9933","observed_orcids":["https://orcid.org/0000-0003-2687-9933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiro Morimoto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2687-9933","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037062908","display_name":"Atsushi Fushimi","orcid":"https://orcid.org/0000-0003-1328-8835","observed_orcids":["https://orcid.org/0000-0003-1328-8835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsushi Fushimi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1328-8835","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013660351","display_name":"Rehan Ahmad","orcid":"https://orcid.org/0000-0003-2612-2818","observed_orcids":["https://orcid.org/0000-0003-2612-2818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rehan Ahmad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2612-2818","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036087604","display_name":"Atrayee Bhattacharya","orcid":"https://orcid.org/0000-0002-3322-6175","observed_orcids":["https://orcid.org/0000-0002-3322-6175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atrayee Bhattacharya","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3322-6175","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078157913","display_name":"Tatsuaki Daimon","orcid":"https://orcid.org/0000-0003-4997-452X","observed_orcids":["https://orcid.org/0000-0003-4997-452X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuaki Daimon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4997-452X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086171353","display_name":"Naoki Haratake","orcid":"https://orcid.org/0000-0002-3098-4798","observed_orcids":["https://orcid.org/0000-0002-3098-4798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Haratake","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3098-4798","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067076071","display_name":"Yuka Inoue","orcid":"https://orcid.org/0000-0001-5793-6086","observed_orcids":["https://orcid.org/0000-0001-5793-6086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuka Inoue","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5793-6086","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010644036","display_name":"Satoshi Ishikawa","orcid":"https://orcid.org/0000-0002-6015-8921","observed_orcids":["https://orcid.org/0000-0002-6015-8921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Ishikawa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6015-8921","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101725188","display_name":"Masaaki Yamamoto","orcid":"https://orcid.org/0000-0001-7719-1800","observed_orcids":["https://orcid.org/0000-0001-7719-1800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaaki Yamamoto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7719-1800","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080152839","display_name":"Tsuyoshi Hata","orcid":"https://orcid.org/0000-0001-6616-9069","observed_orcids":["https://orcid.org/0000-0001-6616-9069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsuyoshi Hata","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6616-9069","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032527233","display_name":"Sayuri Akiyoshi","orcid":"https://orcid.org/0000-0002-1237-5366","observed_orcids":["https://orcid.org/0000-0002-1237-5366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sayuri Akiyoshi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1237-5366","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056585446","display_name":"Qiang Hu","orcid":"https://orcid.org/0000-0002-4090-5539","observed_orcids":["https://orcid.org/0000-0002-4090-5539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiang Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4090-5539","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tao Liu","orcid":"https://orcid.org/0000-0002-8818-8313","observed_orcids":["https://orcid.org/0000-0002-8818-8313"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8818-8313","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011722423","display_name":"Henry G. Withers","orcid":"https://orcid.org/0000-0002-9746-9352","observed_orcids":["https://orcid.org/0000-0002-9746-9352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Withers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9746-9352","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100339600","display_name":"Song Liu","orcid":"https://orcid.org/0000-0001-6351-2941","observed_orcids":["https://orcid.org/0000-0001-6351-2941","https://orcid.org/0000-0003-2827-6319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Song Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6351-2941","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045419282","display_name":"Geoffrey Ira Shapiro","orcid":"https://orcid.org/0000-0002-3331-4095","observed_orcids":["https://orcid.org/0000-0002-3331-4095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey I. Shapiro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3331-4095","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037162068","display_name":"Tomoharu Yoshizumi","orcid":"https://orcid.org/0000-0002-4497-1816","observed_orcids":["https://orcid.org/0000-0002-4497-1816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoharu Yoshizumi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4497-1816","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028515700","display_name":"Mark D. Long","orcid":"https://orcid.org/0000-0003-1120-8176","observed_orcids":["https://orcid.org/0000-0003-1120-8176"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark D. Long","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1120-8176","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067054634","display_name":"Donald W. Kufe","orcid":"https://orcid.org/0000-0001-5743-8888","observed_orcids":["https://orcid.org/0000-0001-5743-8888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald Kufe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5743-8888","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6338000297546387,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6338000297546387,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muc1-c","display_name":"MUC1-C","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pbrm1","display_name":"PBRM1","score":0.996999979019165},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/irf-1","display_name":"IRF1","score":1.0},{"id":"https://openalex.org/keywords/dna-damage-resistance","display_name":"DNA damage resistance","score":0.7419999837875366},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.953000009059906},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7260000109672546},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.46299999952316284},{"id":"https://openalex.org/keywords/bt-549-cells","display_name":"BT-549 cells","score":0.7519999742507935},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7746000289916992},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6685000061988831},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6330000162124634},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.536300003528595},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5227000117301941},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5058000087738037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.476500004529953},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.4726000130176544},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4636000096797943},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42820000648498535},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.364300012588501},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.3497999906539917},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3458999991416931},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.34279999136924744},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.33709999918937683},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.32170000672340393},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.30730000138282776},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2897000014781952},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26919999718666077},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.2513999938964844},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.30733193","doi":"https://doi.org/10.1158/1541-7786.30733193","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.30733193","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.30733193","doi":"https://doi.org/10.1158/1541-7786.30733193","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.30733193","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416764852","https://openalex.org/W4416764885","https://openalex.org/W4416764789","https://openalex.org/W4416764899","https://openalex.org/W4416764850","https://openalex.org/W4392702670","https://openalex.org/W4310360171","https://openalex.org/W4416764800","https://openalex.org/W4396588269","https://openalex.org/W4220981105"],"abstract_inverted_index":{"MUC1-C":[0],"regulates":[1],"PBRM1":[2,22,76,124,168,206],"expression":[3],"and":[4,10,58,87,155,176,200,217,262,266,296,311,319,354,383,399,423],"function":[5],"in":[6,24,101,231,352,397],"activating":[7],"the":[8,21,50,70,116,123,133,167,246,273,308,348,359,375,394,415],"STAT1":[9,312,395],"IRF1":[11,310,350,361],"genes.":[12],"A,":[13],"Genome":[14,341,387],"browser":[15,342,388],"snapshots":[16,343,389],"of":[17,52,108,122,128,195,238,338,344,377,390,417],"ATAC-seq":[18,345,391],"data":[19,346,392],"from":[20,137,253,279,331,347,358,393],"gene":[23,125],"BT-549/tet-MUC1shRNA":[25,62,138,280],"cells":[26,63,104,139,202,234,255,281],"treated":[27,64,140,282],"with":[28,65,98,113,126,141,150,164,187,190,228,243,258,270,283,292,305,328],"vehicle":[29,66,142,284],"or":[30,67,143,285],"DOX":[31,68,144,286],"for":[32,39,69,75,145,166,205,287,307,365,405],"7":[33,146,288],"days":[34,72,147,289],"(left).":[35,81,211],"Chromatin":[36,357,402],"was":[37,148,290,363,403],"analyzed":[38,74,204,364,404],"accessibility":[40,366,406],"by":[41,79,162,209,303,367,407],"nuclease":[42,368,408],"digestion":[43],"(right).":[44,119,249],"The":[45,82,157,171,212,298,314,370,410],"results":[46,83,172,213,315,371,411],"are":[47,90,179,220,322,372,412],"expressed":[48,91,180,221,323,373,413],"as":[49,92,96,181,185,222,226,324,326,374,414],"percentage":[51,376,416],"undigested":[53,378,418],"chromatin":[54,136,278,334,379,419],"(mean":[55,84,173,214,316,380,420],"\u00b1":[56,85,174,215,317,381,421],"SD":[57,86,175,216,318,382,422],"individual":[59,88,177,218,320,384,424],"values).":[60,385,425],"B,":[61],"indicated":[71,117,247,274,309,349,360],"were":[73,111,160,203,241,256,268,301],"mRNA":[77,94,207,224],"levels":[78,95,208,225],"qRT-PCR":[80,210],"values)":[89,178,219,321],"relative":[93,182,223],"compared":[97,186,227,327],"that":[99,188,229,329],"obtained":[100,189,230,330],"control":[102,152,232,260,294,332],"vehicle-treated":[103,233],"(assigned":[105,192,235,335],"a":[106,129,151,193,236,259,293,336],"value":[107,194,237,337],"1).":[109,196,239,339],"Lysates":[110,240],"immunoblotted":[112,242,269],"antibodies":[114,244,271],"against":[115,245,272],"proteins":[118,248,265],"C,":[120],"Schema":[121],"localization":[127],"PLS":[130,169,396],"downstream":[131],"to":[132],"TSS.":[134],"Soluble":[135,277],"precipitated":[149,257,291],"IgG,":[153],"anti\u2013MUC1-C":[154],"anti-IRF1.":[156],"DNA":[158,299],"samples":[159,300],"amplified":[161,302],"qPCR":[163,304],"primers":[165,306],"region.":[170],"fold":[183],"enrichment":[184],"IgG":[191,261,295],"D,":[197],"BT-549/CshRNA,":[198],"BT-549/IRF1shRNA":[199],"BT-549/IRF1shRNA#2":[201],"E,":[250],"Nuclear":[251],"lysates":[252],"BT-549":[254],"anti\u2013MUC1-C.":[263],"Input":[264],"precipitates":[267],"proteins.":[275],"F,":[276],"anti-PBRM1.":[297],"regions.":[313],"fold-enrichment":[325],"IgG-precipitated":[333],"G,":[340],"regions":[351,362],"BT-549/CshRNA":[353,398],"BT-549/PBRM1shRNA":[355,400],"cells.":[356,401],"digestion.":[369,409],"H,":[386],"*,":[426],"P":[427,431,435,439],"\u2264":[428,432,436,440],"0.05;":[429],"**,":[430],"0.01;":[433],"***,":[434],"0.001;":[437],"****,":[438],"0.0001.":[441]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-28T00:00:00"}