{"id":"https://openalex.org/W4416764577","doi":"https://doi.org/10.1111/imr.70081","title":"The Making of a cDC1 : Precision Programming of Progenitor Potential","display_name":"The Making of a cDC1 : Precision Programming of Progenitor Potential","publication_year":2025,"publication_date":"2025-11-27","ids":{"openalex":"https://openalex.org/W4416764577","doi":"https://doi.org/10.1111/imr.70081","pmid":"https://pubmed.ncbi.nlm.nih.gov/41307331"},"language":"en","primary_location":{"id":"doi:10.1111/imr.70081","doi":"https://doi.org/10.1111/imr.70081","is_oa":true,"landing_page_url":"https://doi.org/10.1111/imr.70081","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imr.70081","source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imr.70081","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109258193","display_name":"Theresa L. Murphy","orcid":"https://orcid.org/0000-0001-6539-8142","observed_orcids":["https://orcid.org/0000-0001-6539-8142"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa L. Murphy","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040420168","display_name":"KENNETH M. M. MURPHY","orcid":"https://orcid.org/0000-0002-3505-9630","observed_orcids":["https://orcid.org/0000-0002-3505-9630"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth M. Murphy","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":"https://orcid.org/0000-0002-3505-9630","affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040420168"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.5533,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.52821159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"337","issue":"1","first_page":"e70081","last_page":"e70081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5077999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5077999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.31839999556541443,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-dendritic-cells","display_name":"myeloid dendritic cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/dendritic-cell-development","display_name":"dendritic cell development","score":0.7289999723434448},{"id":"https://openalex.org/keywords/irf8","display_name":"IRF8","score":0.9409999847412109},{"id":"https://openalex.org/keywords/c-ebpalpha","display_name":"C/EBP\u03b1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/nfil3","display_name":"NFIL3","score":0.8169999718666077},{"id":"https://openalex.org/keywords/zeb2","display_name":"ZEB2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/batf3","display_name":"Batf3","score":0.921999990940094},{"id":"https://openalex.org/keywords/id2","display_name":"Id2","score":0.8790000081062317},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.890999972820282},{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9210000038146973},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cis-regulation","display_name":"cis-regulation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/lineage-commitment","display_name":"lineage commitment","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8431000113487244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7192999720573425},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7010999917984009},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.5562000274658203},{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.531499981880188},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.450300008058548},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.41830000281333923},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4047999978065491},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33880001306533813},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3206999897956848},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.30570000410079956},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.29319998621940613},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.29120001196861267},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.2745000123977661},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2745000123977661},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2648000121116638},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.26260000467300415},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25850000977516174},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.25029999017715454}],"mesh":[{"descriptor_ui":"D000099185","descriptor_name":"Interferon Regulatory Factor-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/imr.70081","doi":"https://doi.org/10.1111/imr.70081","is_oa":true,"landing_page_url":"https://doi.org/10.1111/imr.70081","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imr.70081","source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:41307331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41307331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/imr.70081","doi":"https://doi.org/10.1111/imr.70081","is_oa":true,"landing_page_url":"https://doi.org/10.1111/imr.70081","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imr.70081","source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1133205708","display_name":null,"funder_award_id":"CRI5306","funder_id":"https://openalex.org/F4320306155","funder_display_name":"Cancer Research Institute"},{"id":"https://openalex.org/G6922260792","display_name":"Function of Wdfy4 in cross-presentation and immunity","funder_award_id":"R01AI150297","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7699451604","display_name":"Transcriptional basis of embryonic macrophage development","funder_award_id":"R21AI163421","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000862414","display_name":"Understanding the Mechanisms of DC Licensing in CD8 T Cell Priming","funder_award_id":"R01CA248919","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000907068","display_name":"Molecular Basis of cDC1 Development","funder_award_id":"R01AI162643","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332884","display_name":"McDonnell Center for Systems Neuroscience","ror":"https://ror.org/01yc7t268"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416764577.pdf","grobid_xml":"https://content.openalex.org/works/W4416764577.grobid-xml"},"referenced_works_count":140,"referenced_works":["https://openalex.org/W179818011","https://openalex.org/W1504628996","https://openalex.org/W1511974199","https://openalex.org/W1528284784","https://openalex.org/W1534412053","https://openalex.org/W1545447189","https://openalex.org/W1579102917","https://openalex.org/W1585007907","https://openalex.org/W1592326302","https://openalex.org/W1655527987","https://openalex.org/W1742769645","https://openalex.org/W1752957211","https://openalex.org/W1847275787","https://openalex.org/W1965218665","https://openalex.org/W1968458512","https://openalex.org/W1974426489","https://openalex.org/W1976209715","https://openalex.org/W1977795184","https://openalex.org/W1979514172","https://openalex.org/W1981004209","https://openalex.org/W1981743414","https://openalex.org/W1986683530","https://openalex.org/W1997512963","https://openalex.org/W1999656485","https://openalex.org/W2001042507","https://openalex.org/W2002964220","https://openalex.org/W2005606581","https://openalex.org/W2006786538","https://openalex.org/W2008228521","https://openalex.org/W2009761514","https://openalex.org/W2010562798","https://openalex.org/W2012574191","https://openalex.org/W2014366092","https://openalex.org/W2018718597","https://openalex.org/W2021340905","https://openalex.org/W2024310422","https://openalex.org/W2028850807","https://openalex.org/W2029995552","https://openalex.org/W2031482377","https://openalex.org/W2032197035","https://openalex.org/W2033810895","https://openalex.org/W2036012609","https://openalex.org/W2036564362","https://openalex.org/W2038271225","https://openalex.org/W2040805319","https://openalex.org/W2043663222","https://openalex.org/W2044726214","https://openalex.org/W2045067923","https://openalex.org/W2045901162","https://openalex.org/W2046205086","https://openalex.org/W2046505430","https://openalex.org/W2047604395","https://openalex.org/W2048793063","https://openalex.org/W2049909747","https://openalex.org/W2055192078","https://openalex.org/W2055257235","https://openalex.org/W2065085347","https://openalex.org/W2065391646","https://openalex.org/W2065593489","https://openalex.org/W2067389920","https://openalex.org/W2070417053","https://openalex.org/W2074079796","https://openalex.org/W2076236096","https://openalex.org/W2076477779","https://openalex.org/W2076497575","https://openalex.org/W2080177623","https://openalex.org/W2081135713","https://openalex.org/W2094504570","https://openalex.org/W2097598963","https://openalex.org/W2097807376","https://openalex.org/W2100244924","https://openalex.org/W2106837952","https://openalex.org/W2107746036","https://openalex.org/W2108399976","https://openalex.org/W2111435630","https://openalex.org/W2113104975","https://openalex.org/W2113594480","https://openalex.org/W2114675972","https://openalex.org/W2120419169","https://openalex.org/W2121496836","https://openalex.org/W2123602250","https://openalex.org/W2126093778","https://openalex.org/W2127944870","https://openalex.org/W2128701949","https://openalex.org/W2132456274","https://openalex.org/W2133019048","https://openalex.org/W2136442347","https://openalex.org/W2138200311","https://openalex.org/W2141925741","https://openalex.org/W2144206734","https://openalex.org/W2145034432","https://openalex.org/W2151369808","https://openalex.org/W2157293007","https://openalex.org/W2159864583","https://openalex.org/W2161702641","https://openalex.org/W2171657550","https://openalex.org/W2234409764","https://openalex.org/W2308616703","https://openalex.org/W2333469654","https://openalex.org/W2334209689","https://openalex.org/W2345943684","https://openalex.org/W2411956266","https://openalex.org/W2464000940","https://openalex.org/W2469912802","https://openalex.org/W2519385241","https://openalex.org/W2597588685","https://openalex.org/W2755564243","https://openalex.org/W2781617771","https://openalex.org/W2782181940","https://openalex.org/W2794862639","https://openalex.org/W2800548555","https://openalex.org/W2804487653","https://openalex.org/W2891879783","https://openalex.org/W2961406494","https://openalex.org/W2967647113","https://openalex.org/W2968141004","https://openalex.org/W2999776248","https://openalex.org/W3011819195","https://openalex.org/W3032104981","https://openalex.org/W3048756957","https://openalex.org/W3129349478","https://openalex.org/W3133716533","https://openalex.org/W3136167697","https://openalex.org/W3163255344","https://openalex.org/W3196583938","https://openalex.org/W3197597917","https://openalex.org/W4210623056","https://openalex.org/W4283275063","https://openalex.org/W4313331188","https://openalex.org/W4313347785","https://openalex.org/W4321766771","https://openalex.org/W4361292770","https://openalex.org/W4383872307","https://openalex.org/W4387675471","https://openalex.org/W4390672896","https://openalex.org/W4390940878","https://openalex.org/W4393406332","https://openalex.org/W4403195453","https://openalex.org/W4410427157","https://openalex.org/W7095603623"],"related_works":["https://openalex.org/W2967647113","https://openalex.org/W4402088742","https://openalex.org/W4410427157","https://openalex.org/W4313383032","https://openalex.org/W2988700259","https://openalex.org/W4403432876","https://openalex.org/W4412521480","https://openalex.org/W4403195453","https://openalex.org/W2968593126","https://openalex.org/W4361292770"],"abstract_inverted_index":{"The":[0,181],"development":[1,182],"of":[2,84,108,150,175,183,197,228,245,256],"type":[3],"1":[4],"classical":[5],"dendritic":[6,67],"cells":[7],"(cDC1s)":[8],"from":[9],"bone":[10],"marrow":[11],"progenitors":[12,51,62],"is":[13,26,38,47,89,156,170,236,249,287],"a":[14,19,92,133,167,217,239,292],"multistage":[15],"process":[16],"directed":[17],"by":[18,52,91,200,204,238],"complex":[20],"transcriptional":[21],"network.":[22],"At":[23],"its":[24,157,284],"center":[25],"interferon":[27],"regulatory":[28],"factor-8":[29],"(IRF8),":[30],"the":[31,41,56,65,71,75,82,102,116,124,144,151,173,176,184,194,243,252,257,261,271],"lineage-determining":[32],"factor":[33,163],"whose":[34],"precise,":[35],"stage-specific":[36],"expression":[37],"integrated":[39],"at":[40,55,74],"Irf8":[42,59,78,154],"super-enhancer.":[43],"This":[44,87,113,264],"developmental":[45],"sequence":[46],"initiated":[48],"in":[49,97,101,143,190,214,299],"early":[50],"C/EBP\u03b1":[53],"acting":[54],"+56":[57],"kb":[58,77,118,126,153],"enhancer.":[60],"As":[61],"transition":[63],"to":[64,141,216,222,269],"common":[66],"cell":[68],"progenitor":[69],"(CDP),":[70],"E-protein":[72],"activity":[73,120],"+41":[76,117],"enhancer":[79,155,230,248,259],"further":[80],"augments":[81],"level":[83],"IRF8":[85,138],"expression.":[86],"progression":[88],"followed":[90],"critical":[93,171],"\"enhancer":[94],"switch\"":[95],"network,":[96],"which":[98],"NFIL3":[99,201,220],"induced":[100,130],"CDP":[103],"suppresses":[104],"ZEB2,":[105],"causing":[106],"de-repression":[107],"both":[109],"ID2":[110],"and":[111,139,178,202],"BATF3.":[112],"step":[114],"terminates":[115],"enhancer's":[119],"while":[121],"simultaneously":[122],"engaging":[123],"+32":[125,152],"enhancer,":[127],"where":[128,219],"newly":[129],"BATF3":[131],"forms":[132],"stable":[134],"auto-regulatory":[135],"loop":[136],"with":[137],"JUN":[140],"lock":[142],"cDC1":[145,177,185,224],"fate.":[146],"A":[147],"notable":[148],"feature":[149],"low-affinity":[158],"elements":[159],"that":[160,169,192,233],"purposely":[161],"detune":[162],"binding,":[164],"called":[165],"suboptimization,":[166],"property":[168],"for":[172,274,295],"divergence":[174],"cDC2":[179],"progenitors.":[180],"can":[186,211],"also":[187],"be":[188,270],"abrogated":[189],"settings":[191],"disturb":[193],"normal":[195],"balance":[196],"Zeb2":[198],"repression":[199],"activation":[203,255,267],"C/EBP":[205],"factors.":[206],"Tumors":[207],"producing":[208],"IL-6":[209],"systemically":[210],"elevate":[212],"C/EBP\u03b2":[213],"CDPs":[215],"point":[218],"fails":[221],"induce":[223],"specification.":[225],"Finally,":[226],"studies":[227],"compound":[229],"deletions":[231],"reveal":[232],"this":[234,289],"cascade":[235],"governed":[237],"strictly":[240],"cis-dependent":[241],"mechanism:":[242],"function":[244],"each":[246],"subsequent":[247],"contingent":[250],"on":[251,260],"successful":[253],"prior":[254],"preceding":[258],"same":[262],"chromosome.":[263],"sequential,":[265],"cis-regulated":[266],"appears":[268],"core":[272],"mechanism":[273],"progressively":[275],"tuning":[276],"chromatin":[277],"accessibility,":[278],"ensuring":[279],"robust":[280],"lineage":[281],"commitment.":[282],"While":[283],"molecular":[285],"basis":[286],"obscure,":[288],"dependency":[290],"offers":[291],"new":[293],"model":[294],"understanding":[296],"genomic":[297],"regulation":[298],"development.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-28T00:00:00"}