{"id":"https://openalex.org/W4416745915","doi":"https://doi.org/10.1007/s11060-025-05352-y","title":"Short-course radiotherapy with or without temozolomide in elderly patients with newly diagnosed glioblastoma: a time-to-event meta-analysis of overall and progression-free survival","display_name":"Short-course radiotherapy with or without temozolomide in elderly patients with newly diagnosed glioblastoma: a time-to-event meta-analysis of overall and progression-free survival","publication_year":2025,"publication_date":"2025-11-27","ids":{"openalex":"https://openalex.org/W4416745915","doi":"https://doi.org/10.1007/s11060-025-05352-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/41307742"},"language":"en","primary_location":{"id":"doi:10.1007/s11060-025-05352-y","doi":"https://doi.org/10.1007/s11060-025-05352-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11060-025-05352-y","pdf_url":null,"source":{"id":"https://openalex.org/S175922936","display_name":"Journal of Neuro-Oncology","issn_l":"0167-594X","issn":["0167-594X","1573-7373"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006851035","display_name":"Kwadwo Darko","orcid":"https://orcid.org/0000-0002-7734-195X","observed_orcids":["https://orcid.org/0000-0002-7734-195X"]},"institutions":[{"id":"https://openalex.org/I2803053305","display_name":"Korle Bu Teaching Hospital","ror":"https://ror.org/01vzp6a32","country_code":"GH","type":"healthcare","lineage":["https://openalex.org/I2803053305"]}],"countries":["GH"],"is_corresponding":true,"raw_author_name":"Kwadwo Darko","raw_affiliation_strings":["Department of Neurosurgery, Korle Bu Teaching Hospital, 25 Harley Street, Accra, Ghana. darkobhp@gmail.com","Department of Neurosurgery, Korle Bu Teaching Hospital, 25 Harley Street, Accra, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Korle Bu Teaching Hospital, 25 Harley Street, Accra, Ghana. darkobhp@gmail.com","institution_ids":["https://openalex.org/I2803053305"]},{"raw_affiliation_string":"Department of Neurosurgery, Korle Bu Teaching Hospital, 25 Harley Street, Accra, Ghana","institution_ids":["https://openalex.org/I2803053305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100701920","display_name":"Jianan Chen","orcid":"https://orcid.org/0000-0002-6673-6884","observed_orcids":["https://orcid.org/0000-0002-6673-6884"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianan Chen","raw_affiliation_strings":["Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040994175","display_name":"Jeanette E. Eckel\u2010Passow","orcid":"https://orcid.org/0000-0002-6113-1114","observed_orcids":["https://orcid.org/0000-0002-6113-1114"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanette E. Eckel-Passow","raw_affiliation_strings":["Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045792465","display_name":"Ekokobe Fonkem","orcid":"https://orcid.org/0000-0001-6382-8866","observed_orcids":["https://orcid.org/0000-0001-6382-8866","https://orcid.org/0000-0002-0304-5912"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekokobe Fonkem","raw_affiliation_strings":["Banner MD Anderson Cancer Hospital, University of Arizona, Houston, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner MD Anderson Cancer Hospital, University of Arizona, Houston, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109345278","display_name":"Susan Michelle Geyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Geyer","raw_affiliation_strings":["Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072969261","display_name":"Arnold B. Etame","orcid":"https://orcid.org/0000-0002-9656-4702","observed_orcids":["https://orcid.org/0000-0002-9656-4702"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold B. Etame","raw_affiliation_strings":["Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006851035"],"corresponding_institution_ids":["https://openalex.org/I2803053305"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10444328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"176","issue":"1","first_page":"98","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/short-course-radiotherapy","display_name":"short-course radiotherapy","score":0.7509999871253967},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.996999979019165},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.996999979019165},{"id":"https://openalex.org/keywords/newly-diagnosed-glioblastoma","display_name":"newly diagnosed glioblastoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9739999771118164},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.46000000834465027},{"id":"https://openalex.org/keywords/restricted-mean-survival-time","display_name":"restricted mean survival time","score":0.7440000176429749},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.652999997138977},{"id":"https://openalex.org/keywords/karnofsky-performance-status","display_name":"Karnofsky performance status","score":0.8790000081062317},{"id":"https://openalex.org/keywords/treatment-intolerance","display_name":"treatment intolerance","score":0.5009999871253967},{"id":"https://openalex.org/keywords/hazard-ratio","display_name":"hazard ratio","score":0.4970000088214874},{"id":"https://openalex.org/keywords/time-to-event","display_name":"time to event","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.8805000185966492},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.816100001335144},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.671500027179718},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6290000081062317},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5703999996185303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5562999844551086},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5060999989509583},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.49410000443458557},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4869000017642975},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39010000228881836},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.3709000051021576},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3474000096321106},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3319999873638153},{"id":"https://openalex.org/C2910123053","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Karnofsky Performance Status","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2572000026702881}],"mesh":[{"descriptor_ui":"D000077204","descriptor_name":"Temozolomide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D059248","descriptor_name":"Chemoradiotherapy","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11060-025-05352-y","doi":"https://doi.org/10.1007/s11060-025-05352-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11060-025-05352-y","pdf_url":null,"source":{"id":"https://openalex.org/S175922936","display_name":"Journal of Neuro-Oncology","issn_l":"0167-594X","issn":["0167-594X","1573-7373"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuro-Oncology","raw_type":"journal-article"},{"id":"pmid:41307742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41307742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuro-oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1982967337","https://openalex.org/W1988029997","https://openalex.org/W2096287682","https://openalex.org/W2099703779","https://openalex.org/W2105100844","https://openalex.org/W2107731988","https://openalex.org/W2131499647","https://openalex.org/W2133611748","https://openalex.org/W2154526619","https://openalex.org/W2162605078","https://openalex.org/W2531269403","https://openalex.org/W2538994991","https://openalex.org/W2599173434","https://openalex.org/W2599750069","https://openalex.org/W2607898650","https://openalex.org/W2918212993","https://openalex.org/W2970684805","https://openalex.org/W3012937109","https://openalex.org/W3022749088","https://openalex.org/W3177129926","https://openalex.org/W4288388806","https://openalex.org/W4400543475","https://openalex.org/W4404286612"],"related_works":["https://openalex.org/W1917879716","https://openalex.org/W1999790169","https://openalex.org/W2599750069","https://openalex.org/W4252177547","https://openalex.org/W2972196274","https://openalex.org/W2311232889","https://openalex.org/W2928975553","https://openalex.org/W2262593106","https://openalex.org/W2559782817","https://openalex.org/W4288388806"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-28T00:00:00"}