{"id":"https://openalex.org/W4416738228","doi":"https://doi.org/10.1002/cam4.71332","title":"Histologic Response to Induction Chemotherapy in High\u2010Risk Neuroblastoma","display_name":"Histologic Response to Induction Chemotherapy in High\u2010Risk Neuroblastoma","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4416738228","doi":"https://doi.org/10.1002/cam4.71332","pmid":"https://pubmed.ncbi.nlm.nih.gov/41294259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12648435"},"language":"en","primary_location":{"id":"doi:10.1002/cam4.71332","doi":"https://doi.org/10.1002/cam4.71332","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.71332","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.71332","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.71332","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055633447","display_name":"Monica M. Pomaville","orcid":"https://orcid.org/0009-0008-0498-5544","observed_orcids":["https://orcid.org/0009-0008-0498-5544"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Pomaville","raw_affiliation_strings":["Department of Pediatric Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"],"raw_orcid":"https://orcid.org/0009-0008-0498-5544","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053168617","display_name":"Pei\u2010Chi Kao","orcid":"https://orcid.org/0000-0003-0702-8324","observed_orcids":["https://orcid.org/0000-0003-0702-8324"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pei\u2010Chi Kao","raw_affiliation_strings":["Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts USA","Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210166317"]},{"raw_affiliation_string":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089782174","display_name":"Antonio R. P\u00e9rez\u2010Atayde","orcid":"https://orcid.org/0000-0001-8036-6288","observed_orcids":["https://orcid.org/0000-0001-8036-6288"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Perez\u2010Atayde","raw_affiliation_strings":["Department of Pathology Boston Children's Hospital  Boston Massachusetts USA","Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"],"raw_orcid":"https://orcid.org/0000-0001-8036-6288","affiliations":[{"raw_affiliation_string":"Department of Pathology Boston Children's Hospital  Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003639088","display_name":"Wendy B. London","orcid":"https://orcid.org/0000-0003-3571-6538","observed_orcids":["https://orcid.org/0000-0003-3571-6538"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wendy B. London","raw_affiliation_strings":["Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts USA","Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210166317"]},{"raw_affiliation_string":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002000126","display_name":"Rani E. George","orcid":"https://orcid.org/0000-0003-4206-1779","observed_orcids":["https://orcid.org/0000-0003-4206-1779"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rani E. George","raw_affiliation_strings":["Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts USA","Department of Pediatric Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA","Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210166317"]},{"raw_affiliation_string":"Department of Pediatric Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5002000126","https://openalex.org/A5003639088"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210166317"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":{"value":4700,"currency":"USD","value_usd":4700},"fwci":0.5492,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70217897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"14","issue":"22","first_page":"e71332","last_page":"e71332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/high-risk-neuroblastoma","display_name":"high-risk neuroblastoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-histology","display_name":"tumor histology","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mitosis-karyorrhexis-index","display_name":"mitosis-karyorrhexis index","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neuropil","display_name":"neuropil","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.703000009059906},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7200000286102295},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.6359999775886536},{"id":"https://openalex.org/keywords/histological-response","display_name":"histological response","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8138999938964844},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.7802000045776367},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7728000283241272},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.769599974155426},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.5830000042915344},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4869999885559082},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4796999990940094},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.4754999876022339},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45879998803138733},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.39489999413490295},{"id":"https://openalex.org/C2991767035","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Induction therapy","level":3,"score":0.32760000228881836},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.2718000113964081},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.25699999928474426},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.25270000100135803}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018305","descriptor_name":"Ganglioneuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018305","descriptor_name":"Ganglioneuroblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018305","descriptor_name":"Ganglioneuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018305","descriptor_name":"Ganglioneuroblastoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060828","descriptor_name":"Induction Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cam4.71332","doi":"https://doi.org/10.1002/cam4.71332","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.71332","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.71332","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},{"id":"pmid:41294259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41294259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f6635835217e4872b88c19c12ed9197e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f6635835217e4872b88c19c12ed9197e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Medicine, Vol 14, Iss 22, Pp n/a-n/a (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/cam4.71332","doi":"https://doi.org/10.1002/cam4.71332","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.71332","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.71332","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3645226278","display_name":null,"funder_award_id":"2T32CA009615","funder_id":"https://openalex.org/F4320317053","funder_display_name":"Abramson Cancer Center"},{"id":"https://openalex.org/G4379540926","display_name":"Children's Oncology Group Statistics and Data Center","funder_award_id":"U10CA180899","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5094520579","display_name":"COG NCTN Network Group Operations Center","funder_award_id":"U10CA180886","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000877712","display_name":"Cancer Center Research Training Program","funder_award_id":"T32CA009615","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320317053","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416738228.pdf","grobid_xml":"https://content.openalex.org/works/W4416738228.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1508921470","https://openalex.org/W1809880856","https://openalex.org/W1855252512","https://openalex.org/W1926885922","https://openalex.org/W1994195812","https://openalex.org/W2008620986","https://openalex.org/W2019137723","https://openalex.org/W2021482723","https://openalex.org/W2063960043","https://openalex.org/W2064013031","https://openalex.org/W2073335655","https://openalex.org/W2074394224","https://openalex.org/W2096398040","https://openalex.org/W2097120541","https://openalex.org/W2103443623","https://openalex.org/W2120781745","https://openalex.org/W2130925781","https://openalex.org/W2147800896","https://openalex.org/W2152420890","https://openalex.org/W2239109793","https://openalex.org/W2523575310","https://openalex.org/W2611071372","https://openalex.org/W2752019124","https://openalex.org/W2758777848","https://openalex.org/W2883859240","https://openalex.org/W2935510920","https://openalex.org/W2994797254","https://openalex.org/W3016358793","https://openalex.org/W3045192899","https://openalex.org/W3184057816","https://openalex.org/W4211147182","https://openalex.org/W4296038583","https://openalex.org/W4319338186","https://openalex.org/W4321509052","https://openalex.org/W4402910917","https://openalex.org/W4404126866"],"related_works":["https://openalex.org/W1994195812","https://openalex.org/W2350852338","https://openalex.org/W4281755725","https://openalex.org/W1968975254","https://openalex.org/W4402910917","https://openalex.org/W3016358793","https://openalex.org/W4283584609","https://openalex.org/W2090742031","https://openalex.org/W2935510920","https://openalex.org/W2021522825"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Tumor":[1,82],"histology":[2,83,133],"at":[3,87,184,205,233,238,300],"diagnosis":[4,69,88,135,154,185,206,222,234,308],"is":[5,32,311],"used":[6],"in":[7,61,64,100,131,159,181],"conjunction":[8],"with":[9,17,26,96,142,188,203],"other":[10,198],"prognostic":[11,76,295],"features":[12,63],"to":[13,20,34,57,108,223,235,283,309],"risk":[14],"stratify":[15],"patients":[16,25,95],"neuroblastoma":[18,98,273],"and":[19,45,70,72,89,123,136,146,155,192,255],"assign":[21],"therapy":[22,31],"regimens.":[23],"In":[24],"high-risk":[27,97],"disease,":[28],"adjustment":[29],"of":[30,47,53,78,111,116,125,178,212,219,246,296],"tailored":[33],"treatment":[35],"response,":[36],"largely":[37],"based":[38],"on":[39],"disease":[40],"imaging":[41],"following":[42,172,280],"induction":[43,173,281],"chemotherapy":[44,282],"resection":[46,90,137,156,224,239,301,310],"the":[48,65,75,291,305],"primary":[49,66,272],"tumor.":[50],"The":[51,209,228],"goals":[52],"this":[54],"study":[55],"were":[56,128,138,157],"(i)":[58],"quantify":[59],"changes":[60,152],"histologic":[62,161,199],"tumor":[67,132,171,182,210],"between":[68,134,153],"resection,":[71],"(ii)":[73],"assess":[74],"capability":[77],"such":[79],"alterations.":[80],"METHODS:":[81],"from":[84,93,106,221,230,307],"paired":[85],"samples":[86],"was":[91,186,201],"evaluated":[92],"94":[94],"enrolled":[99],"Children's":[101],"Oncology":[102],"Group":[103],"(COG)":[104],"trials":[105],"2001":[107],"2013.":[109],"Presence":[110],"Schwannian":[112],"stroma,":[113],"neuropil,":[114],"degree":[115],"differentiation,":[117],"mitosis":[118],"karyorrhexis":[119],"index":[120],"(MKI),":[121],"necrosis,":[122],"percentage":[124,177,211],"neuroblastic":[126],"cells":[127,183],"annotated.":[129],"Changes":[130],"analyzed":[139],"for":[140],"association":[141],"overall":[143],"survival":[144,148,204],"(OS)":[145],"progression-free":[147],"(PFS).":[149],"RESULTS:":[150],"Significant":[151],"observed":[158],"all":[160],"parameters":[162],"(p":[163,194,225],"<":[164,195,226],"0.01),":[165],"suggesting":[166],"a":[167,189,217,241,276,284],"more":[168],"phenotypically":[169],"differentiated":[170],"therapy.":[174],"A":[175],"higher":[176],"intermediate-high":[179,213],"MKI":[180,214,232,237],"associated":[187,202],"lower":[190],"PFS":[191,242],"OS":[193,256],"0.05).":[196],"No":[197],"factor":[200],"or":[207,303],"resection.":[208],"decreased":[215],"by":[216],"mean":[218],"75%":[220],"0.0001).":[227],"shift":[229,279],"intermediate/high":[231],"low":[236],"had":[240],"hazard":[243],"ratio":[244],"(HR)":[245],"2.1":[247],"(95%":[248,260],"CI:":[249,261],"0.9,":[250,262],"4.9;":[251],"p":[252,264],"=":[253,258,265],"0.0908)":[254],"HR":[257],"2.3":[259],"5.9;":[263],"0.0773).":[266],"CONCLUSION:":[267],"Our":[268],"findings":[269],"suggest":[270],"that":[271],"tumors":[274],"undergo":[275],"significant":[277],"morphologic":[278],"differentiated,":[285],"less":[286],"mitotically":[287],"active":[288],"phenotype.":[289],"However,":[290],"alterations":[292],"are":[293],"not":[294],"patient":[297],"outcome":[298],"either":[299],"alone,":[302],"when":[304],"change":[306],"considered.":[312]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-27T00:00:00"}
