{"id":"https://openalex.org/W4416731237","doi":"https://doi.org/10.1186/s12920-025-02279-1","title":"Genetic crossroads of cardiovascular disease and its comorbidities: toward holistic therapeutic strategies","display_name":"Genetic crossroads of cardiovascular disease and its comorbidities: toward holistic therapeutic strategies","publication_year":2025,"publication_date":"2025-11-26","ids":{"openalex":"https://openalex.org/W4416731237","doi":"https://doi.org/10.1186/s12920-025-02279-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/41299637"},"language":"en","primary_location":{"id":"doi:10.1186/s12920-025-02279-1","doi":"https://doi.org/10.1186/s12920-025-02279-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12920-025-02279-1","pdf_url":null,"source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12920-025-02279-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004628893","display_name":"Binisha Hamal Mishra","orcid":"https://orcid.org/0000-0002-5605-5196","observed_orcids":["https://orcid.org/0000-0002-5605-5196"]},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I4210133601","display_name":"Fimlab (Finland)","ror":"https://ror.org/031y6w871","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210133601"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Binisha H. Mishra","raw_affiliation_strings":["Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133601","https://openalex.org/I4387153886"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059968020","display_name":"Pashupati Prasad Mishra","orcid":"https://orcid.org/0000-0001-5177-3431","observed_orcids":["https://orcid.org/0000-0001-5177-3431"]},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I4210133601","display_name":"Fimlab (Finland)","ror":"https://ror.org/031y6w871","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210133601"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Pashupati P. Mishra","raw_affiliation_strings":["Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland. pashupati.mishra@tuni.fi","Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland. pashupati.mishra@tuni.fi","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133601","https://openalex.org/I4387153886"]},{"raw_affiliation_string":"Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133601","https://openalex.org/I4387153886"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059968020"],"corresponding_institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133601","https://openalex.org/I4387153886"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32519104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.8619999885559082},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/shared-genetic-architecture","display_name":"genetic overlap","score":0.8029999732971191},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.7590000033378601},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9520000219345093},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9710000157356262},{"id":"https://openalex.org/keywords/transient-ischemic-attack","display_name":"transient ischemic attack","score":0.9869999885559082},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6119999885559082},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7310000061988831},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8730000257492065},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5950000286102295},{"id":"https://openalex.org/keywords/gingivitis","display_name":"gingivitis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/novel-genetic-loci","display_name":"novel genetic loci","score":0.7860000133514404},{"id":"https://openalex.org/keywords/npc1","display_name":"NPC1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tmem106b","display_name":"TMEM106B","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ptpn22","display_name":"PTPN22","score":0.9919999837875366},{"id":"https://openalex.org/keywords/map2k5","display_name":"MAP2K5","score":0.9750000238418579},{"id":"https://openalex.org/keywords/msra","display_name":"MsrA","score":0.8090000152587891},{"id":"https://openalex.org/keywords/finnish-population","display_name":"Finnish population","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.6956999897956848},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6450999975204468},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6414999961853027},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6366999745368958},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.5899999737739563},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5331000089645386},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.48010000586509705},{"id":"https://openalex.org/C70616004","wikidata":"https://www.wikidata.org/wiki/Q5532885","display_name":"Genetic correlation","level":4,"score":0.4657999873161316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4465999901294708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37439998984336853},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3668000102043152},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.36309999227523804},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.33500000834465027},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3343999981880188},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.295199990272522},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.2856000065803528},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.275299996137619},{"id":"https://openalex.org/C169594400","wikidata":"https://www.wikidata.org/wiki/Q244775","display_name":"Twin study","level":3,"score":0.26420000195503235},{"id":"https://openalex.org/C2910691881","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Multifactorial Inheritance","level":5,"score":0.263700008392334},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.2547000050544739}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12920-025-02279-1","doi":"https://doi.org/10.1186/s12920-025-02279-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12920-025-02279-1","pdf_url":null,"source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},{"id":"pmid:41299637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41299637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical genomics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0605efb21df34dae994ccb0d3ac54450","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0605efb21df34dae994ccb0d3ac54450","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Genomics, Vol 19, Iss 1, Pp 1-9 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12763896","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12763896/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Genomics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12920-025-02279-1","doi":"https://doi.org/10.1186/s12920-025-02279-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12920-025-02279-1","pdf_url":null,"source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2010545640","https://openalex.org/W2011667964","https://openalex.org/W2039829190","https://openalex.org/W2060630008","https://openalex.org/W2078097821","https://openalex.org/W2086096310","https://openalex.org/W2099085143","https://openalex.org/W2132618298","https://openalex.org/W2153860431","https://openalex.org/W2176384544","https://openalex.org/W2195783463","https://openalex.org/W2309952293","https://openalex.org/W2395375311","https://openalex.org/W2520166589","https://openalex.org/W2883649875","https://openalex.org/W2937611850","https://openalex.org/W2943991355","https://openalex.org/W2951007379","https://openalex.org/W3032555314","https://openalex.org/W3158329869","https://openalex.org/W3215313738","https://openalex.org/W4280560143","https://openalex.org/W4303684124","https://openalex.org/W4317390883","https://openalex.org/W4384155212","https://openalex.org/W4386193043","https://openalex.org/W4392195745","https://openalex.org/W4395460569","https://openalex.org/W4407884030","https://openalex.org/W4409423701"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"With":[1],"increasing":[2],"life":[3],"expectancy,":[4],"the":[5,35,66,138,178,206,232,239],"prevalence":[6],"of":[7,37,137,177,209,234,241],"cardiovascular":[8],"disease":[9,84],"(CVD)":[10],"accompanied":[11],"by":[12],"comorbidities":[13,57,155],"is":[14],"rising,":[15],"presenting":[16],"a":[17,126,218],"growing":[18],"challenge":[19],"for":[20,41,117],"healthcare":[21],"systems.":[22],"Understanding":[23],"shared":[24,132,207,219],"genetic":[25,51,97,133,172,220,229],"factors":[26],"underlying":[27],"CVD":[28,54,210,223],"and":[29,43,55,95,107,150,153,167,201,211,224,244],"its":[30,212,225],"comorbid":[31],"conditions":[32],"may":[33],"facilitate":[34],"development":[36],"more":[38],"effective":[39],"strategies":[40],"prevention":[42],"treatment.":[44],"METHODS:":[45],"In":[46],"this":[47],"study,":[48],"we":[49,81],"investigated":[50],"correlations":[52,110],"between":[53,222],"common":[56],"using":[58,86],"genome-wide":[59],"association":[60],"study":[61],"(GWAS)":[62],"summary":[63],"statistics":[64],"from":[65,72],"FinnGen":[67],"R12":[68],"release,":[69],"comprising":[70],"data":[71],"500,000":[73],"Finnish":[74],"individuals.":[75],"Following":[76],"standard":[77],"quality":[78],"control":[79],"procedures,":[80],"examined":[82],"19":[83,139],"endpoints":[85],"linkage":[87],"disequilibrium":[88],"score":[89],"regression":[90],"(LDSC)":[91],"to":[92,124],"estimate":[93],"heritability":[94,103],"pairwise":[96],"correlations.":[98,173],"Disease":[99],"traits":[100],"with":[101,192],"significant":[102,109,171],"(z-score":[104],"\u2265":[105],"4)":[106],"Bonferroni-corrected":[108],"(adjusted":[111],"p":[112],"<":[113],"0.05)":[114],"were":[115],"selected":[116],"genomic":[118,128],"structural":[119],"equation":[120],"modeling":[121],"(Genomic":[122],"SEM)":[123],"construct":[125],"latent":[127],"factor":[129],"(LGF),":[130],"representing":[131],"liability.":[134],"RESULTS:":[135],"Out":[136],"diseases,":[140],"four":[141],"CVDs":[142],"(transient":[143],"ischemic":[144],"attack,":[145],"atrial":[146],"fibrillation,":[147],"myocardial":[148],"infarction":[149],"heart":[151],"failure)":[152],"seven":[154],"(type":[156],"2":[157],"diabetes,":[158],"asthma,":[159],"obesity,":[160],"depression,":[161],"chronic":[162],"obstructive":[163],"pulmonary":[164],"disease,":[165],"gingivitis":[166],"hypertension)":[168],"showed":[169],"statistically":[170],"A":[174],"multivariate":[175],"GWAS":[176],"LGF":[179],"identified":[180],"141":[181],"novel":[182],"associated":[183],"loci":[184,190],"across":[185],"29":[186],"independent":[187],"SNPs.":[188],"These":[189,215],"overlapped":[191],"16":[193],"protein-coding":[194],"genes,":[195],"including":[196],"NPC1,":[197],"TMEM106B,":[198],"PTPN22,":[199],"MAP2K5":[200],"MSRA,":[202],"implicating":[203],"them":[204],"in":[205,238],"pathogenesis":[208],"comorbidities.":[213,226],"CONCLUSIONS:":[214],"findings":[216],"underscore":[217],"architecture":[221],"We":[227],"provide":[228],"evidence":[230],"supporting":[231],"re-evaluation":[233],"these":[235],"gene":[236],"targets":[237],"context":[240],"integrated,":[242],"holistic":[243],"multi-disease":[245],"treatment":[246],"strategies.":[247]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-11-27T00:00:00"}