{"id":"https://openalex.org/W4416731010","doi":"https://doi.org/10.1055/s-0044-1787411","title":"Evaluation von tumorspezifischer ctDNA als objektiver Marker f\u00fcr postoperativen Tumorrest beim high-grade ser\u00f6sen Ovarialkarzinom","display_name":"Evaluation von tumorspezifischer ctDNA als objektiver Marker f\u00fcr postoperativen Tumorrest beim high-grade ser\u00f6sen Ovarialkarzinom","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4416731010","doi":"https://doi.org/10.1055/s-0044-1787411"},"language":"de","primary_location":{"id":"doi:10.1055/s-0044-1787411","doi":"https://doi.org/10.1055/s-0044-1787411","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1787411","pdf_url":null,"source":{"id":"https://openalex.org/S146294059","display_name":"Geburtshilfe und Frauenheilkunde","issn_l":"0016-5751","issn":["0016-5751","1438-8804","2199-6989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geburtshilfe und Frauenheilkunde","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065692126","display_name":"Christina Victoria Isabella Tauber","orcid":"https://orcid.org/0000-0002-2970-877X","observed_orcids":["https://orcid.org/0000-0002-2970-877X"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4387156288","display_name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe","ror":"https://ror.org/02794jc95","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4387156288","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Tauber","raw_affiliation_strings":["LMU Klinikum, Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, M\u00fcnchen, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LMU Klinikum, Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, M\u00fcnchen, Deutschland","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I4387156288","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Gliga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4387156288","display_name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe","ror":"https://ror.org/02794jc95","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4387156288","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Gliga","raw_affiliation_strings":["LMU Klinikum, Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, M\u00fcnchen, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LMU Klinikum, Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, M\u00fcnchen, Deutschland","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I4387156288","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014807097","display_name":"Valentina Paspalj","orcid":"https://orcid.org/0000-0003-4743-5805","observed_orcids":["https://orcid.org/0000-0003-4743-5805"]},"institutions":[{"id":"https://openalex.org/I4210101060","display_name":"Starnberg Hospital","ror":"https://ror.org/019ca7044","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210101060"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"V. Paspalj","raw_affiliation_strings":["Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Klinikum Starnberg, Starnberg, Deutschland","Medizinische Universit\u00e4t Wien, Klinische Abteilung f\u00fcr Allgemeine Gyn\u00e4kologie und gyn\u00e4kologische Onkologie, Wien, \u00d6sterreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Klinikum Starnberg, Starnberg, Deutschland","institution_ids":["https://openalex.org/I4210101060"]},{"raw_affiliation_string":"Medizinische Universit\u00e4t Wien, Klinische Abteilung f\u00fcr Allgemeine Gyn\u00e4kologie und gyn\u00e4kologische Onkologie, Wien, \u00d6sterreich","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052492893","display_name":"Magdalena Postl","orcid":"https://orcid.org/0000-0001-7570-0907","observed_orcids":["https://orcid.org/0000-0001-7570-0907"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Postl","raw_affiliation_strings":["Medizinische Universit\u00e4t Wien, Klinische Abteilung f\u00fcr Allgemeine Gyn\u00e4kologie und gyn\u00e4kologische Onkologie, Wien, \u00d6sterreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4t Wien, Klinische Abteilung f\u00fcr Allgemeine Gyn\u00e4kologie und gyn\u00e4kologische Onkologie, Wien, \u00d6sterreich","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012114222","display_name":"N\u00faria Segu\u00ed","orcid":"https://orcid.org/0009-0006-7922-2272","observed_orcids":["https://orcid.org/0009-0006-7922-2272"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Segui","raw_affiliation_strings":["SAGA Diagnostics AB, Lund, Schweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAGA Diagnostics AB, Lund, Schweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060662654","display_name":"Christian Brueffer","orcid":"https://orcid.org/0000-0002-3826-0989","observed_orcids":["https://orcid.org/0000-0002-3826-0989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Brueffer","raw_affiliation_strings":["SAGA Diagnostics AB, Lund, Schweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAGA Diagnostics AB, Lund, Schweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051247957","display_name":"Miguel Alcaide","orcid":"https://orcid.org/0009-0002-9439-3388","observed_orcids":["https://orcid.org/0009-0002-9439-3388","https://orcid.org/0000-0001-6945-0972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Alcaide","raw_affiliation_strings":["SAGA Diagnostics AB, Lund, Schweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAGA Diagnostics AB, Lund, Schweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011049342","display_name":"Lucia Oton","orcid":"https://orcid.org/0000-0002-8515-6754","observed_orcids":["https://orcid.org/0000-0002-8515-6754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Oton","raw_affiliation_strings":["SAGA Diagnostics AB, Lund, Schweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAGA Diagnostics AB, Lund, Schweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109044826","display_name":"Y. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Chen","raw_affiliation_strings":["SAGA Diagnostics AB, Lund, Schweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAGA Diagnostics AB, Lund, Schweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016805282","display_name":"Lao H. Saal","orcid":"https://orcid.org/0000-0002-0815-1896","observed_orcids":["https://orcid.org/0000-0002-0815-1896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. H. Saal","raw_affiliation_strings":["SAGA Diagnostics AB, Lund, Schweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAGA Diagnostics AB, Lund, Schweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054387977","display_name":"Gerda Hofstetter","orcid":"https://orcid.org/0000-0001-8912-3725","observed_orcids":["https://orcid.org/0000-0001-8912-3725"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G. Hofstetter","raw_affiliation_strings":["Medizinische Universit\u00e4t Wien, Abteilung f\u00fcr Pathologie, Wien, \u00d6sterreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4t Wien, Abteilung f\u00fcr Pathologie, Wien, \u00d6sterreich","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002216760","display_name":"Leonhard M\u00fcllauer","orcid":"https://orcid.org/0000-0002-3399-078X","observed_orcids":["https://orcid.org/0000-0002-3399-078X"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"L. M\u00fcllauer","raw_affiliation_strings":["Medizinische Universit\u00e4t Wien, Abteilung f\u00fcr Pathologie, Wien, \u00d6sterreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4t Wien, Abteilung f\u00fcr Pathologie, Wien, \u00d6sterreich","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022789402","display_name":"Mirjana Kessler","orcid":"https://orcid.org/0000-0002-9879-1052","observed_orcids":["https://orcid.org/0000-0002-9879-1052"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4387156288","display_name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe","ror":"https://ror.org/02794jc95","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4387156288","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Kessler","raw_affiliation_strings":["LMU Klinikum, Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, M\u00fcnchen, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LMU Klinikum, Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, M\u00fcnchen, Deutschland","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I4387156288","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091217089","display_name":"Fabian Trillsch","orcid":"https://orcid.org/0000-0002-1860-4350","observed_orcids":["https://orcid.org/0000-0002-1860-4350"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4387156288","display_name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe","ror":"https://ror.org/02794jc95","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4387156288","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Trillsch","raw_affiliation_strings":["LMU Klinikum, Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, M\u00fcnchen, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LMU Klinikum, Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, M\u00fcnchen, Deutschland","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I4387156288","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051069867","display_name":"Christoph Grimm","orcid":"https://orcid.org/0000-0003-2948-8129","observed_orcids":["https://orcid.org/0000-0003-2948-8129"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"C. Grimm","raw_affiliation_strings":["Medizinische Universit\u00e4t Wien, Klinische Abteilung f\u00fcr Allgemeine Gyn\u00e4kologie und gyn\u00e4kologische Onkologie, Wien, \u00d6sterreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4t Wien, Klinische Abteilung f\u00fcr Allgemeine Gyn\u00e4kologie und gyn\u00e4kologische Onkologie, Wien, \u00d6sterreich","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"06","first_page":"e43","last_page":"e43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9739999771118164},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/postoperative-residual-tumor","display_name":"residual tumor after surgery","score":0.7089999914169312},{"id":"https://openalex.org/keywords/complete-cytoreduction","display_name":"complete cytoreduction","score":0.6050000190734863},{"id":"https://openalex.org/keywords/digital-pcr","display_name":"digital PCR","score":0.32100000977516174},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6240000128746033},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.675000011920929},{"id":"https://openalex.org/keywords/single-nucleotide-variants","display_name":"single nucleotide variants","score":0.7269999980926514},{"id":"https://openalex.org/keywords/indels","display_name":"indels","score":0.6460000276565552},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6200000047683716},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.7559999823570251},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8165000081062317},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.44269999861717224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3458000123500824},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2745000123977661},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.24819999933242798},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.24779999256134033},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21610000729560852},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.20909999310970306},{"id":"https://openalex.org/C3018130915","wikidata":"https://www.wikidata.org/wiki/Q1752284","display_name":"Neoplasm staging","level":3,"score":0.2087000012397766},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.20090000331401825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0044-1787411","doi":"https://doi.org/10.1055/s-0044-1787411","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1787411","pdf_url":null,"source":{"id":"https://openalex.org/S146294059","display_name":"Geburtshilfe und Frauenheilkunde","issn_l":"0016-5751","issn":["0016-5751","1438-8804","2199-6989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geburtshilfe und Frauenheilkunde","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4229060281","https://openalex.org/W4399380518","https://openalex.org/W4387135664","https://openalex.org/W7148891445","https://openalex.org/W4407943370","https://openalex.org/W4387824916","https://openalex.org/W3022353828","https://openalex.org/W2899398398","https://openalex.org/W4386913763","https://openalex.org/W2889716800"],"abstract_inverted_index":{"Einleitung":[0],"Die":[1,19,275,286],"makroskopische":[2],"Komplettresektion":[3],"bei":[4,12,174,181,212,239],"Prim\u00e4roperation":[5],"ist":[6],"der":[7,26,29,33,170,177,232,247],"wichtigste":[8],"klinisch":[9],"beeinflussbare":[10],"Prognosefaktor":[11],"Patientinnen":[13,77,178,194,199,213,240],"mit":[14,78,200,214,226,241,266],"high-grade":[15],"ser\u00f6sem":[16],"Ovarialkarzinom":[17],"(HGSOC).":[18],"Klassifizierung":[20],"des":[21,44,283,302],"postoperativen":[22,45,63,185,271,276,284,303],"Resektionsstatus":[23],"basiert":[24],"auf":[25,208],"subjektiven":[27],"Einsch\u00e4tzung":[28,43],"Operierenden":[30],"am":[31,105,108,184],"Ende":[32],"Operation.":[34],"Ein":[35],"objektiver":[36],"und":[37,66,86,107,129,161,180,254,270,297],"m\u00f6glichst":[38],"indikativer":[39],"Marker":[40,61],"f\u00fcr":[41,62,136,298],"die":[42,82,137,157,217,299],"Tumorrestes":[46,304],"existiert":[47],"bisher":[48,75],"nicht.":[49],"In":[50,169],"dieser":[51,70],"Studie":[52],"untersuchen":[53],"wir":[54],"zirkulierende":[55],"Tumor-DNA":[56],"(ctDNA)":[57],"als":[58,273],"potenziellen":[59],"pr\u00e4diktiven":[60],"Tumorrest.":[64],"Material":[65],"Methodik":[67],"Im":[68,191,235],"Rahmen":[69],"prospektiven,":[71],"multizentrischen":[72],"Machbarkeitsstudie":[73],"wurden":[74,117,156],"45":[76],"fortgeschrittenem":[79],"HGSOC":[80,308],"eingeschlossen,":[81],"zwischen":[83,252],"Juli":[84],"2021":[85],"Dezember":[87],"2023":[88],"eine":[89],"prim\u00e4re":[90],"Debulking-Operation":[91],"erhielten.":[92],"Intraoperativ":[93],"wurde":[94,238],"Tumorgewebe":[95,131],"von":[96,148],"verschiedenen":[97],"betroffenen":[98],"Stellen":[99],"sowie":[100,122],"perioperative":[101],"Blutproben":[102],"gewonnen":[103],"(pr\u00e4operativ,":[104],"zweiten":[106],"zehnten":[109],"Tag":[110,186],"postoperativ).":[111],"Mittels":[112],"Whole":[113],"Genome":[114],"Sequencing":[115],"(WGS)":[116],"Strukturvarianten":[118],"(SVs),":[119],"Einzelnukleotidvarianten":[120],"(SNVs)":[121],"Indels":[123],"in":[124,164,281],"frisch":[125],"gefrorenem":[126],"oder":[127],"Formalin-fixierten":[128],"Paraffin-eingebetteten":[130],"identifiziert,":[132],"um":[133,250],"personalisierte":[134],"Multiplex-Fingerprint-Tests":[135],"digitale":[138],"Polymerase-Kettenreaktion":[139],"(dPCR)":[140],"zu":[141,193],"entwickeln.":[142],"Ergebnisse":[143],"Mit":[144],"einer":[145],"hohen":[146,268],"Anzahl":[147],"detektierten":[149],"SVs":[150],"(Median":[151],"90":[152],"SVs,":[153],"Spanne":[154],"24-287)":[155],"dPCR-Assays":[158],"erfolgreich":[159],"entwickelt":[160],"konnten":[162],"entsprechend":[163],"allen":[165],"Tumorproben":[166],"validiert":[167],"werden.":[168,190,310],"Gesamtkohorte":[171],"konnte":[172],"ctDNA":[173],"96%":[175],"(n=43/45)":[176],"pr\u00e4operativ":[179],"87%":[182],"(n=39/45)":[183],"10":[187],"(d10)":[188],"nachgewiesen":[189],"Vergleich":[192],"ohne":[195],"makroskopischen":[196,215],"Tumorrest":[197,202],"wiesen":[198],"postoperativem":[201],"an":[203,219],"d10":[204,220],"signifikant":[205],"h\u00f6here":[206],"ctDNA-Werte":[207,218,249,277],"(p<0,001).":[209],"Au\u00dferdem":[210],"blieben":[211],"Tumorresten":[216],"(%":[221],"variante":[222],"Allelfraktion":[223],"(VAF))":[224],"vergleichbar":[225],"den":[227],"pr\u00e4operativen":[228],"ctDNA-Werten":[229],"(4%":[230],"Abnahme":[231],"medianen":[233,248],"ctDNA-Werte).":[234],"Gegensatz":[236],"dazu":[237],"makroskopisch":[242],"vollst\u00e4ndiger":[243],"Resektion":[244],"ein":[245],"R\u00fcckgang":[246],"97%":[251],"pr\u00e4operativer":[253],"d10-Ergebnisse":[255],"festgestellt.":[256],"Zusammenfassung":[257],"Der":[258],"vorliegende":[259],"Ansatz":[260],"eines":[261,288],"tumorspezifischen":[262],"ctDNA-dPCR-SV-Fingerprints":[263],"erweist":[264],"sich":[265,279],"sehr":[267],"pr\u00e4-":[269],"Nachweisraten":[272],"praktikabel.":[274],"unterschieden":[278],"wesentlich":[280],"Abh\u00e4ngigkeit":[282],"Tumorrestes.":[285],"Etablierung":[287],"personalisierten":[289],"dPCR-SV-Assays":[290],"k\u00f6nnte":[291],"zuk\u00fcnftig":[292],"einen":[293],"klinischen":[294],"Nutzen":[295],"bieten":[296],"objektive":[300],"Beurteilung":[301],"beim":[305],"prim\u00e4r":[306],"fortgeschrittenen":[307],"eingesetzt":[309],"Publication":[311],"History":[312],"Article":[313],"published":[314],"online:":[315],"14":[316],"June":[317],"2024":[318],"\u00a9":[319],"2024.":[320],"Thieme.":[321],"All":[322],"rights":[323],"reserved.":[324],"Georg":[325],"Thieme":[326],"Verlag":[327],"KG":[328],"R\u00fcdigerstra\u00dfe":[329],"14,":[330],"70469":[331],"Stuttgart,":[332],"Germany":[333]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-11-28T00:00:00"}
