{"id":"https://openalex.org/W4416728826","doi":"https://doi.org/10.20944/preprints202511.1969.v1","title":"Markerless AR Registration Framework Using Multi-Modal Imaging for Orthopedic Surgical Guidance","display_name":"Markerless AR Registration Framework Using Multi-Modal Imaging for Orthopedic Surgical Guidance","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416728826","doi":"https://doi.org/10.20944/preprints202511.1969.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202511.1969.v1","doi":"https://doi.org/10.20944/preprints202511.1969.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202511.1969.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/b165bae77112c4ac1558c8b2777558d8/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.preprints.org/frontend/manuscript/b165bae77112c4ac1558c8b2777558d8/download_pub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"James R. Whitmore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"James R. Whitmore","raw_affiliation_strings":["Department of Orthopaedics and Musculoskeletal Science , University College London , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Musculoskeletal Science , University College London , United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101524616","display_name":"Hui Lin","orcid":"https://orcid.org/0000-0001-7512-0734","observed_orcids":["https://orcid.org/0000-0001-7512-0734","https://orcid.org/0000-0001-9536-2909"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hui Lin","raw_affiliation_strings":["Nuffield Department of Orthopaedics , Rheumatology and Musculoskeletal Sciences , University of Oxford , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Orthopaedics , Rheumatology and Musculoskeletal Sciences , University of Oxford , United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Charlotte P. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charlotte P. Evans","raw_affiliation_strings":["Department of Orthopaedics and Musculoskeletal Science , University College London , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Musculoskeletal Science , University College London , United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David K. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David K. Mitchell","raw_affiliation_strings":["Nuffield Department of Orthopaedics , Rheumatology and Musculoskeletal Sciences , University of Oxford , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Orthopaedics , Rheumatology and Musculoskeletal Sciences , University of Oxford , United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030449063","display_name":"Sophie L. Carter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sophie L. Carter","raw_affiliation_strings":["Department of Orthopaedics and Musculoskeletal Science , University College London , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Musculoskeletal Science , University College London , United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10888","display_name":"Augmented Reality Applications","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10888","display_name":"Augmented Reality Applications","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.12929999828338623,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/markerless-registration","display_name":"markerless registration","score":0.9900000095367432},{"id":"https://openalex.org/keywords/augmented-reality","display_name":"augmented reality","score":0.7250000238418579},{"id":"https://openalex.org/keywords/multimodal-image-fusion","display_name":"multimodal image fusion","score":0.6359999775886536},{"id":"https://openalex.org/keywords/depth-imaging","display_name":"depth imaging","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ct-mri","display_name":"CT/MRI","score":0.6570000052452087},{"id":"https://openalex.org/keywords/mutual-information-optimization","display_name":"mutual information optimization","score":0.8820000290870667},{"id":"https://openalex.org/keywords/iterative-closest-point","display_name":"iterative closest point","score":0.7649999856948853},{"id":"https://openalex.org/keywords/u-net-segmentation","display_name":"U-Net segmentation","score":0.843999981880188},{"id":"https://openalex.org/keywords/adaptive-weight-learning","display_name":"adaptive weight learning","score":0.8320000171661377},{"id":"https://openalex.org/keywords/surgical-navigation","display_name":"surgical navigation","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.6621000170707703},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.6342999935150146},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5842000246047974},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5590999722480774},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.555400013923645},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.5360999703407288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4706000089645386},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.453900009393692},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.3982999920845032},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.3961000144481659},{"id":"https://openalex.org/C126042441","wikidata":"https://www.wikidata.org/wiki/Q1324888","display_name":"Frame (networking)","level":2,"score":0.3476000130176544},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.33980000019073486},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3384000062942505},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3296999931335449},{"id":"https://openalex.org/C2777017458","wikidata":"https://www.wikidata.org/wiki/Q4011334","display_name":"Image-guided surgery","level":2,"score":0.3158999979496002},{"id":"https://openalex.org/C153715457","wikidata":"https://www.wikidata.org/wiki/Q254183","display_name":"Augmented reality","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C3261483","wikidata":"https://www.wikidata.org/wiki/Q119565","display_name":"Frame rate","level":2,"score":0.27880001068115234},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2612000107765198},{"id":"https://openalex.org/C21034978","wikidata":"https://www.wikidata.org/wiki/Q17074238","display_name":"Patient registration","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.25459998846054077},{"id":"https://openalex.org/C2910979460","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic Procedures","level":3,"score":0.2542000114917755},{"id":"https://openalex.org/C3019611579","wikidata":"https://www.wikidata.org/wiki/Q6641956","display_name":"Surgical procedures","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202511.1969.v1","doi":"https://doi.org/10.20944/preprints202511.1969.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202511.1969.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/b165bae77112c4ac1558c8b2777558d8/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202511.1969.v1","doi":"https://doi.org/10.20944/preprints202511.1969.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202511.1969.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/b165bae77112c4ac1558c8b2777558d8/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416728826.pdf","grobid_xml":"https://content.openalex.org/works/W4416728826.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4414884199"],"related_works":["https://openalex.org/W4414884199","https://openalex.org/W4389537691","https://openalex.org/W7220286096","https://openalex.org/W7104056942","https://openalex.org/W7220012961","https://openalex.org/W3007222539","https://openalex.org/W4417458469","https://openalex.org/W4388562874","https://openalex.org/W4415214307","https://openalex.org/W4411111594"],"abstract_inverted_index":{"Orthopedic":[0],"surgery":[1],"demands":[2],"precise":[3],"bone":[4],"alignment,":[5],"yet":[6],"marker-based":[7,64],"navigation":[8],"adds":[9],"cost":[10],"and":[11,38,71],"complexity.":[12],"We":[13],"propose":[14],"a":[15,34],"markerless":[16],"registration":[17],"framework":[18,78],"fusing":[19],"depth":[20],"imaging":[21],"with":[22,33,63],"preoperative":[23],"CT/MRI":[24],"via":[25],"mutual":[26],"information":[27],"optimization.":[28],"Anatomical":[29],"features":[30],"are":[31],"extracted":[32],"U-Net":[35],"segmentation":[36],"model,":[37],"alignment":[39],"is":[40],"performed":[41],"using":[42],"multi-modal":[43],"ICP":[44],"enhanced":[45],"by":[46,69],"adaptive":[47],"weight":[48],"learning.":[49],"In":[50],"15":[51],"phantom":[52],"surgeries,":[53],"mean":[54],"TRE":[55],"was":[56],"1.4":[57],"mm,":[58],"compared":[59],"to":[60],"2.6":[61],"mm":[62],"setups.":[65],"Preparation":[66],"time":[67],"decreased":[68],"35%,":[70],"frame":[72],"rates":[73],"reached":[74],"25":[75],"fps.":[76],"The":[77],"reduces":[79],"invasiveness":[80],"while":[81],"preserving":[82],"surgical":[83],"accuracy,":[84],"offering":[85],"clinical":[86],"scalability.":[87]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-11-27T00:00:00"}