{"id":"https://openalex.org/W4416728258","doi":"https://doi.org/10.1101/2025.11.21.689729","title":"Effects of a novel proteasome inhibitor, UR238 on the tumor immune microenvironment and growth in epithelial ovarian cancer","display_name":"Effects of a novel proteasome inhibitor, UR238 on the tumor immune microenvironment and growth in epithelial ovarian cancer","publication_year":2025,"publication_date":"2025-11-24","ids":{"openalex":"https://openalex.org/W4416728258","doi":"https://doi.org/10.1101/2025.11.21.689729"},"language":"en","primary_location":{"id":"doi:10.1101/2025.11.21.689729","doi":"https://doi.org/10.1101/2025.11.21.689729","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.21.689729","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/24/2025.11.21.689729.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/24/2025.11.21.689729.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023194705","display_name":"J. Miller","orcid":"https://orcid.org/0000-0001-8786-5442","observed_orcids":["https://orcid.org/0000-0001-8786-5442"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Phillip Miller","raw_affiliation_strings":["University of Rochester"],"raw_orcid":"https://orcid.org/0000-0001-8786-5442","affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074141111","display_name":"Naixin Zhang","orcid":"https://orcid.org/0000-0001-8946-0318","observed_orcids":["https://orcid.org/0000-0001-8946-0318"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naixin Zhang","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037000390","display_name":"Kyukwang Kim","orcid":"https://orcid.org/0000-0002-0386-3712","observed_orcids":["https://orcid.org/0000-0002-0386-3712","https://orcid.org/0000-0001-5571-4949"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyukwang Kim","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050445670","display_name":"Cameron W. A. Snyder","orcid":"https://orcid.org/0000-0001-7421-9767","observed_orcids":["https://orcid.org/0000-0001-7421-9767"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cameron WA Snyder","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008173106","display_name":"Jamie Linn McDowell","orcid":"https://orcid.org/0000-0001-8499-3270","observed_orcids":["https://orcid.org/0000-0001-8499-3270"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Linn McDowell","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051713222","display_name":"Michelle Whittum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Elizabeth Whittum","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089217769","display_name":"Negar Khazan","orcid":"https://orcid.org/0000-0002-5517-6017","observed_orcids":["https://orcid.org/0000-0002-5517-6017"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Negar Khazan","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014799646","display_name":"Niloy A. Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niloy Singh","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017822354","display_name":"Myla S. Strawderman","orcid":"https://orcid.org/0000-0002-6016-968X","observed_orcids":["https://orcid.org/0000-0002-6016-968X"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myla Strawderman","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052236281","display_name":"Richard G. Moore","orcid":"https://orcid.org/0000-0001-5598-5263","observed_orcids":["https://orcid.org/0000-0001-5598-5263"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Moore","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060794463","display_name":"Rakesh K. Singh","orcid":"https://orcid.org/0000-0002-1124-9202","observed_orcids":["https://orcid.org/0000-0002-1124-9202"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rakesh Singh","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046273057","display_name":"Rachael B. Rowswell-Turner","orcid":"https://orcid.org/0000-0002-8726-4628","observed_orcids":["https://orcid.org/0000-0002-8726-4628"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachael B. Rowswell-Turner","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046273057"],"corresponding_institution_ids":["https://openalex.org/I5388228"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.4032999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9679999947547913},{"id":"https://openalex.org/keywords/psmb4","display_name":"PSMB4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.7609999775886536},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8270000219345093},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.675000011920929},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5019999742507935},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.70169997215271},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.6937000155448914},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6714000105857849},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6690000295639038},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6190000176429749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5627999901771545},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.4291999936103821},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41940000653266907},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.37860000133514404},{"id":"https://openalex.org/C2780084626","wikidata":"https://www.wikidata.org/wiki/Q11793790","display_name":"Ovarian tumor","level":4,"score":0.3495999872684479},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33160001039505005},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3095000088214874},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.30660000443458557},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28780001401901245},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.2612000107765198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2605000138282776},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.2533000111579895},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.25279998779296875},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.11.21.689729","doi":"https://doi.org/10.1101/2025.11.21.689729","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.21.689729","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/24/2025.11.21.689729.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.11.21.689729","doi":"https://doi.org/10.1101/2025.11.21.689729","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.21.689729","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/24/2025.11.21.689729.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320310246","display_name":"University of Rochester","ror":"https://ror.org/022kthw22"},{"id":"https://openalex.org/F4320314727","display_name":"Ovarian Cancer Research Alliance","ror":"https://ror.org/05hg41718"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416728258.pdf","grobid_xml":"https://content.openalex.org/works/W4416728258.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1503285048","https://openalex.org/W1604083967","https://openalex.org/W1885931729","https://openalex.org/W1970001436","https://openalex.org/W1980181125","https://openalex.org/W1980376109","https://openalex.org/W1981610638","https://openalex.org/W2004252053","https://openalex.org/W2094438078","https://openalex.org/W2136735139","https://openalex.org/W2137074525","https://openalex.org/W2147622445","https://openalex.org/W2152261493","https://openalex.org/W2166350458","https://openalex.org/W2171792232","https://openalex.org/W2580091136","https://openalex.org/W2620731633","https://openalex.org/W2748892474","https://openalex.org/W2749746182","https://openalex.org/W2767122952","https://openalex.org/W2789897492","https://openalex.org/W2890365959","https://openalex.org/W2901666999","https://openalex.org/W2902728878","https://openalex.org/W2967433500","https://openalex.org/W2999249974","https://openalex.org/W3081926493","https://openalex.org/W3156547118","https://openalex.org/W3158243812","https://openalex.org/W4200321736","https://openalex.org/W4211203170","https://openalex.org/W4281898206","https://openalex.org/W4283464621","https://openalex.org/W4363651439","https://openalex.org/W4381664342","https://openalex.org/W4387494986","https://openalex.org/W4391651676","https://openalex.org/W4391723488","https://openalex.org/W4404939878"],"related_works":["https://openalex.org/W4414649283","https://openalex.org/W3040217994","https://openalex.org/W2152643523","https://openalex.org/W7133281082","https://openalex.org/W4399326197","https://openalex.org/W4412461158","https://openalex.org/W3178799725","https://openalex.org/W3133635381","https://openalex.org/W2892058240","https://openalex.org/W3187866775"],"abstract_inverted_index":{"Abstract":[0],"High-grade":[1],"serous":[2],"ovarian":[3,63,75,211,236],"cancer":[4,64,76,237],"(HGSOC)":[5],"is":[6],"a":[7,123,148,180,194,214],"deadly":[8],"gynecologic":[9],"malignancy,":[10],"often":[11],"diagnosed":[12],"at":[13],"an":[14,164],"advanced":[15],"stage":[16],"and":[17,23,78,116,135,143,171],"most":[18],"patients":[19],"will":[20,229],"experience":[21],"recurrence":[22],"resistance":[24],"to":[25,43,86,112,163],"platinum-based":[26],"chemotherapy.":[27],"While":[28],"there":[29,37],"are":[30,38],"few":[31],"targeted":[32],"therapies":[33],"available":[34,42],"for":[35,89,207,235],"HGSOC,":[36],"no":[39],"effective":[40],"immunotherapies":[41],"treat":[44],"this":[45],"disease.":[46],"The":[47],"ubiquitin-proteasome":[48],"system":[49],"(UPS)":[50],"maintains":[51],"cellular":[52],"protein":[53],"homeostasis":[54],"by":[55],"degrading":[56],"misfolded":[57],"or":[58,216],"damaged":[59],"proteins.":[60],"In":[61,147],"epithelial":[62,74],"(EOC)":[65],"elevated":[66],"expression":[67,174],"of":[68,94,101,130,205,210,226],"proteasome":[69,82,125],"subunit":[70],"PSMB4":[71],"correlates":[72],"with":[73,167,219],"growth":[77],"poor":[79,117],"prognosis.":[80],"A":[81],"inhibitor":[83],"has":[84],"yet":[85],"be":[87,230],"approved":[88],"EOC":[90,132,150],"treatment":[91,153,209],"despite":[92],"evidence":[93],"activity":[95],"in":[96,139,179,189,197,217,232],"phase-1/2":[97],"clinical":[98],"trials.":[99],"Limitations":[100],"past":[102],"generation":[103],"proteosome":[104],"inhibitors":[105],"include":[106],"sub-optimal":[107],"solid":[108],"tumor/tissue":[109],"penetration":[110],"due":[111],"boronic":[113],"acid":[114],"functionality,":[115],"solubility.":[118],"Here,":[119],"we":[120],"show":[121],"that":[122],"novel":[124],"inhibitor,":[126],"UR238,":[127],"suppresses":[128],"viability":[129],"several":[131],"cell":[133],"lines":[134],"reduces":[136],"tumor":[137,155,198],"burden":[138],"both":[140],"murine":[141],"xenograft":[142],"rat":[144,149],"syngeneic":[145],"models.":[146],"model,":[151,182],"UR238":[152,183,206],"reduced":[154,168],"burden,":[156],"shifted":[157],"the":[158,203,208,223],"predominantly":[159],"suppressive":[160,169],"immune":[161,187,224],"microenvironment":[162],"inflammatory":[165],"phenotype":[166],"macrophages,":[170],"decreased":[172],"PD-L1":[173],"on":[175],"myeloid":[176],"cells.":[177],"Additionally,":[178],"mouse":[181],"also":[184],"induced":[185],"robust":[186],"changes":[188],"HGSOC":[190],"bearing":[191],"mice":[192],"without":[193],"corresponding":[195],"reduction":[196],"burden.":[199],"Our":[200],"data":[201],"highlights":[202],"promise":[204],"cancers":[212],"as":[213],"single-agent":[215],"combination":[218],"immunotherapies,":[220],"where":[221],"modulating":[222],"composition":[225],"these":[227],"tumors":[228],"important":[231],"improving":[233],"outcomes":[234],"patients.":[238]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-25T00:00:00"}