{"id":"https://openalex.org/W4416722673","doi":"https://doi.org/10.1128/jvi.00337-26","title":"AAV2 bypasses direct endosomal escape by using AAVR to access the trans-Golgi network en route to the nucleus","display_name":"AAV2 bypasses direct endosomal escape by using AAVR to access the trans-Golgi network en route to the nucleus","publication_year":2026,"publication_date":"2026-07-29","ids":{"openalex":"https://openalex.org/W4416722673","doi":"https://doi.org/10.1128/jvi.00337-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42523117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13483459"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00337-26","doi":"https://doi.org/10.1128/jvi.00337-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00337-26","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/jvi.00337-26","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013135529","display_name":"Marti Cabanes\u2010Creus","orcid":"https://orcid.org/0000-0002-5412-5701","observed_orcids":["https://orcid.org/0000-0002-5412-5701"]},"institutions":[{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Marti Cabanes-Creus","raw_affiliation_strings":["Children's Medical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Research Institute","institution_ids":["https://openalex.org/I146584863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109527469","display_name":"Sophia H.Y. Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sophia H.Y. Liao","raw_affiliation_strings":["Children's Medical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Research Institute","institution_ids":["https://openalex.org/I146584863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120384657","display_name":"Marta Pardo-Pi\u00f1\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210118072","display_name":"Instituto Biofisika","ror":"https://ror.org/01pf2cj55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I169108374","https://openalex.org/I4210118072"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Pardo-Pi\u00f1\u00f3n","raw_affiliation_strings":["Biofisika Institute (CSIC-UPV/EHU), University of the Basque Country"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biofisika Institute (CSIC-UPV/EHU), University of the Basque Country","institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210118072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055703506","display_name":"Adriana Lucely Rojas","orcid":"https://orcid.org/0000-0002-7358-3505","observed_orcids":["https://orcid.org/0000-0002-7358-3505"]},"institutions":[{"id":"https://openalex.org/I4210112728","display_name":"CIC bioGUNE","ror":"https://ror.org/02x5c5y60","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210112728"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adriana L. Rojas","raw_affiliation_strings":["Electron Microscopy and Crystallography Platforms, CIC bioGUNE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electron Microscopy and Crystallography Platforms, CIC bioGUNE","institution_ids":["https://openalex.org/I4210112728"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063725791","display_name":"Joseph M. Kelich","orcid":"https://orcid.org/0000-0003-4132-6261","observed_orcids":["https://orcid.org/0000-0003-4132-6261"]},"institutions":[{"id":"https://openalex.org/I4210102540","display_name":"Spark Therapeutics (United States)","ror":"https://ror.org/00s93j442","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Kelich","raw_affiliation_strings":["Spark Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spark Therapeutics","institution_ids":["https://openalex.org/I4210102540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120521761","display_name":"Jackson Coyne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102540","display_name":"Spark Therapeutics (United States)","ror":"https://ror.org/00s93j442","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jackson Coyne","raw_affiliation_strings":["Spark Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spark Therapeutics","institution_ids":["https://openalex.org/I4210102540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075054076","display_name":"Maddison Knight","orcid":"https://orcid.org/0000-0002-8009-067X","observed_orcids":["https://orcid.org/0000-0002-8009-067X"]},"institutions":[{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Maddison Knight","raw_affiliation_strings":["Children's Medical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Research Institute","institution_ids":["https://openalex.org/I146584863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062542457","display_name":"Deborah Nazareth","orcid":"https://orcid.org/0000-0002-5983-3571","observed_orcids":["https://orcid.org/0000-0002-5983-3571"]},"institutions":[{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Deborah Nazareth","raw_affiliation_strings":["Children's Medical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Research Institute","institution_ids":["https://openalex.org/I146584863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011305423","display_name":"Ramon Roca-Pinilla","orcid":"https://orcid.org/0000-0002-7393-6200","observed_orcids":["https://orcid.org/0000-0002-7393-6200"]},"institutions":[{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ramon Roca-Pinilla","raw_affiliation_strings":["Children's Medical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Research Institute","institution_ids":["https://openalex.org/I146584863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071952817","display_name":"Sujata Senapati","orcid":"https://orcid.org/0000-0001-5579-3544","observed_orcids":["https://orcid.org/0000-0001-5579-3544"]},"institutions":[{"id":"https://openalex.org/I4210102540","display_name":"Spark Therapeutics (United States)","ror":"https://ror.org/00s93j442","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujata Senapati","raw_affiliation_strings":["Spark Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spark Therapeutics","institution_ids":["https://openalex.org/I4210102540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066777150","display_name":"Matthew C. Walsh","orcid":"https://orcid.org/0000-0002-0237-2831","observed_orcids":["https://orcid.org/0000-0002-0237-2831"]},"institutions":[{"id":"https://openalex.org/I4210102540","display_name":"Spark Therapeutics (United States)","ror":"https://ror.org/00s93j442","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew C. Walsh","raw_affiliation_strings":["Spark Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spark Therapeutics","institution_ids":["https://openalex.org/I4210102540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066593806","display_name":"Pedro Joel Cejas","orcid":"https://orcid.org/0009-0000-2952-6135","observed_orcids":["https://orcid.org/0009-0000-2952-6135"]},"institutions":[{"id":"https://openalex.org/I4210102540","display_name":"Spark Therapeutics (United States)","ror":"https://ror.org/00s93j442","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro J Cejas","raw_affiliation_strings":["Spark Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spark Therapeutics","institution_ids":["https://openalex.org/I4210102540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050063788","display_name":"Sean M. Armour","orcid":"https://orcid.org/0000-0003-4297-4324","observed_orcids":["https://orcid.org/0000-0003-4297-4324"]},"institutions":[{"id":"https://openalex.org/I4210102540","display_name":"Spark Therapeutics (United States)","ror":"https://ror.org/00s93j442","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean M Armour","raw_affiliation_strings":["Spark Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spark Therapeutics","institution_ids":["https://openalex.org/I4210102540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089893327","display_name":"Aitor Hierro","orcid":"https://orcid.org/0000-0002-7721-1581","observed_orcids":["https://orcid.org/0000-0002-7721-1581"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210118072","display_name":"Instituto Biofisika","ror":"https://ror.org/01pf2cj55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I169108374","https://openalex.org/I4210118072"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aitor Hierro","raw_affiliation_strings":["Biofisika Institute (CSIC-UPV/EHU), University of the Basque Country"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biofisika Institute (CSIC-UPV/EHU), University of the Basque Country","institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210118072"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046626975","display_name":"Leszek Lisowski","orcid":"https://orcid.org/0000-0002-4772-8651","observed_orcids":["https://orcid.org/0000-0002-4772-8651"]},"institutions":[{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Leszek Lisowski","raw_affiliation_strings":["Children's Medical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Research Institute","institution_ids":["https://openalex.org/I146584863"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5046626975"],"corresponding_institution_ids":["https://openalex.org/I146584863"],"apc_list":null,"apc_paid":null,"fwci":3.9268,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.86093828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"100","issue":"8","first_page":"e0033726","last_page":"e0033726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.03929999843239784,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus-2","display_name":"adeno-associated virus type 2","score":0.9110000133514404},{"id":"https://openalex.org/keywords/aav-receptor","display_name":"AAV receptor","score":0.800000011920929},{"id":"https://openalex.org/keywords/retromer-complex","display_name":"retromer complex","score":0.8209999799728394},{"id":"https://openalex.org/keywords/snx3","display_name":"SNX3","score":0.9829999804496765},{"id":"https://openalex.org/keywords/retrograde-trafficking","display_name":"retrograde trafficking","score":0.8939999938011169},{"id":"https://openalex.org/keywords/trans-golgi-network","display_name":"trans-Golgi network","score":0.9819999933242798},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.9869999885559082},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.652999997138977},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.9607999920845032},{"id":"https://openalex.org/C145458877","wikidata":"https://www.wikidata.org/wiki/Q7317044","display_name":"Retromer","level":4,"score":0.8762000203132629},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6995000243186951},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5346999764442444},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5218999981880188},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5087000131607056},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.4966000020503998},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.4909000098705292},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4641000032424927},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.45019999146461487},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.4474000036716461},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.3668000102043152},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.36399999260902405},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.33160001039505005},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31349998712539673},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.30720001459121704},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.2946999967098236},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C2910636507","wikidata":"https://www.wikidata.org/wiki/Q4082043","display_name":"Vesicular Transport Proteins","level":5,"score":0.29190000891685486},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.2847000062465668}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021601","descriptor_name":"trans-Golgi Network","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021601","descriptor_name":"trans-Golgi Network","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1128/jvi.00337-26","doi":"https://doi.org/10.1128/jvi.00337-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00337-26","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"doi:10.1101/2025.11.22.689972","doi":"https://doi.org/10.1101/2025.11.22.689972","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.22.689972","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13483459","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13483459/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13483459/pdf/jvi.00337-26.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:42523117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42523117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/444032","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/444032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:9c1b9dda97f2448480c42b4406a8a89c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9c1b9dda97f2448480c42b4406a8a89c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, Vol 100, Iss 8 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/jvi.00337-26","doi":"https://doi.org/10.1128/jvi.00337-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00337-26","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5257682798","display_name":null,"funder_award_id":"PID2023-151986NB-I00","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1966374792","https://openalex.org/W1985169370","https://openalex.org/W1988513056","https://openalex.org/W2002565864","https://openalex.org/W2003264964","https://openalex.org/W2016745966","https://openalex.org/W2030278423","https://openalex.org/W2040266789","https://openalex.org/W2057548071","https://openalex.org/W2059202997","https://openalex.org/W2075170026","https://openalex.org/W2086400040","https://openalex.org/W2090661761","https://openalex.org/W2098880579","https://openalex.org/W2105017686","https://openalex.org/W2108585827","https://openalex.org/W2115185064","https://openalex.org/W2148223197","https://openalex.org/W2154329712","https://openalex.org/W2162807448","https://openalex.org/W2163665861","https://openalex.org/W2164625869","https://openalex.org/W2170392860","https://openalex.org/W2266837556","https://openalex.org/W2553944165","https://openalex.org/W2889632501","https://openalex.org/W2910221008","https://openalex.org/W2943673194","https://openalex.org/W2946762521","https://openalex.org/W2991022372","https://openalex.org/W3025923811","https://openalex.org/W3044226803","https://openalex.org/W3076058986","https://openalex.org/W3083969602","https://openalex.org/W3134311741","https://openalex.org/W3157294108","https://openalex.org/W4253415877","https://openalex.org/W4281731708","https://openalex.org/W4321004399","https://openalex.org/W4379878663","https://openalex.org/W4392376488","https://openalex.org/W4392809113","https://openalex.org/W4394960825","https://openalex.org/W4404755712","https://openalex.org/W4412423213"],"related_works":["https://openalex.org/W2075170026","https://openalex.org/W7163517792","https://openalex.org/W2732628005","https://openalex.org/W2107204011","https://openalex.org/W2143529139","https://openalex.org/W4231683493","https://openalex.org/W7163917916","https://openalex.org/W2158417626","https://openalex.org/W2034351145","https://openalex.org/W2226328347"],"abstract_inverted_index":{"ABSTRACT":[0],"Vectors":[1],"based":[2],"on":[3,239],"the":[4,20,52,80,142,164,178,184,214,229,271,293],"adeno-associated":[5],"virus":[6],"are":[7,98,245],"widely":[8,165],"used":[9],"as":[10,59,131,193,218],"delivery":[11],"methods":[12],"in":[13,66,102,186,292],"gene":[14],"therapy":[15],"applications,":[16],"yet":[17],"understanding":[18],"of":[19,89,118,168,183],"mechanisms":[21],"governing":[22],"its":[23,282],"intracellular":[24],"trafficking":[25,151],"remains":[26],"incomplete.":[27],"Traditional":[28],"models":[29],"suggest":[30],"that":[31,50,72,145,202,242,266,279],"AAV":[32,54,188,191],"escapes":[33],"from":[34,127],"endosomes":[35,207],"via":[36,208],"membrane":[37,85,120,209],"disruption,":[38],"but":[39,100,152,211,273],"direct":[40,169],"evidence":[41,117],"for":[42,149,154,177,235],"this":[43,276],"process":[44],"is":[45,76,147],"lacking.":[46],"Here,":[47],"we":[48,70,264],"show":[49,265],"AAVR,":[51],"essential":[53,181,286],"cell":[55],"entry":[56,192],"receptor,":[57],"functions":[58],"a":[60,87,174,194,219,232,289],"bona":[61],"fide":[62],"retromer":[63,220],"cargo.":[64],"Using":[65],"vitro":[67],"reconstitution":[68],"assays,":[69],"demonstrate":[71],"AAVR\u2019s":[73],"cytosolic":[74],"tail":[75],"sufficient":[77],"to":[78,108,222,228,270],"engage":[79],"retromer\u2013SNX3":[81],"complex":[82],"and":[83,106,136,172,281],"drive":[84],"tubulation,":[86],"hallmark":[88],"retrograde":[90,226],"trafficking.":[91],"In":[92],"AAVR-knockout":[93],"HuH-7":[94],"cells,":[95],"AAV2":[96,126,138,203],"particles":[97,244,268],"internalized,":[99],"accumulate":[101,140,274],"early":[103,150],"endosomal":[104,119,170],"compartments,":[105],"fail":[107],"support":[109],"transgene":[110],"expression.":[111],"Galectin-8":[112],"recruitment":[113],"assays":[114],"reveal":[115],"no":[116],"rupture":[121,210],"during":[122],"productive":[123,158,187,236],"transduction,":[124,189],"distinguishing":[125],"lytic":[128],"vectors":[129],"such":[130],"lipid":[132],"nanoparticles.":[133],"Moreover,":[134],"VP1u-deficient":[135,243],"PLA2-mutant":[137],"capsids":[139],"at":[141,275,288],"TGN,":[143],"indicating":[144,278],"VP1u":[146,280],"dispensable":[148],"required":[153],"post-TGN":[155,290],"progression":[156],"toward":[157],"transduction.":[159,237],"These":[160],"findings":[161],"argue":[162],"against":[163],"held":[166],"model":[167],"escape":[171,206],"provide":[173],"mechanistic":[175],"basis":[176],"previously":[179],"described":[180],"role":[182],"TGN":[185,272],"positioning":[190],"vesicle-guided,":[195],"receptor-mediated":[196],"process.":[197],"IMPORTANCE":[198],"The":[199],"study":[200],"demonstrates":[201],"does":[204],"not":[205],"instead":[212],"exploits":[213],"cellular":[215],"receptor":[216],"AAVR":[217],"cargo":[221],"traffic":[223,269],"through":[224],"vesicle-mediated":[225],"transport":[227],"trans-Golgi":[230],"network,":[231],"critical":[233],"checkpoint":[234],"Building":[238],"prior":[240],"observations":[241],"still":[246],"internalized":[247],"(R.":[248],"Popa-Wagner,":[249],"M.":[250,252,254],"Porwal,":[251],"Kann,":[253],"Reuss,":[255],"et":[256],"al.,":[257],"J":[258],"Virol":[259],"86:9163\u20139174,":[260],"2012,":[261],"https://doi.org/10.1128/jvi.00282-12":[262],"),":[263],"these":[267],"compartment,":[277],"PLA2":[283],"activity":[284],"become":[285],"specifically":[287],"step":[291],"transduction":[294],"pathway.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-11-25T00:00:00"}