{"id":"https://openalex.org/W4416719218","doi":"https://doi.org/10.1038/s41598-025-25997-z","title":"Identifying regulators of aged fibroblast activation in 3D tissue models","display_name":"Identifying regulators of aged fibroblast activation in 3D tissue models","publication_year":2025,"publication_date":"2025-11-26","ids":{"openalex":"https://openalex.org/W4416719218","doi":"https://doi.org/10.1038/s41598-025-25997-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/41298573","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12657520"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-025-25997-z","doi":"https://doi.org/10.1038/s41598-025-25997-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-25997-z","pdf_url":"https://www.nature.com/articles/s41598-025-25997-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-025-25997-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113272389","display_name":"Hui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hui Liu","raw_affiliation_strings":["Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland","Division of Biology and Chemistry, Paul Scherrer Institut, 5232, Villigen, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Division of Biology and Chemistry, Paul Scherrer Institut, 5232, Villigen, Switzerland","institution_ids":["https://openalex.org/I2802229908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027856816","display_name":"Luezhen Yuan","orcid":"https://orcid.org/0000-0002-6575-9339","observed_orcids":["https://orcid.org/0000-0002-6575-9339"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Luezhen Yuan","raw_affiliation_strings":["Broad Institute of MIT & Harvard, Cambridge, MA, USA","Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland","Division of Biology and Chemistry, Paul Scherrer Institut, 5232, Villigen, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT & Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Division of Biology and Chemistry, Paul Scherrer Institut, 5232, Villigen, Switzerland","institution_ids":["https://openalex.org/I2802229908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047577595","display_name":"G. V. Shivashankar","orcid":"https://orcid.org/0000-0002-3445-4567","observed_orcids":["https://orcid.org/0000-0002-3445-4567","https://orcid.org/0000-0003-0954-4496"]},"institutions":[{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"G. V. Shivashankar","raw_affiliation_strings":["Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland. gshivasha@ethz.ch","Division of Biology and Chemistry, Paul Scherrer Institut, 5232, Villigen, Switzerland. gshivasha@ethz.ch","Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland","Division of Biology and Chemistry, Paul Scherrer Institut, 5232, Villigen, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland. gshivasha@ethz.ch","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Division of Biology and Chemistry, Paul Scherrer Institut, 5232, Villigen, Switzerland. gshivasha@ethz.ch","institution_ids":["https://openalex.org/I2802229908"]},{"raw_affiliation_string":"Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Division of Biology and Chemistry, Paul Scherrer Institut, 5232, Villigen, Switzerland","institution_ids":["https://openalex.org/I2802229908"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047577595"],"corresponding_institution_ids":["https://openalex.org/I2802229908","https://openalex.org/I35440088"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.5754,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.53266296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"15","issue":"1","first_page":"42119","last_page":"42119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.2460000067949295,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.2460000067949295,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.09520000219345093,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.09359999746084213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/3d-tissue-models","display_name":"3D tissue models","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mechanical-compression","display_name":"mechanical compression","score":0.5640000104904175},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9240000247955322},{"id":"https://openalex.org/keywords/pharmacological-inhibitors","display_name":"pharmacological inhibitors","score":0.8989999890327454},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.7409999966621399},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":1.0},{"id":"https://openalex.org/keywords/pdk1","display_name":"PDK1","score":1.0},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.890999972820282},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.7398999929428101},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4945000112056732},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4921000003814697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4659000039100647},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4616999924182892},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3921999931335449},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.364300012588501},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.35989999771118164},{"id":"https://openalex.org/C111798993","wikidata":"https://www.wikidata.org/wiki/Q21117471","display_name":"Fibroblast activation protein, alpha","level":3,"score":0.33239999413490295},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.3255999982357025},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3237999975681305},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.3149999976158142},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.3018999993801117},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.28619998693466187},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000071161","descriptor_name":"Forkhead Box Protein O1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071161","descriptor_name":"Forkhead Box Protein O1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000087603","descriptor_name":"Cell Culture Techniques, Three Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41598-025-25997-z","doi":"https://doi.org/10.1038/s41598-025-25997-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-25997-z","pdf_url":"https://www.nature.com/articles/s41598-025-25997-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2025.02.10.636275","doi":"https://doi.org/10.1101/2025.02.10.636275","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.02.10.636275","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41298573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41298573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12657520","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12657520/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:dora:psi_83143","doi":null,"is_oa":true,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:83143","pdf_url":"https://www.dora.lib4ri.ch/psi/dload/psi:83143/PDF/view","source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:edcfbe7862b94783bff89675378f56b6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/edcfbe7862b94783bff89675378f56b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)","raw_type":"article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/789074","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/789074","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, 15 (1)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-c-000789074","doi":"https://doi.org/10.3929/ethz-c-000789074","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-c-000789074","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1038/s41598-025-25997-z","doi":"https://doi.org/10.1038/s41598-025-25997-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-25997-z","pdf_url":"https://www.nature.com/articles/s41598-025-25997-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5580260584","display_name":"Mechano-Genomics of Cellular Ageing and Rejuvenation","funder_award_id":"208046","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6083459995","display_name":null,"funder_award_id":"202008440471","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G8690818240","display_name":null,"funder_award_id":"310030","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416719218.pdf","grobid_xml":"https://content.openalex.org/works/W4416719218.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W1994565750","https://openalex.org/W2019755675","https://openalex.org/W2025723633","https://openalex.org/W2030373852","https://openalex.org/W2040127848","https://openalex.org/W2041812600","https://openalex.org/W2044227662","https://openalex.org/W2051019673","https://openalex.org/W2051638902","https://openalex.org/W2052397527","https://openalex.org/W2054466658","https://openalex.org/W2065168551","https://openalex.org/W2067986351","https://openalex.org/W2070050178","https://openalex.org/W2071491944","https://openalex.org/W2073511180","https://openalex.org/W2074178262","https://openalex.org/W2075184009","https://openalex.org/W2086802511","https://openalex.org/W2096173332","https://openalex.org/W2100996687","https://openalex.org/W2101084498","https://openalex.org/W2107281049","https://openalex.org/W2125987139","https://openalex.org/W2132416790","https://openalex.org/W2134542375","https://openalex.org/W2138049320","https://openalex.org/W2141152663","https://openalex.org/W2146337514","https://openalex.org/W2155846733","https://openalex.org/W2156563694","https://openalex.org/W2158409639","https://openalex.org/W2167355903","https://openalex.org/W2192708678","https://openalex.org/W2323939601","https://openalex.org/W2339814286","https://openalex.org/W2345356016","https://openalex.org/W2462053388","https://openalex.org/W2592240998","https://openalex.org/W2618691574","https://openalex.org/W2767569544","https://openalex.org/W2782454362","https://openalex.org/W2800578401","https://openalex.org/W2802314304","https://openalex.org/W2904655808","https://openalex.org/W2907894059","https://openalex.org/W2912671957","https://openalex.org/W2922476675","https://openalex.org/W2926691411","https://openalex.org/W2964395860","https://openalex.org/W2966582885","https://openalex.org/W2980159232","https://openalex.org/W2981754274","https://openalex.org/W2986002996","https://openalex.org/W3005037272","https://openalex.org/W3005380728","https://openalex.org/W3007033255","https://openalex.org/W3010854423","https://openalex.org/W3023457686","https://openalex.org/W3031041252","https://openalex.org/W3042756573","https://openalex.org/W3080500495","https://openalex.org/W3092039012","https://openalex.org/W3107334044","https://openalex.org/W3111507273","https://openalex.org/W3129109666","https://openalex.org/W3132620364","https://openalex.org/W3161094235","https://openalex.org/W3196560901","https://openalex.org/W3215914090","https://openalex.org/W3216146155","https://openalex.org/W4206809567","https://openalex.org/W4210857061","https://openalex.org/W4211262214","https://openalex.org/W4214620227","https://openalex.org/W4225337994","https://openalex.org/W4281864777","https://openalex.org/W4283274869","https://openalex.org/W4285030026","https://openalex.org/W4289836131","https://openalex.org/W4292485618","https://openalex.org/W4306291665","https://openalex.org/W4308834790","https://openalex.org/W4309653438","https://openalex.org/W4318824807","https://openalex.org/W4322743974","https://openalex.org/W4364320831","https://openalex.org/W4384120018","https://openalex.org/W4385396537","https://openalex.org/W4385422834","https://openalex.org/W4385971687","https://openalex.org/W4385984472","https://openalex.org/W4386379847","https://openalex.org/W4388509741","https://openalex.org/W4388656193","https://openalex.org/W4388775931","https://openalex.org/W4390032581","https://openalex.org/W4391641059","https://openalex.org/W4394687744","https://openalex.org/W4408403748","https://openalex.org/W4412159600"],"related_works":["https://openalex.org/W2981890739","https://openalex.org/W7212968863","https://openalex.org/W4281864777","https://openalex.org/W2802314304","https://openalex.org/W2525557074","https://openalex.org/W2030200977","https://openalex.org/W2896168224","https://openalex.org/W7119776607","https://openalex.org/W4212920968","https://openalex.org/W4394062245"],"abstract_inverted_index":{"Robust":[0],"3D":[1],"tissue":[2],"culture":[3],"models":[4],"to":[5,45,55],"activate":[6],"aged":[7,28,72],"fibroblasts":[8,29],"for":[9,41,63,104,129],"cell-based":[10],"therapies":[11],"and":[12,67,87,99,118,122,135],"identify":[13],"regulators":[14,114],"of":[15,59,115],"such":[16],"activation":[17,117],"are":[18],"still":[19],"missing.":[20],"In":[21,48,93],"our":[22],"previous":[23],"study,":[24,50],"we":[25,51,89,95,109],"showed":[26],"that":[27],"can":[30],"be":[31],"activated":[32],"simply":[33],"through":[34],"applying":[35],"compressive":[36],"force,":[37],"without":[38],"the":[39,57],"need":[40],"exogenous":[42],"factors,":[43],"leading":[44],"increased":[46],"migration.":[47],"this":[49],"develop":[52],"a":[53],"pipeline":[54],"evaluate":[56],"role":[58],"specific":[60],"pharmacological":[61],"inhibitors":[62],"transcription":[64],"factor":[65],"inference":[66],"cell":[68,97],"migration":[69,98],"involved":[70],"in":[71],"fibroblast":[73,116],"activation.":[74],"By":[75],"integrating":[76],"RNA-seq":[77],"data":[78],"with":[79],"bioinformatic":[80],"tools":[81],"(prize":[82],"collecting":[83],"Steiner":[84],"tree":[85],"method":[86],"iRegulon)":[88],"inferred":[90],"15":[91],"candidates.":[92,107],"addition,":[94],"used":[96],"heterochromatin":[100],"content":[101],"as":[102],"readouts":[103],"validating":[105],"these":[106],"Furthermore,":[108],"identified":[110],"three":[111],"potential":[112],"master":[113],"rejuvenation:":[119],"FOXO1,":[120],"STAT3,":[121],"PDK1.":[123],"These":[124],"findings":[125],"offer":[126],"valuable":[127],"insights":[128],"future":[130],"drug":[131],"discovery,":[132],"disease":[133],"modeling,":[134],"regenerative":[136],"medicine.":[137]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-11-27T00:00:00"}