{"id":"https://openalex.org/W4416718656","doi":"https://doi.org/10.1186/s12902-025-02094-w","title":"Immune-inflammation markers are related to hormone levels in polycystic ovary syndrome: a case-control study","display_name":"Immune-inflammation markers are related to hormone levels in polycystic ovary syndrome: a case-control study","publication_year":2025,"publication_date":"2025-11-26","ids":{"openalex":"https://openalex.org/W4416718656","doi":"https://doi.org/10.1186/s12902-025-02094-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/41299509"},"language":"en","primary_location":{"id":"doi:10.1186/s12902-025-02094-w","doi":"https://doi.org/10.1186/s12902-025-02094-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12902-025-02094-w","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12902-025-02094-w.pdf","source":{"id":"https://openalex.org/S61153829","display_name":"BMC Endocrine Disorders","issn_l":"1472-6823","issn":["1472-6823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Endocrine Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12902-025-02094-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070208104","display_name":"I\u015f\u0131l \u00c7ak\u0131r","orcid":"https://orcid.org/0000-0001-5728-4671","observed_orcids":["https://orcid.org/0000-0001-5728-4671","https://orcid.org/0000-0002-2573-7231"]},"institutions":[{"id":"https://openalex.org/I4210127232","display_name":"Kayseri E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/02ysppy04","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210127232"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Isil Cakir","raw_affiliation_strings":["Clinics of Biochemistry, Kayseri City Training and Research Hospital, Kayseri, T\u00fcrkiye. isilscakir@gmail.com","Clinics of Biochemistry, Kayseri City Training and Research Hospital, Kayseri, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-5728-4671","affiliations":[{"raw_affiliation_string":"Clinics of Biochemistry, Kayseri City Training and Research Hospital, Kayseri, T\u00fcrkiye. isilscakir@gmail.com","institution_ids":["https://openalex.org/I4210127232"]},{"raw_affiliation_string":"Clinics of Biochemistry, Kayseri City Training and Research Hospital, Kayseri, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210127232"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089459128","display_name":"Nuri \u00c7ak\u0131r","orcid":"https://orcid.org/0000-0002-9935-7397","observed_orcids":["https://orcid.org/0000-0002-9935-7397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nuri \u00c7akir","raw_affiliation_strings":["Clinics of Microbiology, Bunyan State Hospital, Kayseri, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-9935-7397","affiliations":[{"raw_affiliation_string":"Clinics of Microbiology, Bunyan State Hospital, Kayseri, T\u00fcrkiye","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070208104"],"corresponding_institution_ids":["https://openalex.org/I4210127232"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":1.4002,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.8394638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"25","issue":"1","first_page":"274","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":1.0},{"id":"https://openalex.org/keywords/systemic-immune-inflammation-index","display_name":"systemic immune-inflammation index","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pan-immune-inflammation-value","display_name":"pan-immune-inflammation value","score":0.9750000238418579},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6589999794960022},{"id":"https://openalex.org/keywords/serum-hormone-levels","display_name":"serum hormone levels","score":0.4909999966621399},{"id":"https://openalex.org/keywords/free-testosterone","display_name":"free testosterone","score":0.9210000038146973},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.8529999852180481},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8289999961853027},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9259999990463257},{"id":"https://openalex.org/keywords/17-hydroxyprogesterone","display_name":"17-hydroxyprogesterone","score":0.9120000004768372},{"id":"https://openalex.org/keywords/deoxycorticosterone","display_name":"deoxycorticosterone","score":0.9819999933242798},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8912000060081482},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.7921000123023987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6071000099182129},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5530999898910522},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5367000102996826},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.46540001034736633},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.29330000281333923},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C2778780466","wikidata":"https://www.wikidata.org/wiki/Q21108939","display_name":"Anti-M\u00fcllerian hormone","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.2590000033378601}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12902-025-02094-w","doi":"https://doi.org/10.1186/s12902-025-02094-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12902-025-02094-w","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12902-025-02094-w.pdf","source":{"id":"https://openalex.org/S61153829","display_name":"BMC Endocrine Disorders","issn_l":"1472-6823","issn":["1472-6823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Endocrine Disorders","raw_type":"journal-article"},{"id":"pmid:41299509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41299509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC endocrine disorders","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3ac5e302b4364d1fb3d11fd2bab06c73","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3ac5e302b4364d1fb3d11fd2bab06c73","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Endocrine Disorders, Vol 25, Iss 1, Pp 1-6 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12902-025-02094-w","doi":"https://doi.org/10.1186/s12902-025-02094-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12902-025-02094-w","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12902-025-02094-w.pdf","source":{"id":"https://openalex.org/S61153829","display_name":"BMC Endocrine Disorders","issn_l":"1472-6823","issn":["1472-6823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Endocrine Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416718656.pdf","grobid_xml":"https://content.openalex.org/works/W4416718656.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1978371060","https://openalex.org/W2065053712","https://openalex.org/W2107934474","https://openalex.org/W2346278661","https://openalex.org/W2548427433","https://openalex.org/W2801400869","https://openalex.org/W2941801625","https://openalex.org/W3015673024","https://openalex.org/W3143380783","https://openalex.org/W4214814908","https://openalex.org/W4398150246","https://openalex.org/W4403337417","https://openalex.org/W4403482330","https://openalex.org/W4403758867","https://openalex.org/W4403983099","https://openalex.org/W4403988370","https://openalex.org/W4404070307","https://openalex.org/W4404202511"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,100],"aimed":[2],"to":[3],"evaluate":[4],"the":[5,8,13,60,64,124,128,145],"relationships":[6],"between":[7,91],"pan":[9],"immune-inflammation":[10,15],"value":[11],"(PIV),":[12],"systemic":[14],"index":[16],"(SII),":[17],"and":[18,32,43,50,85,93,109,120,138,141,158,166],"hormonal":[19],"levels":[20,68,96],"in":[21,163,169],"patients":[22,170],"with":[23,115,117,171],"polycystic":[24],"ovary":[25],"syndrome":[26],"(PCOS).":[27],"METHODS:":[28],"),":[29],"prolactin,":[30],"free":[31,94],"total":[33],"testosterone,":[34],"estradiol,":[35],"luteinizing":[36],"hormone":[37,41],"(LH),":[38],"17-OH-progesterone,":[39],"follicle-stimulating":[40],"(FSH),":[42],"11-deoxycorticosterone":[44],"were":[45,52,113],"examined.":[46],"Hematological":[47],"indices,":[48],"SII":[49,106,125,157],"PIV,":[51],"calculated.":[53],"Receiver":[54],"operating":[55],"characteristic":[56],"(ROC)":[57],"analysis":[58],"showed":[59],"diagnostic":[61],"potential":[62],"of":[63],"research":[65],"parameters.":[66],"RESULTS:":[67],"(p":[69,97],"=":[70,73,76,79,98,153],"0.006,":[71],"p":[72,75,78,135,152],"0.003,":[74],"0.037,":[77],"0.042,":[80],"respectively).":[81],"A":[82],"statistically":[83],"significant":[84],"positive":[86],"correlation":[87],"was":[88],"also":[89],"observed":[90],"PIV":[92,110,146,159],"testosterone":[95],"0.008).":[99],"found":[101],"that":[102],"a":[103],"baseline":[104],"serum":[105],">":[107,111],"520.0":[108],"262.4":[112],"associated":[114],"PCOS":[116],"65%":[118],"specificity":[119,140],"61%":[121],"sensitivity":[122,143],"for":[123,144],"(area":[126],"under":[127],"curve":[129],"[AUC],":[130],"0.669;":[131],"95%":[132,149],"CI":[133,150],"0.584-0.755;":[134],"<":[136],"0.001)":[137],"58%":[139],"60%":[142],"([AUC],":[147],"0.642;":[148],"0.555-0.729;":[151],"0.002).":[154],"CONCLUSIONS:":[155],"Monitoring":[156],"may":[160],"assist":[161],"clinicians":[162],"evaluating":[164],"inflammation":[165],"treatment":[167],"needs":[168],"PCOS.":[172],"CLINICAL":[173],"TRIAL":[174],"NUMBER:":[175],"Not":[176],"applicable.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-11-27T00:00:00"}