{"id":"https://openalex.org/W4416715705","doi":"https://doi.org/10.2337/db25-0344","title":"Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice","display_name":"Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice","publication_year":2025,"publication_date":"2025-11-26","ids":{"openalex":"https://openalex.org/W4416715705","doi":"https://doi.org/10.2337/db25-0344","pmid":"https://pubmed.ncbi.nlm.nih.gov/41296511"},"language":"en","primary_location":{"id":"doi:10.2337/db25-0344","doi":"https://doi.org/10.2337/db25-0344","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db25-0344","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/doi/10.2337/db25-0344/848214/db250344.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/diabetes/article-pdf/doi/10.2337/db25-0344/848214/db250344.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jiahui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahui Li","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101525437","display_name":"Qinhui Liu","orcid":"https://orcid.org/0000-0001-9510-3704","observed_orcids":["https://orcid.org/0000-0001-9510-3704"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinhui Liu","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yimin Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yimin Xiong","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019609964","display_name":"Ying Xu","orcid":"https://orcid.org/0009-0004-6539-4431","observed_orcids":["https://orcid.org/0009-0004-6539-4431","https://orcid.org/0009-0006-8294-5287"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Xu","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042680232","display_name":"Jinhang Zhang","orcid":"https://orcid.org/0000-0001-8345-614X","observed_orcids":["https://orcid.org/0000-0001-8345-614X"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhang Zhang","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Xia","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035314144","display_name":"Xiandan Jing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiandan Jing","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101751750","display_name":"Zijing Zhang","orcid":"https://orcid.org/0000-0001-5312-8815","observed_orcids":["https://orcid.org/0000-0001-5312-8815","https://orcid.org/0000-0002-3990-1442"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zijing Zhang","raw_affiliation_strings":["West China School of Pharmacy, Sichuan University 2 , Chengdu, Sichuan Province, China","2West China School of Pharmacy, Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West China School of Pharmacy, Sichuan University 2 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"2West China School of Pharmacy, Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073772754","display_name":"Juan Pang","orcid":"https://orcid.org/0000-0001-6272-9890","observed_orcids":["https://orcid.org/0000-0001-6272-9890"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Pang","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023118214","display_name":"Cuiyuan Huang","orcid":"https://orcid.org/0000-0002-4780-6330","observed_orcids":["https://orcid.org/0000-0002-4780-6330"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuiyuan Huang","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102939826","display_name":"Haiying Song","orcid":"https://orcid.org/0000-0003-4086-6194","observed_orcids":["https://orcid.org/0000-0003-4086-6194"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiying Song","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101559301","display_name":"Ailin Zhang","orcid":"https://orcid.org/0000-0001-9598-3772","observed_orcids":["https://orcid.org/0000-0001-9598-3772"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ailin Zhang","raw_affiliation_strings":["West China School of Pharmacy, Sichuan University 2 , Chengdu, Sichuan Province, China","2West China School of Pharmacy, Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West China School of Pharmacy, Sichuan University 2 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"2West China School of Pharmacy, Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385648","display_name":"Yanping Li","orcid":"https://orcid.org/0000-0003-1811-0083","observed_orcids":["https://orcid.org/0000-0003-1811-0083"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanping Li","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101977579","display_name":"Qin Tang","orcid":"https://orcid.org/0000-0001-5279-0276","observed_orcids":["https://orcid.org/0000-0001-5279-0276"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Tang","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":"https://orcid.org/0000-0001-5279-0276","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036939586","display_name":"Jinhan He","orcid":"https://orcid.org/0000-0001-6487-4696","observed_orcids":["https://orcid.org/0000-0001-6487-4696"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhan He","raw_affiliation_strings":["Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","West China School of Pharmacy, Sichuan University 2 , Chengdu, Sichuan Province, China","1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","2West China School of Pharmacy, Sichuan University, Chengdu, Sichuan Province, China"],"raw_orcid":"https://orcid.org/0000-0001-6487-4696","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University 1 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"West China School of Pharmacy, Sichuan University 2 , Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"1Department of Pharmacy, Institute of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"2West China School of Pharmacy, Sichuan University, Chengdu, Sichuan Province, China","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8289,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.8716926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"75","issue":"2","first_page":"241","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgr5","display_name":"TGR5","score":0.9890000224113464},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.703000009059906},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9279999732971191},{"id":"https://openalex.org/keywords/adiponectin-secretion","display_name":"adiponectin secretion","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hepatic-fatty-acid-oxidation","display_name":"hepatic fatty acid oxidation","score":0.968999981880188},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.8169999718666077},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.5839999914169312},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":1.0},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C39321552","wikidata":"https://www.wikidata.org/wiki/Q18052005","display_name":"G protein-coupled bile acid receptor","level":3,"score":0.9474999904632568},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8691999912261963},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8535000085830688},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.75},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.7311999797821045},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.6488999724388123},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.6449000239372253},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.6115000247955322},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5267999768257141},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.49059998989105225},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.4632999897003174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4490000009536743},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.43689998984336853},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.40939998626708984},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.3831999897956848},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29829999804496765},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2870999872684479},{"id":"https://openalex.org/C106646824","wikidata":"https://www.wikidata.org/wiki/Q5425475","display_name":"FGF21","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C2994476132","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid oxidation","level":3,"score":0.2818000018596649},{"id":"https://openalex.org/C2909799055","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid Metabolism Disorder","level":4,"score":0.25760000944137573},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.25529998540878296}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/db25-0344","doi":"https://doi.org/10.2337/db25-0344","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db25-0344","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/doi/10.2337/db25-0344/848214/db250344.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:41296511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41296511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12823343","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12823343/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2337/db25-0344","doi":"https://doi.org/10.2337/db25-0344","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db25-0344","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/doi/10.2337/db25-0344/848214/db250344.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1497365197","display_name":null,"funder_award_id":"2023NSFSC1993","funder_id":"https://openalex.org/F4320322922","funder_display_name":"Department of Science and Technology of Sichuan Province"},{"id":"https://openalex.org/G2366422418","display_name":null,"funder_award_id":"Z2024YY003","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G2903987775","display_name":null,"funder_award_id":"Z2024YY003","funder_id":"https://openalex.org/F4320322990","funder_display_name":"Sichuan University"},{"id":"https://openalex.org/G2906485844","display_name":null,"funder_award_id":"82404771","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3326097881","display_name":null,"funder_award_id":"82025007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3451216598","display_name":null,"funder_award_id":"82300942","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3920132502","display_name":null,"funder_award_id":"U24A20676","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322922","display_name":"Department of Science and Technology of Sichuan Province","ror":"https://ror.org/04323m874"},{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"},{"id":"https://openalex.org/F4320336042","display_name":"West China Hospital, Sichuan University","ror":"https://ror.org/007mrxy13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416715705.pdf","grobid_xml":"https://content.openalex.org/works/W4416715705.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1937474708","https://openalex.org/W1967056255","https://openalex.org/W1997978122","https://openalex.org/W2006707076","https://openalex.org/W2010374889","https://openalex.org/W2011862326","https://openalex.org/W2029711011","https://openalex.org/W2053073979","https://openalex.org/W2053833972","https://openalex.org/W2081028309","https://openalex.org/W2081271380","https://openalex.org/W2095536002","https://openalex.org/W2126377012","https://openalex.org/W2134100055","https://openalex.org/W2508091231","https://openalex.org/W2513854344","https://openalex.org/W2588130051","https://openalex.org/W2770572235","https://openalex.org/W2783262542","https://openalex.org/W2907530724","https://openalex.org/W2944757497","https://openalex.org/W2949364854","https://openalex.org/W2964219562","https://openalex.org/W3081150122","https://openalex.org/W3140314728","https://openalex.org/W3154461390","https://openalex.org/W4220707881","https://openalex.org/W4291972730","https://openalex.org/W4292774827","https://openalex.org/W4319072834","https://openalex.org/W4379194087","https://openalex.org/W4381681857","https://openalex.org/W4386257722","https://openalex.org/W4388408775","https://openalex.org/W4392303948","https://openalex.org/W4395957187","https://openalex.org/W4403964783","https://openalex.org/W4405356785","https://openalex.org/W4406826155","https://openalex.org/W4409142802"],"related_works":[],"abstract_inverted_index":{"Metabolic":[0],"dysfunction\u2013associated":[1],"steatotic":[2,267],"liver":[3,28,268],"disease":[4,269],"(MASLD)":[5],"has":[6],"emerged":[7],"as":[8],"a":[9,33,149,202],"global":[10],"epidemic,":[11],"yet":[12],"its":[13,58,90],"underlying":[14],"molecular":[15],"mechanisms":[16],"remain":[17],"elusive,":[18],"and":[19,29,57,84,109,131,166,212,254],"therapeutic":[20,262,275],"options":[21,263],"are":[22],"limited.":[23],"The":[24],"interorgan":[25],"communication":[26,56],"between":[27],"adipose":[30,54,76,94,116,153,210,219,235],"tissue":[31,77,95,117,154,211,220,236],"plays":[32],"crucial":[34],"role":[35,45,151],"in":[36,53,74,92,124,156,182,209,218,233],"maintaining":[37],"hepatic":[38,61,107,111,127,133,162,169,184,192,222,250],"lipid":[39,62,134,193,223,257],"homeostasis.":[40],"This":[41],"study":[42],"investigates":[43],"the":[44,65,213,260,274],"of":[46,67,138,215,277],"G-protein\u2013coupled":[47],"bile":[48,175],"acid":[49,113,129,164,176,252],"receptor":[50,177],"1":[51,178],"(TGR5)":[52,179],"tissue-liver":[55],"impact":[59],"on":[60,221],"metabolism":[63,194],"during":[64],"progression":[66],"MASLD.":[68],"We":[69,197,225],"observed":[70],"that":[71,227],"TGR5":[72,102,118,155,190,207,216,228,242,280],"expression":[73,230],"white":[75,234],"was":[78,231],"significantly":[79],"upregulated":[80,232],"under":[81],"both":[82],"fasting":[83,200,238],"high-fat":[85,203],"diet":[86,204],"(HFD)":[87,205],"conditions,":[88],"whereas":[89],"levels":[91,208],"brown":[93],"remained":[96],"unchanged.":[97],"Notably,":[98],"mice":[99],"with":[100],"adipocyte-specific":[101],"deletion":[103],"exhibited":[104],"exacerbated":[105,255],"fasting/HFD-induced":[106],"steatosis":[108],"impaired":[110],"fatty":[112,128,163,251],"oxidation.":[114],"Mechanistically,":[115],"deficiency":[119,243],"reduced":[120],"adiponectin":[121,140,158,245],"secretion,":[122,159,246],"which":[123,247],"turn":[125],"suppressed":[126,249],"oxidation":[130,165,253],"aggravated":[132],"accumulation;":[135],"conversely,":[136],"restoration":[137],"circulating":[139],"rescued":[141],"these":[142],"metabolic":[143,265],"abnormalities.":[144],"Collectively,":[145],"our":[146,271],"findings":[147,272],"highlight":[148,273],"critical":[150],"for":[152,264,281],"promoting":[157],"thereby":[160],"enhancing":[161],"protecting":[167],"against":[168],"steatosis.":[170],"ARTICLE":[171],"HIGHLIGHTS:":[172],"Systemic":[173],"G-protein-coupled":[174],"is":[180],"involved":[181],"modulating":[183],"triglyceride":[185],"accumulation,":[186],"but":[187],"whether":[188,199],"adipose-derived":[189],"regulates":[191],"remains":[195],"undefined.":[196],"investigated":[198],"or":[201,239],"altered":[206],"effect":[214],"ablation":[217],"metabolism.":[224],"found":[226],"protein":[229],"upon":[237],"HFD.":[240],"Adipose-specific":[241],"decreased":[244],"ultimately":[248],"intrahepatic":[256],"deposition.":[258],"Given":[259],"limited":[261],"dysfunction-associated":[266],"(MASLD),":[270],"potential":[276],"targeting":[278],"adipocyte":[279],"MASLD":[282],"intervention.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-11-27T00:00:00"}
