{"id":"https://openalex.org/W4416701797","doi":"https://doi.org/10.1016/j.jddst.2025.107834","title":"RNA-encapsulated lipid nanoparticles for breast cancer therapy: Advances, challenges, and translational perspectives","display_name":"RNA-encapsulated lipid nanoparticles for breast cancer therapy: Advances, challenges, and translational perspectives","publication_year":2025,"publication_date":"2025-11-26","ids":{"openalex":"https://openalex.org/W4416701797","doi":"https://doi.org/10.1016/j.jddst.2025.107834"},"language":"en","primary_location":{"id":"doi:10.1016/j.jddst.2025.107834","doi":"https://doi.org/10.1016/j.jddst.2025.107834","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jddst.2025.107834","pdf_url":null,"source":{"id":"https://openalex.org/S97205441","display_name":"Journal of Drug Delivery Science and Technology","issn_l":"1773-2247","issn":["1773-2247","2588-8943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Asiya Jahan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Asiya Jahan","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120615731","display_name":"Aishani Vadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aishani Vadi","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019264503","display_name":"Urushi Rehman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Urushi Rehman","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089935999","display_name":"Khalid Mubarak Orayj","orcid":"https://orcid.org/0000-0001-6651-2306","observed_orcids":["https://orcid.org/0000-0001-6651-2306"]},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Khalid Orayj","raw_affiliation_strings":["Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha \u2013 Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha \u2013 Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064486951","display_name":"Asif Ansari Shaik Mohammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Asif Ansari Shaik Mohammad","raw_affiliation_strings":["Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha \u2013 Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha \u2013 Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Garima Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110360157","display_name":"Lovely Professional University","ror":"https://ror.org/00et6q107","country_code":"IN","type":"education","lineage":["https://openalex.org/I110360157"]},{"id":"https://openalex.org/I1281160679","display_name":"Graphic Era Hill University","ror":"https://ror.org/01bb4h160","country_code":"IN","type":"education","lineage":["https://openalex.org/I1281160679"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Garima Gupta","raw_affiliation_strings":["Graphic Era Hill University, Dehradun, 248002, India","School of Allied Medical Sciences, Lovely Professional University, Phagwara, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graphic Era Hill University, Dehradun, 248002, India","institution_ids":["https://openalex.org/I1281160679"]},{"raw_affiliation_string":"School of Allied Medical Sciences, Lovely Professional University, Phagwara, Punjab, India","institution_ids":["https://openalex.org/I110360157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016364986","display_name":"Khang Wen Goh","orcid":"https://orcid.org/0000-0001-6686-7019","observed_orcids":["https://orcid.org/0000-0001-6686-7019"]},"institutions":[{"id":"https://openalex.org/I12649496","display_name":"INTI International University","ror":"https://ror.org/03fj82m46","country_code":"MY","type":"education","lineage":["https://openalex.org/I12649496"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Khang Wen Goh","raw_affiliation_strings":["Faculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia","institution_ids":["https://openalex.org/I12649496"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045032651","display_name":"Prashant Kesharwani","orcid":"https://orcid.org/0000-0002-0890-769X","observed_orcids":["https://orcid.org/0000-0002-0890-769X"]},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN","TW"],"is_corresponding":true,"raw_author_name":"Prashant Kesharwani","raw_affiliation_strings":["Department of Research and Development, Asia University, Taichung, Taiwan","Next-Generation Translational Nanomedicine Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, 470003, India"],"raw_orcid":"https://orcid.org/0000-0002-0890-769X","affiliations":[{"raw_affiliation_string":"Department of Research and Development, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Next-Generation Translational Nanomedicine Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, 470003, India","institution_ids":["https://openalex.org/I8977528"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045032651"],"corresponding_institution_ids":["https://openalex.org/I143578492","https://openalex.org/I8977528"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.4806,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58534331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"115","issue":null,"first_page":"107834","last_page":"107834"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.8640000224113464},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rna-therapeutics","display_name":"RNA therapeutics","score":0.7080000042915344},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.8270000219345093},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.859000027179718},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.781000018119812},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":1.0},{"id":"https://openalex.org/keywords/ph-sensitive-liposomes","display_name":"pH-sensitive liposomes","score":0.5979999899864197},{"id":"https://openalex.org/keywords/combination-therapy-with-chemotherapy-and-radiotherapy","display_name":"combination therapy with chemotherapy and radiotherapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7680000066757202},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.878000020980835},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7129999995231628},{"id":"https://openalex.org/keywords/translational-barriers","display_name":"translational barriers","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6825000047683716},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5835999846458435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49970000982284546},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49959999322891235},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4684999883174896},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.421099990606308},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4002000093460083},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.35989999771118164},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.3353999853134155},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.32989999651908875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3296000063419342},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.3181000053882599},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.31520000100135803},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31150001287460327},{"id":"https://openalex.org/C2986637895","wikidata":"https://www.wikidata.org/wiki/Q953865","display_name":"Breast tumor","level":4,"score":0.3019999861717224},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.2639999985694885},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.25999999046325684},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.259799987077713},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.2540000081062317}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jddst.2025.107834","doi":"https://doi.org/10.1016/j.jddst.2025.107834","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jddst.2025.107834","pdf_url":null,"source":{"id":"https://openalex.org/S97205441","display_name":"Journal of Drug Delivery Science and Technology","issn_l":"1773-2247","issn":["1773-2247","2588-8943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery Science and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G333346095","display_name":null,"funder_award_id":"RGP1/107/46","funder_id":"https://openalex.org/F4320324433","funder_display_name":"King Khalid University"}],"funders":[{"id":"https://openalex.org/F4320324433","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":112,"referenced_works":["https://openalex.org/W282913044","https://openalex.org/W1519070462","https://openalex.org/W1680239125","https://openalex.org/W1984813107","https://openalex.org/W2014495927","https://openalex.org/W2072715976","https://openalex.org/W2075370291","https://openalex.org/W2080568253","https://openalex.org/W2088467380","https://openalex.org/W2216033157","https://openalex.org/W2281253913","https://openalex.org/W2338891548","https://openalex.org/W2468054108","https://openalex.org/W2507121191","https://openalex.org/W2512243744","https://openalex.org/W2562448283","https://openalex.org/W2630192492","https://openalex.org/W2735580466","https://openalex.org/W2782708334","https://openalex.org/W2784014313","https://openalex.org/W2802528458","https://openalex.org/W2927692082","https://openalex.org/W2966365653","https://openalex.org/W2969814123","https://openalex.org/W2990796297","https://openalex.org/W2995314014","https://openalex.org/W3005651655","https://openalex.org/W3009337396","https://openalex.org/W3017324634","https://openalex.org/W3033869790","https://openalex.org/W3035225041","https://openalex.org/W3045863217","https://openalex.org/W3047836554","https://openalex.org/W3084463300","https://openalex.org/W3107598770","https://openalex.org/W3115880421","https://openalex.org/W3123440589","https://openalex.org/W3124720941","https://openalex.org/W3131796252","https://openalex.org/W3135672591","https://openalex.org/W3137730516","https://openalex.org/W3140707844","https://openalex.org/W3148255637","https://openalex.org/W3157481317","https://openalex.org/W3162573864","https://openalex.org/W3162871690","https://openalex.org/W3165220965","https://openalex.org/W3175813320","https://openalex.org/W3176002381","https://openalex.org/W3188940990","https://openalex.org/W3190273266","https://openalex.org/W3193347331","https://openalex.org/W3199764067","https://openalex.org/W4200179699","https://openalex.org/W4200304551","https://openalex.org/W4200536503","https://openalex.org/W4200556062","https://openalex.org/W4205687692","https://openalex.org/W4210434054","https://openalex.org/W4210534116","https://openalex.org/W4221023617","https://openalex.org/W4224246487","https://openalex.org/W4229452462","https://openalex.org/W4282550182","https://openalex.org/W4282829301","https://openalex.org/W4285731554","https://openalex.org/W4289134391","https://openalex.org/W4289712318","https://openalex.org/W4295290118","https://openalex.org/W4300818743","https://openalex.org/W4300981846","https://openalex.org/W4309935873","https://openalex.org/W4311284752","https://openalex.org/W4312056095","https://openalex.org/W4313488537","https://openalex.org/W4320498039","https://openalex.org/W4320855990","https://openalex.org/W4322769887","https://openalex.org/W4360976563","https://openalex.org/W4378782084","https://openalex.org/W4378782363","https://openalex.org/W4380568974","https://openalex.org/W4381854517","https://openalex.org/W4382068653","https://openalex.org/W4382893761","https://openalex.org/W4382931279","https://openalex.org/W4383369517","https://openalex.org/W4383532757","https://openalex.org/W4385326830","https://openalex.org/W4386188112","https://openalex.org/W4388651232","https://openalex.org/W4388698606","https://openalex.org/W4389010473","https://openalex.org/W4389159526","https://openalex.org/W4391147116","https://openalex.org/W4391248407","https://openalex.org/W4392159382","https://openalex.org/W4394823145","https://openalex.org/W4399097159","https://openalex.org/W4399282288","https://openalex.org/W4401585919","https://openalex.org/W4401729380","https://openalex.org/W4401870013","https://openalex.org/W4403477146","https://openalex.org/W4403558589","https://openalex.org/W4403904867","https://openalex.org/W4405239772","https://openalex.org/W4406071921","https://openalex.org/W4407116243","https://openalex.org/W4409628148","https://openalex.org/W4411920633","https://openalex.org/W4414115329"],"related_works":["https://openalex.org/W4399282288","https://openalex.org/W3090996439","https://openalex.org/W7170189149","https://openalex.org/W4392103953","https://openalex.org/W4383552050","https://openalex.org/W7152675636","https://openalex.org/W4414979969","https://openalex.org/W4405373018","https://openalex.org/W4403548761","https://openalex.org/W7130434672"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-11-27T00:00:00"}