{"id":"https://openalex.org/W4416701512","doi":"https://doi.org/10.1093/femsle/fnaf134","title":"Antibacterial and potentiating activity of 3-methoxycinnamic acid on antibiotics: an in vitro and in silico approach","display_name":"Antibacterial and potentiating activity of 3-methoxycinnamic acid on antibiotics: an in vitro and in silico approach","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4416701512","doi":"https://doi.org/10.1093/femsle/fnaf134","pmid":"https://pubmed.ncbi.nlm.nih.gov/41294272"},"language":"en","primary_location":{"id":"doi:10.1093/femsle/fnaf134","doi":"https://doi.org/10.1093/femsle/fnaf134","is_oa":false,"landing_page_url":"https://doi.org/10.1093/femsle/fnaf134","pdf_url":null,"source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050137443","display_name":"Jos\u00e9 Thy\u00e1lisson da Costa Silva","orcid":"https://orcid.org/0009-0002-7522-2989","observed_orcids":["https://orcid.org/0009-0002-7522-2989"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Thy\u00e1lisson da Costa Silva","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089773363","display_name":"Rafael Pereira da Cruz","orcid":"https://orcid.org/0000-0002-1806-7380","observed_orcids":["https://orcid.org/0000-0002-1806-7380"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael Pereira da Cruz","raw_affiliation_strings":["Center for Biosciences, Federal University of Pernambuco \u2013 UFPE , 50670\u2013901, Recife \u2013 PE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biosciences, Federal University of Pernambuco \u2013 UFPE , 50670\u2013901, Recife \u2013 PE ,","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110923783","display_name":"Ewerton Yago de Sousa Rodrigues","orcid":"https://orcid.org/0000-0001-9395-2008","observed_orcids":["https://orcid.org/0000-0001-9395-2008"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ewerton Yago de Sousa Rodrigues","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111816787","display_name":"Maria Yasmin C\u00e2ndido de Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Yasmin C\u00e2ndido de Oliveira","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083364338","display_name":"Ademar Maia Filho","orcid":"https://orcid.org/0000-0002-4466-6512","observed_orcids":["https://orcid.org/0000-0002-4466-6512"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ademar Maia\u00a0Filho","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112375816","display_name":"C\u00edcera Laura Roque Paulo","orcid":"https://orcid.org/0000-0001-5873-5892","observed_orcids":["https://orcid.org/0000-0001-5873-5892"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cicera Laura Roque Paulo","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guilherme Fernandes Teixeira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Fernandes Teixeira","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090636760","display_name":"Adrielle Rodrigues Costa","orcid":"https://orcid.org/0000-0003-1518-0115","observed_orcids":["https://orcid.org/0000-0003-1518-0115"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adrielle Rodrigues Costa","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002999558","display_name":"Jana\u00edna Esmeraldo Rocha","orcid":"https://orcid.org/0000-0001-7680-0651","observed_orcids":["https://orcid.org/0000-0001-7680-0651"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jana\u00edna Esmeraldo Rocha","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067122689","display_name":"Isaac Moura Ara\u00fajo","orcid":"https://orcid.org/0000-0002-6544-0141","observed_orcids":["https://orcid.org/0000-0002-6544-0141"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isaac Moura Araujo","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033645555","display_name":"Viviane Bezerra da Silva","orcid":"https://orcid.org/0000-0003-0581-2609","observed_orcids":["https://orcid.org/0000-0003-0581-2609"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Viviane Bezerra da Silva","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114159132","display_name":"Maria Eloyse de Melo Sousa","orcid":"https://orcid.org/0009-0002-2659-5869","observed_orcids":["https://orcid.org/0009-0002-2659-5869"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Eloyse de Melo Sousa","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114096649","display_name":"Anita Oliveira Brito Pereira Bezerra Martins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anita Oliveira Brito Pereira Bezerra Martins","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009436951","display_name":"Severino Den\u00edcio Gon\u00e7alves de Sousa","orcid":"https://orcid.org/0000-0002-8706-4941","observed_orcids":["https://orcid.org/0000-0002-8706-4941"]},"institutions":[{"id":"https://openalex.org/I32725510","display_name":"Universidade Federal de Mato Grosso","ror":"https://ror.org/01mqvjv41","country_code":"BR","type":"education","lineage":["https://openalex.org/I32725510"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Severino Denicio Gon\u00e7alves de Sousa","raw_affiliation_strings":["Universidade Federal de Mato Grosso , Cuiab\u00e1 \u2013 UFMT, 78060\u2013900, Cuiab\u00e1 \u2013 MT ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Mato Grosso , Cuiab\u00e1 \u2013 UFMT, 78060\u2013900, Cuiab\u00e1 \u2013 MT ,","institution_ids":["https://openalex.org/I32725510"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Antonio C\u00e9sar Vieira da Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Antonio C\u00e9sar Vieira da Silva","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046892243","display_name":"Carlos Alonso Leite dos Santos","orcid":"https://orcid.org/0009-0008-6626-3117","observed_orcids":["https://orcid.org/0009-0008-6626-3117"]},"institutions":[{"id":"https://openalex.org/I4210090750","display_name":"Universidade Federal do Cariri","ror":"https://ror.org/00a4xxf76","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210090750"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos Alonso Leite dos Santos","raw_affiliation_strings":["Center of Agricultural Sciences and Biodiversity, Federal University of Cariri - UFCA , 63130-025, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Agricultural Sciences and Biodiversity, Federal University of Cariri - UFCA , 63130-025, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210090750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116732632","display_name":"Jefferson de Sales Diodato","orcid":"https://orcid.org/0009-0005-9609-1561","observed_orcids":["https://orcid.org/0009-0005-9609-1561"]},"institutions":[{"id":"https://openalex.org/I4210090750","display_name":"Universidade Federal do Cariri","ror":"https://ror.org/00a4xxf76","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210090750"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jefferson de Sales Diodato","raw_affiliation_strings":["Center of Agricultural Sciences and Biodiversity, Federal University of Cariri - UFCA , 63130-025, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Agricultural Sciences and Biodiversity, Federal University of Cariri - UFCA , 63130-025, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210090750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021850194","display_name":"Jos\u00e9 Maria Barbosa\u2010Filho","orcid":"https://orcid.org/0000-0002-9567-4096","observed_orcids":["https://orcid.org/0000-0002-9567-4096"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Maria Barbosa Filho","raw_affiliation_strings":["Federal University of Para\u00edba \u2013 UFPB Department of Pharmacy, , 58059\u2013900, Jo\u00e3o Pessoa \u2013 PB ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Para\u00edba \u2013 UFPB Department of Pharmacy, , 58059\u2013900, Jo\u00e3o Pessoa \u2013 PB ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054485146","display_name":"Henrique Douglas Melo Coutinho","orcid":"https://orcid.org/0000-0002-6634-4207","observed_orcids":["https://orcid.org/0000-0002-6634-4207"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Henrique Douglas Melo Coutinho","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":"https://orcid.org/0000-0002-6634-4207","affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066070259","display_name":"Jos\u00e9 Weverton Almeida\u2010Bezerra","orcid":"https://orcid.org/0000-0002-0966-9750","observed_orcids":["https://orcid.org/0000-0002-0966-9750"]},"institutions":[{"id":"https://openalex.org/I4210162876","display_name":"Universidade Regional do Cariri","ror":"https://ror.org/05y26ar20","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210162876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Weverton Almeida-Bezerra","raw_affiliation_strings":["Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional University of Cariri \u2013 URCA Department of Biological Chemistry, , 63105-000, Crato \u2013 CE ,","institution_ids":["https://openalex.org/I4210162876"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054485146"],"corresponding_institution_ids":["https://openalex.org/I4210162876"],"apc_list":{"value":2500,"currency":"GBP","value_usd":3297},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"372","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.21559999883174896,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-potentiation","display_name":"antibiotic potentiation","score":0.5519999861717224},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ampicillin","display_name":"ampicillin","score":0.996999979019165},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9810000061988831},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.6790000200271606},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.824999988079071},{"id":"https://openalex.org/keywords/admet-properties","display_name":"ADMET properties","score":0.6729999780654907},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7689999938011169},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.6877999901771545},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6696000099182129},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6287000179290771},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6233000159263611},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5737000107765198},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5281999707221985},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.513700008392334},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5034000277519226},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.48539999127388},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4828999936580658},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.4787999987602234},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.4772999882698059},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4564000070095062},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42969998717308044},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4242999851703644},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41510000824928284},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.3806999921798706},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.31610000133514404},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.3140000104904175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3091999888420105},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27709999680519104},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.2766999900341034},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2621999979019165}],"mesh":[{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/femsle/fnaf134","doi":"https://doi.org/10.1093/femsle/fnaf134","is_oa":false,"landing_page_url":"https://doi.org/10.1093/femsle/fnaf134","pdf_url":null,"source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},{"id":"pmid:41294272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41294272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS microbiology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323202","display_name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/007pgtp80"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W2022100000","https://openalex.org/W2031213053","https://openalex.org/W2098278612","https://openalex.org/W2130479394","https://openalex.org/W2134967712","https://openalex.org/W2896980512","https://openalex.org/W2900523514","https://openalex.org/W2923171352","https://openalex.org/W2970190800","https://openalex.org/W2982531295","https://openalex.org/W2987019646","https://openalex.org/W3112882148","https://openalex.org/W3154258817","https://openalex.org/W3168436232","https://openalex.org/W3175946130","https://openalex.org/W3176806186","https://openalex.org/W3177256857","https://openalex.org/W3178219047","https://openalex.org/W3188967889","https://openalex.org/W3205045387","https://openalex.org/W3205657162","https://openalex.org/W3212547467","https://openalex.org/W3216238012","https://openalex.org/W4205455209","https://openalex.org/W4244629905","https://openalex.org/W4281390238","https://openalex.org/W4291022745","https://openalex.org/W4295422352","https://openalex.org/W4297999967","https://openalex.org/W4308493722","https://openalex.org/W4309039831","https://openalex.org/W4319063331","https://openalex.org/W4324140019","https://openalex.org/W4386780393","https://openalex.org/W4393936599","https://openalex.org/W4401123106","https://openalex.org/W4401973455","https://openalex.org/W4402580625","https://openalex.org/W4405003197","https://openalex.org/W4406305708","https://openalex.org/W4407599672","https://openalex.org/W4410264422","https://openalex.org/W4413858236"],"related_works":["https://openalex.org/W4417286098","https://openalex.org/W4410264422","https://openalex.org/W7214735102","https://openalex.org/W4412759307","https://openalex.org/W4416016103","https://openalex.org/W4405737052","https://openalex.org/W7169158202","https://openalex.org/W4399979140","https://openalex.org/W7171776591","https://openalex.org/W4381054194"],"abstract_inverted_index":{"Antimicrobial":[0],"resistance":[1,122],"is":[2],"a":[3],"global":[4],"health":[5],"threat":[6],"driven":[7],"by":[8],"mechanisms":[9],"like":[10],"biofilm":[11],"formation":[12],"and":[13,24,34,63,84,109,135],"efflux":[14],"pumps.":[15],"This":[16],"study":[17],"evaluated":[18],"the":[19,51],"antibacterial":[20,43],"activity,":[21],"antibiotic-modulating":[22],"potential,":[23],"pharmacokinetic":[25],"properties":[26],"of":[27,53],"3-methoxycinnamic":[28],"acid":[29],"(3MCA)":[30],"using":[31],"in":[32,35,126],"vitro":[33],"silico":[36],"methods.":[37],"Although":[38],"3MCA":[39,116],"showed":[40,98],"no":[41,80],"direct":[42],"effect":[44],"(MIC":[45],">":[46],"512":[47],"\u03bcg/ml),":[48],"it":[49],"enhanced":[50],"efficacy":[52],"gentamicin":[54],"against":[55,65],"multidrug-resistant":[56],"(MDR)":[57],"Escherichia":[58],"coli":[59],"(60.3%":[60],"MIC":[61],"reduction)":[62],"ampicillin":[64],"MDR":[66],"Staphylococcus":[67],"aureus":[68],"(37%":[69],"reduction).":[70],"ADMET":[71],"analysis":[72],"revealed":[73],"good":[74],"drug-like":[75],"properties,":[76],"low":[77],"intestinal":[78],"absorption,":[79],"interaction":[81],"with":[82],"P-glycoprotein,":[83],"effective":[85],"blood-brain":[86],"barrier":[87],"penetration,":[88],"but":[89],"potential":[90],"toxicological":[91],"risks":[92],"such":[93],"as":[94,119],"hepatotoxicity.":[95],"Molecular":[96],"docking":[97],"moderate":[99],"binding":[100],"affinities":[101],"to":[102,131],"target":[103],"proteins":[104],"through":[105],"stable":[106],"hydrogen":[107],"bonds":[108],"aromatic":[110],"interactions.":[111],"These":[112],"results":[113],"suggest":[114],"that":[115],"may":[117],"act":[118],"an":[120],"antibiotic":[121],"modulator,":[123],"although":[124],"further":[125],"vivo":[127],"studies":[128],"are":[129],"necessary":[130],"confirm":[132],"its":[133],"safety":[134],"therapeutic":[136],"potential.":[137]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-11-27T00:00:00"}
