{"id":"https://openalex.org/W4416670735","doi":"https://doi.org/10.1158/1078-0432.30709380","title":"Figure S4 from Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma","display_name":"Figure S4 from Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416670735","doi":"https://doi.org/10.1158/1078-0432.30709380"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.30709380","doi":"https://doi.org/10.1158/1078-0432.30709380","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709380","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S4_from_Subsets_of_IFN_Signaling_Predict_Response_to_Immune_Checkpoint_Blockade_in_Patients_with_Melanoma/30709380/1/files/59834202.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S4_from_Subsets_of_IFN_Signaling_Predict_Response_to_Immune_Checkpoint_Blockade_in_Patients_with_Melanoma/30709380/1/files/59834202.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065832289","display_name":"Brooke Horowitch","orcid":"https://orcid.org/0000-0001-6499-978X","observed_orcids":["https://orcid.org/0000-0001-6499-978X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brooke Horowitch","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6499-978X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101955075","display_name":"Daniel Y. Lee","orcid":"https://orcid.org/0000-0001-9106-9342","observed_orcids":["https://orcid.org/0000-0001-9106-9342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Y. Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9106-9342","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034631075","display_name":"Min Ding","orcid":"https://orcid.org/0009-0006-6173-523X","observed_orcids":["https://orcid.org/0009-0006-6173-523X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Ding","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-6173-523X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069463643","display_name":"Sandra Mart\u00ednez-Morilla","orcid":"https://orcid.org/0000-0003-0931-4906","observed_orcids":["https://orcid.org/0000-0003-0931-4906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Martinez-Morilla","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0931-4906","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011946828","display_name":"Thazin Nwe Aung","orcid":"https://orcid.org/0000-0003-4150-0426","observed_orcids":["https://orcid.org/0000-0003-4150-0426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thazin Nwe Aung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4150-0426","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000678671","display_name":"Feriel Ouerghi","orcid":"https://orcid.org/0009-0000-7841-1713","observed_orcids":["https://orcid.org/0009-0000-7841-1713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feriel Ouerghi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-7841-1713","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634477","display_name":"Xueting Wang","orcid":"https://orcid.org/0000-0002-1005-3072","observed_orcids":["https://orcid.org/0000-0002-1005-3072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueting Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1005-3072","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073006325","display_name":"Wei Wei","orcid":"https://orcid.org/0000-0003-1263-5620","observed_orcids":["https://orcid.org/0000-0003-1263-5620"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Wei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1263-5620","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003399089","display_name":"William Damsky","orcid":"https://orcid.org/0000-0003-0975-4071","observed_orcids":["https://orcid.org/0000-0003-0975-4071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Damsky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0975-4071","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102750517","display_name":"Mario Sznol","orcid":"https://orcid.org/0000-0003-4137-9662","observed_orcids":["https://orcid.org/0000-0003-4137-9662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Sznol","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4137-9662","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001175430","display_name":"Harriet M. Kluger","orcid":"https://orcid.org/0000-0002-4932-9873","observed_orcids":["https://orcid.org/0000-0002-4932-9873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harriet Kluger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4932-9873","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L. Rimm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5820-4397","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067516923","display_name":"Jeffrey Joseph Ishizuka","orcid":"https://orcid.org/0000-0002-4271-7312","observed_orcids":["https://orcid.org/0000-0002-4271-7312"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey J. Ishizuka","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4271-7312","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7540000081062317},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.8560000061988831},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7260000109672546},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.7239999771118164},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6765999794006348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6302000284194946},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.6013000011444092},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5751000046730042},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5224000215530396},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.3659000098705292},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.35670000314712524},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.35440000891685486},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34880000352859497},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.3093999922275543},{"id":"https://openalex.org/C169382597","wikidata":"https://www.wikidata.org/wiki/Q21208025","display_name":"Programmed cell death 1","level":5,"score":0.3061000108718872},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.2743000090122223},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.2678000032901764},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.2623000144958496},{"id":"https://openalex.org/C21705690","wikidata":"https://www.wikidata.org/wiki/Q2907609","display_name":"CTLA-4","level":4,"score":0.2614000141620636},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.25519999861717224}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.30709380","doi":"https://doi.org/10.1158/1078-0432.30709380","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709380","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S4_from_Subsets_of_IFN_Signaling_Predict_Response_to_Immune_Checkpoint_Blockade_in_Patients_with_Melanoma/30709380/1/files/59834202.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30709380","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Figure_S4_from_Subsets_of_IFN_Signaling_Predict_Response_to_Immune_Checkpoint_Blockade_in_Patients_with_Melanoma/30709380","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.30709380","doi":"https://doi.org/10.1158/1078-0432.30709380","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709380","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S4_from_Subsets_of_IFN_Signaling_Predict_Response_to_Immune_Checkpoint_Blockade_in_Patients_with_Melanoma/30709380/1/files/59834202.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416670735.pdf","grobid_xml":"https://content.openalex.org/works/W4416670735.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402787592","https://openalex.org/W4385457764","https://openalex.org/W4402802791","https://openalex.org/W4380488760","https://openalex.org/W4378348559","https://openalex.org/W4402788322","https://openalex.org/W4380568965","https://openalex.org/W4380481334","https://openalex.org/W4402799276","https://openalex.org/W4402800694"],"abstract_inverted_index":{"Supplemental":[0],"Figure":[1],"4:":[2],"STAT1":[3],"in":[4],"the":[5],"nuclear":[6,16],"compartment":[7],"consistently":[8],"predicts":[9],"ICI":[10],"response":[11],"and":[12],"survival":[13],"but":[14],"not":[15],"pSTAT1Y701":[17],"or":[18],"tumor/stromal":[19],"PD-L1":[20]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-25T00:00:00"}