{"id":"https://openalex.org/W4416670634","doi":"https://doi.org/10.1158/1078-0432.30709470","title":"Supplementary Figure S4 from DNA-Methylome\u2013Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy","display_name":"Supplementary Figure S4 from DNA-Methylome\u2013Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416670634","doi":"https://doi.org/10.1158/1078-0432.30709470"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.30709470","doi":"https://doi.org/10.1158/1078-0432.30709470","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709470","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S4_from_DNA-Methylome_Based_Tumor_Hypoxia_Classifier_Identifies_HPV-Negative_Head_and_Neck_Cancer_Patients_at_Risk_for_Locoregional_Recurrence_after_Primary_Radiochemotherapy/30709470/1/files/59834292.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S4_from_DNA-Methylome_Based_Tumor_Hypoxia_Classifier_Identifies_HPV-Negative_Head_and_Neck_Cancer_Patients_at_Risk_for_Locoregional_Recurrence_after_Primary_Radiochemotherapy/30709470/1/files/59834292.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067318323","display_name":"Bouchra Tawk","orcid":"https://orcid.org/0000-0002-7006-2026","observed_orcids":["https://orcid.org/0000-0002-7006-2026"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bouchra Tawk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7006-2026","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032060230","display_name":"Katrin Rein","orcid":"https://orcid.org/0009-0007-2467-4420","observed_orcids":["https://orcid.org/0009-0007-2467-4420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katrin Rein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-2467-4420","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004854883","display_name":"Christian Schwager","orcid":"https://orcid.org/0000-0003-4945-0347","observed_orcids":["https://orcid.org/0000-0003-4945-0347"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Schwager","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4945-0347","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058130130","display_name":"Maximilian Knoll","orcid":"https://orcid.org/0000-0002-9037-3980","observed_orcids":["https://orcid.org/0000-0002-9037-3980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maximilian Knoll","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9037-3980","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038649660","display_name":"Ute Wirkner","orcid":"https://orcid.org/0009-0006-3330-7633","observed_orcids":["https://orcid.org/0009-0006-3330-7633"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ute Wirkner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-3330-7633","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071865752","display_name":"Juliane H\u00f6rner\u2010Rieber","orcid":"https://orcid.org/0000-0003-3911-4438","observed_orcids":["https://orcid.org/0000-0003-3911-4438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juliane H\u00f6rner-Rieber","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3911-4438","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019737145","display_name":"Jakob Liermann","orcid":"https://orcid.org/0000-0002-1445-1940","observed_orcids":["https://orcid.org/0000-0002-1445-1940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jakob Liermann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1445-1940","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039276843","display_name":"Ina Kurth","orcid":"https://orcid.org/0000-0001-9261-5165","observed_orcids":["https://orcid.org/0000-0001-9261-5165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ina Kurth","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9261-5165","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060394068","display_name":"Panagiotis Balermpas","orcid":"https://orcid.org/0000-0001-5261-6446","observed_orcids":["https://orcid.org/0000-0001-5261-6446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Panagiotis Balermpas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5261-6446","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020511633","display_name":"Claus Michael R\u00f6del","orcid":"https://orcid.org/0009-0006-1777-2359","observed_orcids":["https://orcid.org/0009-0006-1777-2359"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claus R\u00f6del","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7409-7093","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067761254","display_name":"Annett Linge","orcid":"https://orcid.org/0000-0001-9636-1721","observed_orcids":["https://orcid.org/0000-0001-9636-1721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annett Linge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9636-1721","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061093685","display_name":"Steffen L\u00f6ck","orcid":"https://orcid.org/0000-0002-7017-3738","observed_orcids":["https://orcid.org/0000-0002-7017-3738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steffen L\u00f6ck","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7017-3738","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038338085","display_name":"Fabian Lohaus","orcid":"https://orcid.org/0000-0003-4043-7066","observed_orcids":["https://orcid.org/0000-0003-4043-7066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabian Lohaus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4043-7066","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045907839","display_name":"Ingeborg Tinhofer","orcid":"https://orcid.org/0000-0002-0512-549X","observed_orcids":["https://orcid.org/0000-0002-0512-549X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ingeborg Tinhofer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0512-549X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028492548","display_name":"Mechthild Krause","orcid":"https://orcid.org/0000-0003-1776-9556","observed_orcids":["https://orcid.org/0000-0003-1776-9556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mechtild Krause","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1776-9556","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071494218","display_name":"Martin Stuschke","orcid":"https://orcid.org/0000-0001-6836-0940","observed_orcids":["https://orcid.org/0000-0001-6836-0940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Stuschke","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6836-0940","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043313789","display_name":"Anca\u2010Ligia Grosu","orcid":"https://orcid.org/0000-0003-2255-2255","observed_orcids":["https://orcid.org/0000-0003-2255-2255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anca Ligia Grosu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2255-2255","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002463670","display_name":"Daniel Zips","orcid":"https://orcid.org/0000-0001-5779-9675","observed_orcids":["https://orcid.org/0000-0001-5779-9675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Zips","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5779-9675","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032259979","display_name":"Stephanie Elisabeth Combs","orcid":"https://orcid.org/0000-0002-5233-1536","observed_orcids":["https://orcid.org/0000-0002-5233-1536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie E. Combs","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5233-1536","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038323479","display_name":"Claus Belka","orcid":"https://orcid.org/0000-0002-1287-7825","observed_orcids":["https://orcid.org/0000-0002-1287-7825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claus Belka","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1287-7825","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026607584","display_name":"Albrecht Stenzinger","orcid":"https://orcid.org/0000-0003-1001-103X","observed_orcids":["https://orcid.org/0000-0003-1001-103X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Albrecht Stenzinger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1001-103X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025477516","display_name":"Christel C. Herold\u2010Mende","orcid":"https://orcid.org/0000-0002-1915-745X","observed_orcids":["https://orcid.org/0000-0002-1915-745X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christel Herold-Mende","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1915-745X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083101824","display_name":"Michael A. Baumann","orcid":"https://orcid.org/0000-0002-9340-974X","observed_orcids":["https://orcid.org/0000-0002-9340-974X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Baumann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9340-974X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081978650","display_name":"Peter Schirmacher","orcid":"https://orcid.org/0000-0002-0950-3339","observed_orcids":["https://orcid.org/0000-0002-0950-3339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Schirmacher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0950-3339","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078003238","display_name":"J\u00fcrgen Debus","orcid":"https://orcid.org/0000-0002-6411-4811","observed_orcids":["https://orcid.org/0000-0002-6411-4811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Debus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6411-4811","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075116222","display_name":"Amir Abdollahi","orcid":"https://orcid.org/0000-0002-8016-5897","observed_orcids":["https://orcid.org/0000-0002-8016-5897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amir Abdollahi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8016-5897","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-negative-head-and-neck-squamous-cell-carcinoma","display_name":"HPV-negative head and neck squamous cell carcinoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8769999742507935},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8519999980926514},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8600000143051147},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8938000202178955},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6930000185966492},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6851999759674072},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.6396999955177307},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5307000279426575},{"id":"https://openalex.org/C3019926457","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Distant metastasis","level":4,"score":0.48420000076293945},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.4810999929904938},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4203000068664551},{"id":"https://openalex.org/C2778162587","wikidata":"https://www.wikidata.org/wiki/Q6664621","display_name":"Localized disease","level":4,"score":0.38190001249313354},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3799000084400177},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.30979999899864197},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3089999854564667},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.28349998593330383},{"id":"https://openalex.org/C2779081379","wikidata":"https://www.wikidata.org/wiki/Q7852677","display_name":"Tumor hypoxia","level":3,"score":0.275299996137619},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27300000190734863},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.2678999900817871},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2587999999523163},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2565000057220459},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.30709470","doi":"https://doi.org/10.1158/1078-0432.30709470","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709470","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S4_from_DNA-Methylome_Based_Tumor_Hypoxia_Classifier_Identifies_HPV-Negative_Head_and_Neck_Cancer_Patients_at_Risk_for_Locoregional_Recurrence_after_Primary_Radiochemotherapy/30709470/1/files/59834292.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30709470","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_S4_from_DNA-Methylome_Based_Tumor_Hypoxia_Classifier_Identifies_HPV-Negative_Head_and_Neck_Cancer_Patients_at_Risk_for_Locoregional_Recurrence_after_Primary_Radiochemotherapy/30709470","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.30709470","doi":"https://doi.org/10.1158/1078-0432.30709470","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709470","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S4_from_DNA-Methylome_Based_Tumor_Hypoxia_Classifier_Identifies_HPV-Negative_Head_and_Neck_Cancer_Patients_at_Risk_for_Locoregional_Recurrence_after_Primary_Radiochemotherapy/30709470/1/files/59834292.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4416670634.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385838290","https://openalex.org/W4402797069","https://openalex.org/W4365479058"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"4":[2],"(Top).":[3],"CD8":[4],"T":[5],"cell":[6,40],"enrichment":[7],"is":[8],"prognostic":[9],"for":[10,22,38,47,53,72],"Overall":[11],"Survival":[12],"(OS),":[13],"local":[14,48,73],"recurrence":[15,49,74],"(LR)":[16],"and":[17,52],"disease":[18,54],"progression":[19,55],"but":[20],"not":[21],"distant":[23],"metastasis":[24],"(DM)":[25],"in":[26,30],"HPV":[27],"negative":[28],"HNSCC":[29],"the":[31],"DKTK-ROG":[32],"cohort":[33],"(n=88).":[34],"(Bottom)":[35],"After":[36],"adjusting":[37],"Immune":[39],"Infiltration,":[41],"Hypoxia-M":[42],"remained":[43],"an":[44,69,77],"independent":[45,70],"prognosticator":[46,71],"(HR=3.06,":[50],"p<0.01)":[51],"(HR=2.14,":[56],"p<0.04)":[57],"with":[58],"a":[59],"trend":[60],"towards":[61],"worsened":[62],"OS":[63],"(HR=1.92,":[64],"p<0.09).":[65],"CD8-IHC":[66],"staining":[67],"was":[68],"(HR=0.41,":[75],"p<0.03)":[76]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-25T00:00:00"}