{"id":"https://openalex.org/W4416640807","doi":"https://doi.org/10.1016/j.redox.2025.103942","title":"TRPA1 activation prompts lysosome-mediated Nrf2 degradation enhancing the killing of colorectal cancer cells","display_name":"TRPA1 activation prompts lysosome-mediated Nrf2 degradation enhancing the killing of colorectal cancer cells","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416640807","doi":"https://doi.org/10.1016/j.redox.2025.103942","pmid":"https://pubmed.ncbi.nlm.nih.gov/41330216"},"language":"en","primary_location":{"id":"doi:10.1016/j.redox.2025.103942","doi":"https://doi.org/10.1016/j.redox.2025.103942","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2025.103942","pdf_url":null,"source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.redox.2025.103942","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080401169","display_name":"Najmeh Eskandari","orcid":"https://orcid.org/0000-0002-4031-7649","observed_orcids":["https://orcid.org/0000-0002-4031-7649"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Najmeh Eskandari","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061981477","display_name":"Davide Delisi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davide Delisi","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080240014","display_name":"Maedeh Vakili Saatloo","orcid":"https://orcid.org/0000-0002-3724-7520","observed_orcids":["https://orcid.org/0000-0002-3724-7520"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maedeh Vakili Saatloo","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States; Department of Periodontology, Henry M. Goldman School of Dental Medicine, Boston University, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States; Department of Periodontology, Henry M. Goldman School of Dental Medicine, Boston University, MA, United States","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058924500","display_name":"Gizem Keceli","orcid":"https://orcid.org/0000-0002-9562-7994","observed_orcids":["https://orcid.org/0000-0002-9562-7994"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gizem Keceli","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Johns Hopkins University, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Johns Hopkins University, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016723441","display_name":"Nathalia Pinheiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathalia Pinheiro","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032927381","display_name":"Scott T. Eblen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Eblen","raw_affiliation_strings":["Department of Pharmacology and Immunology, Medical University of South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Immunology, Medical University of South Carolina, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010660115","display_name":"Nazareno Paolocci","orcid":"https://orcid.org/0000-0001-7011-997X","observed_orcids":["https://orcid.org/0000-0001-7011-997X"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Nazareno Paolocci","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Johns Hopkins University, United States; Dipartimento di Scienze Biomediche, Universita' di Padova, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Johns Hopkins University, United States; Dipartimento di Scienze Biomediche, Universita' di Padova, United States","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102350379","display_name":"Saverio Gentile","orcid":"https://orcid.org/0009-0001-3870-3305","observed_orcids":["https://orcid.org/0009-0001-3870-3305"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saverio Gentile","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States. Electronic address: gentilsa@musc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Medical University of South Carolina, United States. Electronic address: gentilsa@musc.edu","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5102350379"],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":{"value":4310,"currency":"USD","value_usd":4310},"apc_paid":{"value":4310,"currency":"USD","value_usd":4310},"fwci":1.0225,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.75498627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"88","issue":null,"first_page":"103942","last_page":"103942"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpa1","display_name":"TRPA1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nrf2-degradation","display_name":"Nrf2 degradation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":0.9010000228881836},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.4830000102519989},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7490000128746033},{"id":"https://openalex.org/keywords/oxaliplatin-sensitivity","display_name":"oxaliplatin sensitivity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8339999914169312},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6389999985694885},{"id":"https://openalex.org/keywords/bioelectric-signaling","display_name":"bioelectric signaling","score":0.5289999842643738},{"id":"https://openalex.org/keywords/lamp2a","display_name":"LAMP2A","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6783000230789185},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6395000219345093},{"id":"https://openalex.org/C2776529522","wikidata":"https://www.wikidata.org/wiki/Q18034700","display_name":"KEAP1","level":4,"score":0.6141999959945679},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.5620999932289124},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5375000238418579},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5333999991416931},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5059000253677368},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4837000072002411},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4765999913215637},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.46399998664855957},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4253000020980835},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4156999886035919},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4154999852180481},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4101000130176544},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4041999876499176},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.3937999904155731},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.39079999923706055},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.38029998540878296},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3686999976634979},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3269999921321869},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32659998536109924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32420000433921814},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C132647116","wikidata":"https://www.wikidata.org/wiki/Q18032677","display_name":"TFEB","level":4,"score":0.3163999915122986},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.2976999878883362},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2540000081062317},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.redox.2025.103942","doi":"https://doi.org/10.1016/j.redox.2025.103942","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2025.103942","pdf_url":null,"source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},{"id":"pmid:41330216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41330216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:823e13e1526a4c44aa317ebdf3491fab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/823e13e1526a4c44aa317ebdf3491fab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biology, Vol 88, Iss , Pp 103942- (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12719038","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12719038/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.redox.2025.103942","doi":"https://doi.org/10.1016/j.redox.2025.103942","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2025.103942","pdf_url":null,"source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W775311174","https://openalex.org/W1881061730","https://openalex.org/W1980255492","https://openalex.org/W1992724001","https://openalex.org/W2015021076","https://openalex.org/W2030749349","https://openalex.org/W2035676834","https://openalex.org/W2038612772","https://openalex.org/W2118394016","https://openalex.org/W2145718930","https://openalex.org/W2146356730","https://openalex.org/W2606513998","https://openalex.org/W2804011812","https://openalex.org/W2882137215","https://openalex.org/W2899445806","https://openalex.org/W2901265038","https://openalex.org/W2903214769","https://openalex.org/W2967282709","https://openalex.org/W2971999469","https://openalex.org/W3015784228","https://openalex.org/W3041426930","https://openalex.org/W3124146154","https://openalex.org/W3129563346","https://openalex.org/W3133766872","https://openalex.org/W3137644993","https://openalex.org/W3141412661","https://openalex.org/W3170902207","https://openalex.org/W4224316217","https://openalex.org/W4319222006","https://openalex.org/W4367183442","https://openalex.org/W4376643848","https://openalex.org/W4378716506","https://openalex.org/W4382796544","https://openalex.org/W4385609595","https://openalex.org/W4388071131","https://openalex.org/W4403144085","https://openalex.org/W4405184801","https://openalex.org/W4406618943","https://openalex.org/W4408579775","https://openalex.org/W4409378894","https://openalex.org/W4410831090","https://openalex.org/W4412070625"],"related_works":[],"abstract_inverted_index":{".":[0],"Redox":[1],"homeostasis":[2,85],"is":[3,25,37],"crucial":[4],"for":[5,130,262],"cancer":[6,92],"cell":[7,98,223],"survival":[8],"and":[9,22,47,86,104,115,124,153,193,218,254],"resistance":[10],"to":[11,30,148,170,184,208,236],"therapy.":[12],"The":[13,54],"transcription":[14],"factor":[15],"NRF2,":[16,186],"a":[17,138,154,177,228,258],"master":[18],"regulator":[19],"of":[20,74,247],"antioxidant":[21],"metabolic":[23],"genes,":[24],"often":[26],"upregulated":[27],"in":[28,50,90,131,239],"tumors":[29],"mitigate":[31],"oxidative":[32,65,163,252],"stress.":[33],"Although":[34],"NRF2":[35,52,88,116,237,248],"stability":[36],"canonically":[38],"governed":[39],"by":[40,56,80,143],"KEAP1\u2013CUL3\u2013proteasome":[41],"degradation,":[42],"emerging":[43],"evidence":[44],"implicates":[45],"lysosomal":[46,122,197],"autophagic":[48],"pathways":[49,60],"non-canonical":[51,229],"turnover.":[53],"mechanisms":[55],"which":[57],"these":[58],"alternative":[59],"are":[61],"engaged":[62],"during":[63],"chronic":[64],"signaling":[66],"remain":[67],"unclear.":[68],"We":[69],"investigated":[70],"whether":[71],"sustained":[72,251],"activation":[73,136,204],"the":[75,245],"redox-sensitive":[76],"ion":[77],"channel":[78],"TRPA1":[79,135,203,234,256],"cannabidiol":[81],"(CBD)":[82],"disrupts":[83],"redox":[84],"promotes":[87],"degradation":[89,172],"colorectal":[91,240],"models.":[93],"Using":[94],"five":[95],"independent":[96],"CRC":[97,206],"lines":[99],"(RKO,":[100],"HCT116,":[101],"HT29,":[102],"SW480,":[103],"MC38),":[105],"we":[106],"assessed":[107],"reactive":[108],"oxygen":[109],"species":[110],"(ROS),":[111],"mitochondrial":[112,149,160],"function,":[113],"autophagy,":[114],"protein":[117],"dynamics":[118],"through":[119],"biochemical":[120],"assays,":[121],"fractionation,":[123],"imaging.":[125],"Xenograft":[126],"models":[127],"were":[128,216],"used":[129],"vivo":[132],"validation.":[133],"Chronic":[134],"induced":[137],"biphasic":[139],"ROS":[140,156],"response,":[141],"characterized":[142],"an":[144],"early":[145],"increase":[146],"linked":[147],"Ca":[150],"2+":[151],"influx":[152],"delayed":[155],"surge":[157],"associated":[158],"with":[159,196],"dysfunction.":[161],"This":[162,242],"trajectory":[164],"initially":[165],"stabilized":[166],"but":[167],"subsequently":[168],"led":[169],"its":[171,191],"after":[173],"24":[174],"hours":[175],"via":[176],"KEAP1-independent,":[178],"autophagy\u2013lysosome":[179],"pathway.":[180],"Proteasome":[181],"inhibition":[182],"failed":[183],"rescue":[185],"whereas":[187],"bafilomycin":[188],"A1":[189],"restored":[190],"levels":[192],"blocked":[194],"co-localization":[195],"markers":[198],"(e.g.,":[199],"LAMP2A).":[200],"Importantly,":[201],"CBD-induced":[202],"sensitized":[205],"cells":[207],"oxaliplatin,":[209],"triggering":[210],"apoptotic\u2014not":[211],"senescent\u2014cell":[212],"death.":[213],"These":[214],"effects":[215],"dose-dependent":[217],"consistent":[219],"across":[220],"all":[221],"tested":[222],"lines.":[224],"Our":[225],"findings":[226],"reveal":[227],"bioelectric\u2013lysosomal":[230],"axis":[231],"that":[232],"links":[233],"activity":[235],"destabilization":[238],"cancer.":[241],"work":[243],"expands":[244],"understanding":[246],"proteostasis":[249],"under":[250],"stress":[253],"highlights":[255],"as":[257],"tractable":[259],"redox-modulating":[260],"target":[261],"overcoming":[263],"chemoresistance.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-11-25T00:00:00"}
