{"id":"https://openalex.org/W4416640301","doi":"https://doi.org/10.1016/j.jacadv.2025.102370","title":"Sex Differences in the Clinical Recognition of Significant Aortic Stenosis","display_name":"Sex Differences in the Clinical Recognition of Significant Aortic Stenosis","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416640301","doi":"https://doi.org/10.1016/j.jacadv.2025.102370","pmid":"https://pubmed.ncbi.nlm.nih.gov/41447283"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacadv.2025.102370","doi":"https://doi.org/10.1016/j.jacadv.2025.102370","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacadv.2025.102370","pdf_url":null,"source":{"id":"https://openalex.org/S4220651314","display_name":"JACC Advances","issn_l":"2772-963X","issn":["2772-963X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jacadv.2025.102370","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029838858","display_name":"Daniela R. Crousillat","orcid":"https://orcid.org/0000-0001-8403-2445","observed_orcids":["https://orcid.org/0000-0001-8403-2445"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniela Crousillat","raw_affiliation_strings":["Division of Cardiovascular Science, Department of Medicine and Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa General Heart and Vascular Institute, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Science, Department of Medicine and Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa General Heart and Vascular Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007255799","display_name":"Dayana Shariff","orcid":"https://orcid.org/0009-0000-7691-8502","observed_orcids":["https://orcid.org/0009-0000-7691-8502"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dayana Shariff","raw_affiliation_strings":["University of California, San Francisco School of Medicine, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco School of Medicine, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064429889","display_name":"Rong Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Duan","raw_affiliation_strings":["Division of Cardiology, University of California, San Francisco School of Medicine, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of California, San Francisco School of Medicine, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058791450","display_name":"Varsha Keelara Tanguturi","orcid":"https://orcid.org/0000-0002-7437-182X","observed_orcids":["https://orcid.org/0000-0002-7437-182X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varsha Tanguturi","raw_affiliation_strings":["Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048045955","display_name":"Sammy Elmariah","orcid":"https://orcid.org/0000-0002-8013-8733","observed_orcids":["https://orcid.org/0000-0002-8013-8733"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sammy Elmariah","raw_affiliation_strings":["Division of Cardiology, University of California, San Francisco School of Medicine, San Francisco, California, USA. Electronic address: Sammy.elmariah@ucsf.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of California, San Francisco School of Medicine, San Francisco, California, USA. Electronic address: Sammy.elmariah@ucsf.edu","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007255799","https://openalex.org/A5029838858","https://openalex.org/A5048045955"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I2613432","https://openalex.org/I4210110664"],"apc_list":{"value":2936,"currency":"USD","value_usd":2936},"apc_paid":{"value":2936,"currency":"USD","value_usd":2936},"fwci":3.2428,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.93296067,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"4","issue":"12","first_page":"102370","last_page":"102370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9470000267028809},{"id":"https://openalex.org/keywords/clinical-recognition","display_name":"clinical recognition","score":0.6230000257492065},{"id":"https://openalex.org/keywords/transthoracic-echocardiography","display_name":"transthoracic echocardiography","score":0.9160000085830688},{"id":"https://openalex.org/keywords/low-gradient-aortic-stenosis","display_name":"low-gradient aortic stenosis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/aortic-valve-replacement","display_name":"aortic valve replacement","score":0.7889999747276306},{"id":"https://openalex.org/keywords/sex-disparities","display_name":"sex disparities","score":0.5870000123977661},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8190000057220459},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6779999732971191},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6442999839782715},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5838000178337097},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4641000032424927},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3255000114440918},{"id":"https://openalex.org/C2781414266","wikidata":"https://www.wikidata.org/wiki/Q531019","display_name":"Aortic valve stenosis","level":3,"score":0.3183000087738037},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23770000040531158}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jacadv.2025.102370","doi":"https://doi.org/10.1016/j.jacadv.2025.102370","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacadv.2025.102370","pdf_url":null,"source":{"id":"https://openalex.org/S4220651314","display_name":"JACC Advances","issn_l":"2772-963X","issn":["2772-963X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Advances","raw_type":"journal-article"},{"id":"pmid:41447283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41447283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC. Advances","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b0bd52135a5c41e6bfb9bc9c782658b1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b0bd52135a5c41e6bfb9bc9c782658b1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC: Advances, Vol 4, Iss 12, Pp 102370- (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12686702","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12686702/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jacadv.2025.102370","doi":"https://doi.org/10.1016/j.jacadv.2025.102370","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacadv.2025.102370","pdf_url":null,"source":{"id":"https://openalex.org/S4220651314","display_name":"JACC Advances","issn_l":"2772-963X","issn":["2772-963X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/10","score":0.7578999996185303,"display_name":"Reduced inequalities"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1357828253","display_name":null,"funder_award_id":"R01HL151838","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W71708631","https://openalex.org/W1605103485","https://openalex.org/W2087018232","https://openalex.org/W2096466407","https://openalex.org/W2316603865","https://openalex.org/W2338558028","https://openalex.org/W2756716095","https://openalex.org/W2770408899","https://openalex.org/W2900683034","https://openalex.org/W2972012128","https://openalex.org/W3021366268","https://openalex.org/W3114861573","https://openalex.org/W3115258265","https://openalex.org/W3164794198","https://openalex.org/W3179788925","https://openalex.org/W3189007768","https://openalex.org/W4214711178","https://openalex.org/W4280496521","https://openalex.org/W4283698404","https://openalex.org/W4293368074","https://openalex.org/W4307788283","https://openalex.org/W4311441990","https://openalex.org/W4312093621","https://openalex.org/W4381331160","https://openalex.org/W4385294736","https://openalex.org/W4396695951","https://openalex.org/W4410411615"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Women":[1],"with":[2,21,125,140,160,174],"significant":[3,40],"aortic":[4,12],"stenosis":[5],"(AS)":[6],"are":[7,211,227],"under-represented":[8],"among":[9,158],"patients":[10,110,159],"undergoing":[11],"valve":[13],"replacement":[14],"in":[15,242],"the":[16,31,36,86,115,231],"United":[17],"States":[18],"as":[19,138,172],"compared":[20,139,173],"men":[22,141],"despite":[23],"similar":[24],"disease":[25,219],"prevalence.":[26],"OBJECTIVES:":[27],"This":[28],"study":[29],"evaluated":[30],"impact":[32],"of":[33,39,59,62,67,90,104,118,147,184,187,202,205,234],"sex":[34,240],"on":[35],"clinical":[37,60,119,145,185,203,232],"recognition":[38,120,186,204,233],"AS":[41,63,75,91,95,98,129,148,191,206,218,223,236],"following":[42,76,121,207],"diagnostic":[43,78,123,209],"transthoracic":[44],"echocardiogram":[45],"(TTE).":[46],"METHODS:":[47],"Using":[48],"data":[49],"from":[50],"a":[51,77,122,144,208],"large":[52],"administrative":[53],"multicenter":[54],"database,":[55],"we":[56],"assessed":[57],"rates":[58,183],"diagnosis":[61,92,146,171,243],"defined":[64],"by":[65,93,181,216],"assignment":[66],"an":[68,169],"Internal":[69],"Classification":[70],"Diagnosis":[71],"(ICD)":[72],"code":[73],"for":[74,101],"TTE.":[79],"Fine-Gray":[80],"models":[81],"were":[82,135,164],"used":[83],"to":[84,142,167,229,238],"evaluate":[85],"1-year":[87,116],"cumulative":[88],"rate":[89,117],"sex,":[94,217],"severity,":[96,220],"and":[97,133,213,221,237,244],"phenotype":[99],"accounting":[100],"competing":[102],"risk":[103],"death.":[105],"RESULTS:":[106],"Among":[107],"2,036":[108],"included":[109],"(48.9%":[111],"female,":[112],"51.1%":[113],"male),":[114],"TTE":[124,210],"at":[126],"least":[127],"moderate":[128],"was":[130],"low":[131,189],"(52.4%),":[132],"women":[134,163],"less":[136,165],"likely":[137,166],"receive":[143,168],"(55.7%":[149],"male":[150,193],"vs":[151,177,194],"48.9%":[152],"female;":[153,196],"P":[154,197],"=":[155,198],"0.003).":[156],"Specifically,":[157],"severe":[161,188,222],"AS,":[162],"ICD":[170],"males":[175],"(64.1%":[176],"74.3%),":[178],"driven":[179],"primarily":[180],"lower":[182],"gradient":[190],"(66.9%":[192],"54.3%":[195],"0.004).":[199],"CONCLUSIONS:":[200],"Rates":[201],"low,":[212],"vary":[214],"significantly":[215],"phenotype.":[224],"Further":[225],"studies":[226],"needed":[228],"maximize":[230],"TTE-confirmed":[235],"mitigate":[239],"disparities":[241],"treatment.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-11-25T00:00:00"}
