{"id":"https://openalex.org/W4416638937","doi":"https://doi.org/10.1183/13993003.congress-2025.pa917","title":"Pulmonary hypertension targeted therapies in patients with operable chronic thromboembolic pulmonary hypertension: USA referral center analysis","display_name":"Pulmonary hypertension targeted therapies in patients with operable chronic thromboembolic pulmonary hypertension: USA referral center analysis","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416638937","doi":"https://doi.org/10.1183/13993003.congress-2025.pa917"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa917","doi":"https://doi.org/10.1183/13993003.congress-2025.pa917","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa917","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary hypertension","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Barbara Teixeira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095157","display_name":"Unidade Local de Sa\u00fade de S\u00e3o Jos\u00e9","ror":"https://ror.org/00k6r3f30","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210095157"]},{"id":"https://openalex.org/I4210097124","display_name":"Hospital de S\u00e3o Jos\u00e9","ror":"https://ror.org/00zc7y345","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210095157","https://openalex.org/I4210097124"]},{"id":"https://openalex.org/I4210146236","display_name":"Hospital de Santa Marta","ror":"https://ror.org/05cvd2j85","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210095157","https://openalex.org/I4210146236"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Barbara Teixeira","raw_affiliation_strings":["1Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar Universit\u00e1rio de Lisboa Central, Unidade Local de Sa\u00fade de S\u00e3o Jos\u00e9, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar Universit\u00e1rio de Lisboa Central, Unidade Local de Sa\u00fade de S\u00e3o Jos\u00e9, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210095157","https://openalex.org/I4210097124","https://openalex.org/I4210146236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024218721","display_name":"Jenny Z. Yang","orcid":"https://orcid.org/0000-0002-4844-8715","observed_orcids":["https://orcid.org/0000-0002-4844-8715"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Z. Yang","raw_affiliation_strings":["2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073571554","display_name":"Mona Alotaibi","orcid":"https://orcid.org/0000-0001-8492-9930","observed_orcids":["https://orcid.org/0000-0001-8492-9930"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona Alotaibi","raw_affiliation_strings":["2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085541294","display_name":"Demosthenes G. Papamatheakis","orcid":"https://orcid.org/0000-0001-8956-2357","observed_orcids":["https://orcid.org/0000-0001-8956-2357"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Demosthenes G. Papamatheakis","raw_affiliation_strings":["2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002582833","display_name":"David S. Poch","orcid":"https://orcid.org/0000-0002-7669-3662","observed_orcids":["https://orcid.org/0000-0002-7669-3662"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Poch","raw_affiliation_strings":["2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022955601","display_name":"Timothy M. Fernandes","orcid":"https://orcid.org/0000-0001-9319-4200","observed_orcids":["https://orcid.org/0000-0001-9319-4200"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy M. Fernandes","raw_affiliation_strings":["2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085642665","display_name":"Kim M. Kerr","orcid":"https://orcid.org/0000-0002-8193-8097","observed_orcids":["https://orcid.org/0000-0002-8193-8097"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim M. Kerr","raw_affiliation_strings":["2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103477146","display_name":"Angela P. Bautista","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Bautista","raw_affiliation_strings":["2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008149142","display_name":"Victor Gert Pretorius","orcid":"https://orcid.org/0000-0001-6360-4002","observed_orcids":["https://orcid.org/0000-0001-6360-4002"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor G. Pretorius","raw_affiliation_strings":["3Division of Cardiovascular and Thoracic Surgery, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Cardiovascular and Thoracic Surgery, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063915907","display_name":"Michael M. Madani","orcid":"https://orcid.org/0000-0001-8056-8007","observed_orcids":["https://orcid.org/0000-0001-8056-8007"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Madani","raw_affiliation_strings":["3Division of Cardiovascular and Thoracic Surgery, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Cardiovascular and Thoracic Surgery, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004518217","display_name":"Nick H. Kim","orcid":"https://orcid.org/0000-0003-4702-650X","observed_orcids":["https://orcid.org/0000-0003-4702-650X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nick H. Kim","raw_affiliation_strings":["2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA917","last_page":"PA917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-thromboembolic-pulmonary-hypertension","display_name":"chronic thromboembolic pulmonary hypertension","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pulmonary-endarterectomy","display_name":"pulmonary endarterectomy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bridging-therapy","display_name":"bridging therapy","score":0.6470000147819519},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8759999871253967},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9623000025749207},{"id":"https://openalex.org/C2777428986","wikidata":"https://www.wikidata.org/wiki/Q1958249","display_name":"Chronic thromboembolic pulmonary hypertension","level":3,"score":0.6674000024795532},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.6323000192642212},{"id":"https://openalex.org/C2779916996","wikidata":"https://www.wikidata.org/wiki/Q56324884","display_name":"Pulmonary thromboendarterectomy","level":4,"score":0.6312000155448914},{"id":"https://openalex.org/C2776135927","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Referral","level":2,"score":0.5370000004768372},{"id":"https://openalex.org/C2776304953","wikidata":"https://www.wikidata.org/wiki/Q2154494","display_name":"Riociguat","level":4,"score":0.4853000044822693},{"id":"https://openalex.org/C2776265017","wikidata":"https://www.wikidata.org/wiki/Q220570","display_name":"Pulmonary embolism","level":2,"score":0.47519999742507935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.426800012588501},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.40549999475479126},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3977999985218048},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3912999927997589},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36160001158714294},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.3212999999523163},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.2921000123023987},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2773999869823456},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C2992931291","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Patient referral","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C3019035139","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Thromboembolic disease","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa917","doi":"https://doi.org/10.1183/13993003.congress-2025.pa917","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa917","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary hypertension","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037902031","https://openalex.org/W2184900533","https://openalex.org/W4396500813","https://openalex.org/W7163884852","https://openalex.org/W4403812845","https://openalex.org/W4416102509","https://openalex.org/W4221053444","https://openalex.org/W2761796241","https://openalex.org/W3028424550","https://openalex.org/W7139990665"],"abstract_inverted_index":{"Rationale:":[0],"Data":[1],"on":[2,38,181],"bridging":[3],"medical":[4],"therapy":[5,97,202],"prior":[6],"to":[7,34,197],"pulmonary":[8,23],"thromboendarterectomy":[9],"(PTE)":[10],"are":[11],"limited.":[12],"Recent":[13],"CTEPH":[14,45],"treatment":[15],"guidelines":[16],"do":[17],"not":[18],"address":[19],"the":[20,36,39,58,80,111,118,123,125,136,147],"topic":[21],"of":[22,41,64,94,105,110,127,158,200],"hypertension":[24],"(PH)":[25],"targeted":[26,96],"therapies":[27,43,130,164,184],"for":[28,203],"operable":[29,204],"cases.":[30],"This":[31],"analysis":[32,63],"aims":[33],"determine":[35],"prevalence":[37],"use":[40,93,126,199],"PH":[42,95,129,163,183,201],"in":[44,69,79,102,108,165],"patients":[46,66,76,159,179],"undergoing":[47,67],"PTE,":[48],"across":[49,146],"three":[50,112,167],"different":[51],"time":[52,113,139,168],"periods:":[53],"before,":[54],"during":[55,186],"and":[56,72,88,100,150,176],"after":[57],"COVID-19":[59],"pandemic.":[60],"Methods:":[61],"Retrospective":[62],"consecutive":[65],"PTE":[68,173],"2019,":[70,84],"2021":[71,87],"2023.":[73,91],"Results:":[74],"518":[75],"were":[77,144,174],"included":[78],"analysis:":[81],"188":[82],"from":[83,86,90],"162":[85],"168":[89],"The":[92],"was":[98,131],"prevalent":[99],"observed":[101],"over":[103],"half":[104],"operated":[106,178],"cases":[107],"each":[109],"periods.":[114,140,169],"In":[115,170],"2021,":[116,171],"representing":[117],"period":[119],"most":[120],"impacted":[121],"by":[122],"pandemic,":[124],"combination":[128,182],"higher":[132],"(19.1%,":[133],"p=0.004)":[134],"than":[135,185],"other":[137],"two":[138],"No":[141],"major":[142],"differences":[143],"noted":[145],"baseline":[148],"characteristics":[149],"overall":[151],"in-hospital":[152],"mortality":[153],"(1.9%,":[154],"p=0.289).":[155],"Conclusion:":[156],"Majority":[157],"presented":[160,180],"treated":[161],"with":[162],"all":[166],"fewer":[172],"performed":[175],"more":[177],"either":[187],"pre-":[188],"or":[189],"post-pandemic":[190],"years.":[191],"Whether":[192],"pandemic":[193],"related":[194],"delays":[195],"contributed":[196],"increase":[198],"disease":[205],"is":[206],"unclear.":[207],"erj;66/suppl_69/PA917/F1":[208],"F1":[209,210]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}