{"id":"https://openalex.org/W4416638893","doi":"https://doi.org/10.1183/13993003.congress-2025.pa759","title":"Automatic bronchus artery and mucus plug analysis of adult bronchiectasis disease patients treated with dornase alfa","display_name":"Automatic bronchus artery and mucus plug analysis of adult bronchiectasis disease patients treated with dornase alfa","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416638893","doi":"https://doi.org/10.1183/13993003.congress-2025.pa759"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa759","doi":"https://doi.org/10.1183/13993003.congress-2025.pa759","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa759","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory infections and bronchiectasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035692787","display_name":"F. Mollica","orcid":"https://orcid.org/0000-0001-8417-9201","observed_orcids":["https://orcid.org/0000-0001-8417-9201"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Federico Mollica","raw_affiliation_strings":["1Erasmus MC \u2013 Sophia Children\u2019s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Erasmus MC \u2013 Sophia Children\u2019s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072543674","display_name":"Christina M. Mingora","orcid":"https://orcid.org/0000-0001-9369-8505","observed_orcids":["https://orcid.org/0000-0001-9369-8505"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Mingora","raw_affiliation_strings":["2Medical University of South Carolina, Charleston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medical University of South Carolina, Charleston, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029954459","display_name":"Caroline Brailsford","orcid":"https://orcid.org/0000-0003-3320-7596","observed_orcids":["https://orcid.org/0000-0003-3320-7596"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Brailsford","raw_affiliation_strings":["2Medical University of South Carolina, Charleston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medical University of South Carolina, Charleston, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095944514","display_name":"Punitkumar Makani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Punit Makani","raw_affiliation_strings":["1Erasmus MC \u2013 Sophia Children\u2019s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Erasmus MC \u2013 Sophia Children\u2019s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079863825","display_name":"Daan Caudri","orcid":"https://orcid.org/0000-0002-8191-8598","observed_orcids":["https://orcid.org/0000-0002-8191-8598"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Daan Caudri","raw_affiliation_strings":["1Erasmus MC \u2013 Sophia Children\u2019s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Erasmus MC \u2013 Sophia Children\u2019s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112534903","display_name":"Harm A.M.W. Tiddens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harm Tiddens","raw_affiliation_strings":["3Thirona B.V, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Thirona B.V, Nijmegen, Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005915390","display_name":"Patrick A. Flume","orcid":"https://orcid.org/0000-0002-1560-6879","observed_orcids":["https://orcid.org/0000-0002-1560-6879"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Flume","raw_affiliation_strings":["2Medical University of South Carolina, Charleston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medical University of South Carolina, Charleston, United States","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA759","last_page":"PA759"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bronchiectasis","display_name":"bronchiectasis","score":1.0},{"id":"https://openalex.org/keywords/dornase-alfa","display_name":"dornase alfa","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mucus-plugs","display_name":"mucus plugs","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bronchial-wall-thickness","display_name":"bronchial wall thickness","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mucolytic-therapy","display_name":"mucolytic therapy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9162999987602234},{"id":"https://openalex.org/C2779379686","wikidata":"https://www.wikidata.org/wiki/Q32778","display_name":"Bronchiectasis","level":3,"score":0.7353000044822693},{"id":"https://openalex.org/C2780314925","wikidata":"https://www.wikidata.org/wiki/Q181602","display_name":"Bronchus","level":4,"score":0.6948000192642212},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5669000148773193},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5169000029563904},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.4325000047683716},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.36739999055862427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3458999991416931},{"id":"https://openalex.org/C2911171335","wikidata":"https://www.wikidata.org/wiki/Q181602","display_name":"Main Bronchus","level":5,"score":0.3142000138759613},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.3012999892234802},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2928999960422516},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2888999879360199},{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C2909399824","wikidata":"https://www.wikidata.org/wiki/Q181602","display_name":"Right Main Bronchus","level":5,"score":0.2815000116825104},{"id":"https://openalex.org/C2780977465","wikidata":"https://www.wikidata.org/wiki/Q927103","display_name":"Bronchial artery","level":3,"score":0.2549000084400177},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.2542000114917755},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.2542000114917755},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa759","doi":"https://doi.org/10.1183/13993003.congress-2025.pa759","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa759","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory infections and bronchiectasis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4413961235","https://openalex.org/W4404103357","https://openalex.org/W4401756610","https://openalex.org/W2045572299","https://openalex.org/W7161542389","https://openalex.org/W4416638060","https://openalex.org/W2024929417","https://openalex.org/W4404103749","https://openalex.org/W2113774097","https://openalex.org/W2906650821"],"abstract_inverted_index":{"Introduction:":[0],"In":[1],"this":[2,245],"retrospective":[3,246],"study":[4,248],"we":[5],"analysed":[6],"CTs":[7,155,176,215],"of":[8,47,118,124,138,236,258],"bronchiectasis":[9],"(BE)":[10],"disease":[11,56],"patients":[12,42,57,202],"to":[13,26,112,254],"assess":[14,113,255],"changes":[15],"in":[16,24,40,244],"mucus":[17],"plugs":[18],"(MP)":[19],"and":[20,49,64,81,85,89,91,98,116,128,134,136,167,172,183,189,192,213,218,220,224,228,233,238,240],"bronchus":[21,79],"artery":[22],"(BA)-dimensions":[23],"response":[25],"inhaled":[27],"dornase":[28,37],"alfa":[29,38],"started":[30],"for":[31,73,105,130,216,221,261],"clinical":[32],"reasons.":[33],"We":[34,120],"hypothesized":[35],"that":[36],"treatment":[39,212],"BE":[41,55,262],"would":[43],"reduce":[44],"the":[45,76,93,114,122,210,256],"number":[46,115,137,223],"MP":[48,182,185,191,194,222,229,241],"bronchial":[50],"wall":[51,101],"thickness":[52],"(Bwt).":[53],"Methods:":[54],"who":[58],"had":[59],"one":[60,65],"CT":[61,66],"before":[62],"start":[63],"while":[67],"on":[68,170,173,187,196,211],"DNase":[69],"therapy.":[70],"LungQ-BA":[71,164,227],"measures":[72],"each":[74,106],"BA-pair":[75],"following":[77],"diameters:":[78],"outer":[80,103],"inner":[82],"diameter":[83],"(Bout":[84],"Bin),":[86],"arterial":[87],"diameter(A),":[88],"Bwt":[90],"computes":[92],"ratios:":[94],"Bout/A,":[95,125],"Bin/A,":[96,126],"Bwt/A":[97,127],"Bwa/Boa":[99,129],"(bronchus":[100],"area/bronchus":[102],"area)":[104],"segmental":[107,131],"generation.":[108],"LungQ-MP":[109,179],"was":[110,204],"used":[111],"volume":[117,135,186,195],"MP.":[119,139],"compared":[121],"median":[123],"generations":[132],"G1-6":[133],"Results":[140],"shown":[141],"are":[142],"mean[SD].":[143],"Results:":[144],"7":[145],"adults":[146],"(all":[147],"females,":[148],"age":[149],"75[10]":[150],"years)":[151],"with":[152],"two":[153],"timepoint":[154],"(median":[156],"1":[157],"month;":[158],"range":[159],"1-2":[160],"months)":[161],"were":[162],"selected.":[163],"detected":[165,180],"165[93]":[166],"131[66]":[168],"BA-pairs":[169],"baseline":[171,188,214],"follow":[174,197],"up":[175,198],"from":[177],"G1-6.":[178],"28.3[36.6]":[181],"2.1ml[3.2]":[184],"22.3[23.4]":[190],"1.2ml[1.3]":[193],"CTs.":[199],"For":[200],"all":[201],"there":[203],"no":[205],"statistically":[206],"significant":[207],"differences":[208],"between":[209],"BA-dimensions":[217,237],"ratios":[219,239],"volume.":[225],"Conclusions:":[226],"analysis":[230],"allowed":[231],"sensitive":[232],"accurate":[234],"monitoring":[235],"over":[242],"time":[243],"observational":[247],"which":[249],"could":[250],"play":[251],"a":[252],"role":[253],"efficacy":[257],"mucolytic":[259],"treatments":[260],"patients.":[263]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-11-25T00:00:00"}