{"id":"https://openalex.org/W4416638186","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1387","title":"Modelling the impact of earlier biologic initiation in severe asthma patients","display_name":"Modelling the impact of earlier biologic initiation in severe asthma patients","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416638186","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1387"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa1387","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1387","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1387","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074335927","display_name":"Simon Couillard","orcid":"https://orcid.org/0000-0002-4057-6886","observed_orcids":["https://orcid.org/0000-0002-4057-6886"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Simon Couillard","raw_affiliation_strings":["1Universit\u00e9 de Sherbrooke, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 de Sherbrooke, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020629887","display_name":"Njira Lucia Lugogo","orcid":"https://orcid.org/0000-0002-0235-7105","observed_orcids":["https://orcid.org/0000-0002-0235-7105"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Njira Lugogo","raw_affiliation_strings":["2University of Michigan, Ann Arbor, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038207068","display_name":"Tonya A. Winders","orcid":"https://orcid.org/0000-0001-7689-6438","observed_orcids":["https://orcid.org/0000-0001-7689-6438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tonya Winders","raw_affiliation_strings":["3Global Allergy Asthma Patient Platform (GAAPP), Vienna, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Global Allergy Asthma Patient Platform (GAAPP), Vienna, VA, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012347750","display_name":"Mohit Bhutani","orcid":"https://orcid.org/0000-0002-1911-4169","observed_orcids":["https://orcid.org/0000-0002-1911-4169"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mohit Bhutani","raw_affiliation_strings":["4University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071870974","display_name":"Laurel Bates","orcid":"https://orcid.org/0000-0003-0142-4975","observed_orcids":["https://orcid.org/0000-0003-0142-4975"]},"institutions":[{"id":"https://openalex.org/I4210146586","display_name":"Aquarius Population Health","ror":"https://ror.org/050h08n21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210146586"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laurel Bates","raw_affiliation_strings":["5Aquarius Population Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Aquarius Population Health, London, United Kingdom","institution_ids":["https://openalex.org/I4210146586"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Erik Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146586","display_name":"Aquarius Population Health","ror":"https://ror.org/050h08n21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210146586"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Erik Robinson","raw_affiliation_strings":["5Aquarius Population Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Aquarius Population Health, London, United Kingdom","institution_ids":["https://openalex.org/I4210146586"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alison Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alison Evans","raw_affiliation_strings":["6Global Policy & Advocacy, Global Corporate Affairs, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Global Policy & Advocacy, Global Corporate Affairs, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062561971","display_name":"Soram Patel","orcid":"https://orcid.org/0009-0009-1388-4339","observed_orcids":["https://orcid.org/0009-0009-1388-4339"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Soram Patel","raw_affiliation_strings":["7Medical Execution, Global Biopharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Medical Execution, Global Biopharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060904655","display_name":"Danny Gibson","orcid":"https://orcid.org/0009-0004-5979-1756","observed_orcids":["https://orcid.org/0009-0004-5979-1756"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Danny Gibson","raw_affiliation_strings":["8Health Economics & Payor Evidence, Respiratory & Immunology, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Health Economics & Payor Evidence, Respiratory & Immunology, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052175038","display_name":"David Brendan Price","orcid":"https://orcid.org/0000-0002-9728-9992","observed_orcids":["https://orcid.org/0000-0002-9728-9992","https://orcid.org/0000-0002-1195-039X"]},"institutions":[{"id":"https://openalex.org/I4210118135","display_name":"Observational & Pragmatic Research Institute","ror":"https://ror.org/02gq3ch54","country_code":"SG","type":"other","lineage":["https://openalex.org/I4210118135"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"David Price","raw_affiliation_strings":["9Observational and Pragmatic Research Institute, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Observational and Pragmatic Research Institute, Singapore, Singapore","institution_ids":["https://openalex.org/I4210118135"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1387","last_page":"PA1387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/early-treatment-initiation","display_name":"early treatment initiation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/oral-corticosteroid-use","display_name":"oral corticosteroid use","score":0.8930000066757202},{"id":"https://openalex.org/keywords/corticosteroid-side-effects","display_name":"corticosteroid adverse effects","score":0.9020000100135803},{"id":"https://openalex.org/keywords/asthma-mortality","display_name":"asthma mortality","score":0.7350000143051147},{"id":"https://openalex.org/keywords/health-care-utilization","display_name":"health care utilization","score":0.8029999732971191},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.9319999814033508},{"id":"https://openalex.org/keywords/economic-impact","display_name":"economic impact","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9532999992370605},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6969000101089478},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6585999727249146},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6190999746322632},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47519999742507935},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46299999952316284},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.44519999623298645},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4447000026702881},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3792000114917755},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.3749000132083893},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C64332521","wikidata":"https://www.wikidata.org/wiki/Q614165","display_name":"Quality-adjusted life year","level":3,"score":0.27720001339912415},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2653000056743622},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C2911221801","wikidata":"https://www.wikidata.org/wiki/Q2742406","display_name":"Biologic Agents","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C2982889124","wikidata":"https://www.wikidata.org/wiki/Q107439039","display_name":"Disease management","level":4,"score":0.25369998812675476},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.2535000145435333}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa1387","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1387","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1387","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410274621","https://openalex.org/W4313168699","https://openalex.org/W7133681197","https://openalex.org/W4379877876","https://openalex.org/W4404098170","https://openalex.org/W7212015544","https://openalex.org/W4416639815","https://openalex.org/W4225707832","https://openalex.org/W4404100978","https://openalex.org/W4409839248"],"abstract_inverted_index":{"Introduction:":[0],"Many":[1],"patients":[2,93,146,201,226],"with":[3,41,140,203,227],"severe":[4,144,162,199,228],"asthma":[5,145,163,200,229],"experience":[6],"uncontrolled":[7],"disease":[8,46],"and":[9,26,32,48,56,66,70,109,130,175,182,193,208,219,234],"use":[10],"high":[11],"cumulative":[12],"oral":[13],"corticosteroid":[14],"(OCS)":[15],"doses.":[16],"Biologic":[17,123],"therapy":[18,43,142,205],"has":[19],"been":[20],"shown":[21],"to":[22,191],"reduce":[23,235],"patients'":[24],"exacerbations":[25,65,192],"OCS":[27,67,155],"use,":[28],"reducing":[29,215],"OCS-attributable":[30],"mortality":[31,207],"healthcare":[33,115,188,236],"resource":[34],"utilisation":[35],"(HCRU).":[36],"We":[37,98],"suspect":[38],"earlier":[39,75,84,150,202,223],"intervention":[40,139],"biologic":[42,78,85,141,204],"could":[44],"minimise":[45],"progression":[47],"prevent":[49],"key":[50],"OCS\u2013related":[51],"adverse":[52,68,195],"events,":[53],"improving":[54],"clinical":[55,63],"economic":[57,71],"outcomes.":[58],"Aims:":[59],"To":[60],"explore":[61],"the":[62,131],"(mortality,":[64],"events)":[69],"(HCRU)":[72],"impact":[73,82],"of":[74,77,83,133,160,211],"initiation":[76,86],"treatments.":[79],"Methods:":[80],"The":[81],"against":[87],"typical":[88],"care":[89],"was":[90,135],"assessed":[91],"for":[92,225],"treated":[94],"at":[95],"age":[96],"50.":[97],"developed":[99],"a":[100,113,119,128,158],"cost-consequence":[101],"Markov":[102],"cohort":[103,159],"model,":[104],"informed":[105],"by":[106],"real-world":[107],"studies":[108],"expert":[110],"opinion,":[111],"taking":[112],"UK":[114],"system":[116],"perspective":[117],"over":[118],"lifetime":[120],"time":[121],"horizon.":[122],"therapies":[124],"were":[125],"modelled":[126],"as":[127],"class,":[129],"cost":[132],"biologics":[134],"excluded.":[136],"Results:":[137],"Earlier":[138],"in":[143,152,167,186,217],"only":[147],"5":[148],"years":[149],"resulted":[151,166],"1.91g":[153],"less":[154],"use.":[156],"For":[157],"54,121":[161],"patients,":[164],"this":[165],"1,975":[168],"fewer":[169,172],"deaths,":[170],"157,700":[171],"GP,":[173],"ED":[174],"hospital":[176],"visits,":[177],"18,000":[178],"quality-adjusted":[179],"life-years":[180],"gained":[181],"saved":[183],"\u00a3336":[184],"million":[185],"direct":[187],"costs":[189],"attributable":[190],"OCS-related":[194],"events.":[196],"Conclusion:":[197],"Treating":[198],"reduces":[206],"improves":[209],"quality":[210],"life":[212],"while":[213],"simultaneously":[214],"HCRU":[216],"primary":[218],"secondary":[220],"care.":[221],"Implementing":[222],"treatment":[224],"would":[230],"benefit":[231],"patient":[232],"outcomes":[233],"costs.":[237],"Study":[238],"Funding":[239],"AstraZeneca":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}
