{"id":"https://openalex.org/W4416637701","doi":"https://doi.org/10.1183/13993003.congress-2025.pa3599","title":"Efficacy of ivy leaf dry extract EA575 in an acute inflammation animal model","display_name":"Efficacy of ivy leaf dry extract EA575 in an acute inflammation animal model","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416637701","doi":"https://doi.org/10.1183/13993003.congress-2025.pa3599"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa3599","doi":"https://doi.org/10.1183/13993003.congress-2025.pa3599","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa3599","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080681056","display_name":"Matthias Hufnagel","orcid":"https://orcid.org/0000-0002-6982-4820","observed_orcids":["https://orcid.org/0000-0002-6982-4820"]},"institutions":[{"id":"https://openalex.org/I4210112949","display_name":"Engelhard Arzneimittel (Germany)","ror":"https://ror.org/01yac3k46","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210112949"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Hufnagel","raw_affiliation_strings":["1Engelhard Arzneimittel GmbH & Co. KG, Niederdorfelden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Engelhard Arzneimittel GmbH & Co. KG, Niederdorfelden, Germany","institution_ids":["https://openalex.org/I4210112949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120517668","display_name":"Natalia Machajewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112949","display_name":"Engelhard Arzneimittel (Germany)","ror":"https://ror.org/01yac3k46","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210112949"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Natalia Machajewski","raw_affiliation_strings":["1Engelhard Arzneimittel GmbH & Co. KG, Niederdorfelden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Engelhard Arzneimittel GmbH & Co. KG, Niederdorfelden, Germany","institution_ids":["https://openalex.org/I4210112949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106645502","display_name":"Andr\u00e9 Rademaekers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112949","display_name":"Engelhard Arzneimittel (Germany)","ror":"https://ror.org/01yac3k46","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210112949"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Rademaekers","raw_affiliation_strings":["1Engelhard Arzneimittel GmbH & Co. KG, Niederdorfelden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Engelhard Arzneimittel GmbH & Co. KG, Niederdorfelden, Germany","institution_ids":["https://openalex.org/I4210112949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110042557","display_name":"Hanns H\u00e4berlein","orcid":"https://orcid.org/0000-0001-5595-5144","observed_orcids":["https://orcid.org/0000-0001-5595-5144"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanns H\u00e4berlein","raw_affiliation_strings":["2Institute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056165657","display_name":"Sebastian Franken","orcid":"https://orcid.org/0000-0003-4844-6389","observed_orcids":["https://orcid.org/0000-0003-4844-6389"]},"institutions":[{"id":"https://openalex.org/I155417937","display_name":"Hochschule Bonn-Rhein-Sieg","ror":"https://ror.org/04m2anh63","country_code":"DE","type":"education","lineage":["https://openalex.org/I155417937"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Franken","raw_affiliation_strings":["3Institute for Functional Gene Analytics, Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, Rheinbach, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Institute for Functional Gene Analytics, Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, Rheinbach, Germany","institution_ids":["https://openalex.org/I155417937"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA3599","last_page":"PA3599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.2809999883174896,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.2809999883174896,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.27950000762939453,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.17710000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bleomycin-induced-lung-injury","display_name":"bleomycin-induced lung injury","score":0.8640000224113464},{"id":"https://openalex.org/keywords/acute-lung-inflammation","display_name":"acute lung inflammation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/goblet-cell-metaplasia","display_name":"goblet cell metaplasia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mucus-production","display_name":"mucus production","score":0.9350000023841858},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/neutrophil-and-macrophage-infiltration","display_name":"neutrophil and macrophage infiltration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/respiratory-tract-inflammation","display_name":"respiratory inflammation","score":0.3779999911785126},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C2775941134","wikidata":"https://www.wikidata.org/wiki/Q813622","display_name":"Goblet cell","level":3,"score":0.840499997138977},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7714999914169312},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.6876999735832214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6445000171661377},{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.6313999891281128},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.6173999905586243},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5730999708175659},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5647000074386597},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5598000288009644},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.541100025177002},{"id":"https://openalex.org/C18823058","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cytology","level":2,"score":0.4456999897956848},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.44209998846054077},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.41850000619888306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38420000672340393},{"id":"https://openalex.org/C2778981785","wikidata":"https://www.wikidata.org/wiki/Q7581956","display_name":"Squamous metaplasia","level":3,"score":0.3716000020503998},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3684999942779541},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.32269999384880066},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25609999895095825},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.2547999918460846},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.2506999969482422},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa3599","doi":"https://doi.org/10.1183/13993003.congress-2025.pa3599","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa3599","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"},{"id":"pmh:oai:pub.h-brs.de:9431","doi":null,"is_oa":false,"landing_page_url":"https://pub.h-brs.de/frontdoor/index/index/docId/9431","pdf_url":null,"source":{"id":"https://openalex.org/S4306400385","display_name":"Publication Server of Bonn-Rhein-Sieg University of Applied Sciences (Bonn-Rhein-Sieg University of Applied Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135140700","host_organization_name":"University of Bonn","host_organization_lineage":["https://openalex.org/I135140700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal 2025 66(suppl 69): PA3599","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7133619443","https://openalex.org/W4414079121","https://openalex.org/W7213109803","https://openalex.org/W2799349558","https://openalex.org/W7001938910","https://openalex.org/W2465006501","https://openalex.org/W2883625566","https://openalex.org/W3021726529","https://openalex.org/W3208904748","https://openalex.org/W7140051497"],"abstract_inverted_index":{"In":[0],"vitro":[1],"mode":[2],"of":[3,5,35,41,153,183],"action":[4],"ivy":[6],"leaf":[7],"dry":[8],"extract":[9],"EA575":[10,36,46,94,154,176],"is":[11,28,205],"well":[12],"documented,":[13],"but":[14],"so":[15],"far":[16],"in":[17,37,79,105,121,155,181],"vivo":[18],"data":[19],"to":[20],"extrapolate":[21],"cellular":[22],"mechanisms":[23],"into":[24],"a":[25,38],"physiological":[26],"context":[27],"scarce.":[29],"This":[30],"study":[31,71],"evaluated":[32],"anti-inflammatory":[33],"effects":[34],"mouse":[39],"model":[40],"bleomycin-induced":[42],"acute":[43,157],"lung":[44,109],"inflammation.":[45],"was":[47,91,136,219],"administered":[48],"twice":[49],"daily":[50],"by":[51,161,168,216],"oral":[52],"gavage":[53],"for":[54,212],"3":[55,112,128,140,198],"or":[56],"7":[57,114,142],"days":[58],"(d)":[59],"with":[60],"21.5,":[61],"107.6,":[62],"and":[63,74,84,103,108,164],"215.25":[64],"mg/kg":[65],"bw/d":[66],"following":[67],"bleomycin":[68,184],"challenge.":[69],"Upon":[70],"termination,":[72],"cytology":[73],"cytokine":[75],"levels":[76,117],"were":[77,123],"analyzed":[78],"bronchoalveolar":[80],"lavage":[81],"fluid":[82],"(BALF)":[83],"histopathology":[85],"incl.":[86],"goblet":[87,169,178],"cell":[88,98,132,179],"metaplasia":[89,133,180],"assessment":[90],"carried":[92],"out.":[93],"treatment":[95],"reduced":[96,125,145],"inflammatory":[97],"influx,":[99],"namely":[100],"neutrophils,":[101],"lymphocytes,":[102],"macrophages,":[104],"both":[106],"BALF":[107,122],"tissue":[110],"after":[111,139],"&":[113,129,141],"d.":[115],"Cytokine":[116],"(e.g.,":[118],"IL-6,":[119],"TNF-\u03b1)":[120],"dose-dependently":[124,138],"at":[126],"day":[127],"7.":[130],"Goblet":[131],"pathology":[134],"score":[135],"decreased":[137],"d,":[143],"suggesting":[144],"mucus":[146,166],"production.":[147],"The":[148],"results":[149],"highlight":[150],"the":[151],"benefits":[152],"treating":[156],"inflammation-related":[158],"respiratory":[159],"diseases":[160],"reducing":[162],"inflammation":[163],"excessive":[165],"production":[167],"cells.":[170],"erj;66/suppl_69/PA3599/F1":[171],"F1":[172,173],"Figure":[174],"1:":[175],"reduces":[177],"lungs":[182],"(BLM)-challenged":[185],"mice.":[186],"Pathology":[187],"score:":[188],"0":[189],"\u2013":[190,193,196,199,202],"absent,":[191],"1":[192],"minimal,":[194],"2":[195],"mild,":[197],"moderate,":[200],"4":[201],"severe.":[203],"Data":[204],"shown":[206],"as":[207],"mean":[208],"\u00b1":[209],"SD":[210],"(n=5-8),":[211],"statistics":[213],"ANOVA":[214],"followed":[215],"Dunnett\u2019s":[217],"test":[218],"applied":[220],"(*":[221],"p\u22640.05,":[222],"**":[223],"p\u22640.01,":[224],"***":[225],"p":[226],"\u22640.001).":[227]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-11-25T00:00:00"}