{"id":"https://openalex.org/W4416637078","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5133","title":"Epigentics in Pulmonary Sarcoidosis Inflammatoy Phenotype","display_name":"Epigentics in Pulmonary Sarcoidosis Inflammatoy Phenotype","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416637078","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5133"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa5133","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5133","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa5133","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sarcoidosis and other granulomatous ILD/DPLD","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.qub.ac.uk/en/publications/631b421e-da05-4e7a-b6e3-8b0918f142c4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120379256","display_name":"Rachel Snoddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32375777","display_name":"Northern Health and Social Care Trust","ror":"https://ror.org/01bgbk171","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I32375777"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rachel Snoddy","raw_affiliation_strings":["1Northern HSC Trust, Antrim, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Northern HSC Trust, Antrim, United Kingdom","institution_ids":["https://openalex.org/I32375777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007830810","display_name":"Mark A. Watson","orcid":"https://orcid.org/0000-0002-3935-9980","observed_orcids":["https://orcid.org/0000-0002-3935-9980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Watson","raw_affiliation_strings":["2C-TRIC, Antrim, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2C-TRIC, Antrim, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120613324","display_name":"Rebekah Gilpin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32375777","display_name":"Northern Health and Social Care Trust","ror":"https://ror.org/01bgbk171","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I32375777"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebekah Gilpin","raw_affiliation_strings":["1Northern HSC Trust, Antrim, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Northern HSC Trust, Antrim, United Kingdom","institution_ids":["https://openalex.org/I32375777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114518070","display_name":"P Logue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32375777","display_name":"Northern Health and Social Care Trust","ror":"https://ror.org/01bgbk171","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I32375777"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip Logue","raw_affiliation_strings":["1Northern HSC Trust, Antrim, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Northern HSC Trust, Antrim, United Kingdom","institution_ids":["https://openalex.org/I32375777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072432214","display_name":"Dermot A. Linden","orcid":"https://orcid.org/0000-0003-0552-1115","observed_orcids":["https://orcid.org/0000-0003-0552-1115"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dermot Linden","raw_affiliation_strings":["3QUB, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3QUB, Belfast, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046600444","display_name":"Paul Minnis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32375777","display_name":"Northern Health and Social Care Trust","ror":"https://ror.org/01bgbk171","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I32375777"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Minnis","raw_affiliation_strings":["1Northern HSC Trust, Antrim, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Northern HSC Trust, Antrim, United Kingdom","institution_ids":["https://openalex.org/I32375777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA5133","last_page":"PA5133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-sarcoidosis","display_name":"pulmonary sarcoidosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.968999981880188},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/differentially-methylated-genes","display_name":"differentially methylated genes","score":0.8510000109672546},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/neutrophil-degranulation","display_name":"neutrophil degranulation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.7960000038146973},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6888999938964844},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6777999997138977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6679999828338623},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6047999858856201},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6035000085830688},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6017000079154968},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5569000244140625},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5454999804496765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4875999987125397},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.4781000018119812},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44929999113082886},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4392000138759613},{"id":"https://openalex.org/C2781301800","wikidata":"https://www.wikidata.org/wiki/Q193894","display_name":"Sarcoidosis","level":2,"score":0.35499998927116394},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34610000252723694},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3100000023841858},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.2987000048160553},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.29760000109672546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27799999713897705},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25440001487731934}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa5133","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5133","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa5133","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sarcoidosis and other granulomatous ILD/DPLD","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/631b421e-da05-4e7a-b6e3-8b0918f142c4","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/631b421e-da05-4e7a-b6e3-8b0918f142c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Snoddy, R, Watson, M, Gilpin, R, Logue, P, Linden, D & Minnis, P 2025, 'Epigentics in pulmonary sarcoidosis inflammatory phenotype', European Respiratory Journal, vol. 66, no. suppl 69, pp. PA5133. https://doi.org/10.1183/13993003.congress-2025.PA5133","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/631b421e-da05-4e7a-b6e3-8b0918f142c4","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/631b421e-da05-4e7a-b6e3-8b0918f142c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Snoddy, R, Watson, M, Gilpin, R, Logue, P, Linden, D & Minnis, P 2025, 'Epigentics in pulmonary sarcoidosis inflammatory phenotype', European Respiratory Journal, vol. 66, no. suppl 69, pp. PA5133. https://doi.org/10.1183/13993003.congress-2025.PA5133","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Aim:":[0],"Epigenetic":[1],"modifications":[2],"are":[3,214],"emerging":[4],"as":[5,116],"important":[6],"in":[7,16,57,119,126,133,163,189,216],"regulating":[8],"immune":[9,203],"and":[10,178,192],"fibrotic":[11],"processes":[12],"through":[13],"gene":[14,129,136],"expression":[15],"lung":[17],"disease.":[18],"We":[19,60,84],"aim":[20],"to":[21,28,169,201],"assess":[22],"how":[23],"this":[24],"can":[25],"be":[26],"applied":[27],"sarcoidosis.":[29,220],"Methods:":[30],"79":[31],"patents":[32],"with":[33,88,158,184],"sarcoidosis":[34],"underwent":[35],"methylation":[36,125,132],"analysis":[37,49,155],"of":[38,40,65,75,166,212,219],"100ng":[39],"genomic":[41],"DNA":[42],"extracted":[43],"from":[44],"peripheral":[45],"white":[46],"blood":[47,76],"cells,":[48],"was":[50],"carried":[51],"out":[52],"using":[53],"the":[54,202,217],"methylkit":[55],"package":[56],"R.":[58],"Results:":[59],"stratified":[61],"patients":[62,79],"by":[63],"detection":[64],"systemic":[66],"inflammation":[67,127,134],"(ESR":[68],">20":[69],"or":[70,102,208],"CRP":[71],">7)":[72],"at":[73],"time":[74],"draw.":[77],"67":[78],"had":[80,97],"no":[81],"inflammatory":[82],"signal.":[83],"identified":[85,115],"120":[86],"targets":[87],"q":[89],"value":[90],">":[91,98],"0.05,":[92],"focusing":[93],"on":[94],"genes":[95,113,157,196],"which":[96,213],"5":[99],"log2":[100],"fold":[101,106],"<":[103],"-5":[104],"Log2":[105],"change.":[107],"erj;66/suppl_69/PA5133/F1":[108],"F1":[109,110],"The":[111],"following":[112],"were":[114,161,187],"differentially":[117],"methylated":[118],"inflammation.":[120],"erj;66/suppl_69/PA5133/TB1":[121],"T1":[122],"TB1":[123],"Increased":[124],"(reduced":[128],"expression)":[130,137],"Decreased":[131],"(increased":[135],"ADRA2A":[138],"PTPN":[139],"APC2":[140],"SFRP1":[141],"GHSR":[142],"SMDC2":[143],"ITGBL1":[144],"ADAMTS17":[145],"SHH":[146],"DUOXA1":[147],"PAX1":[148],"SLC19A1":[149],"PPL":[150],"SHISAL1":[151],"CPNE2":[152],"Conslusion":[153],"Pathway":[154],"indicated":[156],"reduced":[159],"activity":[160,186],"involved":[162,188],"a":[164],"range":[165],"functions":[167,198],"related":[168],"Sarcoidosis":[170],"including":[171],"adaptive":[172],"immunity,":[173],"interferon":[174],"signalling,":[175,191,210],"cell":[176,181,209],"migration,":[177],"regulation":[179],"T":[180],"immunity.":[182],"Genes":[183],"increased":[185],"Interleukin":[190],"neutrophil":[193],"degranulation.":[194],"These":[195],"have":[197],"directly":[199],"linked":[200],"system,":[204],"tissue":[205],"remodelling,":[206],"inflammation,":[207],"all":[211],"central":[215],"pathophysiology":[218]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2025-11-25T00:00:00"}
