{"id":"https://openalex.org/W4416636427","doi":"https://doi.org/10.1183/13993003.congress-2025.pa4720","title":"The relationship between atopy, IgE levels and response to tezepelumab in severe asthma","display_name":"The relationship between atopy, IgE levels and response to tezepelumab in severe asthma","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416636427","doi":"https://doi.org/10.1183/13993003.congress-2025.pa4720"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa4720","doi":"https://doi.org/10.1183/13993003.congress-2025.pa4720","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa4720","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and immunology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038995288","display_name":"Francesca Cefaloni","orcid":"https://orcid.org/0009-0004-6929-0912","observed_orcids":["https://orcid.org/0009-0004-6929-0912"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francesca Cefaloni","raw_affiliation_strings":["1School of Immunology & Microbial Sciences, King\u2019s College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Immunology & Microbial Sciences, King\u2019s College, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007393526","display_name":"Jessica Gates","orcid":"https://orcid.org/0000-0002-7777-0201","observed_orcids":["https://orcid.org/0000-0002-7777-0201"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jessica Gates","raw_affiliation_strings":["2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Faizan Haris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Faizan Haris","raw_affiliation_strings":["2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Filip Wilk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Filip Wilk","raw_affiliation_strings":["1School of Immunology & Microbial Sciences, King\u2019s College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Immunology & Microbial Sciences, King\u2019s College, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115092071","display_name":"Tanweer Kamaly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tanweer Kamaly","raw_affiliation_strings":["1School of Immunology & Microbial Sciences, King\u2019s College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Immunology & Microbial Sciences, King\u2019s College, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043579437","display_name":"Paniz Khooshemehri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paniz Khooshemehri","raw_affiliation_strings":["1School of Immunology & Microbial Sciences, King\u2019s College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Immunology & Microbial Sciences, King\u2019s College, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010059787","display_name":"Jaideep Dhariwal","orcid":"https://orcid.org/0000-0003-2352-5638","observed_orcids":["https://orcid.org/0000-0003-2352-5638"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jaideep Dhariwal","raw_affiliation_strings":["2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109486002","display_name":"Alexandra M. Nanzer","orcid":"https://orcid.org/0000-0002-7928-6317","observed_orcids":["https://orcid.org/0000-0002-7928-6317"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexandra M. Nanzer","raw_affiliation_strings":["2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200166805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073147866","display_name":"David J. Jackson","orcid":"https://orcid.org/0000-0002-2299-868X","observed_orcids":["https://orcid.org/0000-0002-2299-868X"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J Jackson","raw_affiliation_strings":["2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Guy\u2019s Severe Asthma Centre, Guy\u2019s & St Thomas\u2019 NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200166805"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA4720","last_page":"PA4720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tezepelumab","display_name":"tezepelumab","score":0.9900000095367432},{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/atopy","display_name":"atopy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/eosinophilic-asthma","display_name":"eosinophilic asthma","score":0.8190000057220459},{"id":"https://openalex.org/keywords/total-serum-ige","display_name":"total IgE","score":0.6349999904632568},{"id":"https://openalex.org/keywords/asthma-phenotypes","display_name":"asthma phenotypes","score":0.7080000042915344},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.5550000071525574},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.578000009059906},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8636999726295471},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.7250999808311462},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.6625999808311462},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6624000072479248},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5281000137329102},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.3490000069141388},{"id":"https://openalex.org/C2776953665","wikidata":"https://www.wikidata.org/wiki/Q4732121","display_name":"Allergic response","level":4,"score":0.3273000121116638},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.31839999556541443},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.30570000410079956},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2937000095844269},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2741999924182892},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C88675164","wikidata":"https://www.wikidata.org/wiki/Q22677314","display_name":"Eosinophil cationic protein","level":4,"score":0.2624000012874603}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa4720","doi":"https://doi.org/10.1183/13993003.congress-2025.pa4720","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa4720","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and immunology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7138918040","https://openalex.org/W4390232386","https://openalex.org/W4403979455","https://openalex.org/W4416105404","https://openalex.org/W4416635771","https://openalex.org/W4404046866","https://openalex.org/W4416105350","https://openalex.org/W4200568464","https://openalex.org/W4389429670","https://openalex.org/W4388410823"],"abstract_inverted_index":{"Introduction:":[0],"Tezepelumab":[1],"is":[2,47],"an":[3,59,147],"anti-TSLP":[4],"mAb":[5],"with":[6,75,126,129],"broad":[7],"downstream":[8],"anti-T2":[9],"effects":[10],"in":[11,114,133,154,179,186,220,226,239],"severe":[12],"asthma":[13],"(SA).":[14],"These":[15],"include":[16],"the":[17,62,95,222],"ability":[18],"to":[19,65,203,237],"reduce":[20],"IL-5,":[21],"IL-13":[22],"and":[23,37,90,143,164,170,229],"IgE":[24,116,195],"levels":[25,117,196],"making":[26],"it":[27],"equally":[28],"appropriate":[29],"as":[30,80,103],"a":[31,48,213],"therapeutic":[32],"option":[33],"for":[34],"both":[35],"atopic":[36,69,81,87,227],"eosinophilic":[38,71,82,85,228,231],"phenotypes":[39,72],"of":[40,61,73,97,108,120,156,159,162,166,192,217],"SA.":[41,76],"It":[42],"remains":[43],"unclear":[44],"whether":[45],"there":[46],"differential":[49],"clinical":[50,63,223],"response":[51,64,102],"based":[52,67],"on":[53,68],"these":[54],"phenotypes.":[55],"Methods:":[56],"We":[57,110],"conducted":[58],"analysis":[60,216],"tezepelumab":[66,130,218],"and/or":[70],"patients":[74,125,181,188,232],"Individuals":[77],"were":[78,131,141,173,182,233],"classified":[79],"(AE),":[83],"non-atopic":[84,91,230],"(NAE),":[86],"non-eosinophilic":[88,92,241],"(ANE)":[89],"(NANE).":[93],"For":[94],"purposes":[96],"this":[98,134],"analysis,":[99],"we":[100],"defined":[101],"becoming":[104],"exacerbation-free":[105,142,150],"following":[106,118],"initiation":[107,119,191],"tezepelumab.":[109,121],"additionally":[111],"analysed":[112],"change":[113],"serum":[115],"Results:":[122],"118":[123],"adult":[124],"SA":[127],"treated":[128],"included":[132],"analysis.":[135],"After":[136],"12-month":[137],"treatment":[138],"63":[139],"(53%)":[140],"61":[144],"(52%)":[145],"achieved":[146,153],"ACQ<1.5.":[148],"The":[149],"threshold":[151],"was":[152],"35%":[155],"AE,":[157],"32%":[158],"NAE,":[160],"25%":[161],"ANE":[163],"8%":[165],"NANE":[167],"patients.":[168,242],"EA":[169],"ENA":[171],"rates":[172,178],"statistically":[174],"comparable":[175,234],"(p=0.8),":[176],"however":[177],"NEA":[180],"significantly":[183,197],"greater":[184],"than":[185],"NENA":[187],"(p<0.001).":[189],"Following":[190],"tezepelumab,":[193],"total":[194],"decreased":[198],"from":[199],"205":[200],"kU/L":[201,205],"(641)":[202],"105":[204],"(353),":[206],"p<0.01":[207],"at":[208],"1":[209],"year.":[210],"Conclusions:":[211],"In":[212],"large":[214],"real-world":[215],"effectiveness":[219],"SA,":[221],"responses":[224],"observed":[225],"but":[235],"superior":[236],"those":[238],"non-atopic,":[240]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}
