{"id":"https://openalex.org/W4416636401","doi":"https://doi.org/10.1183/13993003.congress-2025.pa3171","title":"New insights into the neutrophilic phenotype from the NOVELTY study","display_name":"New insights into the neutrophilic phenotype from the NOVELTY study","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416636401","doi":"https://doi.org/10.1183/13993003.congress-2025.pa3171"},"language":null,"primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa3171","doi":"https://doi.org/10.1183/13993003.congress-2025.pa3171","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa3171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway cell biology and immunopathology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056342735","display_name":"Rosa Faner","orcid":"https://orcid.org/0000-0002-8159-0115","observed_orcids":["https://orcid.org/0000-0002-8159-0115"]},"institutions":[{"id":"https://openalex.org/I4210099160","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias","ror":"https://ror.org/0119pby33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210099160","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosa Faner","raw_affiliation_strings":["1Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and CIBER Enfermedades Respiratorias, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and CIBER Enfermedades Respiratorias, Barcelona, Spain","institution_ids":["https://openalex.org/I4210099160","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036257231","display_name":"Adnan Azim","orcid":"https://orcid.org/0000-0001-5960-1159","observed_orcids":["https://orcid.org/0000-0001-5960-1159"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adnan Azim","raw_affiliation_strings":["2Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006172437","display_name":"Neha Cheemalavagu","orcid":"https://orcid.org/0000-0002-5947-8864","observed_orcids":["https://orcid.org/0000-0002-5947-8864"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neha Cheemalavagu","raw_affiliation_strings":["3Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg MD, United States","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066132363","display_name":"Arun R. Jayaraman","orcid":"https://orcid.org/0000-0002-2398-9988","observed_orcids":["https://orcid.org/0000-0002-2398-9988"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun Jayaraman","raw_affiliation_strings":["3Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg MD, United States","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120790305","display_name":"Zhi Liu","orcid":"https://orcid.org/0000-0002-7261-5675","observed_orcids":["https://orcid.org/0000-0002-7261-5675"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi Liu","raw_affiliation_strings":["3Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg MD, United States","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039155418","display_name":"Greet De Baets","orcid":"https://orcid.org/0000-0001-8844-800X","observed_orcids":["https://orcid.org/0000-0001-8844-800X"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Greet De Baets","raw_affiliation_strings":["2Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079065702","display_name":"Adam Platt","orcid":"https://orcid.org/0000-0002-3455-1789","observed_orcids":["https://orcid.org/0000-0002-3455-1789"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam Platt","raw_affiliation_strings":["2Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008084743","display_name":"Gary P. Anderson","orcid":"https://orcid.org/0000-0001-6580-3398","observed_orcids":["https://orcid.org/0000-0001-6580-3398"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gary P Anderson","raw_affiliation_strings":["4Lung Health Research Centre, Dept Biochemistry and Pharmacology, University of Melbourne, Melbourne VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Lung Health Research Centre, Dept Biochemistry and Pharmacology, University of Melbourne, Melbourne VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103258710","display_name":"Rod Hughes","orcid":"https://orcid.org/0009-0006-1200-5580","observed_orcids":["https://orcid.org/0009-0006-1200-5580"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rod Hughes","raw_affiliation_strings":["5External Scientific Engagement, BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5External Scientific Engagement, BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023632504","display_name":"Hana M\u00fcllerov\u00e1","orcid":"https://orcid.org/0000-0002-0949-0101","observed_orcids":["https://orcid.org/0000-0002-0949-0101"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hana M\u00fcllerov\u00e1","raw_affiliation_strings":["6Respiratory & Immunology, Medical and Payer Evidence Strategy, BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Respiratory & Immunology, Medical and Payer Evidence Strategy, BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015290217","display_name":"Lisa \u00d6berg","orcid":"https://orcid.org/0000-0001-7127-1711","observed_orcids":["https://orcid.org/0000-0001-7127-1711"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lisa \u00d6berg","raw_affiliation_strings":["7Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011926591","display_name":"Helen Kathryn Reddel","orcid":"https://orcid.org/0000-0002-6695-6350","observed_orcids":["https://orcid.org/0000-0002-6695-6350"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800858616","display_name":"Woolcock Institute of Medical Research","ror":"https://ror.org/04hy0x592","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2799732068","https://openalex.org/I2800858616","https://openalex.org/I99043593"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Helen K Reddel","raw_affiliation_strings":["8The Woolcock Institute of Medical Research and Macquarie University, and The University of Sydney, Sydney NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8The Woolcock Institute of Medical Research and Macquarie University, and The University of Sydney, Sydney NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800858616","https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005408745","display_name":"Stephanie A. Christenson","orcid":"https://orcid.org/0000-0003-1550-2815","observed_orcids":["https://orcid.org/0000-0003-1550-2815"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Christenson","raw_affiliation_strings":["9The Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9The Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco CA, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000474513","display_name":"Maarten van den Berge","orcid":"https://orcid.org/0000-0002-9336-7340","observed_orcids":["https://orcid.org/0000-0002-9336-7340"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maarten Van Den Berge","raw_affiliation_strings":["10Department of Pulmonary Diseases, Medical Center Groningen, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Pulmonary Diseases, Medical Center Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093133721","display_name":"For The Novelty Scientific Community And The","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"- For The Novelty Scientific Community And The","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA3171","last_page":"PA3171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.07150000333786011,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophilic-inflammation","display_name":"neutrophilic inflammation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7670000195503235},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/asthma-copd-overlap","display_name":"asthma-COPD overlap","score":0.8169999718666077},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.7400000095367432},{"id":"https://openalex.org/keywords/neutrophil-count","display_name":"neutrophil count","score":0.8109999895095825},{"id":"https://openalex.org/keywords/neutrophil-degranulation","display_name":"neutrophil degranulation","score":0.984000027179718},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9929999709129333},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":1.0},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9990000128746033},{"id":"https://openalex.org/keywords/viral-proteins","display_name":"viral proteins","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6661999821662903},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6654000282287598},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6215000152587891},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5239999890327454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5216000080108643},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4657000005245209},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42250001430511475},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.3939000070095062},{"id":"https://openalex.org/C2778738651","wikidata":"https://www.wikidata.org/wiki/Q16546687","display_name":"Novelty","level":2,"score":0.3937999904155731},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.35659998655319214},{"id":"https://openalex.org/C2988731192","wikidata":"https://www.wikidata.org/wiki/Q7410159","display_name":"Blood sampling","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.31690001487731934},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3131999969482422},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2669999897480011},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.2623000144958496},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.2621000111103058},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.2558000087738037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa3171","doi":"https://doi.org/10.1183/13993003.congress-2025.pa3171","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa3171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway cell biology and immunopathology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Neutrophilic":[1,172],"phenotypes":[2],"have":[3],"been":[4],"described":[5],"in":[6,9,34,42],"asthma":[7,99,140,192],"and":[8,18,30,40,105,111,119,134,141,150,164,185,193],"chronic":[10],"obstructive":[11],"pulmonary":[12],"disease":[13,179],"(COPD),":[14],"but":[15],"their":[16,81],"similarities":[17],"differences":[19],"are":[20],"poorly":[21],"understood.":[22],"We":[23],"explored":[24],"associations":[25,128,144,160],"between":[26],"plasma":[27],"proteomic":[28],"signatures":[29],"blood":[31,84,122],"neutrophil":[32,123,130],"counts":[33],"patients":[35,97],"with":[36,83,98,121,129,145,161,183],"physician-diagnosed":[37],"asthma,":[38],"asthma+COPD":[39,102],"COPD":[41,106],"the":[43,70,151,189],"observational":[44],"NOVELTY":[45],"study":[46],"(":[47],"NCT02760329":[48],").":[49],"Methods:":[50],"Blood":[51],"samples":[52],"were":[53,67,115,154,167],"obtained":[54],"at":[55],"baseline":[56],"from":[57],"a":[58],"stratified":[59],"sample":[60],"of":[61,136,191],"consenting":[62],"patients.":[63],"Over":[64],"5000":[65],"proteins":[66,163],"measured":[68],"using":[69,86],"OLINK":[71],"Explore":[72],"HT":[73],"platform.":[74],"Regression":[75],"analysis":[76,91,126],"was":[77],"used":[78],"to":[79,139,156,169,175,177],"describe":[80],"association":[82],"neutrophils":[85],"fast":[87],"gene":[88],"set":[89],"enrichment":[90],"for":[92],"pathway":[93],"analysis.":[94],"Results:":[95],"In":[96,158],"(n=359":[100],"[42.0%]),":[101],"(n=179":[103],"[20.9%])":[104],"(n=317":[107],"[37.1%]),":[108],"372,":[109],"52":[110],"241":[112],"proteins,":[113],"respectively,":[114],"differentially":[116],"abundant":[117],"(Figure)":[118],"associated":[120,182],"counts.":[124],"Pathway":[125],"revealed":[127],"degranulation,":[131],"antimicrobial":[132],"peptides":[133],"activation":[135],"metalloproteinases":[137],"common":[138],"COPD,":[142],"whereas":[143],"tumour":[146],"necrosis":[147],"factor,":[148],"interleukin-17":[149],"renin\u2013angiotensin":[152],"system":[153],"unique":[155,168,186],"asthma.":[157],"contrast,":[159],"viral":[162],"cellular":[165],"metabolism":[166],"COPD.":[170,194],"Conclusions:":[171],"inflammation,":[173],"thought":[174],"contribute":[176],"airway":[178],"pathogenesis,":[180],"is":[181],"shared":[184],"biology":[187],"across":[188],"spectrum":[190],"erj;66/suppl_69/PA3171/F1":[195],"F1":[196,197]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-11-25T00:00:00"}